PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7164017-6 1982 H2O2 mimicked characteristically the impairment effects of L-amino acid oxidase and the venom. Hydrogen Peroxide 0-4 interleukin 4 induced 1 Homo sapiens 59-79 7164017-8 1982 It is concluded that hydrogen peroxide formed by the venom L-amino acid oxidase plays a role in affecting platelet aggregation and thus could contribute to the extended bleeding typical to persons bitten by E. colorata. Hydrogen Peroxide 21-38 interleukin 4 induced 1 Homo sapiens 59-79 30692577-6 2019 Cytotoxicity caused by LAAO was mediated by H2O2 and treated cells underwent autophagy, followed by apoptosis and necrosis. Hydrogen Peroxide 44-48 interleukin 4 induced 1 Homo sapiens 23-27 33646117-4 2021 Using mammalian expressed recombinant proteins, we found venom LAAO kills cells via hydrogen peroxide generation. Hydrogen Peroxide 84-101 interleukin 4 induced 1 Homo sapiens 63-67 32822860-3 2020 The determinant of potent antibacterial/antiparasitic activity is the H2O2 byproduct of LAO enzymatic activity that utilizes the l-amino acid as a substrate. Hydrogen Peroxide 70-74 interleukin 4 induced 1 Homo sapiens 88-91 32267491-5 2020 It is proposed that PLA2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA2 to produce reactive oxygen species during lipolysis and formation of H2O2 from LAAO catalytic activity which consequently lead to cell death. Hydrogen Peroxide 212-216 interleukin 4 induced 1 Homo sapiens 29-33 32267491-5 2020 It is proposed that PLA2 and LAAO contribute to an elevated oxidative stress due to their catalytic actions, for instance, the ability of PLA2 to produce reactive oxygen species during lipolysis and formation of H2O2 from LAAO catalytic activity which consequently lead to cell death. Hydrogen Peroxide 212-216 interleukin 4 induced 1 Homo sapiens 222-226 29738841-9 2018 In conclusion, our data suggest that CR-LAAO possesses higher binding affinity to HepG2 tumor cells than to PBMC, its genotoxic mechanism is possibly caused by the oxidative stress related to the production of H2O2, and is also capable of modulating genes related to the DNA repair system and antioxidant pathways. Hydrogen Peroxide 210-214 interleukin 4 induced 1 Homo sapiens 40-44 26812110-0 2016 CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide. Hydrogen Peroxide 82-99 interleukin 4 induced 1 Homo sapiens 3-7 29407871-3 2018 LAAO converts L-amino acid into alpha-keto acid and release ammonia and hydrogen peroxide as by-products. Hydrogen Peroxide 72-89 interleukin 4 induced 1 Homo sapiens 0-4 29407871-5 2018 Furthermore, L-amino acid oxidase has been shown to selectively bind to cell membranes of specific phospholipid composition and deliver the hydrogen peroxide to localized regions on the cell surface. Hydrogen Peroxide 140-157 interleukin 4 induced 1 Homo sapiens 13-33 28943466-5 2017 The damaging effect of LAAO appears to be due to its enzymatic activity, that produces hydrogen peroxide which can then induce oxidative stress within the cells. Hydrogen Peroxide 87-104 interleukin 4 induced 1 Homo sapiens 23-27 28943466-7 2017 Co-treatment with catalase significantly reduced the cytotoxic effect of Cmp-LAAO, thereby affirming that hydrogen peroxide is probably the main mediator of Cmp-LAAO cytotoxicity. Hydrogen Peroxide 106-123 interleukin 4 induced 1 Homo sapiens 77-81 28943466-7 2017 Co-treatment with catalase significantly reduced the cytotoxic effect of Cmp-LAAO, thereby affirming that hydrogen peroxide is probably the main mediator of Cmp-LAAO cytotoxicity. Hydrogen Peroxide 106-123 interleukin 4 induced 1 Homo sapiens 161-165 26812110-6 2016 The H2O2 produced during the enzymatic action of CR-LAAO mediated its cytotoxic effect. Hydrogen Peroxide 4-8 interleukin 4 induced 1 Homo sapiens 52-56 25778793-3 2015 Indeed, IL4I1 inhibits T-cell proliferation via hydrogen peroxide toxicity on effector/memory T cells. Hydrogen Peroxide 48-65 interleukin 4 induced 1 Homo sapiens 8-13 26655928-0 2015 Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-beta signal pathway. Hydrogen Peroxide 88-92 interleukin 4 induced 1 Homo sapiens 5-9 26655928-6 2015 The inhibition of Akbu-LAAO to HepG2 growth partially relied on enzymatic-released H2O2 as catalase only partially antagonized this effect. Hydrogen Peroxide 83-87 interleukin 4 induced 1 Homo sapiens 23-27 25778793-1 2015 IL4I1 (interleukin-4-induced gene 1) is a phenylalanine oxidase produced mainly by APCs of myeloid origin, and converts phenylalanine (Phe) to phenylpyruvate, hydrogen peroxide, and ammonia. Hydrogen Peroxide 159-176 interleukin 4 induced 1 Homo sapiens 0-5 26599209-2 2015 IL4I1 protein can inhibit T cell proliferation by releasing its enzymatic catabolite, H2O2, and this effect is associated with transient down-regulation of T cell CD3 receptor-zeta (TCRzeta) expression. Hydrogen Peroxide 86-90 interleukin 4 induced 1 Homo sapiens 0-5 25778793-1 2015 IL4I1 (interleukin-4-induced gene 1) is a phenylalanine oxidase produced mainly by APCs of myeloid origin, and converts phenylalanine (Phe) to phenylpyruvate, hydrogen peroxide, and ammonia. Hydrogen Peroxide 159-176 interleukin 4 induced 1 Homo sapiens 7-35 23355881-1 2013 L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H2O2 and ammonia. Hydrogen Peroxide 148-152 interleukin 4 induced 1 Homo sapiens 0-21 24376540-4 2013 By extracting the LAAO-generated H2O2 concentration, the LAAO activity can be quantitatively determined. Hydrogen Peroxide 33-37 interleukin 4 induced 1 Homo sapiens 18-22 24376540-4 2013 By extracting the LAAO-generated H2O2 concentration, the LAAO activity can be quantitatively determined. Hydrogen Peroxide 33-37 interleukin 4 induced 1 Homo sapiens 57-61 23355881-1 2013 L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H2O2 and ammonia. Hydrogen Peroxide 148-152 interleukin 4 induced 1 Homo sapiens 23-27 21539897-6 2011 Bl-LAAO catalyzes oxidative deamination of l-amino acids with the generation of H2O2. Hydrogen Peroxide 80-84 interleukin 4 induced 1 Homo sapiens 3-7 21539897-14 2011 CONCLUSION: Bl-LAAO, a major component of B. leucurus venom, is a cytotoxin acting primarily via the generation of high amounts of H2O2 which kill the cells. Hydrogen Peroxide 131-135 interleukin 4 induced 1 Homo sapiens 15-19 17356132-9 2007 hIL4I1 inhibitory effect was dependent on enzymatic activity and H(2)O(2) production and associated with a transient down-regulation of TCRzeta expression. Hydrogen Peroxide 65-73 interleukin 4 induced 1 Homo sapiens 0-6 18180850-5 2008 A low concentration of NA-LAAO greatly promoted the effect of hydrogen peroxide, whereas hydrogen peroxide itself had little activation effect on platelets. Hydrogen Peroxide 62-79 interleukin 4 induced 1 Homo sapiens 26-30 16770529-7 2006 Thus induction of cell death by LAAO appears to involve both the generation of H2O2 and the molecular interaction of the glycan moiety of the enzyme with structures at the cell surface. Hydrogen Peroxide 79-83 interleukin 4 induced 1 Homo sapiens 32-36 12818190-1 2003 One of haemorrhagic toxins present in snake venoms is L-amino acid oxidase (LAO), which catalyzes the oxidative deamination of L-amino acids with the generation of hydrogen peroxide. Hydrogen Peroxide 164-181 interleukin 4 induced 1 Homo sapiens 76-79 15498141-4 2004 LAO catalyzes H2O2 production by oxidizing some plasma membrane proteins of VEC, disintegrins interfere with binding of integrins with their ligands. Hydrogen Peroxide 14-18 interleukin 4 induced 1 Homo sapiens 0-3 9990127-1 1999 We have found that L-amino acid oxidase (LAO) induces apoptosis in several cultured cell lines by generating H2O2 [Suhr, S.M. Hydrogen Peroxide 109-113 interleukin 4 induced 1 Homo sapiens 19-39 11319613-2 2001 AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP. Hydrogen Peroxide 198-202 interleukin 4 induced 1 Homo sapiens 52-72 11319613-2 2001 AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP. Hydrogen Peroxide 198-202 interleukin 4 induced 1 Homo sapiens 74-77 11319613-2 2001 AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP. Hydrogen Peroxide 198-202 interleukin 4 induced 1 Homo sapiens 216-219 9990127-1 1999 We have found that L-amino acid oxidase (LAO) induces apoptosis in several cultured cell lines by generating H2O2 [Suhr, S.M. Hydrogen Peroxide 109-113 interleukin 4 induced 1 Homo sapiens 41-44 9990127-8 1999 It is demonstrated in the present work that the LAO-induced apoptotic mechanism is clearly distinguished from the one stimulated directly by exogenous H2O2. Hydrogen Peroxide 151-155 interleukin 4 induced 1 Homo sapiens 48-51 9990127-13 1999 Several lines of experimental evidence suggest that apoptotic cell death induced by LAO is not due solely to the hydrogen peroxide produced by the enzymatic reaction. Hydrogen Peroxide 113-130 interleukin 4 induced 1 Homo sapiens 84-87 34106313-3 2021 LAAO catalyzes the oxidative deamination of specific L-amino acids with the generation of hydrogen peroxide and L-amino acid metabolites. Hydrogen Peroxide 90-107 interleukin 4 induced 1 Homo sapiens 0-4 7886693-9 1994 These results suggest that L-amino acid oxidase induces human platelet aggregation through the formation of H2O2, and subsequent thromboxane A2 synthesis requiring Ca2+ but independent of ADP release. Hydrogen Peroxide 108-112 interleukin 4 induced 1 Homo sapiens 27-47 34941741-6 2021 Interestingly, when tested on human glioblastoma U87 cells, CC-LAAO induced a dose-dependent apoptotic effect through the H2O2 generated during the enzymatic reaction. Hydrogen Peroxide 122-126 interleukin 4 induced 1 Homo sapiens 63-67