PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21085594-3 2010 As an example, the p38 MAP kinase is activated by several stress-related stimuli that are often accompanied by in vitro generation of hydrogen peroxide. Hydrogen Peroxide 134-151 mitogen-activated protein kinase 14 Homo sapiens 19-22 21085594-4 2010 We noted that hydrogen peroxide inhibited p38 activity despite paradoxically increasing the activating phosphorylation of p38. Hydrogen Peroxide 14-31 mitogen-activated protein kinase 14 Homo sapiens 42-45 21085594-4 2010 We noted that hydrogen peroxide inhibited p38 activity despite paradoxically increasing the activating phosphorylation of p38. Hydrogen Peroxide 14-31 mitogen-activated protein kinase 14 Homo sapiens 122-125 21085594-6 2010 This procedure, PROP, demonstrated in vivo oxidation of p38 in response to hydrogen peroxide and also to the natural inflammatory lipid prostaglandin J2. Hydrogen Peroxide 75-92 mitogen-activated protein kinase 14 Homo sapiens 56-59 19497102-8 2009 We clarified the downstream pathways regulated by ROS after treatment with H2O2, which showed negative control between FRK and p38 kinase activities for uPA regulation. Hydrogen Peroxide 75-79 mitogen-activated protein kinase 14 Homo sapiens 127-130 20674765-6 2010 In COS-7 or HEK 293A cells treated with H(2)O(2), expression of PPEF2 abrogated sustained activation of p38 and one of the JNK p46 isoforms, and prevented ASK1-dependent caspase-3 cleavage and activation. Hydrogen Peroxide 40-48 mitogen-activated protein kinase 14 Homo sapiens 104-107 20599910-0 2010 Dihydrotestosterone protects human vascular endothelial cells from H(2)O(2)-induced apoptosis through inhibition of caspase-3, caspase-9 and p38 MAPK. Hydrogen Peroxide 67-75 mitogen-activated protein kinase 14 Homo sapiens 141-144 19482949-7 2009 TACE activation induced by hydrogen peroxide was dependent on p38 mitogen-activated protein kinase signalling, whereas protein kinase C, phosphoinositide 3-kinase, and caspases were not involved. Hydrogen Peroxide 27-44 mitogen-activated protein kinase 14 Homo sapiens 62-65 20806083-10 2010 Further studies showed that RES also inhibited H(2)O(2) induced p38 and JNK phosphorylation. Hydrogen Peroxide 47-55 mitogen-activated protein kinase 14 Homo sapiens 64-67 20039104-8 2010 In addition, H(2)O(2) treatment significantly induced p38 MAPK phosphorylation, NF-kappaB activation, NOS expression, and NO production. Hydrogen Peroxide 13-21 mitogen-activated protein kinase 14 Homo sapiens 54-57 19925863-3 2010 In contrast, in response to H2O2, C3G behaves as a pro-apoptotic molecule, as its knock-down or knock-out enhances survival through up-regulation of p38alpha activation, which plays an anti-apoptotic role under these conditions. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 14 Homo sapiens 149-157 19058221-8 2009 On the other hand, p38, which also intervenes in the up-regulation of PTN expression by low concentrations of HP, seems to act upstream of eNOS and does not intervene in the SNP-induced PTN expression and cell migration. Hydrogen Peroxide 110-112 mitogen-activated protein kinase 14 Homo sapiens 19-22 19108947-6 2009 Taken together, we concluded that high concentration of AA, through H(2)O(2), induces apoptosis of AGS cells by p38-MAPK-dependent upregulation of TfR. Hydrogen Peroxide 68-76 mitogen-activated protein kinase 14 Homo sapiens 112-115 18977016-7 2009 We observed increased phosphorylation of p38, a member of the MAP kinase family, following treatment with Fas L or H2O2. Hydrogen Peroxide 115-119 mitogen-activated protein kinase 14 Homo sapiens 41-44 18552392-11 2008 Pretreatment of cells with SB203580, an inhibitor for p38MAP kinase, reduced the H(2)O(2)- and TGF-beta2-stimulated Hsp27 expression, whereas pretreatment with PD98059 and U0126, specific inhibitors of ERK1/2, and SP600125, a specific c-Jun N-terminal kinase inhibitor, had no effects. Hydrogen Peroxide 81-89 mitogen-activated protein kinase 14 Homo sapiens 54-67 18681888-8 2008 These findings suggest that Hsp105alpha and Hsp105beta suppress H2O2-induced apoptosis by suppression of p38 MAPK signaling, one of the essential pathways for apoptosis. Hydrogen Peroxide 64-68 mitogen-activated protein kinase 14 Homo sapiens 105-108 18974961-13 2008 These results indicate that H(2)O(2) acts as an inducer of IL-8 secretion via activation of ERK, p38, and JNK in PDL cells. Hydrogen Peroxide 28-36 mitogen-activated protein kinase 14 Homo sapiens 97-100 18681888-0 2008 Mammalian 105 kDa heat shock family proteins suppress hydrogen peroxide-induced apoptosis through a p38 MAPK-dependent mitochondrial pathway in HeLa cells. Hydrogen Peroxide 54-71 mitogen-activated protein kinase 14 Homo sapiens 100-108 18681888-6 2008 Furthermore, both c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) were activated by treatment with H2O2, and the activation of both kinases was suppressed by overexpression of Hsp105alpha and Hsp105beta. Hydrogen Peroxide 133-137 mitogen-activated protein kinase 14 Homo sapiens 52-88 18634931-4 2008 Antioxidants and inhibitors of HO-1, phosphatidylinositol-3"-kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase blocked H2O2-induced cytotoxicity and the expression of HO-1 and DSPP mRNA in pulp cells. Hydrogen Peroxide 157-161 mitogen-activated protein kinase 14 Homo sapiens 112-115 18681888-6 2008 Furthermore, both c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) were activated by treatment with H2O2, and the activation of both kinases was suppressed by overexpression of Hsp105alpha and Hsp105beta. Hydrogen Peroxide 133-137 mitogen-activated protein kinase 14 Homo sapiens 90-98 18681888-7 2008 However, H2O2-induced apoptosis was suppressed by treatment with a potent inhibitor of p38 MAPK, SB202190, but not a JNK inhibitor, SP600125. Hydrogen Peroxide 9-13 mitogen-activated protein kinase 14 Homo sapiens 87-95 18634931-5 2008 These data suggest that the induction of HO-1 by H2O2 in pulp cells plays a protective role against the cytotoxic effects of H2O2 and stimulates DSPP expression, resulting in premature odontoblast differentiation through pathways that involve phosphatidylinositol-3"-kinase, p38, and extracellular signal-regulated kinase. Hydrogen Peroxide 49-53 mitogen-activated protein kinase 14 Homo sapiens 275-278 18575770-0 2008 Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. Hydrogen Peroxide 41-45 mitogen-activated protein kinase 14 Homo sapiens 77-80 18440775-2 2008 VEGF-induced HSP27 phosphorylation at serines 15, 78 and 82, but whereas HSP27 phosphorylation induced by H2O2 and TNFalpha was completely blocked by the p38 kinase inhibitor, SB203580, VEGF-stimulated serine 82 phosphorylation was resistant to SB203580 and small interfering(si)RNA-mediated knockdown of p38 kinase and MAPKAPK2. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 14 Homo sapiens 154-157 18440775-2 2008 VEGF-induced HSP27 phosphorylation at serines 15, 78 and 82, but whereas HSP27 phosphorylation induced by H2O2 and TNFalpha was completely blocked by the p38 kinase inhibitor, SB203580, VEGF-stimulated serine 82 phosphorylation was resistant to SB203580 and small interfering(si)RNA-mediated knockdown of p38 kinase and MAPKAPK2. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 14 Homo sapiens 305-308 18575770-8 2008 Also, H2O2 treatment activates JNK and p38 MAPK, and executive caspase 3 in B10BR cells. Hydrogen Peroxide 6-10 mitogen-activated protein kinase 14 Homo sapiens 39-42 18575770-9 2008 Minocycline significantly inhibits H2O2-induced activation of JNK, p38 MAPK and caspase 3. Hydrogen Peroxide 35-39 mitogen-activated protein kinase 14 Homo sapiens 67-70 18439424-5 2008 Moreover, we demonstrate that phosphorylation of caveolin 1 during treatment with H(2)O(2) is dependent on p38alpha mitogen-activated protein kinase. Hydrogen Peroxide 82-90 mitogen-activated protein kinase 14 Homo sapiens 107-115 18501712-5 2008 In Prx-1 knockdown cells, ASK1, p38, and JNK were quickly activated, leading to apoptosis in response to H2O2. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 14 Homo sapiens 32-35 18411303-5 2008 Translocation was increased after stimulation of p38 MAPK with anisomycin, mannitol, or H2O2. Hydrogen Peroxide 88-92 mitogen-activated protein kinase 14 Homo sapiens 49-52 17924117-0 2008 The involvement of a P38-like MAP kinase in ABA-induced and H2O2-mediated stomatal closure in Vicia faba L. SB203580 is a specific inhibitor of p38 mitogen-activated protein (MAP) kinase and has been widely used to investigate the physiological roles of p38 in animal and yeast cells. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 14 Homo sapiens 21-24 17928891-3 2008 Interesting parallels between lipid raft disruption and oxidative stress can be drawn as hydrogen peroxide induces p38 activation and HB-EGF synthesis in keratinocytes. Hydrogen Peroxide 89-106 mitogen-activated protein kinase 14 Homo sapiens 115-118 17924117-0 2008 The involvement of a P38-like MAP kinase in ABA-induced and H2O2-mediated stomatal closure in Vicia faba L. SB203580 is a specific inhibitor of p38 mitogen-activated protein (MAP) kinase and has been widely used to investigate the physiological roles of p38 in animal and yeast cells. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 14 Homo sapiens 144-147 17924117-0 2008 The involvement of a P38-like MAP kinase in ABA-induced and H2O2-mediated stomatal closure in Vicia faba L. SB203580 is a specific inhibitor of p38 mitogen-activated protein (MAP) kinase and has been widely used to investigate the physiological roles of p38 in animal and yeast cells. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 14 Homo sapiens 254-257 17965288-10 2007 The inhibition of p38 attenuated dilation to either H2O2 or to the conditioned buffer from stimulated myocytes by a similar degree, but SB-203580 did not attenuate dilation to nitroprusside. Hydrogen Peroxide 52-56 mitogen-activated protein kinase 14 Homo sapiens 18-21 17965288-11 2007 Western blot analysis for the activated form of p38 (phospho-p38) in the isolated aortae revealed robust activation of this enzyme by H2O2. Hydrogen Peroxide 134-138 mitogen-activated protein kinase 14 Homo sapiens 48-51 17965288-11 2007 Western blot analysis for the activated form of p38 (phospho-p38) in the isolated aortae revealed robust activation of this enzyme by H2O2. Hydrogen Peroxide 134-138 mitogen-activated protein kinase 14 Homo sapiens 61-64 17965288-12 2007 Taken together, our results show that an active component of cardiac metabolic dilation, like that of H2O2, produces dilation by the oxidation of thiols, which are predominantly intracellular and dependent activation on the p38 MAP kinase. Hydrogen Peroxide 102-106 mitogen-activated protein kinase 14 Homo sapiens 224-238 17558278-0 2007 p38 mitogen-activated protein kinase independent SB203580 block of H2O2-induced increase in GABAergic mIPSC amplitude. Hydrogen Peroxide 67-71 mitogen-activated protein kinase 14 Homo sapiens 0-3 18031790-4 2007 METHODS AND MATERIALS: In the liver of aged rats and in H(2)O(2)-stimulated HepG2 cells the ROS content, the HMG-CoA reductase activation state, its regulatory enzymes and the p38 downstream pathway involved in reductase deregulation, have been studied. Hydrogen Peroxide 56-64 mitogen-activated protein kinase 14 Homo sapiens 176-179 18031790-7 2007 Moreover, H(2)O(2)-stimulated HepG2 cell line shows that the ROS effect on the HMG-CoAR dephosphorylation is mediated by the activation of p38/MAPK pathway. Hydrogen Peroxide 10-18 mitogen-activated protein kinase 14 Homo sapiens 139-142 17507666-2 2007 We have shown previously that asbestos-induced p38 mitogen-activated protein (MAP) kinase activation and TNF-alpha expression are mediated by H(2)O(2) in blood monocytes. Hydrogen Peroxide 142-150 mitogen-activated protein kinase 14 Homo sapiens 47-50 17558278-3 2007 This effect of H2O2 was reversed by the p38 antagonist SB203580, but not by the extracellular signal-regulated kinase 1/2 antagonist PD98059, or the Jun N-terminal kinase antagonist, SP600125. Hydrogen Peroxide 15-19 mitogen-activated protein kinase 14 Homo sapiens 40-43 17065531-11 2006 In addition, dPGJ(2) significantly extended hydrogen peroxide-induced activation of JNK and p38, but not of Akt. Hydrogen Peroxide 44-61 mitogen-activated protein kinase 14 Homo sapiens 92-95 17034759-6 2006 In contrast, the PKC inhibitor (GF109203x) did not affect p38 activation, indicating that p38 MAPK activation occurs upstream of PKC activation in H(2)O(2)-induced apoptosis. Hydrogen Peroxide 147-155 mitogen-activated protein kinase 14 Homo sapiens 90-93 16927023-5 2006 Exposure to a lethal dose of H(2)O(2) elicited Bax translocation to the mitochondria and release of apoptosis-inducing factor (AIF) from the mitochondria, both of which were abolished by either JNK- or p38-specific inhibitors. Hydrogen Peroxide 29-37 mitogen-activated protein kinase 14 Homo sapiens 202-205 16927023-6 2006 Both H(2)O(2)-induced cell death and JNK/p38 phosphorylation were partially inhibited by C. difficile toxin B, inhibitor of Rho, Rac, and cdc42. Hydrogen Peroxide 5-13 mitogen-activated protein kinase 14 Homo sapiens 41-44 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 14 Homo sapiens 73-76 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 145-153 mitogen-activated protein kinase 14 Homo sapiens 73-76 16927023-8 2006 This study is the first to demonstrate that H(2)O(2) induces a Rac1/JNK1/p38 signaling cascade, and that JNK and p38 activation is important for H(2)O(2)-induced apoptosis as well as AIF/Bax translocation of RPE cells. Hydrogen Peroxide 145-153 mitogen-activated protein kinase 14 Homo sapiens 113-116 17014422-6 2007 Inhibition of the pathway indicated that the p38 pathway is necessary for various signals to induce ATF3, including anisomycin, IL-1beta (interleukin 1beta), TNFalpha (tumour necrosis factor alpha) and H2O2. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 14 Homo sapiens 45-48 17101135-2 2006 We showed herein that p38(MAPK) was phosphorylated after exposure of IMR-90 hTERT cells to H2O2. Hydrogen Peroxide 91-95 mitogen-activated protein kinase 14 Homo sapiens 22-25 17101135-5 2006 Using this array, p38(MAPK) inhibitor and p38(MAPK) small interferent RNA, we identified several p38(MAPK)-target genes differentially expressed in H2O2-stressed IMR-90 hTERT fibroblasts. Hydrogen Peroxide 148-152 mitogen-activated protein kinase 14 Homo sapiens 18-21 17101135-5 2006 Using this array, p38(MAPK) inhibitor and p38(MAPK) small interferent RNA, we identified several p38(MAPK)-target genes differentially expressed in H2O2-stressed IMR-90 hTERT fibroblasts. Hydrogen Peroxide 148-152 mitogen-activated protein kinase 14 Homo sapiens 42-45 17101135-5 2006 Using this array, p38(MAPK) inhibitor and p38(MAPK) small interferent RNA, we identified several p38(MAPK)-target genes differentially expressed in H2O2-stressed IMR-90 hTERT fibroblasts. Hydrogen Peroxide 148-152 mitogen-activated protein kinase 14 Homo sapiens 42-45 16564553-10 2006 However, it had little inhibitory effect on UVB- and H2O2-induced ERK and p38 activation even at a higher concentration, suggesting indirectly that JNK activation is required for the induction of apoptosis in keratinocytes exposed to UVB. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Homo sapiens 74-77 16710743-3 2006 H(2)O(2)-induced activation of p38-MAPK (7.04 +/- 0.20-fold relative to control values) was totally attenuated by L-ascorbic acid (100 microM) or catalase (150 U/ml). Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Homo sapiens 31-39 16508959-11 2006 Caveolin 1 induction and stresses with both IL-1beta and H2O2 up-regulated p53 and p21 and down-regulated phosphorylated retinoblastoma (Rb), suggesting that the p53/p21/Rb phosphorylation pathway, as well as prolonged p38 MAPK activation, may mediate the features of chondrocyte senescence induced by stress. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 14 Homo sapiens 219-222 16483542-7 2006 PEDF can also prevent H(2)O(2)-induced stress kinase p38/27-kDa heat shock protein signaling which is known to mediate actin rearrangement. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 14 Homo sapiens 53-56 16356119-3 2005 Exposure of different cell lines to micromolar concentrations of hydrogen peroxide leads to the activation of stress kinases such as c-Jun N-terminal kinase, p38, I kappaB kinase, and extracellular receptor kinase 1/2. Hydrogen Peroxide 65-82 mitogen-activated protein kinase 14 Homo sapiens 158-161 16543060-7 2006 RESULTS: Butyrate and trichostastin A stimulated p38 MAPK phosphorylation via a H(2)O(2)-dependent mechanism. Hydrogen Peroxide 80-88 mitogen-activated protein kinase 14 Homo sapiens 49-52 16380078-4 2006 The inhibitory effect of LDL on Na+/H+ exchange was mimicked by H2O2, which directly activates p38MAPK. Hydrogen Peroxide 64-68 mitogen-activated protein kinase 14 Homo sapiens 95-102 16380078-5 2006 Exposure of platelets to LDL or H2O2 led to phosphorylation of p38MAPK, its upstream regulator MAP kinase kinase 3/6 (MKK 3/6), and its downstream target heat shock protein 27 (HSP27), and this effect was abrogated in SKF86002-pretreated platelets. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 14 Homo sapiens 63-70 16380078-6 2006 In addition, both LDL and H2O2 produced the SKF86002-sensitive phosphorylation of an oligopeptide encompassing p38MAPK phosphorylation sequence derived from NHE-1, a major Na+/H+ exchanger in platelets. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 14 Homo sapiens 111-118 15917192-4 2005 Therefore this study examines the role of hydrogen peroxide, both alone and in combination with lipopolysaccharide (LPS), in the regulation of activation of two key MAPK, p38 and JNK, regulation of phenotype, and regulation of apoptosis in human monocyte-derived DC. Hydrogen Peroxide 42-59 mitogen-activated protein kinase 14 Homo sapiens 171-174 15917193-1 2005 Hydrogen peroxide (HP) induced the phosphorylation of cAMP response element binding protein (CREB) on Ser133 in Jurkat T lymphocytes via p38 and MSK1. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Homo sapiens 137-140 16055121-0 2005 p38 mitogen-activated protein kinase (p38MAPK) upregulates catalase levels in response to low dose H2O2 treatment through enhancement of mRNA stability. Hydrogen Peroxide 99-103 mitogen-activated protein kinase 14 Homo sapiens 0-36 16055121-0 2005 p38 mitogen-activated protein kinase (p38MAPK) upregulates catalase levels in response to low dose H2O2 treatment through enhancement of mRNA stability. Hydrogen Peroxide 99-103 mitogen-activated protein kinase 14 Homo sapiens 38-45 16055121-6 2005 The rise in catalase mRNA levels induced by low concentration (single and multiple dose) H2O2 treatment was established to be unconnected with transcriptional upregulation but was brought forth primarily by an enhancement in catalase mRNA stability through the action of p38MAPK. Hydrogen Peroxide 89-93 mitogen-activated protein kinase 14 Homo sapiens 271-278 16055121-7 2005 Therefore, our data strongly indicate that activation of p38MAPK is a key controlling step in the upregulation of catalase levels by low dose H2O2 treatment. Hydrogen Peroxide 142-146 mitogen-activated protein kinase 14 Homo sapiens 57-64 15917193-1 2005 Hydrogen peroxide (HP) induced the phosphorylation of cAMP response element binding protein (CREB) on Ser133 in Jurkat T lymphocytes via p38 and MSK1. Hydrogen Peroxide 19-21 mitogen-activated protein kinase 14 Homo sapiens 137-140 15917192-5 2005 At low concentrations, hydrogen peroxide activates p38, but does not alter DC phenotype. Hydrogen Peroxide 23-40 mitogen-activated protein kinase 14 Homo sapiens 51-54 15917192-6 2005 At higher concentrations, hydrogen peroxide activates both p38 and JNK. Hydrogen Peroxide 26-43 mitogen-activated protein kinase 14 Homo sapiens 59-62 15782121-2 2005 In the present study, we show that Hsp90 inhibits hydrogen peroxide (H(2)O(2))-induced ASK1-p38 activation in endothelial cells (EC). Hydrogen Peroxide 50-67 mitogen-activated protein kinase 14 Homo sapiens 92-95 15782121-2 2005 In the present study, we show that Hsp90 inhibits hydrogen peroxide (H(2)O(2))-induced ASK1-p38 activation in endothelial cells (EC). Hydrogen Peroxide 69-77 mitogen-activated protein kinase 14 Homo sapiens 92-95 15123696-7 2004 These results show that H(2)O(2) from NAD(P)H oxidase forms GSS-Ras on Cys(118) and increases its activity leading to p38 and Akt phosphorylation, which contributes to the induction of protein synthesis. Hydrogen Peroxide 24-32 mitogen-activated protein kinase 14 Homo sapiens 118-121 15923604-7 2005 Furthermore, the hypoxic activation of p38alpha and HIF-1 was abolished by myxothiazol, a mitochondrial complex III inhibitor, and glutathione peroxidase 1 (GPX1), a scavenger of hydrogen peroxide. Hydrogen Peroxide 179-196 mitogen-activated protein kinase 14 Homo sapiens 39-47 15650391-7 2005 Inhibition of ERK and p38 activation prevented H2O2-induced proliferation. Hydrogen Peroxide 47-51 mitogen-activated protein kinase 14 Homo sapiens 22-25 15650392-2 2005 Tumor necrosis factor-alpha (TNFalpha) and hydrogen peroxide (H2O2) both activated p38, but only TNFalpha activated nuclear factor-kappaB (NF-kappaB). Hydrogen Peroxide 43-60 mitogen-activated protein kinase 14 Homo sapiens 83-86 15650392-2 2005 Tumor necrosis factor-alpha (TNFalpha) and hydrogen peroxide (H2O2) both activated p38, but only TNFalpha activated nuclear factor-kappaB (NF-kappaB). Hydrogen Peroxide 62-66 mitogen-activated protein kinase 14 Homo sapiens 83-86 15650392-3 2005 N-Acetyl-L-cysteine (20 mM) inhibited both H2O2- and TNFalpha-induced p38 phosphorylation (14 +/- 7 and 37 +/- 4% of control, respectively). Hydrogen Peroxide 43-47 mitogen-activated protein kinase 14 Homo sapiens 70-73 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 14 Homo sapiens 102-138 15795422-11 2005 Western blot data revealed that H2O2 upregulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), which was rapidly reversed by quercetin within 30 min; H2O2 activation of c-Jun was downregulated. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 14 Homo sapiens 102-138 14962975-6 2004 Increasing the steady-state levels of H2O2 by using polyethylene glycol superoxide dismutase, an antioxidant that crosses the cell membrane, or aminotriazole, an irreversible inhibitor of catalase, allowed the p38 MAP kinase to be activated in alveolar macrophages. Hydrogen Peroxide 38-42 mitogen-activated protein kinase 14 Homo sapiens 210-224 15225802-4 2004 Furthermore, the neurotoxic effects of hydrogen peroxide was dependent on c-Jun N-terminal kinase (JNK)- and p38- mitogen-activated protein kinase (MAPK) activity. Hydrogen Peroxide 39-56 mitogen-activated protein kinase 14 Homo sapiens 109-112 15003539-3 2004 We demonstrate that brief H2O2 exposure results in transient phosphorylations of p38 and ERK which peaked by 15 min. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 14 Homo sapiens 81-84 15003539-8 2004 In conclusion, primary adult cardiac fibroblasts exposed to brief H2O2 exhibit an altered phenotype characterized by reduced migration and apoptosis and increased necrosis resulting, in part, from the differential effects of p38 and ERK signaling. Hydrogen Peroxide 66-70 mitogen-activated protein kinase 14 Homo sapiens 225-228 12957654-0 2003 Activation of p38 mitogen-activated protein kinase/cytosolic phospholipase A2 cascade in hydroperoxide-stressed platelets. Hydrogen Peroxide 89-102 mitogen-activated protein kinase 14 Homo sapiens 14-17 14757132-0 2004 Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide. Hydrogen Peroxide 89-106 mitogen-activated protein kinase 14 Homo sapiens 17-53 14668614-10 2003 MEASUREMENTS AND MAIN RESULTS: The results showed that H2O2 induced ASK1 phosphorylation and concomitantly p38 MAPK and JNK phosphorylation as well as induced caspase-3 activation in pulmonary vascular endothelial cells. Hydrogen Peroxide 55-59 mitogen-activated protein kinase 14 Homo sapiens 107-110 14668614-13 2003 CONCLUSION: ASK1-p38 MAPK/JNK cascade regulates apoptosis of H2O2-stimulated human pulmonary vascular endothelial cells. Hydrogen Peroxide 61-65 mitogen-activated protein kinase 14 Homo sapiens 17-20 12957654-8 2003 In conclusion, our data provide a new insight into the mechanism of 12-HpETE-induced platelet priming, suggesting that hydroperoxide-induced p38 MAPK activation could play a relevant role in the exacerbated platelet activation associated with oxidative stress as found in diabetes. Hydrogen Peroxide 119-132 mitogen-activated protein kinase 14 Homo sapiens 141-144 12183063-2 2002 In human umbilical vein endothelial cells (HUVEC), the H(2)O(2)-induced membrane blebbing was found to be a transient process executed by two parallel signaling mechanisms: (i) mobilization of cytosolic [Ca(2+)](i) through a pathway requiring oxidation of reduced glutathione (GSH), and (ii) activation of p38 mitogen-activated protein kinases (MAPK) independently of GSH oxidation and Ca(2+) mobilization. Hydrogen Peroxide 55-63 mitogen-activated protein kinase 14 Homo sapiens 306-309 14501030-5 2003 H2O2- induced phosphorylation (activation) of p42/p44(ERK) and p38 within 10 min of 200 microM H2O2 exposure. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 63-66 14501030-5 2003 H2O2- induced phosphorylation (activation) of p42/p44(ERK) and p38 within 10 min of 200 microM H2O2 exposure. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 14 Homo sapiens 63-66 14501030-8 2003 In contrast, the p38 inhibitor SB202190 has no inhibitory effect on AP-1 activation but partially prevented H2O2 from inducing p70S6K1 activation and cell enlargement. Hydrogen Peroxide 108-112 mitogen-activated protein kinase 14 Homo sapiens 17-20 12496360-8 2002 These results suggest that the accumulated H(2)O(2) potentiated the activation of p38MAPK after irradiation in cells overexpressing MnSOD, which led to the protection of cells from irradiation-mediated cell death through the G(2)-M checkpoint. Hydrogen Peroxide 43-51 mitogen-activated protein kinase 14 Homo sapiens 82-89 12419465-4 2002 Here we show that sustained p38(MAPK) phosphorylation is responsible for both H2O2-induced overexpression of TGF-beta 1 and subsequent TGF-beta 1-induced appearance of these biomarkers. Hydrogen Peroxide 78-82 mitogen-activated protein kinase 14 Homo sapiens 28-31 12419465-5 2002 p38(MAPK) phosphorylation is shown to be necessary for a self-sustained TGF-beta 1 overexpression after H2O2 stress through the activation of ATF-2 transcription factor, thereby creating a regulatory loop between sustained p38(MAPK) activation and sustained TGF-beta 1 overexpression after stress. Hydrogen Peroxide 104-108 mitogen-activated protein kinase 14 Homo sapiens 0-3 12374624-4 2002 Stimulation of Jurkat T cells with H(2)O(2) induces the phosphorylation of ERK, p38, and JNK members of MAPK family. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 14 Homo sapiens 80-83 12899942-3 2003 TcR cross-linking of primary human T blasts and Jurkat human T cells rapidly activated the ERK, JNK, p38 and Akt kinases within minutes, and was temporally associated with TcR-stimulated production of hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 201-218 mitogen-activated protein kinase 14 Homo sapiens 101-104 12810757-5 2003 The H2O2-induced phosphorylation of CREB was partially blocked by inhibition of either extracellular signal-regulated protein kinase kinase by PD98059 or of p38 mitogen-activated protein kinase (MAPK) by SB203580. Hydrogen Peroxide 4-8 mitogen-activated protein kinase 14 Homo sapiens 157-193 12444032-7 2002 Both MEK and p38 kinase inhibitors inhibited the hydrogen peroxide effect on AA release and specific cPLA(2) activity. Hydrogen Peroxide 49-66 mitogen-activated protein kinase 14 Homo sapiens 13-16 12444032-9 2002 Collectively, these data show that hydrogen peroxide increases cPLA(2) activity through its phosphorylation utilizing an epithelial growth factor/Ras/extracellular signal-regulated kinase and p38 pathway. Hydrogen Peroxide 35-52 mitogen-activated protein kinase 14 Homo sapiens 192-195 12417261-3 2002 In synchronized, quiescent SMCs from LIMA, oxidative stress (H(2)O(2) stimulation)-induced membrane translocation of Rac(1), p38 phosphorylation, membrane translocation, and phosphorylation of HSP27. Hydrogen Peroxide 61-69 mitogen-activated protein kinase 14 Homo sapiens 125-128 12374624-7 2002 Transfection with wtHePTP inhibited H(2)O(2)-induced ERK and p38 phosphorylation without inhibiting JNK phosphorylation. Hydrogen Peroxide 36-44 mitogen-activated protein kinase 14 Homo sapiens 61-64 12374624-8 2002 The Src-family kinase inhibitor, PP2, inhibited the H(2)O(2)-induced phosphorylation of ERK, p38, and JNK. Hydrogen Peroxide 52-60 mitogen-activated protein kinase 14 Homo sapiens 93-96 12374624-9 2002 The phospholipase C (PLC) inhibitor, U73122, or the protein kinase C (PKC) inhibitor, Ro-31-8425, blocked H(2)O(2)-induced ERK phosphorylation, whereas the same treatment did not inhibit p38 or JNK phosphorylation. Hydrogen Peroxide 106-114 mitogen-activated protein kinase 14 Homo sapiens 187-190 12215219-3 2002 In B cells, p38 is activated by hydrogen peroxide (H(2)O(2)) stimulation. Hydrogen Peroxide 32-49 mitogen-activated protein kinase 14 Homo sapiens 12-15 12164931-2 2002 In this study, the role of the p38 mitogen-activated protein kinase for the activation of human monocytes after exposure to four structurally unrelated contact sensitizers was analyzed in comparison with the irritant benzalkonium chloride and an inductor of oxidative stress (H2O2) using immunofluorescence, Western blotting, and enzyme-linked immunosorbent assay techniques. Hydrogen Peroxide 276-280 mitogen-activated protein kinase 14 Homo sapiens 31-34 12161102-6 2002 We further investigated the effect of green tea polyphenol on these protein kinases, and demonstrated that H(2)O(2)-induced phosphorylation of JNK and p38 but not p44/42 was inhibited by green tea polyphenol in A549 cells. Hydrogen Peroxide 107-115 mitogen-activated protein kinase 14 Homo sapiens 151-154 12161102-7 2002 We speculate that green tea polyphenol may inhibit H(2)O(2)-induced IL-8 production from A549 cells through inactivation of JNK and p38. Hydrogen Peroxide 51-59 mitogen-activated protein kinase 14 Homo sapiens 132-135 12003789-9 2002 Brief treatment with exogenous H(2)O(2) during normoxia also induced phosphorylation of p38 as hypoxia, but this effect was not abolished by myxothiazol or DIDS. Hydrogen Peroxide 31-39 mitogen-activated protein kinase 14 Homo sapiens 88-91 12003789-10 2002 The antioxidant N-acetyl-cysteine abolished the p38 response to hypoxia, presumably by scavenging H(2)O(2), but the mitogen extracellular receptor kinase inhibitor PD-98059 did not inhibit p38 phosphorylation during hypoxia. Hydrogen Peroxide 98-106 mitogen-activated protein kinase 14 Homo sapiens 48-51 12003789-11 2002 Thus physiological hypoxia leads to p38 phosphorylation through a mechanism that requires electron flux in the proximal region of the mitochondrial electron transport chain, which suggests that either H(2)O(2) or superoxide participates in activating that process. Hydrogen Peroxide 201-209 mitogen-activated protein kinase 14 Homo sapiens 36-39 12215219-5 2002 H(2)O(2)-induced p38 activation is abrogated in phospholipase C-gamma2 (PLC-gamma2)-deficient as well as Syk-deficient cells, suggesting that Syk activates p38 through PLC-gamma2 upon H(2)O(2) stimulation. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Homo sapiens 17-20 12215219-5 2002 H(2)O(2)-induced p38 activation is abrogated in phospholipase C-gamma2 (PLC-gamma2)-deficient as well as Syk-deficient cells, suggesting that Syk activates p38 through PLC-gamma2 upon H(2)O(2) stimulation. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Homo sapiens 156-159 12215219-5 2002 H(2)O(2)-induced p38 activation is abrogated in phospholipase C-gamma2 (PLC-gamma2)-deficient as well as Syk-deficient cells, suggesting that Syk activates p38 through PLC-gamma2 upon H(2)O(2) stimulation. Hydrogen Peroxide 184-192 mitogen-activated protein kinase 14 Homo sapiens 17-20 12215219-5 2002 H(2)O(2)-induced p38 activation is abrogated in phospholipase C-gamma2 (PLC-gamma2)-deficient as well as Syk-deficient cells, suggesting that Syk activates p38 through PLC-gamma2 upon H(2)O(2) stimulation. Hydrogen Peroxide 184-192 mitogen-activated protein kinase 14 Homo sapiens 156-159 11696540-10 2002 Increased HSP-27 expression in LLC-PK(1) cells results in reduced H(2)O(2)-induced phosphorylation of JNK1/2 and p38. Hydrogen Peroxide 66-74 mitogen-activated protein kinase 14 Homo sapiens 113-116 11716760-8 2001 The much lower activation of p38 in CEM cells in response to H(2)O(2) could explain the lack of stabilization of IL-8 mRNA in these cells. Hydrogen Peroxide 61-69 mitogen-activated protein kinase 14 Homo sapiens 29-32 11769330-13 2001 These data therefore suggest that the toxic effects of beta-amyloid involve the generation of hydrogen peroxide, leading to the activation of p38 and the down-regulation of ERK. Hydrogen Peroxide 94-111 mitogen-activated protein kinase 14 Homo sapiens 142-145 11689443-1 2001 Apoptosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase (MAPKKK) that activates the JNK and p38 MAP kinase cascades and is activated in response to oxidative stress such as hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 191-208 mitogen-activated protein kinase 14 Homo sapiens 110-113 11572474-0 2001 The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability. Hydrogen Peroxide 30-47 mitogen-activated protein kinase 14 Homo sapiens 12-15 11597988-6 2001 Ang II, as well as exogenous H(2)O(2), activated ERK, p38 MAPK, and JNK, which were significantly inhibited by N-acetylcysteine and DPI. Hydrogen Peroxide 29-37 mitogen-activated protein kinase 14 Homo sapiens 54-57 11605009-3 2001 The phosphorylation of p38 started at 5 min post UV irradiation, peaked at about 30 min, and remained elevated up to 2 h. The phosphorylation of AKT started at 15 min post UV treatment, peaked at about 1 h, and remained elevated up to 2 h. We also found that H2O2 induced phosphorylation of p38 and AKT in a time- dependent manner. Hydrogen Peroxide 259-263 mitogen-activated protein kinase 14 Homo sapiens 23-26 11494050-4 2001 H2O2 also strongly induced p38 activation in a time dependent manner. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 27-30 11572474-1 2001 OBJECTIVE: The purpose of this study was to determine the contribution of p38 MAP kinase activity during hydrogen peroxide mediated increased endothelial solute permeability. Hydrogen Peroxide 105-122 mitogen-activated protein kinase 14 Homo sapiens 74-77 11572474-2 2001 We also sought to identify the role of p38 MAP kinase-mediated changes in endothelial cell architecture due to hydrogen peroxide challenge. Hydrogen Peroxide 111-128 mitogen-activated protein kinase 14 Homo sapiens 39-42 11572474-10 2001 CONCLUSIONS: These data demonstrate that p38 MAP kinase activity is involved in hydrogen peroxide mediated permeability, stress fiber formation, and intracellular gap formation. Hydrogen Peroxide 80-97 mitogen-activated protein kinase 14 Homo sapiens 41-44 10593919-6 1999 In vitro kinase analyses revealed that 1 mM H(2)O(2) stimulated the activity of JNK by approximately 8-fold, MAPKAP-K2 (the downstream target of p38 MAP kinase) by approximately 12-fold and that of PKB by up to 34-fold. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 14 Homo sapiens 145-159 10972672-6 2000 RESULTS: Mesangial cells exposed to H2O2 exhibited rapid phosphorylation of JNK, ERKs, and p38 MAP kinase. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 14 Homo sapiens 91-105 10837470-3 2000 In human leukemia cells, two reactive oxygen species, singlet oxygen and hydrogen peroxide (H(2)O(2)), selectively stimulated the phosphorylation of p38. Hydrogen Peroxide 73-90 mitogen-activated protein kinase 14 Homo sapiens 149-152 10837470-3 2000 In human leukemia cells, two reactive oxygen species, singlet oxygen and hydrogen peroxide (H(2)O(2)), selectively stimulated the phosphorylation of p38. Hydrogen Peroxide 92-100 mitogen-activated protein kinase 14 Homo sapiens 149-152 10843711-7 2000 Inhibition of p38 with SB203580 attenuated H2O2 production stimulated by Fc gamma RIIIb or heterotypic cross-linking, but had no effect on Fc gamma RIIa-stimulated H2O2 production. Hydrogen Peroxide 43-47 mitogen-activated protein kinase 14 Homo sapiens 14-17 12214088-5 2000 H2O2-treatment resulted in dose-dependent increases in cell death due to genomic and mitochondrial DNA damage associated with increased levels of 8-OHdG and the p53 and CD95 pro-apoptosis genes, reduced levels of the Bcl-2 survival gene, activation of JNK and p38 stress kinases, and inhibition of PI3 kinase survival signaling. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 260-263 11035067-5 2000 Lowering the intracellular GSH/GSH disulfide ratio by BCNU, HP, or NO resulted in all cases in the fulminant enhancement of Jun-N-terminal kinase and p38 mitogen-activated protein kinase but not extracellular signal-regulated kinase 1/2. Hydrogen Peroxide 60-62 mitogen-activated protein kinase 14 Homo sapiens 150-186 10856288-3 2000 U937 human lymphoid cells treated with low dose (0.02 mm) H(2)O(2) rapidly caused p38 MAPK cascade activation detectable by phosphorylation of MKK3/6, p38 MAPK, activating transcription factor-2, and cAMP-responsive element-binding protein, leaving the JNK and NF-kappaB cascades unaffected. Hydrogen Peroxide 58-66 mitogen-activated protein kinase 14 Homo sapiens 82-85 10856288-3 2000 U937 human lymphoid cells treated with low dose (0.02 mm) H(2)O(2) rapidly caused p38 MAPK cascade activation detectable by phosphorylation of MKK3/6, p38 MAPK, activating transcription factor-2, and cAMP-responsive element-binding protein, leaving the JNK and NF-kappaB cascades unaffected. Hydrogen Peroxide 58-66 mitogen-activated protein kinase 14 Homo sapiens 151-154 10967199-4 2000 Of particular importance is hydrogen peroxide, which mediates angiotensin II stimulation of such important intracellular signals as EGF-receptor transactivation, p38 mitogen activated protein kinase, and Akt. Hydrogen Peroxide 28-45 mitogen-activated protein kinase 14 Homo sapiens 162-165 9718372-1 1998 The fission yeast Sty1/Spc1 MAP kinase, like the mammalian JNK/SAPK and p38/CSBP1 kinases, is activated by a range of environmental insults including osmotic stress, hydrogen peroxide, heat shock, UV light and the protein synthesis inhibitor anisomycin. Hydrogen Peroxide 166-183 mitogen-activated protein kinase 14 Homo sapiens 72-75 10567216-3 1999 Treatment of human platelets with H(2)O(2) stimulated SAPK2a and its downstream target mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP-K2). Hydrogen Peroxide 34-42 mitogen-activated protein kinase 14 Homo sapiens 54-60 10601882-11 1999 iNOS induction involves activation by phosphorylation of the MAP kinase p38 and can be induced in cultured astrocytes by IL-1beta or H2O2. Hydrogen Peroxide 133-137 mitogen-activated protein kinase 14 Homo sapiens 72-75 9766656-5 1998 p38 is also phosphorylated by ALA-PDT in the human melanoma cell lines Bro and SkMel-23, applying doses that lead to 80-95% cell death after 24 h. Hence, the effects of ALA-PDT on MAPKs are similar to stresses like UV irradiation or exposure to hydrogen peroxide with respect to activation of JNK and p38 MAPKs. Hydrogen Peroxide 245-262 mitogen-activated protein kinase 14 Homo sapiens 0-3 9718372-1 1998 The fission yeast Sty1/Spc1 MAP kinase, like the mammalian JNK/SAPK and p38/CSBP1 kinases, is activated by a range of environmental insults including osmotic stress, hydrogen peroxide, heat shock, UV light and the protein synthesis inhibitor anisomycin. Hydrogen Peroxide 166-183 mitogen-activated protein kinase 14 Homo sapiens 76-81 9712062-10 1998 Timed delivery of the compound during the lag phase preceding H2O2 production suggested that p38 kinase activity was required throughout the lag but not after the oxidase was assembled. Hydrogen Peroxide 62-66 mitogen-activated protein kinase 14 Homo sapiens 93-96 9139689-5 1997 Tumor necrosis factor-alpha and hydrogen peroxide, in contrast, led to NF-kappaB activation but only modestly stimulated p38. Hydrogen Peroxide 32-49 mitogen-activated protein kinase 14 Homo sapiens 121-124 9545260-7 1998 However other stresses such as heat shock, sorbitol, and H2O2, which also stimulate p38 MAP kinase and increase Mnk1 activity, do not increase phosphorylation of eIF4E. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 14 Homo sapiens 84-87 9048659-5 1997 Inhibiting p38 activity with the highly specific inhibitor SB203580 blocked the H2O2-induced endothelial microfilament responses. Hydrogen Peroxide 80-84 mitogen-activated protein kinase 14 Homo sapiens 11-14 33807495-5 2021 In line with the previous results in fission yeast, the phosphorylation of the MAPKs ERK and p38 increased substantially more with the combination treatment than by H2O2 or phenothiazines, whereas INR119 alone did not affect phosphorylation. Hydrogen Peroxide 165-169 mitogen-activated protein kinase 14 Homo sapiens 93-96 8971075-7 1997 The reactivating kinase (RK, also known as p38 mitogen activated protein kinase) is induced by insulin, hydrogen peroxide, or sodium meta-arsenite in hepatoma cells, and these effects are blocked by SB203580, a selective inhibitor of RK. Hydrogen Peroxide 104-121 mitogen-activated protein kinase 14 Homo sapiens 43-46 33349958-8 2021 Under H2 O2 -induced stress, however, it helped to downregulate p38alpha levels, a protein kinase which is receptive to stress impulse (mitogen-activated). Hydrogen Peroxide 6-11 mitogen-activated protein kinase 14 Homo sapiens 64-72 34203307-10 2021 Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-kappaB (NF-kappaB) activation, thereby preventing H2O2-induced neurotoxicity. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 14 Homo sapiens 191-194 35218032-6 2022 Furthermore, preincubation with Orz reduced H2 O2 -mediated the proapoptotic protein of Bak expression and the phosphorylation of ASK1, p38, JNK, and ERK, and increased the anti-apoptotic protein of Bcl-xl expression and anti-oxidative stress proteins of Nrf2 and HO-1 expression. Hydrogen Peroxide 44-49 mitogen-activated protein kinase 14 Homo sapiens 136-139 34741589-7 2022 However, the inhibitory effect of tCQA on JNK and P38 levels activated by the JNK agonist anisomycin is not obvious; meanwhile, tCQA could inhibit the activation of JNK/P38 induced by H2 O2 , which suggests that tCQA might inhibit the JNK/P38 signaling pathway by reducing ROS. Hydrogen Peroxide 184-189 mitogen-activated protein kinase 14 Homo sapiens 169-172 34741589-7 2022 However, the inhibitory effect of tCQA on JNK and P38 levels activated by the JNK agonist anisomycin is not obvious; meanwhile, tCQA could inhibit the activation of JNK/P38 induced by H2 O2 , which suggests that tCQA might inhibit the JNK/P38 signaling pathway by reducing ROS. Hydrogen Peroxide 184-189 mitogen-activated protein kinase 14 Homo sapiens 239-242 33641168-8 2021 Furthermore, H2 O2 -induced increases in intracellular Zn2+ activated the p38 cAMP response element-binding protein/mitogen-activated protein kinase (p38 CREB/MAPK) cascade, upregulated nuclear factor kappa B (NF-kappaB) DNA binding, and increased the expression of inflammatory cytokines and matrix metallopeptidase-9 (MMP-9). Hydrogen Peroxide 13-18 mitogen-activated protein kinase 14 Homo sapiens 74-77 33270331-7 2021 Furthermore, the UVB/H2 O2 -induced excessive production of reactive oxygen species, degradation of collagen, activation of MAPKs, including P38, ERK, and JNK, and premature senescence were remarkably attenuated by F-FEJS in dermal fibroblast cells. Hydrogen Peroxide 21-26 mitogen-activated protein kinase 14 Homo sapiens 141-144 31598361-4 2019 In addition, hydrogen peroxide-induced p53 activation and BH3 interacting-domain death agonist (BID) expression were higher in CsA-treated cells than those in non-treated cells, whereas hydrogen peroxide-induced activation of mitogen-activated protein kinases including p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase and activation of protein kinase B were not significantly altered by treatment with CsA. Hydrogen Peroxide 13-30 mitogen-activated protein kinase 14 Homo sapiens 270-273 31629169-0 2020 A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 14 Homo sapiens 72-75 31629169-3 2020 However, the mechanisms of H2O2-induced p38 activation are not yet fully understood. Hydrogen Peroxide 27-31 mitogen-activated protein kinase 14 Homo sapiens 40-43 31313862-5 2019 XD-2 inhibited the H2 O2 -increased phosphorylation levels of c-JUN N-terminal kinase, extracellular signal-regulated kinase, and p38 in HepG2 cells. Hydrogen Peroxide 19-24 mitogen-activated protein kinase 14 Homo sapiens 130-133 33490165-0 2020 Long non-coding RNA nuclear paraspeckle assembly transcript 1 protects human lens epithelial cells against H2O2 stimuli through the nuclear factor kappa b/p65 and p38/mitogen-activated protein kinase axis. Hydrogen Peroxide 107-111 mitogen-activated protein kinase 14 Homo sapiens 163-166 32599142-7 2020 Co-IP assay confirmed that H2O2 induced the phosphorylation of KMT2D to block the ubiquitination degradation, which was mainly mediated by phosphorylation of p38/MAPK. Hydrogen Peroxide 27-31 mitogen-activated protein kinase 14 Homo sapiens 158-166 31313457-6 2019 Phosphorylation of extracellular signal-regulated kinases, c-Jun amino-terminal kinases, and p38, which was induced by H2 O2 , decreased in MSCs overexpressing the HGF gene. Hydrogen Peroxide 119-124 mitogen-activated protein kinase 14 Homo sapiens 93-96 31399951-6 2019 Downregulation of ACTN4 by siRNA or H2O2 treatment promoted normotensive HUVEC apoptosis and increased p38-MAPK phosphorylation along with elevated levels of p53 phosphorylation, caspase cascade proteins, and bax and repressed expression of bcl-2. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 14 Homo sapiens 103-106 31598361-4 2019 In addition, hydrogen peroxide-induced p53 activation and BH3 interacting-domain death agonist (BID) expression were higher in CsA-treated cells than those in non-treated cells, whereas hydrogen peroxide-induced activation of mitogen-activated protein kinases including p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase and activation of protein kinase B were not significantly altered by treatment with CsA. Hydrogen Peroxide 186-203 mitogen-activated protein kinase 14 Homo sapiens 270-273 31185752-8 2019 Inhibition of either p38 or ERK up-regulated the apoptosis induction in EcI- and H2O2-cotreated cells. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 14 Homo sapiens 21-24 28342871-9 2019 We found that the oxidative stress induced by H2O2 increased the apoptosis and subsequently the calcification in the cartilage endplate cells through the ROS/p38/ERK/p65 pathway. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 14 Homo sapiens 158-161 30818884-13 2019 The p38 inhibitor SB203580 and the JNK inhibitor SP600125 suppressed MMP-9 and COX-2 expression in H2O2-treated HaCaT cells. Hydrogen Peroxide 99-103 mitogen-activated protein kinase 14 Homo sapiens 4-7 29783884-10 2019 RESULTS: Hydrogen peroxide significantly induced cell senescence and p38 MAPK phosphorylation, and it significantly decreased SIRT3 expression in full-thickness fetal membrane explants and chorion cells. Hydrogen Peroxide 9-26 mitogen-activated protein kinase 14 Homo sapiens 69-72 30682387-9 2019 Both p38alpha inhibition and siRNA-mediated silencing attenuated H2O2- or 0.45-0.75 mM PA-mediated augmentation of DHEA production with relatively stable 17OHP levels, indicating that activated p38alpha mediates oxidative stress-induced 17,20-lyase activation and androgen synthesis stimulation, which may underlie hyperandrogenism in PCOS. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 14 Homo sapiens 194-202 29767257-8 2018 In addition, alterations in c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) expression were examined, and pretreatment with BMP-6 was demonstrated to reduce H2O2-induced activation of JNK and p38 MAPK. Hydrogen Peroxide 195-199 mitogen-activated protein kinase 14 Homo sapiens 70-106 30448513-7 2019 The oxidative inactivation of Sac1 results in the accumulation of PtdIns(4)P at the Golgi, with this effect also being supported by the H2O2-induced activation of p38 mitogen-activated protein kinase (MAPK), which was previously shown to promote the translocation of Sac1 from the Golgi to the endoplasmic reticulum. Hydrogen Peroxide 136-140 mitogen-activated protein kinase 14 Homo sapiens 163-199 28429287-6 2018 Furthermore, it inhibited H2O2-induced p38 MAPK phosphorylation. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 14 Homo sapiens 39-42 29615910-7 2018 Human umbilical vein endothelial cell (HUVEC) neovascularization induced by conditioned medium (CM) from H2O2-stimulated RPE cells was attenuated by treatment with Kin, VEGF antagonist, NF-kappaB, Erk-MAPK, and p38-MAPK inhibitors. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 14 Homo sapiens 211-214 29615910-8 2018 Additionally, H2O2-activated phosphorylated expression of IkappaBalpha, p65, Erk, and p38 in RPE cells was inhibited by treatment with Kin. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 14 Homo sapiens 86-89 29615910-10 2018 This could be ascribed to the inhibition of Erk/p38/NF-kappaB signaling by Kin that contributed to the resulting decreased VEGF expression in H2O2-treated RPE cells. Hydrogen Peroxide 142-146 mitogen-activated protein kinase 14 Homo sapiens 48-51 28864417-5 2017 Hydrogen peroxide also induces primarily p38 MAPK and some p42/44 MAPK phosphorylation. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Homo sapiens 41-44 29039448-0 2017 Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting alpha-synuclein expression via the p38 MAPK pathway. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 14 Homo sapiens 122-125 28219939-6 2017 We discovered that the TnPrx1 POX and CAT-like activities possessed different kinetic features in the reduction of H2O2 The overexpression of wild-type TnPrx1 and mutants differentially regulated the intracellular levels of reactive oxygen species (ROS) and the phosphorylation of p38 in HEK-293T cells treated with H2O2 Prx1 is a dual-function enzyme by acting as POX and CAT with varied affinities towards ROS. Hydrogen Peroxide 115-119 mitogen-activated protein kinase 14 Homo sapiens 281-284 28659586-0 2017 PGC-1alpha attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3beta inactivation mediated by activated p38 in HK-2 Cells. Hydrogen Peroxide 22-39 mitogen-activated protein kinase 14 Homo sapiens 139-142 28659586-8 2017 Taken together, we suggest that PGC-1alpha protects human renal tubule cells from H2O2-mediated apoptotic injury by upregulating Nrf-2 via GSK3beta inactivation mediated by activated p38. Hydrogen Peroxide 82-86 mitogen-activated protein kinase 14 Homo sapiens 183-186 27357344-6 2017 In osteoblastic MC3T3-E1 and MG-63 cells, H2 O2 triggered p38, JNK, ERK and p66Shc phosphorylation, and cell apoptosis. Hydrogen Peroxide 42-47 mitogen-activated protein kinase 14 Homo sapiens 58-61 27357344-8 2017 H2 O2 -induced p38 and ERK phosphorylation and apoptosis were both decreased by pre-treatment with specific kinase inhibitors or PTHrP (1-37) in both osteoblastic cell types. Hydrogen Peroxide 0-5 mitogen-activated protein kinase 14 Homo sapiens 15-18 28450955-8 2017 H2O2-stimulated p38 mitogen-activated protein kinase activation was repressed following treatment with alpha- and/or beta-Naphthoflavone, along with a decreased expression of the apoptosis-related factors and inhibited caspase-3 activation. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 16-19 27810738-6 2016 Moreover, hydroxytyrosol (but not tyrosol), was able to diminish the late sustained phase of H2O2-induced JNK and p38 phosphorylation. Hydrogen Peroxide 93-97 mitogen-activated protein kinase 14 Homo sapiens 114-117 27896567-8 2017 Moreover, FOXO1 and LXRalpha transcription factors participate in H2O2-triggered downregulation of apoA-I gene together with Src, JNK, p38, and AMPK kinase cascades. Hydrogen Peroxide 66-70 mitogen-activated protein kinase 14 Homo sapiens 135-138 27890795-4 2017 Here, we show that CTK7A-induced hydrogen peroxide (H2O2) generation in CoCl2-exposed and invasive gastric cancer cells (GCCs) leads to p38 MAPK-mediated Noxa expression and thereafter, mitochondrial apoptotic events. Hydrogen Peroxide 33-50 mitogen-activated protein kinase 14 Homo sapiens 136-139 27890795-4 2017 Here, we show that CTK7A-induced hydrogen peroxide (H2O2) generation in CoCl2-exposed and invasive gastric cancer cells (GCCs) leads to p38 MAPK-mediated Noxa expression and thereafter, mitochondrial apoptotic events. Hydrogen Peroxide 52-56 mitogen-activated protein kinase 14 Homo sapiens 136-139 27387771-0 2016 Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis. Hydrogen Peroxide 37-41 mitogen-activated protein kinase 14 Homo sapiens 107-110 27339454-9 2016 Furthermore, AcEGCG effectively suppressed H2 O2 -induced p38 mitogen-activated protein kinase phosphorylation, which has been suggested to contribute to melanocyte damage. Hydrogen Peroxide 43-48 mitogen-activated protein kinase 14 Homo sapiens 58-61 27142525-5 2016 Oxidative stress, which was generated by exposure to 500 microM H2O2, induces a rapid dephosphorylation of NPM at T199 that depends on phosphatase PP2A, another partner of the NPM/p38 complex. Hydrogen Peroxide 64-68 mitogen-activated protein kinase 14 Homo sapiens 180-183 27387771-6 2016 It was observed that spatiotemporal changes in intracellular labile iron, induced by H2O2, influenced the oxidation pattern of the upstream MAP3K ASK1 and promoted the sustained activation of JNK-p38 axis in a defined time-dependent context. Hydrogen Peroxide 85-89 mitogen-activated protein kinase 14 Homo sapiens 196-199 27237042-4 2016 Since p38 activation is involved in microparticle generation in some cell models and p38 inhibition is one of the mechanisms of action of pirfenidone, we investigated the hypothesis that H2O2-induced generation of microparticles by alveolar cells is dependent on p38 phosphorylation and is inhibited by pirfenidone. Hydrogen Peroxide 187-191 mitogen-activated protein kinase 14 Homo sapiens 6-9 27237042-4 2016 Since p38 activation is involved in microparticle generation in some cell models and p38 inhibition is one of the mechanisms of action of pirfenidone, we investigated the hypothesis that H2O2-induced generation of microparticles by alveolar cells is dependent on p38 phosphorylation and is inhibited by pirfenidone. Hydrogen Peroxide 187-191 mitogen-activated protein kinase 14 Homo sapiens 85-88 27237042-4 2016 Since p38 activation is involved in microparticle generation in some cell models and p38 inhibition is one of the mechanisms of action of pirfenidone, we investigated the hypothesis that H2O2-induced generation of microparticles by alveolar cells is dependent on p38 phosphorylation and is inhibited by pirfenidone. Hydrogen Peroxide 187-191 mitogen-activated protein kinase 14 Homo sapiens 85-88 27237042-5 2016 H2O2 stimulation of alveolar cells caused p38 phosphorylation that was inhibited by pirfenidone. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 42-45 26794217-0 2016 Erratum to: Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H2O2-induced apoptosis in human lens epithelial cells. Hydrogen Peroxide 89-93 mitogen-activated protein kinase 14 Homo sapiens 26-29 26891889-5 2016 Sublytic concentrations of hydrogen peroxide (H2O2) plus NO donor S-nitroso-N-acetyl-D, L-penicillamine (SNAP) enabled to induce a toxic oxidative/nitrosative stress through activating both p38 MAPK and p53 cascades, and cause DNA damage and protein tyrosine nitration in primary neuronal cultures. Hydrogen Peroxide 27-44 mitogen-activated protein kinase 14 Homo sapiens 190-193 26891889-5 2016 Sublytic concentrations of hydrogen peroxide (H2O2) plus NO donor S-nitroso-N-acetyl-D, L-penicillamine (SNAP) enabled to induce a toxic oxidative/nitrosative stress through activating both p38 MAPK and p53 cascades, and cause DNA damage and protein tyrosine nitration in primary neuronal cultures. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 14 Homo sapiens 190-193 26631726-5 2016 Here, we describe that, in astrocytes exposed to oxidative stress by hydrogen peroxide (H2O2), p38 activation did not inhibit AKT (protein kinase B) activation by IGF-I, which is in contrast to our previous observations in neurons. Hydrogen Peroxide 69-86 mitogen-activated protein kinase 14 Homo sapiens 95-98 26874034-10 2016 Pretreatment with Dau, Pec, and Ast inhibited phosphorylation of MAPK, such as extracellular protein regulated protein kinase, p38, and c-Jun N-terminal kinase by H2O2. Hydrogen Peroxide 163-167 mitogen-activated protein kinase 14 Homo sapiens 127-130 26631726-5 2016 Here, we describe that, in astrocytes exposed to oxidative stress by hydrogen peroxide (H2O2), p38 activation did not inhibit AKT (protein kinase B) activation by IGF-I, which is in contrast to our previous observations in neurons. Hydrogen Peroxide 88-92 mitogen-activated protein kinase 14 Homo sapiens 95-98 30192113-4 2016 Here, in order to confirm the implication of p38 in the H2O2-induced senescence of hMESCs, we applied another highly specific inhibitor of p38 : BIRB796 (BIRB). Hydrogen Peroxide 56-60 mitogen-activated protein kinase 14 Homo sapiens 45-48 26682012-4 2016 Furthermore, it inhibited H2O2-induced p38 MAPK phosphorylation. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 14 Homo sapiens 39-42 30192113-4 2016 Here, in order to confirm the implication of p38 in the H2O2-induced senescence of hMESCs, we applied another highly specific inhibitor of p38 : BIRB796 (BIRB). Hydrogen Peroxide 56-60 mitogen-activated protein kinase 14 Homo sapiens 139-142 30192113-6 2016 Summarizing the obtained results we can postulate p38 implication in H2O2-induced senescence of hMESCs, and suggest p38 inhibition as a promising approach in prevention of premature senescence. Hydrogen Peroxide 69-73 mitogen-activated protein kinase 14 Homo sapiens 50-53 26143291-0 2015 Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H2O2-induced apoptosis in human lens epithelial cells. Hydrogen Peroxide 77-81 mitogen-activated protein kinase 14 Homo sapiens 14-17 26456053-6 2015 Mechanistically, H2O2-induced cell death involves inhibition of pro-survival signaling proteins (Akt, Nrf2) and activation of pro-death signaling proteins (p38, JNK1). Hydrogen Peroxide 17-21 mitogen-activated protein kinase 14 Homo sapiens 156-159 26143291-3 2015 The purpose of this study was to investigate the role of phosphorylated p38 mitogen-activated protein kinase in H2O2-induced apoptosis in cultured human lens epithelial (HLE) cells. Hydrogen Peroxide 112-116 mitogen-activated protein kinase 14 Homo sapiens 72-75 26535076-5 2015 H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 56-92 26143291-10 2015 The level of p-p38 was increased when cells were exposed to H2O2 and significantly SB203580-inhibited phosphorylation of p38. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 14 Homo sapiens 15-18 26143291-10 2015 The level of p-p38 was increased when cells were exposed to H2O2 and significantly SB203580-inhibited phosphorylation of p38. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 14 Homo sapiens 121-124 26495060-7 2015 Furthermore, propofol significantly ameliorated H2O2-induced phosphorylation of p38 MAPK, JNK, and Akt in HUVECs. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 14 Homo sapiens 80-83 26439801-0 2015 Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Homo sapiens 79-82 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 14 Homo sapiens 196-199 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 14 Homo sapiens 196-199 26439801-4 2015 The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 98059 (ERK inhibitor), SB 203580 (p38 MAPK inhibitor), polyethylene glycol-conjugated catalase (PEG-CAT), or the siRNA specific to SOD2. Hydrogen Peroxide 77-81 mitogen-activated protein kinase 14 Homo sapiens 187-190 26495060-8 2015 CONCLUSIONS: Propofol can protect HUVECs against H2O2-induced apoptosis via a mechanism that may involve p38 MAPK, JNK, and Akt signaling pathways. Hydrogen Peroxide 49-53 mitogen-activated protein kinase 14 Homo sapiens 105-108 26088136-5 2015 The overexpression of wild-type TnPrx1 and mutants differentially regulated the intracellular levels of reactive oxygen species and p38 phosphorylation in HEK-293T cells treated with H2O2. Hydrogen Peroxide 183-187 mitogen-activated protein kinase 14 Homo sapiens 132-135 26337541-4 2015 Hydrogen peroxide (H2O2) at subcytotoxic concentrations transiently increased the intracellular levels of reactive oxygen species, activated the p38 MAPK, ERKs, JNKs and Akt signalling pathways and induced the nuclear translocation of NF-kappaBeta and Nrf2. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Homo sapiens 145-148 26337541-4 2015 Hydrogen peroxide (H2O2) at subcytotoxic concentrations transiently increased the intracellular levels of reactive oxygen species, activated the p38 MAPK, ERKs, JNKs and Akt signalling pathways and induced the nuclear translocation of NF-kappaBeta and Nrf2. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 14 Homo sapiens 145-148 25975679-8 2015 We also found that melatonin attenuated the H2 O2 -stimulated phosphorylation of p38 mitogen-activated protein kinase, decreased expression of the senescence-associated protein p16(INK) (4alpha) , and increased SIRT1. Hydrogen Peroxide 44-49 mitogen-activated protein kinase 14 Homo sapiens 81-117 26622762-11 2015 In Prx1-knockdown DOK cells, ASK1 and p38 were activated, leading to enhanced levels of apoptosis in response to H2O2. Hydrogen Peroxide 113-117 mitogen-activated protein kinase 14 Homo sapiens 38-41 26054856-12 2015 CONCLUSIONS: Current findings suggest that LPE exerts neuroprotective effects against H2O2-induced apoptotic cell death by modulating p38 activation in SH-SY5Y cells. Hydrogen Peroxide 86-90 mitogen-activated protein kinase 14 Homo sapiens 134-137 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. Hydrogen Peroxide 226-230 mitogen-activated protein kinase 14 Homo sapiens 146-182 25997250-7 2015 Propofol also inhibited H2O2-induced p38 MAPK, JNK and Akt phosphorylation. Hydrogen Peroxide 24-28 mitogen-activated protein kinase 14 Homo sapiens 37-40 25720812-4 2015 In addition, pretreatment with THF attenuated H2O2-induced rapid and significant phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinases (PI3K)/Akt. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 14 Homo sapiens 131-167 25621814-6 2015 Contrastingly, sustained decreased H2O2 levels are required for the activation of p38 signaling and trigger a shift from proliferation to quiescence. Hydrogen Peroxide 35-39 mitogen-activated protein kinase 14 Homo sapiens 82-85 25621814-12 2015 H2O2 constitutes an important trigger for the proliferation and quiescence transition in hepatocytes via the concentration-dependent activation of the ERK or p38 pathway. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 158-161 25631293-5 2015 In addition, DHEA reduced the H2O2-induced phosphorylation of ERK and p38 in a dose-dependent manner. Hydrogen Peroxide 30-34 mitogen-activated protein kinase 14 Homo sapiens 70-73 25789565-4 2015 The upregulation of miR-200-3p in turn modulates the H2O2-mediated oxidative stress response by targeting p38alpha. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Homo sapiens 106-114 25789565-8 2015 In addition, we show that p38alpha can directly phosphorylate p53 at serine 33 upon H2O2 exposure. Hydrogen Peroxide 84-88 mitogen-activated protein kinase 14 Homo sapiens 26-34 26064424-5 2015 Moreover, RNSP significantly attenuated the H2O2-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase 1/2 (ERK 1/2) in SH-SY5Y cells. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 14 Homo sapiens 76-112 26510982-7 2015 Western blotting and immunofluorescence staining showed that HOEC inhibited H2O2-induced p38 phosphorylation and NF-kappaB activation. Hydrogen Peroxide 76-80 mitogen-activated protein kinase 14 Homo sapiens 89-92 25823229-5 2014 It was observed that TNFalpha, NFkappaB and p38 MAPK were not induced in UVC-bystander cells, but their expression was suppressed in the UVC-bystander cells treated with UVC or H2O2. Hydrogen Peroxide 177-181 mitogen-activated protein kinase 14 Homo sapiens 44-52 25791156-7 2015 Hydrogen peroxide (H2O2), cytomix (tumour necrosis factor-alpha + IL-1beta + interferon-gamma) and lipopolysaccharide (LPS) upregulated IL-8 mRNA at 1 or 2 h. p38 MAPKalpha mRNA was significantly increased after H2O2 and LPS treatment. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 14 Homo sapiens 159-162 24602443-9 2014 Furthermore, digitoflavone decreased H2O2-induced oxidative stress and cell death via p38 MAPK-Nrf2/ARE pathway. Hydrogen Peroxide 37-41 mitogen-activated protein kinase 14 Homo sapiens 86-89 24906456-0 2014 Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus. Hydrogen Peroxide 64-81 mitogen-activated protein kinase 14 Homo sapiens 23-26 24820448-11 2014 Addition of JNK inhibitor SP600125 or p38 inhibitor SB203580 to myocytes plus H2O2 prevented H2O2 decrease in viability and increased hUCBC beneficial effects. Hydrogen Peroxide 93-97 mitogen-activated protein kinase 14 Homo sapiens 38-41 24712558-6 2014 RESULTS: Hydrogen peroxide induced apoptotic cell death in fibroblasts, accompanied by induction of phosphorylation of JNK and p38 and activation of caspase-3. Hydrogen Peroxide 9-26 mitogen-activated protein kinase 14 Homo sapiens 127-130 23815460-9 2014 Inhibition of SDF-1 and MCP-1 blocked the H2 O2 -induced activation of Akt, p38, ERK and NF-kB. Hydrogen Peroxide 42-47 mitogen-activated protein kinase 14 Homo sapiens 76-79 23799549-12 2013 In particular, p38 inhibitor increased ROS levels in H2O2-treated HeLa cells, while NAC and PG attenuated H2O2-induced HeLa cell death by suppressing ROS levels. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 14 Homo sapiens 15-18 25431609-5 2014 In addition, H2O2 produced transcriptional changes in p53, JNK, p38 MAPK, AKT, BAX, and CDK4 that were inclined towards apoptosis, while GBR-extracts showed some transcriptional changes (upregulation of BAX and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, AKT, JNK, and p38 MAPK) suggested that GBR-extracts favored survival of the HepG2 cells. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 14 Homo sapiens 64-67 25431609-5 2014 In addition, H2O2 produced transcriptional changes in p53, JNK, p38 MAPK, AKT, BAX, and CDK4 that were inclined towards apoptosis, while GBR-extracts showed some transcriptional changes (upregulation of BAX and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, AKT, JNK, and p38 MAPK) suggested that GBR-extracts favored survival of the HepG2 cells. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 14 Homo sapiens 333-336 24292713-6 2014 We found that ATN-224-induced cell death was mediated through H(2)O(2)-dependent activation of P38 MAPK and that P38 activation led to a decrease in the antiapoptotic factor MCL1, which is often upregulated in NSCLC. Hydrogen Peroxide 62-70 mitogen-activated protein kinase 14 Homo sapiens 95-98 24090642-1 2014 Four hydrophobic p38alpha mitogen-activated protein kinase inhibitors were refluxed with 7.5% hydrogen peroxide at 80 C and irradiated with visible light in order to generate more hydrophilic conversion products. Hydrogen Peroxide 94-111 mitogen-activated protein kinase 14 Homo sapiens 17-25 23726950-10 2013 H2O2 induced NF-kappaB activation and IkappaB-alpha degradation, but the increased nuclear NF-kappaB activation was counteracted by MSP or by a p38 MAPK inhibitor. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 144-147 23726950-12 2013 These findings suggest that MSP attenuates H2O2-induced apoptosis in HK-2 cells by modulating the p38 and NF-kappaB, as well as PI3K/Akt, signaling pathways. Hydrogen Peroxide 43-47 mitogen-activated protein kinase 14 Homo sapiens 98-101 23418094-7 2013 H2 O2 also induced the phosphorylation and subsequent activation of ERK, p38 MAPK, and Akt. Hydrogen Peroxide 0-5 mitogen-activated protein kinase 14 Homo sapiens 73-76 23417568-4 2013 In the current study, we scrutinized the effects of hydrogen peroxide and/or menadione (superoxide anion generator) on JNK/p38-MAPKs and JAK2-STAT3 pathways to elucidate the mechanism(s) by which each oxidant modulated the above-mentioned pathways leading to SK-N-MC cell death. Hydrogen Peroxide 52-69 mitogen-activated protein kinase 14 Homo sapiens 123-126 23874911-3 2013 We found that ME is superior in attenuating the activation of hydrogen peroxide-induced pro-inflammatory mediators, ERK and P38 in human aortic endothelial cells. Hydrogen Peroxide 62-79 mitogen-activated protein kinase 14 Homo sapiens 124-127 23417568-5 2013 Our results delineated that hydrogen peroxide and superoxide anion radical induced distinct responses as we showed that STAT3 and p38 were activated in response to hydrogen peroxide, but not superoxide anion radicals indicating the specificity in ROS-induced signaling pathways activations and behaviors. Hydrogen Peroxide 28-45 mitogen-activated protein kinase 14 Homo sapiens 130-133 23417568-5 2013 Our results delineated that hydrogen peroxide and superoxide anion radical induced distinct responses as we showed that STAT3 and p38 were activated in response to hydrogen peroxide, but not superoxide anion radicals indicating the specificity in ROS-induced signaling pathways activations and behaviors. Hydrogen Peroxide 164-181 mitogen-activated protein kinase 14 Homo sapiens 130-133 23849857-5 2013 Reactive oxygen species (ROS), such as hydrogen peroxide, have been reported to activate ERKs, JNKs, and p38 MAPKs, but the mechanisms by which ROS can activate these kinases are unclear. Hydrogen Peroxide 39-56 mitogen-activated protein kinase 14 Homo sapiens 105-108 23607503-4 2013 H2O2-induced ROS increased the phosphorylation of p38 MAPK and JNK; this was inhibited by DK pretreatment. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 50-53 23607503-5 2013 H2O2 treatment increased the phosphorylation of NF-kappaB, which was blocked by pretreatment with SB 203580, a p38 MAPK inhibitor, or SP 600125, a JNK inhibitor. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 14 Homo sapiens 111-114 22198289-4 2012 Moreover, the p38 in HUVEC was phosphorylated by DS released from PMN and also by H(2)O(2), but not by O(2) (-) induced by myeloperoxidase (MPO) of PMN. Hydrogen Peroxide 82-90 mitogen-activated protein kinase 14 Homo sapiens 14-17 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Hydrogen Peroxide 18-27 mitogen-activated protein kinase 14 Homo sapiens 66-69 22569306-0 2012 Baicalein protects human melanocytes from H2O2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 14 Homo sapiens 130-133 22569306-8 2012 The results demonstrate for the first time that BE exerts a cytoprotective role in H(2)O(2)-induced apoptosis by inhibiting the mitochondria-dependent caspase activation and p38 MAPK pathway. Hydrogen Peroxide 83-91 mitogen-activated protein kinase 14 Homo sapiens 174-177 22154358-7 2012 Stress stimuli (sorbitol, hydrogen peroxide, and UV irradiation) were used to active p38, which was measured by phospho-antibody. Hydrogen Peroxide 26-43 mitogen-activated protein kinase 14 Homo sapiens 85-88 22708121-10 2012 It also inhibited H2O2-induced phosphorylation of ERK, p38, and JNK. Hydrogen Peroxide 18-22 mitogen-activated protein kinase 14 Homo sapiens 55-58 22310390-6 2012 When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors. Hydrogen Peroxide 49-66 mitogen-activated protein kinase 14 Homo sapiens 29-32 22310390-6 2012 When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors. Hydrogen Peroxide 49-66 mitogen-activated protein kinase 14 Homo sapiens 185-188 21816217-8 2011 Instead, the induction of autophagy by H2O2 depends on the induction of intracellular production of reactive oxygen species (ROS) and activation of the p38 mitogen-activated protein kinase alpha (p38 MAPKalpha) pathway. Hydrogen Peroxide 39-43 mitogen-activated protein kinase 14 Homo sapiens 152-155 22002864-0 2012 H(2)O (2)-induced secretion of tumor necrosis factor-alpha evokes apoptosis of cardiac myocytes through reactive oxygen species-dependent activation of p38 MAPK. Hydrogen Peroxide 0-18 mitogen-activated protein kinase 14 Homo sapiens 161-164 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. Hydrogen Peroxide 80-88 mitogen-activated protein kinase 14 Homo sapiens 43-46 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. Hydrogen Peroxide 194-202 mitogen-activated protein kinase 14 Homo sapiens 43-46 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. Hydrogen Peroxide 194-202 mitogen-activated protein kinase 14 Homo sapiens 150-153 22002864-4 2012 In addition, pretreatment of cells with TNF-alpha increased basal and H(2)O(2)-stimulated p38 MAPK and apoptosis of cardiac myocytes, and p38 MAPK-associated apoptosis of cardiac myocytes induced by TNF-alpha was blocked by inhibition of p38 MAPK with SB. Hydrogen Peroxide 70-78 mitogen-activated protein kinase 14 Homo sapiens 90-93 22002864-5 2012 Finally, H(2)O(2)-induced apoptosis was attenuated by the inhibitors of p38 MAPK or reactive oxygen species (ROS), whereas it was enhanced by p38 MAPK agonist SA. Hydrogen Peroxide 9-17 mitogen-activated protein kinase 14 Homo sapiens 72-75 22002864-5 2012 Finally, H(2)O(2)-induced apoptosis was attenuated by the inhibitors of p38 MAPK or reactive oxygen species (ROS), whereas it was enhanced by p38 MAPK agonist SA. Hydrogen Peroxide 9-17 mitogen-activated protein kinase 14 Homo sapiens 142-145 22002864-6 2012 These results suggest that H(2)O(2)-induced secretion of TNF-alpha increases apoptosis of cardiac myocytes through ROS-dependent activation of p38 MAPK. Hydrogen Peroxide 27-35 mitogen-activated protein kinase 14 Homo sapiens 143-146 22281399-0 2012 Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Hydrogen Peroxide 17-34 mitogen-activated protein kinase 14 Homo sapiens 77-80 22281399-5 2012 Physiological concentrations of H(2)O(2) (flux of 0.1 nM/min and 15 muM added extracellularly) significantly activated both eNOS and p38 MAPK. Hydrogen Peroxide 32-40 mitogen-activated protein kinase 14 Homo sapiens 133-136 22139847-2 2012 The presence of p38alpha increases basal and H(2)O(2)-induced expression of the antioxidant enzymes: superoxide-dismutase 1 (SOD-1), SOD-2, and catalase through different mechanisms, which protects from reactive oxygen species (ROS) accumulation and prevents cell death. Hydrogen Peroxide 45-53 mitogen-activated protein kinase 14 Homo sapiens 16-24 21816217-8 2011 Instead, the induction of autophagy by H2O2 depends on the induction of intracellular production of reactive oxygen species (ROS) and activation of the p38 mitogen-activated protein kinase alpha (p38 MAPKalpha) pathway. Hydrogen Peroxide 39-43 mitogen-activated protein kinase 14 Homo sapiens 196-199 21865167-10 2011 H(2)O(2)- and LPS-induced TACE activity up-regulation were effectively abolished by a variety of selective p38 MAPK inhibitors. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 14 Homo sapiens 107-110 21865167-11 2011 Activation of p38 was redox-sensitive as H(2)O(2) caused p38 phosphorylation, and ROS scavenging significantly reduced LPS-induced phospho-p38 expression. Hydrogen Peroxide 41-49 mitogen-activated protein kinase 14 Homo sapiens 14-17 21865167-11 2011 Activation of p38 was redox-sensitive as H(2)O(2) caused p38 phosphorylation, and ROS scavenging significantly reduced LPS-induced phospho-p38 expression. Hydrogen Peroxide 41-49 mitogen-activated protein kinase 14 Homo sapiens 57-60 21865167-11 2011 Activation of p38 was redox-sensitive as H(2)O(2) caused p38 phosphorylation, and ROS scavenging significantly reduced LPS-induced phospho-p38 expression. Hydrogen Peroxide 41-49 mitogen-activated protein kinase 14 Homo sapiens 57-60 21860593-10 2011 Collectively these data imply that H(2)O(2) induces necroptotic cell death in the GS28 siRNA-transfected cells and that the necroptotic signals are mediated by sequential activations in RIP1/p38/ROS. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 14 Homo sapiens 191-194 21385331-0 2011 Toxoplasma gondii protects against H(2)O(2) -induced apoptosis in ARPE-19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 14 Homo sapiens 167-170 21163347-4 2011 Several recent studies are reviewed that support the concept that direct exposure of mammalian skeletal muscle to an oxidant stress (including hydrogen peroxide) results in stimulation of the serine kinase p38 mitogen-activated protein kinase (p38 MAPK), and that the engagement of this stress-activated p38 MAPK signaling is mechanistically associated with diminished insulin-dependent stimulation of insulin signaling elements and glucose transport activity. Hydrogen Peroxide 143-160 mitogen-activated protein kinase 14 Homo sapiens 206-242 21163347-4 2011 Several recent studies are reviewed that support the concept that direct exposure of mammalian skeletal muscle to an oxidant stress (including hydrogen peroxide) results in stimulation of the serine kinase p38 mitogen-activated protein kinase (p38 MAPK), and that the engagement of this stress-activated p38 MAPK signaling is mechanistically associated with diminished insulin-dependent stimulation of insulin signaling elements and glucose transport activity. Hydrogen Peroxide 143-160 mitogen-activated protein kinase 14 Homo sapiens 244-252 21163347-4 2011 Several recent studies are reviewed that support the concept that direct exposure of mammalian skeletal muscle to an oxidant stress (including hydrogen peroxide) results in stimulation of the serine kinase p38 mitogen-activated protein kinase (p38 MAPK), and that the engagement of this stress-activated p38 MAPK signaling is mechanistically associated with diminished insulin-dependent stimulation of insulin signaling elements and glucose transport activity. Hydrogen Peroxide 143-160 mitogen-activated protein kinase 14 Homo sapiens 206-209 21530592-9 2011 Interestingly, inhibition of p38 MAPK abrogated the production of H(2)O(2), suggesting that there might be a positive feedback loop in the myogenic-redox signalling pathway. Hydrogen Peroxide 66-74 mitogen-activated protein kinase 14 Homo sapiens 29-32 21860593-11 2011 Taken together, these results indicate that GS28 has a protective role in H(2)O(2)-induced necroptosis via inhibition of p38 MAPK in GSH-depleted neuronal cells. Hydrogen Peroxide 74-82 mitogen-activated protein kinase 14 Homo sapiens 121-124 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 179-183 mitogen-activated protein kinase 14 Homo sapiens 127-130 21272161-7 2011 Activation of extracellular regulated kinases (ERK), p38, c-Jun N-terminal kinase (JNK) and Akt was observed after treatment of hydrogen peroxide. Hydrogen Peroxide 128-145 mitogen-activated protein kinase 14 Homo sapiens 53-56 21052844-5 2011 Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 14 Homo sapiens 77-113 21052844-5 2011 Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 14 Homo sapiens 115-123 21052844-5 2011 Moreover, selenium also inhibited HG, AGE, HI and H2O2-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), which indicated that the preventive effects of selenium on COX-2 and P-selectin may be associated with p38. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 14 Homo sapiens 77-80 21052844-6 2011 Our results indicated that selenium supplementation can reduce HG, AGE, HI and H2O2-induced expression of COX-2 and P-selectin by inhibition of the p38 pathway. Hydrogen Peroxide 79-83 mitogen-activated protein kinase 14 Homo sapiens 148-151 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 14 Homo sapiens 127-130 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 179-183 mitogen-activated protein kinase 14 Homo sapiens 277-280 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 14 Homo sapiens 277-280 21264233-10 2011 GSPE also depressed H2O2-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied. Hydrogen Peroxide 20-24 mitogen-activated protein kinase 14 Homo sapiens 56-59 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 179-183 mitogen-activated protein kinase 14 Homo sapiens 127-130 21241662-5 2011 In the presence of insulin, H2O2 decreased total protein expression of IRS-1 at 6 h and IRS-2 at 4 and 6 h. Phosphorylation of p38 MAPK Thr180/Tyr182 was transiently increased by H2O2 in the presence and absence of insulin at 2 and 4 h, but not at 6 h. Selective inhibition of p38 MAPK with A304000 partially rescued the H2O2-induced reduction in insulin-stimulated glucose transport activity. Hydrogen Peroxide 179-183 mitogen-activated protein kinase 14 Homo sapiens 277-280 20838381-4 2011 Expression of p16 was rapidly upregulated following ultraviolet-irradiation and in response to H2O2-induced oxidative stress in a p38 stress-activated protein kinase-dependent manner. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 14 Homo sapiens 130-133 20965163-5 2011 Mechanistically, honokiol suppressed H(2)O(2)-induced phosphorylation of ERK1/2, p38 mitogen-activated protein kinase (MAPK), JNK and Akt. Hydrogen Peroxide 37-45 mitogen-activated protein kinase 14 Homo sapiens 81-117