PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2001413-1	1991	Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the toxic reactions of subsequent XO-derived superoxide, hydrogen peroxide and hydroxyl radical, have been suggested to be critical factors in several mechanisms of tissue pathophysiology.	Hydrogen Peroxide	129-146	xanthine dehydrogenase	Rattus norvegicus	14-36	
2001413-1	1991	Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the toxic reactions of subsequent XO-derived superoxide, hydrogen peroxide and hydroxyl radical, have been suggested to be critical factors in several mechanisms of tissue pathophysiology.	Hydrogen Peroxide	129-146	xanthine dehydrogenase	Rattus norvegicus	38-41	
3162724-1	1988	The reversible and irreversible conversion of xanthine dehydrogenase to xanthine oxidase during ischemia/reperfusion and oxidative stress induced by hydrogen peroxide or diamide and its relationship with glutathione and protein SH groups were studied.	Hydrogen Peroxide	149-166	xanthine dehydrogenase	Rattus norvegicus	46-68	
34481042-0	2021	Protein S-glutathionylation decreases superoxide/hydrogen peroxide production xanthine oxidoreductase.	Hydrogen Peroxide	49-66	xanthine dehydrogenase	Rattus norvegicus	78-101	
3162724-6	1988	Perfusion for 1 h with oxidizing agents like hydrogen peroxide (60 microM) or diamide (100 microM) determines a marked conversion of xanthine dehydrogenase to reversible xanthine oxidase of about 40% and 60%, respectively; this oxidase activity partially reconverts to the dehydrogenase after withdrawing the oxidizing agents from the perfusion medium.	Hydrogen Peroxide	45-62	xanthine dehydrogenase	Rattus norvegicus	133-155	
12398932-10	2002	Although xanthine dehydrogenase conversion to a free radical-producing oxidase can serve as an important source of superoxide and hydrogen peroxide during ischemia/reperfusion, our results suggest that urate formation by xanthine dehydrogenase may provide a significant antioxidant defense against peroxynitrite and related nitric oxide-derived oxidants.	Hydrogen Peroxide	130-147	xanthine dehydrogenase	Rattus norvegicus	9-31	
17301076-3	2007	Here, we present a mutant of rat XOR that displays mainly XO activity with a superoxide:hydrogen peroxide production ratio of about 6:1.	Hydrogen Peroxide	88-105	xanthine dehydrogenase	Rattus norvegicus	33-36