PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33794383-3 2021 NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and migration. Hydrogen Peroxide 15-19 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 44-85 33794383-9 2021 5-HT and H2O2 elicited Ca2+ responses were significantly augmented in CHPH PASMCs; and the augmented Ca2+ responses were obliterated by the 2-Aminoethoxydiphenyl borate (2-APB) and Trpm2-specific siRNA. Hydrogen Peroxide 9-13 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 181-186 33794383-3 2021 NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and migration. Hydrogen Peroxide 15-19 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 87-92 28097492-7 2017 The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ). Hydrogen Peroxide 4-8 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 17-22 34958835-3 2022 When the SNpc was perfused with H2O2, glutamate accumulated in the extracellular compartment and the accumulation was inhibited in the presence of N-(p-amylcinnamoyl)anthranilic acid (ACA), a blocker of the transient receptor potential melastatin 2 (TRPM2) channels. Hydrogen Peroxide 32-36 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 207-248 34958835-3 2022 When the SNpc was perfused with H2O2, glutamate accumulated in the extracellular compartment and the accumulation was inhibited in the presence of N-(p-amylcinnamoyl)anthranilic acid (ACA), a blocker of the transient receptor potential melastatin 2 (TRPM2) channels. Hydrogen Peroxide 32-36 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 250-255 34958835-6 2022 The present study indicates that H2O2 is produced by 6-OHDA taken up through dopamine transporters in the SNpc, is retrogradely transported to presynaptic glutamatergic terminals, activates TRPM2 channels, accumulates glutamate in the extracellular compartment, and induces intracellular Zn2+ dysregulation via AMPA receptor activation, resulting in nigral dopaminergic degeneration prior to movement disorder. Hydrogen Peroxide 33-37 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 190-195 28097492-12 2017 The CAP and H2O2-induced TRPM2 current densities were also decreased by the NADPH oxidase inhibitors apocynin and N-Acetylcysteine. Hydrogen Peroxide 12-16 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 25-30 30075844-8 2018 Interestingly, in hepatocytes treated with either H2O2 or paracetamol, the amount of TRPM2 co-localised with PM is significantly increased, compared to the untreated cells. Hydrogen Peroxide 50-54 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 85-90 28097492-7 2017 The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ). Hydrogen Peroxide 141-145 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 17-22 27320188-9 2016 H2O2 -induced dilatation, which occurred only at concentrations >=100microM, was reduced by a blocking antibody to TRPM2, which had no effect on carbachol-induced responses. Hydrogen Peroxide 0-4 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 118-123 26612073-11 2016 STZ + H2O2-induced TRPM2 gating was totally inhibited by NAC and partially inhibited by N-(p-amylcinnamoyl) anthranilic acid (ACA) and 2-aminoethyl diphenylborinate (2-APB). Hydrogen Peroxide 6-10 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 19-24 25849615-0 2015 The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia. Hydrogen Peroxide 21-38 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 12-17 26612073-9 2016 In whole-cell patch clamp experiments, TRPM2 currents in the DRG following diabetes induction with STZ were gated by H2O2. Hydrogen Peroxide 117-121 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 39-44 25849615-8 2015 TRPM2 was expressed in both neurons and non-neuronal cells in TG, and pretreatment of TG cultures with 2-aminoethoxydiphenyl borate (2-APB), an inhibitor of TRPM2, or siRNA against TRPM2 attenuated H2O2-induced up-regulation of IL-6 and CXCL2. Hydrogen Peroxide 198-202 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 0-5 24434769-6 2014 The H2O2-induced TRPM2 currents were inhibited by 2-aminoethyl diphenylborinate (2-APB) and N-(p-amylcinnamoyl)anthranilic acid (ACA). Hydrogen Peroxide 4-8 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 17-22 24646700-0 2014 Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat beta-cell line RIN-5F. Hydrogen Peroxide 86-103 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 15-20 23512594-5 2013 The H2 O2 -induced TRPM2 current densities in patch-clamp experiments were decreased by ACA and 2-APB incubation. Hydrogen Peroxide 4-9 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 19-24 23943124-6 2013 In whole-cell patch clamp experiments, TRPM2 currents in the DRG incubated with PMA were stimulated by H2O2. Hydrogen Peroxide 103-107 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 39-44 21748272-5 2011 In whole-cell patch clamp experiments, TRPM2 currents in the rat were consistently induced by H(2)O(2) or BSO. Hydrogen Peroxide 94-102 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 39-44 22293297-10 2012 H(2)O(2), an activator of TRPM2 channel, induced a higher [Ca(2+)](i) elevation in hypoxia-exposed cardiac fibroblasts than that in normoxia-exposed cells. Hydrogen Peroxide 0-8 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 26-31 22300897-9 2012 BSO + H(2)O(2)-induced TRPM2 channel gating was totally inhibited by extracellular NAC and partially inhibited by 2-aminoethyl diphenylborinate. Hydrogen Peroxide 6-14 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 23-28 21140288-1 2011 The Na+ and Ca(2+)-permeable melastatin related transient receptor potential 2 (TRPM2) channels can be gated either by ADP-ribose (ADPR) in concert with Ca(2+) or by hydrogen peroxide (H(2)O(2)), an experimental model for oxidative stress, binding to the channel"s enzymatic Nudix domain. Hydrogen Peroxide 166-183 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 80-85 16546253-1 2006 The melastatin-related transient receptor potential channel TRPM2 is a Ca(2+)-permeable channel that is activated by H(2)O(2), and the Ca(2+) influx through TRPM2 mediates cell death. Hydrogen Peroxide 117-125 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 60-65 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydrogen Peroxide 122-130 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 109-114 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydrogen Peroxide 122-130 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 146-151 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydrogen Peroxide 209-217 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 109-114 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydrogen Peroxide 209-217 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 146-151 16766853-1 2006 Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat beta-cell line RIN-5F. Hydrogen Peroxide 98-102 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 44-49 16766853-1 2006 Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat beta-cell line RIN-5F. Hydrogen Peroxide 98-102 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 130-135 16766853-5 2006 H2O2-induced Ca2+ entry through TRPM2 was not affected by extracellular ADP-ribose. Hydrogen Peroxide 0-4 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 32-37 14512294-0 2004 Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Hydrogen Peroxide 0-17 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 40-45 14512294-7 2004 Both stimuli, H2O2 and ADPR, have been reported to activate the recently cloned nonselective cation channel TRPM2. Hydrogen Peroxide 14-18 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 108-113 14512294-10 2004 In conclusion, we describe here a novel calcium influx pathway in microglia coupled to hydrogen peroxide and ADPR and provide evidence that this pathway involves TRPM2. Hydrogen Peroxide 87-104 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 162-167 14512294-11 2004 The increased sensitivity to H2O2 in LPS-stimulated cells suggests a role for TRPM2 in the calcium signaling of activated microglia. Hydrogen Peroxide 29-33 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 78-83 16651700-0 2006 A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. Hydrogen Peroxide 51-68 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 19-24 16651700-2 2006 We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR). Hydrogen Peroxide 40-44 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 87-92 16651700-6 2006 ADPR-induced current responses, H2O2-induced Ca2+ influx, and H2O2-induced cell death were induced in human embryonic kidney cells heterologously expressing rat TRPM2. Hydrogen Peroxide 32-36 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 161-166 16651700-6 2006 ADPR-induced current responses, H2O2-induced Ca2+ influx, and H2O2-induced cell death were induced in human embryonic kidney cells heterologously expressing rat TRPM2. Hydrogen Peroxide 62-66 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 161-166 16651700-7 2006 Treatment of cultured neurons with small interfering RNA against rat TRPM2,which efficiently suppressed immunoreactive TRPM2 content and the H2O2-induced Ca2+ influx,significantly inhibited H2O2-induced neuronal death. Hydrogen Peroxide 141-145 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 69-74 16651700-7 2006 Treatment of cultured neurons with small interfering RNA against rat TRPM2,which efficiently suppressed immunoreactive TRPM2 content and the H2O2-induced Ca2+ influx,significantly inhibited H2O2-induced neuronal death. Hydrogen Peroxide 190-194 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 69-74 16651700-7 2006 Treatment of cultured neurons with small interfering RNA against rat TRPM2,which efficiently suppressed immunoreactive TRPM2 content and the H2O2-induced Ca2+ influx,significantly inhibited H2O2-induced neuronal death. Hydrogen Peroxide 190-194 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 119-124 16651700-8 2006 These results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons. Hydrogen Peroxide 57-61 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 27-32 16104849-0 2005 Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. Hydrogen Peroxide 31-48 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 82-87 16104849-3 2005 Melastatin-like transient receptor potential 2 (TRPM2) is a Ca(2+)-permeant non-selective cation channel, which responds to increases in oxidative stress levels in the cell and is activated by oxidants such as hydrogen peroxide. Hydrogen Peroxide 210-227 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 48-53 16104849-4 2005 We demonstrate here that Abeta and hydrogen peroxide both induce death in cultured rat striatal cells which express TRPM2 endogenously. Hydrogen Peroxide 35-52 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 116-121 16104849-5 2005 Transfection with a splice variant that acts as a dominant negative blocker of TRPM2 function (TRPM2-S) inhibited both hydrogen peroxide- and Abeta-induced increases in intracellular-free Ca(2+) and cell death. Hydrogen Peroxide 119-136 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 79-84 16104849-5 2005 Transfection with a splice variant that acts as a dominant negative blocker of TRPM2 function (TRPM2-S) inhibited both hydrogen peroxide- and Abeta-induced increases in intracellular-free Ca(2+) and cell death. Hydrogen Peroxide 119-136 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 95-100 16104849-6 2005 Functional inhibition of TRPM2 activation by the poly(ADP-ribose)polymerase inhibitor SB-750139, a modulator of intracellular pathways activating TRPM2, attenuated hydrogen peroxide- and Abeta-induced cell death. Hydrogen Peroxide 164-181 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 25-30 16104849-7 2005 Furthermore, a small interfering RNA which targets TRPM2, reduced TRPM2 mRNA levels and the toxicity induced by hydrogen peroxide and Abeta. Hydrogen Peroxide 112-129 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 51-56