PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33523042-9	2021	Thus, in the present study, miRNA-mediated modulation of HK2 during ROS (H2O2)-induced cardiomyocyte apoptosis was investigated.	Hydrogen Peroxide	73-77	hexokinase 2	Homo sapiens	57-60	
12169577-8	2002	A similar protective effect was observed in HK-II-overexpressing cells after treatment with 1 mM hydrogen peroxide for 48 h. At baseline, fluorescence microscopy showed that overexpressed HK-II was localized to mitochondria.	Hydrogen Peroxide	97-114	hexokinase 2	Homo sapiens	44-49	
12169577-8	2002	A similar protective effect was observed in HK-II-overexpressing cells after treatment with 1 mM hydrogen peroxide for 48 h. At baseline, fluorescence microscopy showed that overexpressed HK-II was localized to mitochondria.	Hydrogen Peroxide	97-114	hexokinase 2	Homo sapiens	188-193	
8127021-8	1994	To assess its potential usefulness as a tool for studying injury and repair, HK-2 cells were exposed to a toxic concentration of H2O2 +/- iron chelation (deferoxamine) or hydroxyl radical scavenger (Na benzoate) therapy.	Hydrogen Peroxide	129-133	hexokinase 2	Homo sapiens	77-81	
33523042-10	2021	First, the expression of HK2 in cardiomyocytes exposed to H2O2 was evaluated.	Hydrogen Peroxide	58-62	hexokinase 2	Homo sapiens	25-28	
33523042-11	2021	H2O2 (500muM) induced cardiomyocyte apoptosis and it also decreased the mitochondrial expression of HK2.	Hydrogen Peroxide	0-4	hexokinase 2	Homo sapiens	100-103	
33523042-14	2021	Delivery of anti-miR-181a significantly abrogated the H2O2-induced suppression of HK2 expression and subsequent disruption of mitochondrial membrane potential, improving the survival of cardiomyocytes exposed to H2O2.	Hydrogen Peroxide	54-58	hexokinase 2	Homo sapiens	82-85	
29258429-10	2017	The expression levels of HK2 and ADRB1 regulated by miR143 and Bcl-2 decreased under H2O2 treatment but were restored following MSC-CM treatment.	Hydrogen Peroxide	85-89	hexokinase 2	Homo sapiens	25-28	
29631677-7	2018	Restoration of HK2 in H2O2 treated RPE cells prevents the oxidative stress-suppressed glucose metabolism.	Hydrogen Peroxide	22-26	hexokinase 2	Homo sapiens	15-18	
21786225-8	2012	RESULTS: The proliferation of HK-2 cells was significantly inhibited by PAP, PPD and each mixed with hydrogen peroxide (H2O2).	Hydrogen Peroxide	101-118	hexokinase 2	Homo sapiens	30-34	
27926482-0	2017	Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.	Hydrogen Peroxide	94-98	hexokinase 2	Homo sapiens	0-12	
27926482-6	2017	The following effects were observed with HK2 knockdown: inhibition of cell migration and invasion; reduced SOD2 activity and intracellular H2O2 levels; suppression of pERK1/2, Slug and Vimentin expression; and inhibition of tumour growth and lung metastasis in vivo.	Hydrogen Peroxide	139-143	hexokinase 2	Homo sapiens	41-44	
27926482-7	2017	Conversely, HK2 overexpression promoted cell migration and invasion, increased SOD2 activity and intracellular H2O2, and enhanced expression of pERK1/2, Slug and Vimentin.	Hydrogen Peroxide	111-115	hexokinase 2	Homo sapiens	12-15	
27926482-9	2017	HK2 enhances the metastatic potential of TSCC by stimulating the SOD2-H2O2 pathway.	Hydrogen Peroxide	70-74	hexokinase 2	Homo sapiens	0-3	
26283227-0	2015	Suppression of miR-181a attenuates H2O2-induced death of mesenchymal stem cells by maintaining hexokinase II expression.	Hydrogen Peroxide	35-39	hexokinase 2	Homo sapiens	95-108	
26283227-3	2015	The objective was to identify miRNAs targeting HKII and investigate whether miRNA-mediated modulation of HKII could improve the survival of mesenchymal stem cells (MSCs) exposed to H2O2.	Hydrogen Peroxide	181-185	hexokinase 2	Homo sapiens	105-109	
26283227-6	2015	RESULTS: H2O2 (600 muM) induced cell death of MSCs and decreased mitochondrial HKII expression.	Hydrogen Peroxide	9-13	hexokinase 2	Homo sapiens	79-83	
26283227-7	2015	We have identified miR-181a as a HKII-targeting miRNA and H2O2 increased the expression of miR-181a in MSCs.	Hydrogen Peroxide	58-62	hexokinase 2	Homo sapiens	33-37	
26283227-8	2015	Delivery of anti-miR-181a, which neutralizes endogenous miR-181a, significantly attenuated H2O2-induced decrease of HKII expression and disruption of mitochondrial membrane potential, improving the survival of MSCs exposed to H2O2.	Hydrogen Peroxide	91-95	hexokinase 2	Homo sapiens	116-120	
26283227-9	2015	CONCLUSIONS: These findings suggest that H2O2-induced up-regulation of miR-181a contributes to the cell death of MSCs by down-regulating HKII.	Hydrogen Peroxide	41-45	hexokinase 2	Homo sapiens	137-141	
23000305-8	2012	HK2 cells were injured with H(2)O(2) in order to induce apoptosis: the effect was time- and dose-dependent.	Hydrogen Peroxide	28-36	hexokinase 2	Homo sapiens	0-3	
21786225-8	2012	RESULTS: The proliferation of HK-2 cells was significantly inhibited by PAP, PPD and each mixed with hydrogen peroxide (H2O2).	Hydrogen Peroxide	120-124	hexokinase 2	Homo sapiens	30-34