PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16112139-0	2005	Blockade of 5-HT(3) receptor with MDL7222 and Y25130 reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells.	Hydrogen Peroxide	61-78	5-hydroxytryptamine receptor 3A	Rattus norvegicus	12-28	
16112139-1	2005	The present study was performed to examine the neuroprotective effects of 5-hydroxytryptamine (5-HT)(3) receptor antagonists against hydrogen peroxide (H(2)O(2))-induced neurotoxicity using cultured rat cortical neurons.	Hydrogen Peroxide	133-150	5-hydroxytryptamine receptor 3A	Rattus norvegicus	95-112	
16112139-6	2005	These results suggest that the activation of the 5-HT(3) receptor may be partially involved in H(2)O(2)-induced neurotoxicity, by membrane depolarization for Ca(2+) influx.	Hydrogen Peroxide	95-103	5-hydroxytryptamine receptor 3A	Rattus norvegicus	49-65	
16112139-7	2005	Therefore, the blockade of 5-HT(3) receptor with MDL72222 and Y25130 may ameliorate the H(2)O(2)-induced neurotoxicity by interfering with the increase of [Ca(2+)](c), and then by inhibiting glutamate release, generation of ROS and caspase-3 activity.	Hydrogen Peroxide	88-96	5-hydroxytryptamine receptor 3A	Rattus norvegicus	27-43