PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7789482-9 1995 Co-stimulation of IL-1 beta with H2O2 led to augmentation and prolongation of the effect on NF-kappa B activation compared to stimulation with IL-1 beta alone. Hydrogen Peroxide 33-37 interleukin 1 beta Homo sapiens 18-27 11926949-15 2002 CONCLUSION: In patients with UC, IL-1 beta was increased in colonic circular muscles and may contribute to motor dysfunction after UC through production of hydrogen peroxide. Hydrogen Peroxide 156-173 interleukin 1 beta Homo sapiens 33-42 10802230-1 2000 The release of superoxide (O(2)(*-)) and hydrogen peroxide (H(2)O(2)), induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta), has been studied in the endothelial cell line ECV 304 in the presence and absence of selenium (Se) supplementation. Hydrogen Peroxide 41-58 interleukin 1 beta Homo sapiens 125-142 12101082-4 2002 In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH). Hydrogen Peroxide 116-133 interleukin 1 beta Homo sapiens 47-56 12101082-4 2002 In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH). Hydrogen Peroxide 135-143 interleukin 1 beta Homo sapiens 47-56 9790925-5 1998 Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. Hydrogen Peroxide 176-180 interleukin 1 beta Homo sapiens 242-250 9516157-4 1998 After activation of the IC-bearing endothelial layers with interleukin-1 (IL-1) or tumor necrosis factor (TNF), or both, for 4 hours, rolling adhesion of the neutrophils was induced, accompanied by considerable H2O2 production. Hydrogen Peroxide 211-215 interleukin 1 beta Homo sapiens 24-72 9516157-4 1998 After activation of the IC-bearing endothelial layers with interleukin-1 (IL-1) or tumor necrosis factor (TNF), or both, for 4 hours, rolling adhesion of the neutrophils was induced, accompanied by considerable H2O2 production. Hydrogen Peroxide 211-215 interleukin 1 beta Homo sapiens 74-78 9022680-5 1996 We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Hydrogen Peroxide 281-285 interleukin 1 beta Homo sapiens 15-24 7789482-9 1995 Co-stimulation of IL-1 beta with H2O2 led to augmentation and prolongation of the effect on NF-kappa B activation compared to stimulation with IL-1 beta alone. Hydrogen Peroxide 33-37 interleukin 1 beta Homo sapiens 143-152 8188340-5 1994 TNF, GM-CSF, and IL-8 strongly primed a subpopulation of PMN to produce H2O2 in response to N-formyl-methionyl-leucyl-phenylalanine (FMLP), while IL-1 alpha, IL-1 beta, and IL-6 failed to do so. Hydrogen Peroxide 72-76 interleukin 1 beta Homo sapiens 158-167 30712124-9 2019 The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure. Hydrogen Peroxide 24-28 interleukin 1 beta Homo sapiens 137-142 8109849-0 1993 Hydrogen peroxide primes promonocytic U937 cells to produce IL-1 beta. Hydrogen Peroxide 0-17 interleukin 1 beta Homo sapiens 60-69 32983576-8 2020 Nod-like receptors pyrins-3 (NLRP3), caspase-1, Pro-IL-1beta, and IL-1beta levels were pronouncedly elevated in cells exposed to H2O2. Hydrogen Peroxide 129-133 interleukin 1 beta Homo sapiens 48-60 34414854-10 2021 Transfection of p-LUCAT1 significantly reversed the decreased SOD levels, the increased MDA and ROS content, and the elevated tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) in H2O2-stimulated cells (P < 0.001). Hydrogen Peroxide 226-230 interleukin 1 beta Homo sapiens 193-211 33219897-6 2021 An anti-inflammatory role for EM was also observed in this experimental model, since this anthraquinone decreased the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the H2O2-challenged cells. Hydrogen Peroxide 211-215 interleukin 1 beta Homo sapiens 131-148 33045867-8 2020 Moreover, vitexin decreased expression of interleukin-1beta (IL-1beta), IL-17A and ROS in melanocytes induced by H2O2. Hydrogen Peroxide 113-117 interleukin 1 beta Homo sapiens 42-59 30712124-9 2019 The interaction between H2O2 at 50 muM and LLLT at 4 J showed partially reversion of the higher levels of DNA oxidation, CASP 3, CASP 8, IL-1B, IL-6, and INFy induced by H2O2 exposure. Hydrogen Peroxide 170-174 interleukin 1 beta Homo sapiens 137-142 29724886-9 2018 We discovered that the expression of the factors was significantly increased in pterygium and that caspase-1-dependent pyroptosis presents in both H2O2-treated HPFs and HConECs during which the expression of these factors was significantly elevated and the elevation of downstream factors IL-18 and IL-1beta was restrained after caspase-1 inhibition. Hydrogen Peroxide 147-151 interleukin 1 beta Homo sapiens 299-307 31205026-5 2019 Specifically, FLC-mediated production of H2O2 was shown to activate JAK2/STAT1 signaling, increase production of IL-1beta via induction of capsase-1, and promote activation of TGF-beta via alphavbeta6 integrin. Hydrogen Peroxide 41-45 interleukin 1 beta Homo sapiens 113-121 30563042-5 2018 H2O2 at a high concentration enhances the expression of pro-inflammatory genes (TLR2 and IL1beta) and diminishes the expression of mitochondrial dynamics-related proteins (Mtf1, Tfam) and antioxidant enzymes (Cu/Zn SOD) in PBMCs. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 89-96 30323145-9 2018 BAPTA-AM pretreatment abolished the H2O2-induced activation of NLRP3 inflammasomes, caspase-1 expression, interleukin-1beta expression and apoptosis in SHSY5Y cells, and had no effect in cells with downregulated STAT3 expression by RNAi. Hydrogen Peroxide 36-40 interleukin 1 beta Homo sapiens 106-123 29951874-5 2018 In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6. Hydrogen Peroxide 37-54 interleukin 1 beta Homo sapiens 112-120 29951874-5 2018 In the present study, we showed that hydrogen peroxide (H2O2) remarkably enhances the expression and release of IL-1beta, TNF-alpha, and IL-6. Hydrogen Peroxide 56-60 interleukin 1 beta Homo sapiens 112-120 29951874-6 2018 The maturation of IL-1beta, induced by H2O2, depends on the activation of the NLRP3 inflammasome. Hydrogen Peroxide 39-43 interleukin 1 beta Homo sapiens 18-26 29951874-7 2018 Cyclic stretching enhances the maturation of IL-1beta via promoting H2O2-induced NLRP3 inflammasome activation in tenocytes. Hydrogen Peroxide 68-72 interleukin 1 beta Homo sapiens 45-53 30527115-8 2018 Gene and protein expressions of TNF-alpha and IL-1beta were elevated in cultures with 1000 muM H2O2 compared to controls. Hydrogen Peroxide 95-99 interleukin 1 beta Homo sapiens 46-54 29956729-8 2018 The results demonstrated that pyroptosis in H2O2-treated HLECs, and the mRNA and protein expression of caspase-1 and IL-1beta, was significantly increased compared with control cells. Hydrogen Peroxide 44-48 interleukin 1 beta Homo sapiens 117-125 29956729-10 2018 When HLECs were cotreated with a caspase-1 inhibitor and 100 microM H2O2, caspase-1 and IL-1beta expression were decreased compared with the 100 microM H2O2-only group. Hydrogen Peroxide 68-72 interleukin 1 beta Homo sapiens 88-96 29956729-10 2018 When HLECs were cotreated with a caspase-1 inhibitor and 100 microM H2O2, caspase-1 and IL-1beta expression were decreased compared with the 100 microM H2O2-only group. Hydrogen Peroxide 152-156 interleukin 1 beta Homo sapiens 88-96 29473125-5 2018 The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells. Hydrogen Peroxide 289-293 interleukin 1 beta Homo sapiens 152-169 29971445-7 2018 Similarly, H2O2 upregulated TRPM2 protein expression by 80%, and induced both NLRP3 inflammasome activation and increased bioactive IL-1beta secretion (P <= 0.036), whereas ACA pretreatment suppressed these effects (P <= 0.029). Hydrogen Peroxide 11-15 interleukin 1 beta Homo sapiens 132-140 28643288-6 2017 H2O2 treatment increased both the protein and mRNA levels of IL-1beta, IL-8, and TNF-alpha, as well as those of SAPK/JNK. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 61-69 29408825-8 2018 In particular, TSP-1 contributed to the action of PPARdelta in the regulation of H2O2-induced interleukin-1beta expression. Hydrogen Peroxide 81-85 interleukin 1 beta Homo sapiens 94-111 28849141-7 2017 H2O2-induced injury was associated with enhancing the levels of inflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in the cultured HBMECs, which were attenuated by TSG treatment. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 140-148 29266807-4 2018 The results show that the functionalized surfaces downregulate the release of hydrogen peroxide and proinflammatory cytokines (tumor necrosis factor alpha and interleukin 1 beta) from human monocytes and neutrophils, compared to nonfunctionalized discs. Hydrogen Peroxide 78-95 interleukin 1 beta Homo sapiens 159-177 28643288-8 2017 In summary, the PAR2 antagonist peptide, FSLLRY-NH2, reduces the level of the pro-inflammatory genes IL-8, IL-1beta, and TNF-alpha induced by H2O2, through the SAPK/JNK pathways in HepG2 cells. Hydrogen Peroxide 142-146 interleukin 1 beta Homo sapiens 107-115 27824294-9 2017 H2O2 determined an increase in endogenous cytokines involved in the response to oxidative stress and GO pathogenesis, namely tumor necrosis factor alpha, interleukin 1 beta, and interferon gamma. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 154-172 28408139-7 2017 Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin. Hydrogen Peroxide 197-201 interleukin 1 beta Homo sapiens 75-92 28408139-7 2017 Both mRNA and protein expression levels of the pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and, tumor necrosis factor-alpha (TNF-alpha) which were increased after induction with H2O2, could be attenuated by melatonin. Hydrogen Peroxide 197-201 interleukin 1 beta Homo sapiens 94-102 28265338-5 2017 Furthermore, propolis significantly reduced the H2O2-generated reactive oxygen species (ROS) derived from mitochondria and 8-oxo-2"-deoxyguanosine (8-oxo-dG, the DNA oxidative damage marker) but significantly reversed the fibrillar beta-amyloid and IL-1beta-impaired BDNF-induced Arc expression in SH-SY5Y cells. Hydrogen Peroxide 48-52 interleukin 1 beta Homo sapiens 249-257 28318158-8 2016 2) Compared with H2O2 group, CGRP+H2O2 group significantly increased the SOD activity (P<0.01), ROS content significantly decreased (P<0.01), TNF-alpha, IL-1beta, and IL-6 secretion significantly decreased (P<0.05). Hydrogen Peroxide 34-38 interleukin 1 beta Homo sapiens 159-167 27614934-0 2016 Corrigendum to "Angiotensin(1-7) attenuated angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit": [Free Radic. Hydrogen Peroxide 108-112 interleukin 1 beta Homo sapiens 142-150 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 interleukin 1 beta Homo sapiens 248-256 28598074-5 2016 RESULTS: Compared with the control group,H2O2 not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1beta in human lung epithelial cells A549 (P<0.05),while SF group showed no statistic significance of those indicators above (P>0.05). Hydrogen Peroxide 41-45 interleukin 1 beta Homo sapiens 210-218 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 interleukin 1 beta Homo sapiens 248-256 26682942-6 2016 RESULTS: IL-1beta increased NOX-1 expression, NADPH oxidase activity and ROS production, and decreased NOX-4 expression and H2O2 production in VSMC. Hydrogen Peroxide 124-128 interleukin 1 beta Homo sapiens 9-17 26908203-11 2016 The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide. Hydrogen Peroxide 185-202 interleukin 1 beta Homo sapiens 13-30 26908203-11 2016 The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide. Hydrogen Peroxide 185-202 interleukin 1 beta Homo sapiens 32-40 26789270-7 2016 Tbeta4 activation with a Tbeta4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs. Hydrogen Peroxide 55-59 interleukin 1 beta Homo sapiens 167-175 26123077-7 2015 In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages. Hydrogen Peroxide 63-80 interleukin 1 beta Homo sapiens 97-115 26123077-7 2015 In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages. Hydrogen Peroxide 63-80 interleukin 1 beta Homo sapiens 117-125 26123077-7 2015 In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages. Hydrogen Peroxide 82-86 interleukin 1 beta Homo sapiens 97-115 26123077-7 2015 In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages. Hydrogen Peroxide 82-86 interleukin 1 beta Homo sapiens 117-125 26123077-8 2015 Taken together, our results suggest that genipin modulates NLRP3 inflammasome activation and ATP- or H2O2-mediated IL-1beta release. Hydrogen Peroxide 101-105 interleukin 1 beta Homo sapiens 115-123 26391839-0 2015 Antiinflammatory and antioxidant effects of H2O2 generated by natural sources in Il1beta-treated human endothelial cells. Hydrogen Peroxide 44-48 interleukin 1 beta Homo sapiens 81-88 26391839-3 2015 The results obtained showed that exogenously-generated H2O2 induce anti-inflammatory and antioxidant effects in HUVECs counteracting the pro-inflammatory and pro-oxidant effect of IL-1beta related to the production of superoxide anions. Hydrogen Peroxide 55-59 interleukin 1 beta Homo sapiens 180-188 22684243-6 2012 Pre-exposure to H(2)O(2) significantly delayed the TNFalpha-induced expression of an NF-kappaB reporter gene and inflammatory proteins (intercellular adhesion molecule-1 and IL-1beta). Hydrogen Peroxide 16-24 interleukin 1 beta Homo sapiens 174-182 26317859-13 2015 RESULTS: Results demonstrate that macrophages exposed to H2O2 and ATP in the presence of resolvins show decreased IL-1beta production and activity. Hydrogen Peroxide 57-61 interleukin 1 beta Homo sapiens 114-122 26121854-7 2015 NF-kappaB blockers PDTC and sodium ferulateresisted the effects of H2O2 on A549 cells, that decreased the mRNA and protein expression of NALP3 and the mRNA expression of NF-kappaB (P65), reduced the degeneration of IkappaBalpha and the secretion of IL-1beta (P<0. Hydrogen Peroxide 67-71 interleukin 1 beta Homo sapiens 249-257 24120989-8 2013 Moreover, H2O2-induced release of IL-9, TNF-alpha, MIP-1alpha and MIP-1beta was not counteracted by DPI, whereas no effect was observed in any experimental condition for both IL-6 and IL-1beta. Hydrogen Peroxide 10-14 interleukin 1 beta Homo sapiens 184-192 23934279-5 2013 H2O2 significantly reduced FP-induced GR nuclear localization (3.4+-0.51- vs. 5.7+-0.85-fold increase, P<0.05) and suppression of IL-1beta-induced CXCL8 (62.3+-2.3 vs. 85.1+-7.0%, P<0.05). Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 133-141 26222747-0 2015 Hydrogen Peroxide-Producing Lactobacilli Are Associated With Lower Levels of Vaginal Interleukin-1beta, Independent of Bacterial Vaginosis. Hydrogen Peroxide 0-17 interleukin 1 beta Homo sapiens 85-102 26222747-8 2015 In women with and without BV, IL-1beta was lower in the H2O2+ groups. Hydrogen Peroxide 56-60 interleukin 1 beta Homo sapiens 30-38 24613657-4 2014 Only 6-[4-(6-nitroxyacetyl)piperazin-1-yl]-9H-purine (compound MK128) abolished ATP or H2O2-induced IL-1beta production in the culture medium. Hydrogen Peroxide 87-91 interleukin 1 beta Homo sapiens 100-108 24759736-9 2014 RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect. Hydrogen Peroxide 8-12 interleukin 1 beta Homo sapiens 22-29 24759736-9 2014 RESULT: H2O2 enhanced IL1beta-induced IL-6 and CXCL8 expression in NHBE and BEAS-2B cells whereas H2O2 alone did not have any affect. Hydrogen Peroxide 98-102 interleukin 1 beta Homo sapiens 22-29 23687429-8 2013 In addition, 6.25 muM H2O2 led to significant elevation of the levels of transforming growth factor, beta 1, interleukin-1beta, and superoxide anion in GO fibroblasts, but no significant change in the normal controls. Hydrogen Peroxide 22-26 interleukin 1 beta Homo sapiens 109-126 23687429-9 2013 Pretreatment with N-acetylcysteine or vitamin C reversed the enhanced proliferation capacity and the induction of transforming growth factor, beta 1, interleukin-1beta and superoxide anion of GO fibroblasts in response to 6.25 muM H2O2. Hydrogen Peroxide 231-235 interleukin 1 beta Homo sapiens 150-167 21628463-8 2011 High doses (5 mM) of H(2)O(2) overcome the high antioxidant capacity of THP-1 cells, restore an efficient redox response, and increase the rate of IL-1beta secretion. Hydrogen Peroxide 21-29 interleukin 1 beta Homo sapiens 147-155 21550026-8 2011 Furthermore, intermittent exposure of FATEII cells to the exogenous oxidants X/XO and H(2)O(2) upregulated the secretion of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha; this upregulation was correlated with increasing activity of key glutathione-related enzymes, closely involved with maintaining the cyclic GSH/GSSG equilibrium. Hydrogen Peroxide 86-94 interleukin 1 beta Homo sapiens 151-159 18846238-3 2008 The mechanism by which this occurs is not fully understood, but normal IL-1beta mediated activation of the production of these cytokines occurs via H2O2 dependent signaling. Hydrogen Peroxide 148-152 interleukin 1 beta Homo sapiens 71-79 19797159-7 2010 Hydrogen peroxide (H(2)O(2)) and SIN1 as well as the cytokine mixture (IFN-gamma, IL-1beta, and tumor necrosis factor-alpha) increased mRNA expression and activity of nNOS in A549 cells in a concentration-dependent manner compared with nontreated cells. Hydrogen Peroxide 0-17 interleukin 1 beta Homo sapiens 82-90 20533854-8 2010 H2O2) and NO directly correlated with IL-6, IL-10, IL-1beta, TNFalpha and glutathione. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 51-59 18474597-7 2008 Here we examined the effects of H(2)O(2) on NF-kappaB dynamics and pro-inflammatory activation in cultured cells co-stimulated with TNFalpha or IL-1beta. Hydrogen Peroxide 32-40 interleukin 1 beta Homo sapiens 144-152 16286467-8 2006 Recruitment of NIK to TRAF6 following IL-1beta stimulation was inhibited by H2O2 clearance and Rac1 siRNA, suggesting that Rac-dependent NADPH oxidase may be a source of ROS required for NIK activation. Hydrogen Peroxide 76-80 interleukin 1 beta Homo sapiens 38-46 16723255-4 2006 TNFalpha and IL-1beta increased the production of H2O2 to similar levels in cells, suggesting that increased production of reactive oxygen species might not be the premier factor involved. Hydrogen Peroxide 50-54 interleukin 1 beta Homo sapiens 13-21 17681786-3 2007 In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937). Hydrogen Peroxide 133-150 interleukin 1 beta Homo sapiens 199-207 17027275-8 2007 Since IL-1ra decreased the number of dopaminergic neurons in H2O2-treated cultures, we propose that IL-1 has a neuroprotective role in this system involving GDNF up-regulation. Hydrogen Peroxide 61-65 interleukin 1 beta Homo sapiens 6-10 16286467-0 2006 Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. Hydrogen Peroxide 66-70 interleukin 1 beta Homo sapiens 0-17 16286467-3 2006 In the present report, we describe a mechanism whereby interleukin-1beta (IL-1beta) stimulation of NFkappaB is partially regulated by H2O2-mediated activation of NIK and subsequent NIK-mediated phosphorylation of IKKalpha. Hydrogen Peroxide 134-138 interleukin 1 beta Homo sapiens 55-72 16286467-3 2006 In the present report, we describe a mechanism whereby interleukin-1beta (IL-1beta) stimulation of NFkappaB is partially regulated by H2O2-mediated activation of NIK and subsequent NIK-mediated phosphorylation of IKKalpha. Hydrogen Peroxide 134-138 interleukin 1 beta Homo sapiens 74-82 16286467-4 2006 IL-1beta induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 reduced NFkappaB transcriptional activation by inhibiting NIK-mediated phosphorylation of IKKalpha. Hydrogen Peroxide 17-21 interleukin 1 beta Homo sapiens 0-8 16286467-9 2006 In summary, our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in IL-1beta induction of NFkappaB activation. Hydrogen Peroxide 74-78 interleukin 1 beta Homo sapiens 111-119 16207716-7 2005 Finally, H2O2-oxidized rhTrx-1 reduced IL-1beta mRNA synthesis in lipopolysaccharide-activated HMDM. Hydrogen Peroxide 9-13 interleukin 1 beta Homo sapiens 39-47 16146780-8 2006 These studies support that in addition to ovarian estrogens, mitogenic signals may also come from TNF-alpha and IL-1 beta-generated O2*- and hydrogen peroxide. Hydrogen Peroxide 141-158 interleukin 1 beta Homo sapiens 112-121 16354686-4 2006 Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated IL-1beta-dependent IKK and NF-kappaB activation. Hydrogen Peroxide 33-37 interleukin 1 beta Homo sapiens 100-108 15550558-15 2005 The data suggest that, in esophagitis, IL-1beta causes production of H(2)O(2). Hydrogen Peroxide 69-77 interleukin 1 beta Homo sapiens 39-47 16109311-6 2005 Furthermore, both IL-1beta and TNF-alpha induced the production of H(2)O(2). Hydrogen Peroxide 67-75 interleukin 1 beta Homo sapiens 18-26 15890711-5 2005 Normal muscle incubated (2 h) in IL-1beta and IL-6 had increases in H2O2, PGE2, and PAF levels. Hydrogen Peroxide 68-72 interleukin 1 beta Homo sapiens 33-41 15890711-10 2005 We conclude that IL-1beta-induced production of H2O2 causes formation of PGE2 and PAF that inhibit ACh release from esophageal cholinergic neurons without affecting ACh-induced contraction of esophageal circular muscle. Hydrogen Peroxide 48-52 interleukin 1 beta Homo sapiens 17-25 15571984-3 2004 Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition. Hydrogen Peroxide 64-81 interleukin 1 beta Homo sapiens 42-51 15571984-3 2004 Furthermore, we found that interleukin-1 (IL-1)beta, glutamate, hydrogen peroxide (H2O2), and sodium nitroprusside (SNP) induced the expression of mRNA for occludin and GULT1 under normoxic condition. Hydrogen Peroxide 83-87 interleukin 1 beta Homo sapiens 42-51 15205451-0 2004 Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. Hydrogen Peroxide 40-44 interleukin 1 beta Homo sapiens 0-17 15205451-11 2004 IL-1beta reproduces these changes, possibly by production of H(2)O(2) via sequential activation of MAPKs (ERK1/ERK2) and cPLA(2). Hydrogen Peroxide 61-69 interleukin 1 beta Homo sapiens 0-8 14989826-0 2004 [Hydrogen peroxide upregulates interleukin-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells]. Hydrogen Peroxide 1-18 interleukin 1 beta Homo sapiens 31-48 14989826-1 2004 OBJECTIVE: To investigate the effect of hydrogen peroxide (H(2)O(2)) on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (HPEC). Hydrogen Peroxide 40-57 interleukin 1 beta Homo sapiens 72-89 14989826-1 2004 OBJECTIVE: To investigate the effect of hydrogen peroxide (H(2)O(2)) on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression in human pulmonary epithelial cells (HPEC). Hydrogen Peroxide 40-57 interleukin 1 beta Homo sapiens 91-99 14989826-9 2004 CONCLUSION: Hydrogen peroxide upregulates IL-1beta-induced COX-2 expression in HPEC at transcriptional level. Hydrogen Peroxide 12-29 interleukin 1 beta Homo sapiens 42-50 14686613-0 2003 Hydrogen peroxide mediates interleukin-1beta-induced AP-1 activation in articular chondrocytes: implications for the regulation of iNOS expression. Hydrogen Peroxide 0-17 interleukin 1 beta Homo sapiens 27-44 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 138-155 interleukin 1 beta Homo sapiens 30-47 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 138-155 interleukin 1 beta Homo sapiens 49-53 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 138-155 interleukin 1 beta Homo sapiens 183-187 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 157-161 interleukin 1 beta Homo sapiens 30-47 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 157-161 interleukin 1 beta Homo sapiens 49-53 14686613-1 2003 The pro-inflammatory cytokine interleukin-1beta (IL-1) induces articular chondrocytes to produce reactive oxygen species (ROS), including hydrogen peroxide (H2O2), which mediate some IL-1-induced responses. Hydrogen Peroxide 157-161 interleukin 1 beta Homo sapiens 183-187 14686613-2 2003 This study aimed at elucidating the role of ROS, particularly H2O2, in mediating IL-1-induced activation of the transcription factor activator protein-1 (AP-1) in primary cultures of articular chondrocytes. Hydrogen Peroxide 62-66 interleukin 1 beta Homo sapiens 81-85 14686613-8 2003 These results indicate that H2O2 is a major mediator of IL-1-induced AP-1 activation in articular chondrocytes and that inhibition of ROS production is an effective strategy to block this IL-1-induced response. Hydrogen Peroxide 28-32 interleukin 1 beta Homo sapiens 56-60 14686613-8 2003 These results indicate that H2O2 is a major mediator of IL-1-induced AP-1 activation in articular chondrocytes and that inhibition of ROS production is an effective strategy to block this IL-1-induced response. Hydrogen Peroxide 28-32 interleukin 1 beta Homo sapiens 188-192 12730540-10 2003 CONCLUSIONS: Based on these results we hypothesize that IL-1beta produced by activated monocytes/macrophages increases the production of hydrogen peroxide by chondrocytes. Hydrogen Peroxide 137-154 interleukin 1 beta Homo sapiens 56-64 12755375-11 2003 H2O2 treatment inhibited both LPS and IL-1beta induced gene expressions. Hydrogen Peroxide 0-4 interleukin 1 beta Homo sapiens 38-46