PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14581479-2 2004 Here we report the activation of the tyrosine kinase pp60(src) by H2O2, a mechanism required for the activation of store-mediated Ca2+ entry (SMCE) in human platelets. Hydrogen Peroxide 66-70 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 58-61 14970215-7 2004 Both PMA- and H(2)O(2)-dependent increases in PKC delta-pY(311) are mediated by Src family kinases, but they occur via different mechanisms. Hydrogen Peroxide 14-22 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 80-83 15006543-8 2004 Finally, exposure to 1mM H(2)O(2) significantly increased store depletion-induced p60(src) activation. Hydrogen Peroxide 25-33 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 86-89 14581479-3 2004 Treatment of platelets with H2O2 resulted in a time- and concentration-dependent activation of pp60(src). Hydrogen Peroxide 28-32 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 100-103 14581479-4 2004 Incubation with GF 109203X, a protein kinase C (PKC) inhibitor, prevented H2O2-induced pp60(src) activation. Hydrogen Peroxide 74-78 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 92-95 14581479-5 2004 In contrast, dimethyl-BAPTA loading did not affect this response, suggesting that activation of pp60(src) by H2O2 is independent of increases in [Ca2+](i). Hydrogen Peroxide 109-113 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 101-104 14581479-6 2004 Cytochalasin D, an inhibitor of actin polymerization, significantly reduced H2O2-induced pp60(src) activation. Hydrogen Peroxide 76-80 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 94-97 14581479-10 2004 Consistent with the role of PKC in the activation of pp60(src) by H2O2, the PKC inhibitors GF 109202X and Ro-31-8220 were found to reduced SMCE in platelets. Hydrogen Peroxide 66-70 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 58-61 14581479-11 2004 This study suggests that platelet activation with TG plus Iono or thrombin is associated with H2O2 production, which acts as a second messenger by stimulating pp60(src) by a PKC-dependent pathway and is involved in the activation of SMCE in these cells. Hydrogen Peroxide 94-98 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 164-167 8807585-11 1996 Pretreatment with catalase completely abrogated the H2O2-induced PDGF receptor and c-src tyrosine phosphorylation. Hydrogen Peroxide 52-56 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 83-88 14521054-6 2003 Consistent with this observation, H2O2-stimulated EGFR tyrosine phosphorylation was abolished by specific Src kinase family inhibitor CGP77675, implicating Src in H2O2-induced EGFR activation. Hydrogen Peroxide 163-167 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 106-109 14521054-6 2003 Consistent with this observation, H2O2-stimulated EGFR tyrosine phosphorylation was abolished by specific Src kinase family inhibitor CGP77675, implicating Src in H2O2-induced EGFR activation. Hydrogen Peroxide 163-167 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 156-159 14521054-9 2003 Src kinase family inhibitor CGP77675 blocked STAT3 and STAT1 activation by H2O2 in a concentration-dependent manner. Hydrogen Peroxide 75-79 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 0-3 14521054-11 2003 In Src-/-fibroblasts, activation of both STAT3 and STAT1 by H2O2 was significantly attenuated. Hydrogen Peroxide 60-64 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 3-6 14521054-15 2003 In contrast, H2O2-mediated activation of STAT1 requires only Src kinase activity. Hydrogen Peroxide 13-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 61-64 14521054-16 2003 Herein, we postulate also that H2O2-induced STAT activation in carcinoma cells involves Src-dependent EGFR transactivation. Hydrogen Peroxide 31-35 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 88-91 11321952-2 2001 The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine). Hydrogen Peroxide 255-272 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 63-68 11321952-2 2001 The results showed that the spotaneous oxidation of As(III) to As(V) was very slow and could not be enhanced by aerating for 24 h. The removal rate of As(III) could reach that of As(V) when pre-aerating water samples with ozone for 60 s, putting 7.5 ml/L hydrogen peroxide solution, adding 2.5 mg/L javelle water (sodium hypochlorite) or 15 mg/L bleaching powder(numerated by chlorine). Hydrogen Peroxide 255-272 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 179-184 14750954-5 2003 Phosphorylation of Stat 3/5 in response to p52shc expression, EGF or H2O2 could also be inhibited by introduction into cells of phospho-Tyr 845-specific antibody or by expression of dominant-negative version of c-Src. Hydrogen Peroxide 69-73 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 211-216 12682076-8 2003 On the contrary, PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazole[3,4-d]pyrimidine), an inhibitor of Src kinase, completely prevents DEM- and H2O2-induced AKT activation but has no effect on the pathway of ERKs. Hydrogen Peroxide 145-149 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 104-107 14521054-6 2003 Consistent with this observation, H2O2-stimulated EGFR tyrosine phosphorylation was abolished by specific Src kinase family inhibitor CGP77675, implicating Src in H2O2-induced EGFR activation. Hydrogen Peroxide 34-38 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 106-109 14521054-6 2003 Consistent with this observation, H2O2-stimulated EGFR tyrosine phosphorylation was abolished by specific Src kinase family inhibitor CGP77675, implicating Src in H2O2-induced EGFR activation. Hydrogen Peroxide 34-38 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 156-159 12060808-4 2002 In SH-SY5Y human neuroblastoma cells, H2O2 induced activation of Erk and Src kinases was markedly potentiated by treatment with PBN. Hydrogen Peroxide 38-42 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 73-76 11744698-9 2002 Together, these data indicate that H(2)O(2) promotes calcium-dependent eNOS activity through a coordinated change in the phosphorylation status of the enzyme mediated by Src- and ErbB receptor-dependent PI 3-K activation. Hydrogen Peroxide 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 170-209 11278982-0 2001 c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. Hydrogen Peroxide 38-55 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 86-89 11278982-6 2001 Consistent with this observation, H(2)O(2) stimulated EGFR tyrosine phosphorylation and complex formation with Shc-Grb2 that was abolished by PP2, implicating Src in H(2)O(2)-induced EGFR activation. Hydrogen Peroxide 34-42 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 159-162 11278982-6 2001 Consistent with this observation, H(2)O(2) stimulated EGFR tyrosine phosphorylation and complex formation with Shc-Grb2 that was abolished by PP2, implicating Src in H(2)O(2)-induced EGFR activation. Hydrogen Peroxide 166-174 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 159-162 11278982-8 2001 These data indicate that H(2)O(2)-induced JNK activation in endothelial cells involves the EGFR through an Src-dependent pathway that is distinct from EGFR ligand activation. Hydrogen Peroxide 25-33 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 107-110 10952984-4 2000 In contrast, the injury of endothelial cells mediated by H(2)O(2) is inhibited by PP2, a selective specific inhibitor for protein-tyrosine kinase Src. Hydrogen Peroxide 57-65 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 146-149 10952984-5 2000 Cortactin, a filamentous actin (F-actin)-associated protein, becomes phosphorylated at tyrosine residues upon stimulation by H(2)O(2) in a manner dependent on the activity of Src. Hydrogen Peroxide 125-133 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 175-178 33184429-6 2020 The two events were causally related as suggested by the finding that elevation of ROS by hydrogen peroxide increased Src phosphorylation, while ROS reduction by N-acetyl cysteine partially reversed the phosphorylation. Hydrogen Peroxide 90-107 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 118-121 33865939-0 2021 MiR-137 promotes cell growth and inhibits extracellular matrix protein expression in H2O2-induced human trabecular meshwork cells by targeting Src. Hydrogen Peroxide 85-89 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 143-146 33865939-6 2021 Overexpression of src or activation of the YAP/TAZ pathway partly abrogated the effects of miR-137 on H2O2-induced cell viability and apoptosis and dampened the inhibition effect on ECM protein expression. Hydrogen Peroxide 102-106 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 18-21 33865939-7 2021 In conclusion, miR-137 promotes cell growth and inhibits extracellular matrix protein expression in H2O2-induced human trabecular meshwork cells via the YAP/TAZ pathway by targeting src. Hydrogen Peroxide 100-104 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 182-185 33181128-14 2021 Dual inhibition of SRC/ABL blocked activation of both pathways upon SHIP2 inhibition and H2O2 treatment. Hydrogen Peroxide 89-93 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 19-22 28181111-6 2017 DRm217 also alleviated the effect of H2O2 on inhibition of Na+-K+-ATPase activity, Na+-K+-ATPase cell surface expression, and Src phosphorylation. Hydrogen Peroxide 37-41 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 126-129 31445706-0 2019 Cyclosporin A protects trophoblasts from H2O2-induced oxidative injury via FAK-Src pathway. Hydrogen Peroxide 41-45 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 79-82 30375386-3 2018 Using a combination of biochemical and cell-based studies, we establish the critical importance of two Src cysteine residues, Cys-185 and Cys-277, as targets for H2O2-mediated sulfenylation (Cys-SOH) in redox-dependent kinase activation in response to NADPH oxidase-dependent signaling. Hydrogen Peroxide 162-166 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 103-106 29069627-5 2017 On the other hand, treatment with hydrogen peroxide can enhance Src SUMOylation. Hydrogen Peroxide 34-51 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 64-67 28712859-4 2017 In particular, we found that hydrogen peroxide lead to phosphorylation of RhoA at Tyr42 via tyrosine kinase Src. Hydrogen Peroxide 29-46 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 108-111 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 138-155 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 222-225 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 157-161 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 222-225 31445706-12 2019 CsA administration suppressed H2O2-induced reduction of FAK and Src phosphorylation. Hydrogen Peroxide 30-34 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 64-67 31445706-13 2019 Blocking the activation of FAK or Src attenuated the protective effect of CsA on JEG-3 cells in H2O2-induced oxidative injury. Hydrogen Peroxide 96-100 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 34-37 31445706-14 2019 CsA protects JEG-3 cells from H2O2-induced oxidative injury, and the FAK/Src signaling pathway plays an important role in this process. Hydrogen Peroxide 30-34 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 73-76 25672415-5 2015 Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes. Hydrogen Peroxide 57-61 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 269-272 27896567-8 2017 Moreover, FOXO1 and LXRalpha transcription factors participate in H2O2-triggered downregulation of apoA-I gene together with Src, JNK, p38, and AMPK kinase cascades. Hydrogen Peroxide 66-70 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 125-128 28102840-7 2017 Indeed, H2O2-treated keratinocytes displayed decreased phosphatase and tensin homolog (PTEN) and increased Src activities because of oxidative modification. Hydrogen Peroxide 8-12 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 107-110 27764696-0 2016 Temporospatial evolution and removal mechanisms of As(V) and Se(VI) in ZVI column with H2O2 as corrosion accelerator. Hydrogen Peroxide 87-91 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 51-56 27764696-1 2016 Enhanced removal of As(V) and Se(VI) by zero valent iron (ZVI) has been recently revealed by using H2O2 as the corrosion accelerator, however, the detailed performance of such enhanced removal in ZVI column as well as the underlying mechanism is still unclear. Hydrogen Peroxide 99-103 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 20-25 27764696-8 2016 The reduction of As(V) and Se(VI) to aqueous As(III) and Se(IV) was significantly inhibited at the positions in the presence of H2O2, whereas favorably enhanced in the presence of abundant Fe2+. Hydrogen Peroxide 128-132 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 17-22 27764696-10 2016 In addition, the evolution of different oxidation states of As and Se retained in the column were identified by XPS, further demonstrating the comprehensive mechanisms of As(V)/Se(VI) removal involving reduction and adsorption in the ZVI/H2O2 column. Hydrogen Peroxide 238-242 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 171-176 27650496-4 2016 Moreover, the intrinsic kinase activity of recombinant Src or EGFR was in both cases enhanced by H2O2 but not by GSSG, indicating that the intermediate sulfenylation is the activating modification. Hydrogen Peroxide 97-101 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 55-58 26234813-0 2015 Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells. Hydrogen Peroxide 68-72 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 31-34 26234813-4 2015 The decrease in ERK1/2 phosphorylation induced by H2O2 was inversely correlated with the level of phosphorylation of Src tyrosine 530. Hydrogen Peroxide 50-54 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 117-120 26234813-7 2015 In conclusion, H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation. Hydrogen Peroxide 15-19 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 97-100 26234813-8 2015 Physiological laminar flow abrogates this effect of H2O2 by inducing phosphorylation of Src tyrosine 419. Hydrogen Peroxide 52-56 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 88-91 25585026-11 2015 Taken together, the results indicate that TGF-beta-mediated Src activation operates largely through a redox dependent mechanism, resulting from enhanced H2O2 production through an NADPH oxidase and that cysteines 248, 277, 490, and 501 are critical for this activation. Hydrogen Peroxide 153-157 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 60-63 26461366-4 2014 As Src is activated by various oxidative stimuli and TGF-beta reportedly stimulates H2O2 production, we hypothesize that TGF-beta activates Src through a redox dependent mechanism. Hydrogen Peroxide 84-88 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 140-143 25574848-5 2015 Low H2O2 dose (5microM) rapidly triggered a signaling cascade leading to nSMase2 activation, src and annexin 2 (AnxA2) phosphorylation, and actin remodeling, in fibroblasts and SMC. Hydrogen Peroxide 4-8 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 93-96 25574848-8 2015 Finally we show that nSMase2 activation by H2O2, depends on MMP2 and p38MAPK, and is required for the src-dependent phosphorylation of AnxA2, and actin remodeling. Hydrogen Peroxide 43-47 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 102-105 23651497-7 2013 The H2O2-induced src/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src/PDGFRbeta/SK1. Hydrogen Peroxide 4-8 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 17-20 24632723-0 2014 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. Hydrogen Peroxide 102-106 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 40-43 24632723-2 2014 Here, we report the role of caveolin-1 and Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP-2) in H2O2-induced signaling pathway in brain astrocytes. Hydrogen Peroxide 118-122 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 43-46 24632723-5 2014 In the presence of CSK siRNA, binding between caveolin-1 and SHP-2 was enhanced by H2O2 treatment, which led to reduced Src phosphorylation at tyrosine (Tyr) 530 and enhanced Src phosphorylation at Tyr 419. Hydrogen Peroxide 83-87 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 120-123 24632723-5 2014 In the presence of CSK siRNA, binding between caveolin-1 and SHP-2 was enhanced by H2O2 treatment, which led to reduced Src phosphorylation at tyrosine (Tyr) 530 and enhanced Src phosphorylation at Tyr 419. Hydrogen Peroxide 83-87 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 175-178 24632723-6 2014 In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK). Hydrogen Peroxide 50-54 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 116-119 24632723-6 2014 In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK). Hydrogen Peroxide 50-54 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 182-185 23917332-3 2013 The As(III) species were also determined after oxidation of As(III) ions to As(V) with H2O2 and measurement of the total arsenic content. Hydrogen Peroxide 87-91 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 76-81 24632723-7 2014 Our results collectively indicate that SHP-2 alters Src kinase activity by interfering with the complex formation between CSK and phosphotyrosine caveolin-1 in the presence of H2O2, thus functions as a positive regulator in Src signaling under oxidative stress in brain astrocytes. Hydrogen Peroxide 176-180 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 52-55 24632723-7 2014 Our results collectively indicate that SHP-2 alters Src kinase activity by interfering with the complex formation between CSK and phosphotyrosine caveolin-1 in the presence of H2O2, thus functions as a positive regulator in Src signaling under oxidative stress in brain astrocytes. Hydrogen Peroxide 176-180 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 224-227 23651497-7 2013 The H2O2-induced src/PDGFRbeta/SK1 signaling cascade was impaired in nSMase2-deficient fro/fro cells and was rescued by exogenous C2Cer that activated src/PDGFRbeta/SK1. Hydrogen Peroxide 4-8 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 151-154 22526669-2 2012 The samples were subjected to microwave-assisted extraction using diluted hydrochloric acid and hydrogen peroxide, which solubilised the analytes and oxidised arsenite (As(III)) to arsenate (As(V)). Hydrogen Peroxide 96-113 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 191-196 22894498-0 2012 Real-time imaging elucidates the role of H2O2 in regulating kinetics of epidermal growth factor-induced and Src-mediated tyrosine phosphorylation signaling. Hydrogen Peroxide 41-45 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 108-111 22894498-8 2012 Our evidence also suggested the effect of H(2)O(2) on Src activation is mediated by H(2)O(2)-dependent inhibition of PTPs. Hydrogen Peroxide 42-50 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 54-57 22894498-8 2012 Our evidence also suggested the effect of H(2)O(2) on Src activation is mediated by H(2)O(2)-dependent inhibition of PTPs. Hydrogen Peroxide 84-92 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 54-57 22894498-9 2012 Furthermore, we provide evidence showing global elevation of intracellular H(2)O(2) level attenuates EGF-induced Src signaling. Hydrogen Peroxide 75-83 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 113-116 20378826-0 2010 Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers. Hydrogen Peroxide 0-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 54-59 22420665-0 2012 Luteolin inhibited hydrogen peroxide-induced vascular smooth muscle cells proliferation and migration by suppressing the Src and Akt signalling pathways. Hydrogen Peroxide 19-36 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 121-124 22420665-7 2012 In previous research, we originally explored the function of luteolin in blocking H(2) O(2) -triggered Src and Akt signalling pathways. Hydrogen Peroxide 82-91 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 103-106 22420665-9 2012 CONCLUSIONS: These findings strongly suggested that luteolin suppresses H(2) O(2) -directed migration and proliferation in VSMCs partially due to down-regulation of the Akt and Src signalling pathways, which are important participants in the processes of migration and proliferation of VSMCs. Hydrogen Peroxide 72-81 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 177-180 21606925-9 2011 Hydrogen peroxide rapidly increased the levels of p-MLC (myosin light chain) and c-Src(pY418). Hydrogen Peroxide 0-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 81-86 21566137-6 2011 Disruption of barrier function by H(2)O(2) + NHS rapidly increased Ras expression and Erk and Src phosphorylation, but had no effect on P38 phosphorylation. Hydrogen Peroxide 34-44 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 94-97 21397862-6 2011 A high ratio of O(2)(-):H(2)O(2) oxidizes/activates Src, triggering the PI3K/PKBalpha and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. Hydrogen Peroxide 24-32 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 52-55 20211239-0 2010 Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent. Hydrogen Peroxide 76-80 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 84-87 20211239-7 2010 In accordance with this finding, we also detected Src in the mitochondria and demonstrated that Src is activated upon H(2)O(2) treatment. Hydrogen Peroxide 118-126 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 50-53 20211239-7 2010 In accordance with this finding, we also detected Src in the mitochondria and demonstrated that Src is activated upon H(2)O(2) treatment. Hydrogen Peroxide 118-126 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 96-99 20378826-9 2010 The expression of constitutively active c-Src(Y527F) enhanced cell migration, whereas the expression of dominant negative c-Src(K296R/Y528F) attenuated hydrogen peroxide-induced stimulation of cell migration. Hydrogen Peroxide 152-169 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 122-127 20558542-4 2010 This study investigated the relationship between H(2)O(2) generated after light chain endocytosis by human proximal tubular (HK-2) cells and activation of c-Src, a redox-sensitive tyrosine kinase. Hydrogen Peroxide 49-57 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 155-160 20558542-9 2010 These data show that intracellular H(2)O(2) induced by endocytosis of monoclonal free light chains oxidizes and activates c-Src, which promotes release of MCP-1. Hydrogen Peroxide 35-43 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 122-127 19544888-7 2009 The production of H2O2 was also accompanied by the generation of As(V). Hydrogen Peroxide 18-22 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 65-70 19356149-8 2009 The present study shows that hydrogen peroxide increases the association of PP2A with occludin by a Src kinase-dependent mechanism, and that PP2A activity is involved in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers. Hydrogen Peroxide 29-46 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 100-103 18829466-5 2008 First, we demonstrated that H2O2-induced nuclear export of TERT was abolished in Src, Fyn, and Yes-deficient embryonic fibroblasts. Hydrogen Peroxide 28-32 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 81-84 17931358-4 2007 While the catalytic function of LOX is essential for cross-linking of ECM proteins, we also reported that LOX induced invasive and metastatic properties in breast tumour epithelial cells through hydrogen peroxide-mediated FAK/Src activation. Hydrogen Peroxide 195-212 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 226-229 16814101-3 2006 This H2O2-induced kinase activation was significantly attenuated by a Src kinase inhibitor PP2, or by transient transfection of carboxyl-terminal Src kinase (CSK) that maintained Src in the dormant form. Hydrogen Peroxide 5-9 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 70-73 17164397-6 2007 The application of H(2)O(2) stimulated the activity of endogenous PTK in M-1 cells and increased tyrosine phosphorylation of ROMK in HEK293 cells transfected with GFP-ROMK1 and c-Src. Hydrogen Peroxide 19-27 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 177-182 17115933-1 2007 In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCgamma, Syk, and the Src family, in this order. Hydrogen Peroxide 61-65 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 136-139 16979564-6 2006 H(2)O(2) induces tyrosine phosphorylation and translocation of PIP5Kalpha away from its substrate at the plasma membrane, and both are dependent upon the activity of c-src family kinases. Hydrogen Peroxide 0-8 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 166-171 16987028-9 2006 The other pathway mediated by hydrogen peroxide results in the phosphorylation of Akt on S473 and requires CaM-K, PI3K, and Src activity. Hydrogen Peroxide 30-47 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 124-127 16814101-3 2006 This H2O2-induced kinase activation was significantly attenuated by a Src kinase inhibitor PP2, or by transient transfection of carboxyl-terminal Src kinase (CSK) that maintained Src in the dormant form. Hydrogen Peroxide 5-9 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 146-149 16814101-3 2006 This H2O2-induced kinase activation was significantly attenuated by a Src kinase inhibitor PP2, or by transient transfection of carboxyl-terminal Src kinase (CSK) that maintained Src in the dormant form. Hydrogen Peroxide 5-9 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 146-149 16998541-6 2006 In this study, we used pharmacological inhibitors to investigate the role of receptor and Src-family-PTKs in H2O2-induced PKB phosphorylation. Hydrogen Peroxide 109-113 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 90-93 16998541-10 2006 Moreover, H2O2-induced PKB phosphorylation was associated with increased tyrosine phosphorylation of c-Src and Pyk2 in an AG1024- and PP2-inhibitable manner. Hydrogen Peroxide 10-14 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 101-106 16513647-9 2006 In addition, Src inhibitor PP2 caused nuclear accumulation of Nrf 2 in normal and hydrogen peroxide-treated cells but had no effect on localization of mutant Nrf 2Y568A. Hydrogen Peroxide 82-99 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 13-16 16357151-8 2005 Hydrogen peroxide was produced as a by-product of LOX activity and the removal of hydrogen peroxide by catalase treatment in invasive breast cancer cells led to a dose-dependent loss in Src activation. Hydrogen Peroxide 0-17 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 186-189 16357151-8 2005 Hydrogen peroxide was produced as a by-product of LOX activity and the removal of hydrogen peroxide by catalase treatment in invasive breast cancer cells led to a dose-dependent loss in Src activation. Hydrogen Peroxide 82-99 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 186-189 16357151-9 2005 These results suggest that LOX facilitates migration and cell-matrix adhesion formation in invasive breast cancer cells through a hydrogen peroxide-mediated mechanism involving the FAK/Src signaling pathway. Hydrogen Peroxide 130-147 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 185-188