PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30637731-3 2019 Activation of Trpm2 in adult myocytes with H2 O2 resulted in 10- to 21-fold increases in Pyk2 phosphorylation in wild-type (WT) myocytes which was significantly lower (~40%) in Trpm2 knockout (KO) myocytes. Hydrogen Peroxide 43-48 protein tyrosine kinase 2 beta Homo sapiens 89-93 34026753-5 2021 In addition, down-regulation of Pyk2 by short hairpin RNA (shRNA) protected HUVECs from H2O2 insult. Hydrogen Peroxide 88-92 protein tyrosine kinase 2 beta Homo sapiens 32-36 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 138-155 protein tyrosine kinase 2 beta Homo sapiens 14-18 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 138-155 protein tyrosine kinase 2 beta Homo sapiens 174-178 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 157-161 protein tyrosine kinase 2 beta Homo sapiens 14-18 32792487-8 2020 Subsequently, Pyk2 acted as a scaffold for c-Abl phosphorylating the catalytic domain of NOX5 Tyr476/478 sites, which in turn upregulated hydrogen peroxide (H2O2) inside the Pyk2/NOX5 complex to oxidize and activate local Src. Hydrogen Peroxide 157-161 protein tyrosine kinase 2 beta Homo sapiens 174-178 28831286-6 2017 H2O2-induced hyperactivation of the phosphatidylinositol 3-kinase/protein kinase B (AKT) signaling pathway was suppressed by KPE through regulated expression of forkhead box O3a (FoxO3a) and mammalian target of rapamycin (mTOR). Hydrogen Peroxide 0-4 protein tyrosine kinase 2 beta Homo sapiens 66-82 20029537-3 2009 We have demonstrated that insulin-like growth factor type 1 receptor (IGF-1R) plays a role in transducing the effect of H2O2, leading to protein kinase B (PKB) phosphorylation. Hydrogen Peroxide 120-124 protein tyrosine kinase 2 beta Homo sapiens 137-153 23485815-0 2013 Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H2O2-induced neural progenitor cell injury. Hydrogen Peroxide 102-106 protein tyrosine kinase 2 beta Homo sapiens 30-46 20688918-7 2010 Additionally, H(2)O(2) induced strong Erk activation and ionomycin-stimulated Pyk2 phosphorylation was Erk dependent. Hydrogen Peroxide 14-22 protein tyrosine kinase 2 beta Homo sapiens 78-82 23241309-7 2013 A reduction in H2O2-induced PtdIns5P levels by the overexpression of PIP4K revealed its role in PKB activation. Hydrogen Peroxide 15-19 protein tyrosine kinase 2 beta Homo sapiens 96-99 23241309-8 2013 Suppression of H2O2-induced PtdIns5P generation reduced PKB activation and, surprisingly, reduced cell sensitivity to growth inhibition by H2O2. Hydrogen Peroxide 15-19 protein tyrosine kinase 2 beta Homo sapiens 56-59 20029537-3 2009 We have demonstrated that insulin-like growth factor type 1 receptor (IGF-1R) plays a role in transducing the effect of H2O2, leading to protein kinase B (PKB) phosphorylation. Hydrogen Peroxide 120-124 protein tyrosine kinase 2 beta Homo sapiens 155-158 19545622-6 2009 In addition, calmidazolium and KN-93 blocked H(2)O(2)-induced Pyk2 and insulin-like growth factor-1 receptor (IGF-1R) phosphorylation. Hydrogen Peroxide 45-53 protein tyrosine kinase 2 beta Homo sapiens 62-66 18542050-3 2008 In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evokes Ca(2+) influx through TRPM2 to activate Ca(2+)-dependent tyrosine kinase Pyk2 and amplify Erk signaling via Ras GTPase. Hydrogen Peroxide 25-42 protein tyrosine kinase 2 beta Homo sapiens 134-138 18542050-3 2008 In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evokes Ca(2+) influx through TRPM2 to activate Ca(2+)-dependent tyrosine kinase Pyk2 and amplify Erk signaling via Ras GTPase. Hydrogen Peroxide 44-52 protein tyrosine kinase 2 beta Homo sapiens 134-138 17406055-0 2007 Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling. Hydrogen Peroxide 61-65 protein tyrosine kinase 2 beta Homo sapiens 74-77 17164397-5 2007 Because a previous study showed that H(2)O(2) stimulated the expression of Src family protein tyrosine kinase (PTK) which inhibited SK channels (3), we explored the role of PTK in mediating the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 37-45 protein tyrosine kinase 2 beta Homo sapiens 111-114 17164397-5 2007 Because a previous study showed that H(2)O(2) stimulated the expression of Src family protein tyrosine kinase (PTK) which inhibited SK channels (3), we explored the role of PTK in mediating the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 204-212 protein tyrosine kinase 2 beta Homo sapiens 111-114 17164397-6 2007 The application of H(2)O(2) stimulated the activity of endogenous PTK in M-1 cells and increased tyrosine phosphorylation of ROMK in HEK293 cells transfected with GFP-ROMK1 and c-Src. Hydrogen Peroxide 19-27 protein tyrosine kinase 2 beta Homo sapiens 66-69 17164397-10 2007 However, combined use of ERK, P38, and PTK inhibitors completely abolished the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 89-97 protein tyrosine kinase 2 beta Homo sapiens 39-42 17164397-12 2007 We conclude that addition of H(2)O(2) inhibited SK channels by stimulating PTK activity, P38, and ERK in the CCD and that H(2)O(2) enhances the internalization of the SK channels. Hydrogen Peroxide 29-37 protein tyrosine kinase 2 beta Homo sapiens 75-78 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 0-17 protein tyrosine kinase 2 beta Homo sapiens 154-170 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 0-17 protein tyrosine kinase 2 beta Homo sapiens 172-175 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 19-23 protein tyrosine kinase 2 beta Homo sapiens 154-170 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 19-23 protein tyrosine kinase 2 beta Homo sapiens 172-175 17406055-5 2007 The upstream elements responsible for H2O2-induced ERK1/2 and PKB activation remain poorly characterized, but a potential role of receptor and nonreceptor protein tyrosine kinases (PTKs) as triggers that initiate such events has been postulated. Hydrogen Peroxide 38-42 protein tyrosine kinase 2 beta Homo sapiens 62-65 17406055-6 2007 Therefore, the aim of this review is to highlight the involvement of receptor and nonreceptor PTKs in modulating H2O2-induced ERK1/2 and PKB signaling. Hydrogen Peroxide 113-117 protein tyrosine kinase 2 beta Homo sapiens 137-140 16720330-4 2006 H2O2 increased PYK2 and ERK1/2 phosphorylation, and at the same time decreased Lc20 phosphorylation. Hydrogen Peroxide 0-4 protein tyrosine kinase 2 beta Homo sapiens 15-19 16998541-10 2006 Moreover, H2O2-induced PKB phosphorylation was associated with increased tyrosine phosphorylation of c-Src and Pyk2 in an AG1024- and PP2-inhibitable manner. Hydrogen Peroxide 10-14 protein tyrosine kinase 2 beta Homo sapiens 23-26 16720330-9 2006 This study shows the evidence that H2O2 acts as a relaxing factor and as an activator of PYK2 and ERK1/2 in Human renal VSMC. Hydrogen Peroxide 35-39 protein tyrosine kinase 2 beta Homo sapiens 89-93 16998541-10 2006 Moreover, H2O2-induced PKB phosphorylation was associated with increased tyrosine phosphorylation of c-Src and Pyk2 in an AG1024- and PP2-inhibitable manner. Hydrogen Peroxide 10-14 protein tyrosine kinase 2 beta Homo sapiens 111-115 16998541-11 2006 In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. Hydrogen Peroxide 91-95 protein tyrosine kinase 2 beta Homo sapiens 73-76 16998541-11 2006 In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. Hydrogen Peroxide 91-95 protein tyrosine kinase 2 beta Homo sapiens 103-106 16998541-11 2006 In conclusion, these data provide evidence of the contribution of IGF-1R-PTK in initiating H2O2-evoked PKB phosphorylation in A10 VSMC, with an intermediary role for c-Src and Pyk2 in this process. Hydrogen Peroxide 91-95 protein tyrosine kinase 2 beta Homo sapiens 176-180 16244116-0 2005 PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices. Hydrogen Peroxide 78-82 protein tyrosine kinase 2 beta Homo sapiens 46-49 16998541-0 2006 Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells. Hydrogen Peroxide 73-77 protein tyrosine kinase 2 beta Homo sapiens 86-89 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 63-80 protein tyrosine kinase 2 beta Homo sapiens 200-216 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 63-80 protein tyrosine kinase 2 beta Homo sapiens 218-221 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 82-86 protein tyrosine kinase 2 beta Homo sapiens 200-216 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 82-86 protein tyrosine kinase 2 beta Homo sapiens 218-221 16998541-5 2006 Although a role for epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) in H2O2-induced ERK1/2 signaling has been suggested, the contribution of this PTK or other receptor or nonreceptor PTKs to PKB activation is not well defined in VSMC. Hydrogen Peroxide 93-97 protein tyrosine kinase 2 beta Homo sapiens 85-88 16998541-6 2006 In this study, we used pharmacological inhibitors to investigate the role of receptor and Src-family-PTKs in H2O2-induced PKB phosphorylation. Hydrogen Peroxide 109-113 protein tyrosine kinase 2 beta Homo sapiens 122-125 16244116-7 2005 Platelet-activating factor (PAF) receptor antagonists, lovastatin, and the isoflavone protein tyrosine kinase (PTK) inhibitor genistein each reduced H2O2 secretion by Macs maintained on oxLDL-containing matrices by approximately 60%. Hydrogen Peroxide 149-153 protein tyrosine kinase 2 beta Homo sapiens 111-114 16244116-9 2005 We conclude that matrix-bound and oxidized lipoproteins stimulate Macs to produce H2O2 continuously and in large quantities via a pathway that involves PAF receptors and PTK and is reversibly blocked by inhibitors of protein prenylation. Hydrogen Peroxide 82-86 protein tyrosine kinase 2 beta Homo sapiens 170-173 14729104-0 2004 Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death. Hydrogen Peroxide 37-54 protein tyrosine kinase 2 beta Homo sapiens 30-33 15025937-0 2004 Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cells. Hydrogen Peroxide 60-64 protein tyrosine kinase 2 beta Homo sapiens 109-125 15025937-1 2004 We have shown earlier that extracellular signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), two key mediators of growth-promoting and proliferative responses, are activated by hydrogen peroxide (H(2)O(2)) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 195-212 protein tyrosine kinase 2 beta Homo sapiens 87-103 15025937-1 2004 We have shown earlier that extracellular signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), two key mediators of growth-promoting and proliferative responses, are activated by hydrogen peroxide (H(2)O(2)) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 195-212 protein tyrosine kinase 2 beta Homo sapiens 105-108 15025937-4 2004 BAPTA-AM and EGTA, chelators of intracellular and extracellular Ca(2+), respectively, inhibited H(2)O(2)-stimulated ERK1/2, p38 MAPK, and PKB phosphorylation. Hydrogen Peroxide 96-104 protein tyrosine kinase 2 beta Homo sapiens 138-141 14729104-12 2004 In conclusion, we have shown that H(2)O(2) stimulates robust increases in ERK1/2, JNK and PKB in undifferentiated and differentiated SH-SY5Y cells. Hydrogen Peroxide 34-42 protein tyrosine kinase 2 beta Homo sapiens 90-93 12682076-3 2003 Exposure of cells to H2O2 rapidly increases tyrosine phosphorylation of tyrosine kinase receptors (TKRs) in the absence of growth factor binding, thus inducing the activation of downstream signaling cascades, like that of protein kinase B (AKT). Hydrogen Peroxide 21-25 protein tyrosine kinase 2 beta Homo sapiens 222-238 12213802-0 2002 Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. Hydrogen Peroxide 50-54 protein tyrosine kinase 2 beta Homo sapiens 103-119 12213802-1 2002 This study was designed to elucidate the mechanisms leading to down-regulation of the Akt/protein kinase B (PKB) survival pathway during H2O2-induced cell death. Hydrogen Peroxide 137-141 protein tyrosine kinase 2 beta Homo sapiens 90-106 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 36-40 protein tyrosine kinase 2 beta Homo sapiens 78-81 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 36-40 protein tyrosine kinase 2 beta Homo sapiens 122-125 12361705-7 2002 PKB and extracellular signal-regulated kinase (ERK) were both rapidly and transiently activated by 10 microM H2O2, but the activities of p38 MAPK and JNK were not changed. Hydrogen Peroxide 109-113 protein tyrosine kinase 2 beta Homo sapiens 0-3 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 36-40 protein tyrosine kinase 2 beta Homo sapiens 122-125 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 194-198 protein tyrosine kinase 2 beta Homo sapiens 78-81 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 194-198 protein tyrosine kinase 2 beta Homo sapiens 122-125 12361705-10 2002 Furthermore we found that exogenous H2O2 could stimulate the proliferation of PKB-AS7721 cells transfected with antisense PKB cDNA, which was partly dependent on JNK activation, suggesting that H2O2 stimulated hepatoma cell proliferation via cross-talk between the PI3-K/PKB and the JNK signaling pathways. Hydrogen Peroxide 194-198 protein tyrosine kinase 2 beta Homo sapiens 122-125 10578066-3 1999 Both PI 3,4-bisphosphate and PI 3,4, 5-trisphosphate increased in H(2)O(2)-treated cells, and the elevation of these phospholipids and activation of PKB were concurrently blocked by wortmannin, a potent inhibitor of PI 3-kinase. Hydrogen Peroxide 66-74 protein tyrosine kinase 2 beta Homo sapiens 149-152 10965882-8 2000 H2O2 also enhanced PTK activity. Hydrogen Peroxide 0-4 protein tyrosine kinase 2 beta Homo sapiens 19-22 10593919-6 1999 In vitro kinase analyses revealed that 1 mM H(2)O(2) stimulated the activity of JNK by approximately 8-fold, MAPKAP-K2 (the downstream target of p38 MAP kinase) by approximately 12-fold and that of PKB by up to 34-fold. Hydrogen Peroxide 44-52 protein tyrosine kinase 2 beta Homo sapiens 198-201 8778024-3 1996 Both anti-immunoglobulin M (anti-IgM) and H2O2 induced tyrosine phosphorylation through protein tyrosine kinase (PTK) activation. Hydrogen Peroxide 42-46 protein tyrosine kinase 2 beta Homo sapiens 113-116 34543986-4 2021 This study is to investigate whether HUK can protect endothelial cells after balloon injury or H2O2-induced endothelial cell damage through the proline-rich tyrosine kinase 2 (Pyk2)/mitochondrial calcium uniporter (MCU) pathway. Hydrogen Peroxide 95-99 protein tyrosine kinase 2 beta Homo sapiens 176-180 34543986-5 2021 Intimal hyperplasia, a decrease of pinocytotic vesicles and cell apoptosis were found in the common carotid artery balloon injury and H2O2-induced endothelial cell damage, Pyk2/MCU was also up-regulated in such pathological process. Hydrogen Peroxide 134-138 protein tyrosine kinase 2 beta Homo sapiens 172-176 34543986-8 2021 In short, our results indicate that the Pyk2/MCU pathway is involved in endothelial injury induced by balloon injury or H2O2-induced endothelial cell damage. Hydrogen Peroxide 120-124 protein tyrosine kinase 2 beta Homo sapiens 40-44 34543986-4 2021 This study is to investigate whether HUK can protect endothelial cells after balloon injury or H2O2-induced endothelial cell damage through the proline-rich tyrosine kinase 2 (Pyk2)/mitochondrial calcium uniporter (MCU) pathway. Hydrogen Peroxide 95-99 protein tyrosine kinase 2 beta Homo sapiens 144-174 34949154-11 2022 DHCR24 was down-regulated in H2O2-induced ALI, and overexpression of DHCR24 could inhibit H2O2-induced oxidative stress and apoptosis of A549 cells by activating the Phosphatidylinositol-3-Kinase/Protein Kinase B (PI3K/AKT) signaling pathway. Hydrogen Peroxide 90-94 protein tyrosine kinase 2 beta Homo sapiens 196-212