PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14729299-5 2004 The three complexes have a strong protective action over Delta sod1 mutant of Saccharomyces cerevisiae against reactive oxygen radicals derived from respiration and against those generated by hydrogen peroxide and menadione. Hydrogen Peroxide 192-209 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 63-67 30924879-2 2019 Our results showed the sensitivity of S. cerevisiae antioxidant gene deficient mutants (sod1 , sod2 , cta1 , ctt1 , gtt2 and tsa1 ) against hydrogen peroxide (H2O2) and menadione stress was rescued by magnolol as demonstrated in spot and colony forming unit counts. Hydrogen Peroxide 141-158 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 88-92 12459905-9 2003 For determining the SOD-like activity of the complexes in vivo, we have developed a new method based on the complexes" protective effect on a delta sod1mutant of Saccharomyces cerevisiae against free radicals generated by hydrogen peroxide and menadione as well as free radicals produced in the cellular respiration process. Hydrogen Peroxide 222-239 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 148-152 33671669-5 2021 Its product, hydrogen peroxide, which is also produced by the action of the superoxide dismutase, Sod1p, influences signaling of key regulatory proteins Ras2p and Yck1p/2p. Hydrogen Peroxide 13-30 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 98-103 33218686-2 2021 In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H2O2-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. Hydrogen Peroxide 83-87 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 59-63 33218686-3 2021 In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. Hydrogen Peroxide 44-48 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 31-35 31284117-12 2019 Based on these data we propose that the Cys58-Cys147 bond may act as a sacrificial target for oxidants and protect ySOD1 from oxidative inactivation arising from exposure to Cu2+/H2O2 and auto-inactivation during extended enzymatic turnover. Hydrogen Peroxide 179-183 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 115-120 30924879-2 2019 Our results showed the sensitivity of S. cerevisiae antioxidant gene deficient mutants (sod1 , sod2 , cta1 , ctt1 , gtt2 and tsa1 ) against hydrogen peroxide (H2O2) and menadione stress was rescued by magnolol as demonstrated in spot and colony forming unit counts. Hydrogen Peroxide 160-164 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 88-92 24061560-1 2013 Copper-zinc superoxide dismutase (Sod1) is an abundant intracellular enzyme that catalyzes the disproportionation of superoxide to give hydrogen peroxide and dioxygen. Hydrogen Peroxide 136-153 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 34-38 24136413-4 2013 We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Hydrogen Peroxide 20-37 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 217-221 30576923-1 2019 Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen. Hydrogen Peroxide 149-166 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 28-32 30576923-2 2019 As a consequence, Sod1 serves dual roles in oxidative stress protection and redox signaling by both scavenging cytotoxic superoxide radicals and producing hydrogen peroxide that can be used to oxidize and regulate the activity of downstream targets. Hydrogen Peroxide 155-172 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 18-22 29154829-3 2018 We have previously shown that glucose control in S. cerevisiae involves the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1), where H2O2 generated by SOD1 stabilizes the casein kinase YCK1 for glucose sensing. Hydrogen Peroxide 136-140 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 123-127 29154829-3 2018 We have previously shown that glucose control in S. cerevisiae involves the antioxidant enzyme Cu/Zn superoxide dismutase (SOD1), where H2O2 generated by SOD1 stabilizes the casein kinase YCK1 for glucose sensing. Hydrogen Peroxide 136-140 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 154-158 24136413-4 2013 We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Hydrogen Peroxide 39-43 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 217-221 23515486-5 2013 In addition, treatment of wild-type and mutant cells lacking Cu/Zn-superoxide dismutase (Sod1) and cytoplasmic catalase (Ctt1) with 1 promotes increased survival after H2O2 or menadione (O2 (-) generator) stress, indicating that 1 might act as a Sod1 and Ctt1 mimetic. Hydrogen Peroxide 168-172 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 89-93 24066190-9 2013 Mitochondria are the main source of superoxide radicals, which are converted to H2O2 through two superoxide dismutases, Sod1 and Sod2. Hydrogen Peroxide 80-84 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 120-124 19010334-2 2009 An important enzyme in this process is superoxide dismutase, Sod1, which converts superoxide radicals into water and hydrogen peroxide. Hydrogen Peroxide 117-134 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 61-65 19106092-9 2009 The results indicate that part of hydrogen peroxide consumption by tsa1Deltatsa2Delta cells is mediated by induced Sod1, which oxidizes ethanol to the 1-hydroxyethyl radical, which, in turn, leads to increased DNA damage. Hydrogen Peroxide 34-51 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 115-119 18082141-3 2008 In SOD1-Y, AA-PCD was exacerbated; high H2O2 levels were found, SOD activity increased early, remaining constant en route to AA-PCD, but catalase activity was strongly reduced. Hydrogen Peroxide 40-44 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 3-7