PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12085988-9	2002	H2O2 failed to induce the expression of either hsp70 genes in MEF cells, caused induction of hsp70.1 gene expression in the M-1 cell line.	Hydrogen Peroxide	0-4	heat shock protein 1B	Mus musculus	93-100	
15871184-10	2005	CONCLUSION: HSP70 inhibits Smac release from the mitochondria and protects against H2O2-induced apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	83-87	heat shock protein 1B	Mus musculus	12-17	
16190379-7	2005	HSP70 localized within the cytoplasm of the normal cells, but HSP70 translocated from the cytoplasm to the nucleus and the nucleolus at 1 h after the treatment of oxidative stress (0.5 mmol/L H2O2) by using immunocytochemistry, fluorescent microscopy and immunoblotting for cellular partial proteins.	Hydrogen Peroxide	192-196	heat shock protein 1B	Mus musculus	62-67	
15871184-0	2005	[HSP70 inhibits smac release from the mitochondria and protects against H2O2-induced apoptosis in C2C12 myogenic cells].	Hydrogen Peroxide	72-76	heat shock protein 1B	Mus musculus	1-6	
15871184-1	2005	OBJECTIVE: To observe whether HSP70 could protect against H2O2-induced apoptosis in C2C12 myogenic cells by inhibiting Smac release from the mitochondria.	Hydrogen Peroxide	58-62	heat shock protein 1B	Mus musculus	30-35	
15871184-8	2005	HSP70 overexpression significantly inhibited H2O2-induced and Smac-promoted apoptosis, as shown by no specific DNA ladder pattern in agarose gel electrophoresis, decrease of percentage of apoptotic nuclei, and marked inactivation of caspase-3 and caspase-9.	Hydrogen Peroxide	45-49	heat shock protein 1B	Mus musculus	0-5	
15871184-9	2005	HSP70 could inhibit the release of Smac from the mitochondria to the cytoplasm 2 h after the treatment by H2O2.	Hydrogen Peroxide	106-110	heat shock protein 1B	Mus musculus	0-5	
12085988-10	2002	Hsp70 accumulation by H2O2 and NaCl treatment was mainly due to hsp70.1 expression.	Hydrogen Peroxide	22-26	heat shock protein 1B	Mus musculus	0-5	
12085988-10	2002	Hsp70 accumulation by H2O2 and NaCl treatment was mainly due to hsp70.1 expression.	Hydrogen Peroxide	22-26	heat shock protein 1B	Mus musculus	64-71	
9841496-4	1998	H2O2 decreased expression of Osp94 while inducing levels of Hsp110 and Hsp70 message.	Hydrogen Peroxide	0-4	heat shock protein 1B	Mus musculus	71-76	
11204649-3	2000	In this study myeloma cells NS0/1 were transfected with hsp70, and their susceptibility to apoptosis was challenged by serum deprivation or hydrogen peroxide.	Hydrogen Peroxide	140-157	heat shock protein 1B	Mus musculus	56-61	
7883992-6	1995	Hsp70 overexpression increased viability upon treatment with hydrogen peroxide or menadione, but had no influence on UV-induced O2- release.	Hydrogen Peroxide	61-78	heat shock protein 1B	Mus musculus	0-5	
9132695-5	1997	Glutathione levels decrease less after glucose deprivation or H2O2 exposure (200 microM) in the cells overexpressing HSP70, compared to either beta-galactosidase expressing or uninfected controls (P < 0.01).	Hydrogen Peroxide	62-66	heat shock protein 1B	Mus musculus	117-122	
21960124-0	2012	Heat shock protein 70 inhibits hydrogen peroxide-induced nucleolar fragmentation via suppressing cleavage and down-regulation of nucleolin.	Hydrogen Peroxide	31-48	heat shock protein 1B	Mus musculus	0-21	
31145969-2	2019	In the present study, we investigated the effects of HSP70 against H2O2-induced neuronal stress in NSC34 cells and against spinal cord ischemia in rabbits.	Hydrogen Peroxide	67-71	heat shock protein 1B	Mus musculus	53-58	
31145969-5	2019	Treatment with Tat-HSP70 reduced the generation of reactive oxygen species and cell death induced by H2O2, while the control-HSP70 did not show any significant effect on the NSC34 cells exposed to H2O2.	Hydrogen Peroxide	101-105	heat shock protein 1B	Mus musculus	19-24	
23893458-5	2014	HSP70 mRNA levels were up-regulated two-fold in cell cultures treated with Rhodiolife (10 microg/mL), and expression was further enhanced by exposure to H2 O2 (six-fold, p < 0.05).	Hydrogen Peroxide	153-158	heat shock protein 1B	Mus musculus	0-5	
23893458-6	2014	HSP70 protein levels were maintained in pre-treated cell cultures compared to controls but was significantly lower (-50%) in cells lacking treatment exposed to H2 O2 .	Hydrogen Peroxide	160-165	heat shock protein 1B	Mus musculus	0-5	
34741567-4	2022	We found that Hsp70-treated mice had a more intense clinical disease severity compared to controls that was paralleled by increased levels of cutaneous matrix metalloproteinase 9 and plasma hydrogen peroxide.	Hydrogen Peroxide	190-207	heat shock protein 1B	Mus musculus	14-19	
26613402-7	2016	EVP suppressed expression of SOD1, and increased expression of HSP70, in both H2O2-treated C2C12 myoblasts and sciatic-denervated mice.	Hydrogen Peroxide	78-82	heat shock protein 1B	Mus musculus	63-68	
21960124-5	2012	These results suggested that H(2)O(2)-induced nucleolar fragmentation and HS or Hsp70 inhibit H(2)O(2)-induced nucleolar fragmentation through the translocation of Hsp70 into nucleolar and its protection against impairment of nucleolin.	Hydrogen Peroxide	29-37	heat shock protein 1B	Mus musculus	164-169	
21960124-5	2012	These results suggested that H(2)O(2)-induced nucleolar fragmentation and HS or Hsp70 inhibit H(2)O(2)-induced nucleolar fragmentation through the translocation of Hsp70 into nucleolar and its protection against impairment of nucleolin.	Hydrogen Peroxide	94-102	heat shock protein 1B	Mus musculus	80-85	
21960124-5	2012	These results suggested that H(2)O(2)-induced nucleolar fragmentation and HS or Hsp70 inhibit H(2)O(2)-induced nucleolar fragmentation through the translocation of Hsp70 into nucleolar and its protection against impairment of nucleolin.	Hydrogen Peroxide	94-102	heat shock protein 1B	Mus musculus	164-169	
20050922-1	2010	Although heat shock protein 70 (Hsp70) has been shown to markedly inhibit H(2)O(2)-induced apoptosis in C2C12 cells, and nucleolin/C23 has also been implicated in apoptosis, the relationship of these two molecules is still largely unknown.	Hydrogen Peroxide	74-82	heat shock protein 1B	Mus musculus	9-30	
20890773-1	2011	We have previously shown that heat shock protein 70 (HSP70) markedly inhibits H(2)O(2)-induced apoptosis in mouse C2C12 myogenic cells by reducing the release of Smac.	Hydrogen Peroxide	78-86	heat shock protein 1B	Mus musculus	30-51	
20890773-1	2011	We have previously shown that heat shock protein 70 (HSP70) markedly inhibits H(2)O(2)-induced apoptosis in mouse C2C12 myogenic cells by reducing the release of Smac.	Hydrogen Peroxide	78-86	heat shock protein 1B	Mus musculus	53-58	
20890773-4	2011	An antisense phosphorothioate oligonucleotide against Bcl-2 caused selective inhibition of Bcl-2 protein expression induced by HSP70 and significantly attenuated HSP70-mediated cell protection against H(2)O(2)-induced release of Smac and apoptosis.	Hydrogen Peroxide	201-209	heat shock protein 1B	Mus musculus	162-167	
20050922-1	2010	Although heat shock protein 70 (Hsp70) has been shown to markedly inhibit H(2)O(2)-induced apoptosis in C2C12 cells, and nucleolin/C23 has also been implicated in apoptosis, the relationship of these two molecules is still largely unknown.	Hydrogen Peroxide	74-82	heat shock protein 1B	Mus musculus	32-37	
19476498-7	2009	Taken together, our results provide evidence supporting the role of HSP70 in the protection of C2C12 cells from H(2)O(2)-induced and Smac-promoted apoptosis by preventing the release of Smac from mitochondria, thereby inhibiting activation of caspases-9 and -3.	Hydrogen Peroxide	112-120	heat shock protein 1B	Mus musculus	68-73