PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26234813-0	2015	Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells.	Hydrogen Peroxide	68-72	C-terminal Src kinase	Homo sapiens	0-3	
31125786-5	2019	Treatment with hydrogen peroxide inhibited this modification to a certain extent, but PIAS3, identified as the main specific SUMO E3 ligase for Csk, could significantly enhance SUMO1-Csk level.	Hydrogen Peroxide	15-32	C-terminal Src kinase	Homo sapiens	144-147	
31125786-5	2019	Treatment with hydrogen peroxide inhibited this modification to a certain extent, but PIAS3, identified as the main specific SUMO E3 ligase for Csk, could significantly enhance SUMO1-Csk level.	Hydrogen Peroxide	15-32	C-terminal Src kinase	Homo sapiens	183-186	
26234813-5	2015	Using siRNA, it was found that H2O2-induced suppression of ERK1/2 was dependent on Csk.	Hydrogen Peroxide	31-35	C-terminal Src kinase	Homo sapiens	83-86	
26234813-7	2015	In conclusion, H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation.	Hydrogen Peroxide	15-19	C-terminal Src kinase	Homo sapiens	28-31	
24632723-0	2014	SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes.	Hydrogen Peroxide	102-106	C-terminal Src kinase	Homo sapiens	83-86	
24632723-5	2014	In the presence of CSK siRNA, binding between caveolin-1 and SHP-2 was enhanced by H2O2 treatment, which led to reduced Src phosphorylation at tyrosine (Tyr) 530 and enhanced Src phosphorylation at Tyr 419.	Hydrogen Peroxide	83-87	C-terminal Src kinase	Homo sapiens	19-22	
24632723-7	2014	Our results collectively indicate that SHP-2 alters Src kinase activity by interfering with the complex formation between CSK and phosphotyrosine caveolin-1 in the presence of H2O2, thus functions as a positive regulator in Src signaling under oxidative stress in brain astrocytes.	Hydrogen Peroxide	176-180	C-terminal Src kinase	Homo sapiens	122-125	
24632723-6	2014	In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK).	Hydrogen Peroxide	50-54	C-terminal Src kinase	Homo sapiens	99-102	
16814101-3	2006	This H2O2-induced kinase activation was significantly attenuated by a Src kinase inhibitor PP2, or by transient transfection of carboxyl-terminal Src kinase (CSK) that maintained Src in the dormant form.	Hydrogen Peroxide	5-9	C-terminal Src kinase	Homo sapiens	158-161	
17349748-2	2007	The results demonstrate also that both platelet-derived growth factor (PDGF) and S1P-mediated NADPH oxidase activation and H2O2 production by Gi-protein coupled receptors (GPCRs) and c-Src kinase.	Hydrogen Peroxide	123-127	C-terminal Src kinase	Homo sapiens	183-195	
17349748-5	2007	However, a different time course of H2O2 production in S1P-stimulated cells compared to that obtained in PDGF-stimulated cells has been observed, and this seems to be related to the different activation behavior of c-Src kinase induced after S1P or PDGF stimulation.	Hydrogen Peroxide	36-40	C-terminal Src kinase	Homo sapiens	215-227	
17349748-6	2007	Finally, these data demonstrate that S1P-induced H2O2 production is necessary to maximize c-Src kinase activation, confirming that this is a redox regulated kinase.	Hydrogen Peroxide	49-53	C-terminal Src kinase	Homo sapiens	90-102	
15958730-6	2005	Acute treatment with H(2)O(2) activated multiple signaling pathways, including the mitogen-activated protein kinases (MAPK) members (MAPK3/1-ERK2/1, MAPK8/9-JNK1/2, and MAPK11-p38(mapk)) and the c-src tyrosine kinase (CSK).	Hydrogen Peroxide	21-29	C-terminal Src kinase	Homo sapiens	195-216	
15958730-6	2005	Acute treatment with H(2)O(2) activated multiple signaling pathways, including the mitogen-activated protein kinases (MAPK) members (MAPK3/1-ERK2/1, MAPK8/9-JNK1/2, and MAPK11-p38(mapk)) and the c-src tyrosine kinase (CSK).	Hydrogen Peroxide	21-29	C-terminal Src kinase	Homo sapiens	218-221	
15958730-7	2005	Pharmacological studies demonstrated that, among these pathways, only the blockade of CSK activation abolished H(2)O(2)-induced CAV1 phosphorylation.	Hydrogen Peroxide	111-119	C-terminal Src kinase	Homo sapiens	86-89