PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33968042-6 2021 Cells treated with hydrogen peroxide also exhibited augmented nuclear YAP accompanied by reduction of Dsg3 and alpha-catenin, a negative regulator of YAP. Hydrogen Peroxide 19-36 Yes1 associated transcriptional regulator Homo sapiens 70-73 33865939-6 2021 Overexpression of src or activation of the YAP/TAZ pathway partly abrogated the effects of miR-137 on H2O2-induced cell viability and apoptosis and dampened the inhibition effect on ECM protein expression. Hydrogen Peroxide 102-106 Yes1 associated transcriptional regulator Homo sapiens 43-46 33865939-7 2021 In conclusion, miR-137 promotes cell growth and inhibits extracellular matrix protein expression in H2O2-induced human trabecular meshwork cells via the YAP/TAZ pathway by targeting src. Hydrogen Peroxide 100-104 Yes1 associated transcriptional regulator Homo sapiens 153-156 1525853-7 1992 The finding that H2O2 promotes DNA-binding of human c-jun is consistent with a similar function for PAR1/YAP1/SNQ3 and c-jun in cellular metabolism. Hydrogen Peroxide 17-21 Yes1 associated transcriptional regulator Homo sapiens 105-109 35452623-4 2022 Additionally, differential expression of MST2 and YAP1 was associated with H2O2-induced apoptosis of human lens epithelial B3 (HLE-B3) cells. Hydrogen Peroxide 75-79 Yes1 associated transcriptional regulator Homo sapiens 50-54 35452623-5 2022 CCK-8 and Hoechst 33,342 apoptosis assays showed that MST2 and YAP1 were involved in H2O2-induced apoptosis of LECs. Hydrogen Peroxide 85-89 Yes1 associated transcriptional regulator Homo sapiens 63-67 35452623-6 2022 Subsequent experiments showed that, during MST2-mediated H2O2-induced apoptosis, p-YAP (Ser127) levels were elevated and immunofluorescence revealed nucleoplasmic translocation and inhibition of YAP1 protein expression. Hydrogen Peroxide 57-61 Yes1 associated transcriptional regulator Homo sapiens 83-86 35452623-6 2022 Subsequent experiments showed that, during MST2-mediated H2O2-induced apoptosis, p-YAP (Ser127) levels were elevated and immunofluorescence revealed nucleoplasmic translocation and inhibition of YAP1 protein expression. Hydrogen Peroxide 57-61 Yes1 associated transcriptional regulator Homo sapiens 195-199 33968042-6 2021 Cells treated with hydrogen peroxide also exhibited augmented nuclear YAP accompanied by reduction of Dsg3 and alpha-catenin, a negative regulator of YAP. Hydrogen Peroxide 19-36 Yes1 associated transcriptional regulator Homo sapiens 150-153 33968042-7 2021 As expected, transfection of alpha-catenin-GFP plasmid rendered YAP export from the nucleus evoked by hydrogen peroxide. Hydrogen Peroxide 102-119 Yes1 associated transcriptional regulator Homo sapiens 64-67 33968042-8 2021 In addition, suppression of total YAP was observed in hydrogen peroxide treated cells exposed to antioxidants with enhanced cell-cell adhesion being confirmed by decreased fragmentation in the dispase assay compared to hydrogen peroxide treatment alone. Hydrogen Peroxide 54-71 Yes1 associated transcriptional regulator Homo sapiens 34-37 33968042-8 2021 In addition, suppression of total YAP was observed in hydrogen peroxide treated cells exposed to antioxidants with enhanced cell-cell adhesion being confirmed by decreased fragmentation in the dispase assay compared to hydrogen peroxide treatment alone. Hydrogen Peroxide 219-236 Yes1 associated transcriptional regulator Homo sapiens 34-37 33968042-11 2021 Finally, inhibition of other kinase pathways, including p38MAPK, also demonstrated suppression of YAP induced by hydrogen peroxide. Hydrogen Peroxide 113-130 Yes1 associated transcriptional regulator Homo sapiens 98-101 31690112-5 2019 The increase of NEDD4 expression by H2O2 induced translocation of yes-associated protein (YAP) into the nucleus by decreasing the stability of large tumor suppressor kinase (LATS). Hydrogen Peroxide 36-40 Yes1 associated transcriptional regulator Homo sapiens 66-88 33146386-3 2020 In this work, LC-MS/MS based phosphoproteomics in WRL68 cells showed that the oxidative damage induced by H2O2 increased the phosphorylation of YAP1, a transcriptional coactivator involved in cell survival, and modified the phosphorylation of other proteins involved in transcription. Hydrogen Peroxide 106-110 Yes1 associated transcriptional regulator Homo sapiens 144-148 33146386-4 2020 Genetic or pharmacological inhibition of PARP-1 in H2O2-treated cells reduced YAP1 phosphorylation and degradation and increased cell viability. Hydrogen Peroxide 51-55 Yes1 associated transcriptional regulator Homo sapiens 78-82 33268949-10 2020 RESULTS: H2O2 treatment increased the mRNA and protein expression of YAP-1 in HCC cells (Huh-7, HepG2, and SNU-761). Hydrogen Peroxide 9-13 Yes1 associated transcriptional regulator Homo sapiens 69-74 33268949-11 2020 Suppression of YAP-1 using siRNA transfection resulted in a significant decrease in tumor proliferation during H2O2 treatment both in vitro and in vivo (both P < 0.05). Hydrogen Peroxide 111-115 Yes1 associated transcriptional regulator Homo sapiens 15-20 31690112-7 2019 The mRNA expression levels of catalase and manganese superoxide dismutase, which are well-known targets of YAP, were increased by H2O2 treatment but down-regulated by NEDD4 silencing using a specific small interfering RNA targeting NEDD4 (siNEDD4). Hydrogen Peroxide 130-134 Yes1 associated transcriptional regulator Homo sapiens 107-110 31690112-5 2019 The increase of NEDD4 expression by H2O2 induced translocation of yes-associated protein (YAP) into the nucleus by decreasing the stability of large tumor suppressor kinase (LATS). Hydrogen Peroxide 36-40 Yes1 associated transcriptional regulator Homo sapiens 90-93 24634836-1 2014 The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-kappaB, NOTCH, SP1 and SCREB-1) are reviewed. Hydrogen Peroxide 35-52 Yes1 associated transcriptional regulator Homo sapiens 155-159 24634836-1 2014 The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-kappaB, NOTCH, SP1 and SCREB-1) are reviewed. Hydrogen Peroxide 54-58 Yes1 associated transcriptional regulator Homo sapiens 155-159 24563858-4 2014 We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms. Hydrogen Peroxide 135-152 Yes1 associated transcriptional regulator Homo sapiens 75-79 20401468-6 2011 Increased hydrogen peroxide levels are also involved in the induction of Ty1 retrotransposition rates in response to treatment with carcinogenic genotoxins, as evidenced by disruption of YAP1 gene in the tester cells. Hydrogen Peroxide 10-27 Yes1 associated transcriptional regulator Homo sapiens 187-191