PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30790510-9 2019 To detoxify excess superoxide as a consequence of lowered Nos2, an overexpressed SOD2 in Stat5b silenced cells results in increased H2O2 production. Hydrogen Peroxide 132-136 superoxide dismutase 2, mitochondrial Mus musculus 81-85 33919252-1 2021 Superoxide dismutase (SOD) family isoenzymes, SOD1, SOD2, and SOD3, synthesize hydrogen peroxide (H2O2), which regulates the signal transduction. Hydrogen Peroxide 79-96 superoxide dismutase 2, mitochondrial Mus musculus 52-56 33919252-1 2021 Superoxide dismutase (SOD) family isoenzymes, SOD1, SOD2, and SOD3, synthesize hydrogen peroxide (H2O2), which regulates the signal transduction. Hydrogen Peroxide 98-102 superoxide dismutase 2, mitochondrial Mus musculus 52-56 29992759-5 2018 Kallistatin reversed H2 O2 -mediated inhibition of endothelial nitric oxide synthase (eNOS), SIRT1, catalase and superoxide dismutase (SOD)-2 expression, and kallistatin alone stimulated the synthesis of these antioxidant enzymes. Hydrogen Peroxide 21-26 superoxide dismutase 2, mitochondrial Mus musculus 113-141 30533172-11 2018 In addition, the expressions of Gfap and antioxidant enzyme genes (Txn2, Sod2, and Gpx4) were significantly upregulated in the retina after the H2O2 treatment, compared to the vehicle control group. Hydrogen Peroxide 144-148 superoxide dismutase 2, mitochondrial Mus musculus 73-77 29939281-6 2018 Furthermore, the mRNA level of Cs-mMnSOD was strongly upregulated (more than twofold increase) following exposure to low and high temperatures (4, 30 and 35 C), insecticides (chlorpyrifos and chlorantraniliprole), and chemical reagents (cumene hydroperoxide, paraquat, H2O2 and CdCl2), but slightly elevated (less than twofold increase) in response to 8 C, abamectin and CuSO4. Hydrogen Peroxide 269-273 superoxide dismutase 2, mitochondrial Mus musculus 34-40 26424786-6 2016 Accordingly, INT-777 decreased mitochondrial H2O2 generation and increased the activity of SOD2, which associated with decreased urinary levels of H2O2 and thiobarbituric acid reactive substances. Hydrogen Peroxide 147-151 superoxide dismutase 2, mitochondrial Mus musculus 91-95 29082445-5 2018 We found over-expression of SOD2 protected BM-MSCs from H2O2-induced cell apoptosis. Hydrogen Peroxide 56-60 superoxide dismutase 2, mitochondrial Mus musculus 28-32 28231483-5 2017 Mechanistically, MnP reduces superoxide to hydrogen peroxide, which activates intracellular Nrf2 signaling leading to the induction of antioxidant enzymes, including MnSOD and catalase, and mitochondrial uncoupling protein 3. Hydrogen Peroxide 43-60 superoxide dismutase 2, mitochondrial Mus musculus 166-171 28163078-2 2017 Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme acting within the mitochondria, converts toxic superoxide to hydrogen peroxide. Hydrogen Peroxide 124-141 superoxide dismutase 2, mitochondrial Mus musculus 0-30 28163078-2 2017 Manganese superoxide dismutase (Mn-SOD), an antioxidant enzyme acting within the mitochondria, converts toxic superoxide to hydrogen peroxide. Hydrogen Peroxide 124-141 superoxide dismutase 2, mitochondrial Mus musculus 32-38 22391698-9 2012 This SOD likely belongs to the Fe- or Mn-SOD category due to the fact that it was insensitive to potassium cyanide or hydrogen peroxide inhibition, but was potentially weakly stimulated by hydrogen peroxide, and stimulated by Mn(2+)and Fe(2+) ions. Hydrogen Peroxide 118-135 superoxide dismutase 2, mitochondrial Mus musculus 38-44 26682532-13 2016 The findings indicate that the H(2)O(2) production induced by acute exercise in skeletal muscle mitochondria in the mouse is closely associated with upregulation of the Ref1/Nrf2 signalling pathway and enhancement of antioxidant defense components, including GSH and MnSOD. Hydrogen Peroxide 31-39 superoxide dismutase 2, mitochondrial Mus musculus 267-272 26374996-2 2015 However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. Hydrogen Peroxide 112-116 superoxide dismutase 2, mitochondrial Mus musculus 120-124 26374996-3 2015 To understand the systemic effects of the metabolic dilator, H2O2, we studied mice with cardiac-specific SOD2 overexpression (SOD2-tg), which increases the H2O2 produced by cardiac mitochondria. Hydrogen Peroxide 156-160 superoxide dismutase 2, mitochondrial Mus musculus 105-109 26374996-3 2015 To understand the systemic effects of the metabolic dilator, H2O2, we studied mice with cardiac-specific SOD2 overexpression (SOD2-tg), which increases the H2O2 produced by cardiac mitochondria. Hydrogen Peroxide 156-160 superoxide dismutase 2, mitochondrial Mus musculus 126-130 25523055-10 2015 In neuronal cultures, miR-424 treatment abrogated H2O2-induced injury, as evidenced by decreased lactate dehydrogenase leakage and malondialdehyde level and increased cell viability and MnSOD activity; the protective effects of miR-424 against oxidative stress were reversed by nuclear factor erythroid 2-related factor knockdown and SOD inhibitor treatment. Hydrogen Peroxide 50-54 superoxide dismutase 2, mitochondrial Mus musculus 186-191 26301039-3 2015 Manganese superoxide dismutase (Mn-SOD, SOD2) is a mitochondrial antioxidant enzyme that converts toxic superoxide to hydrogen peroxide. Hydrogen Peroxide 118-135 superoxide dismutase 2, mitochondrial Mus musculus 0-30 23649652-1 2013 Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen. Hydrogen Peroxide 82-99 superoxide dismutase 2, mitochondrial Mus musculus 0-30 23649652-1 2013 Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen. Hydrogen Peroxide 82-99 superoxide dismutase 2, mitochondrial Mus musculus 32-37 23649652-1 2013 Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen. Hydrogen Peroxide 101-105 superoxide dismutase 2, mitochondrial Mus musculus 0-30 23649652-1 2013 Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen. Hydrogen Peroxide 101-105 superoxide dismutase 2, mitochondrial Mus musculus 32-37 22687340-1 2012 BACKGROUND & AIMS: Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Hydrogen Peroxide 162-170 superoxide dismutase 2, mitochondrial Mus musculus 174-178 26301039-3 2015 Manganese superoxide dismutase (Mn-SOD, SOD2) is a mitochondrial antioxidant enzyme that converts toxic superoxide to hydrogen peroxide. Hydrogen Peroxide 118-135 superoxide dismutase 2, mitochondrial Mus musculus 32-38 26301039-3 2015 Manganese superoxide dismutase (Mn-SOD, SOD2) is a mitochondrial antioxidant enzyme that converts toxic superoxide to hydrogen peroxide. Hydrogen Peroxide 118-135 superoxide dismutase 2, mitochondrial Mus musculus 40-44 24859499-6 2014 Mitochondrial superoxide and hydrogen peroxide formation in the myocardium increased in the H/M-Sod2(+/-)+BSO group in comparison with the WT+BSO group (P<0.05). Hydrogen Peroxide 29-46 superoxide dismutase 2, mitochondrial Mus musculus 96-100 24072697-7 2013 Proteomic analyses revealed that superoxide dismutase 2 (SOD2) expression was reduced in TAK1-deficient endothelial cells, resulting in attenuated hydrogen peroxide production but increased mitochondrial superoxide production. Hydrogen Peroxide 147-164 superoxide dismutase 2, mitochondrial Mus musculus 33-55 24072697-7 2013 Proteomic analyses revealed that superoxide dismutase 2 (SOD2) expression was reduced in TAK1-deficient endothelial cells, resulting in attenuated hydrogen peroxide production but increased mitochondrial superoxide production. Hydrogen Peroxide 147-164 superoxide dismutase 2, mitochondrial Mus musculus 57-61 22391698-9 2012 This SOD likely belongs to the Fe- or Mn-SOD category due to the fact that it was insensitive to potassium cyanide or hydrogen peroxide inhibition, but was potentially weakly stimulated by hydrogen peroxide, and stimulated by Mn(2+)and Fe(2+) ions. Hydrogen Peroxide 189-206 superoxide dismutase 2, mitochondrial Mus musculus 38-44 20046060-1 2010 Manganese superoxide dismutase (Mn-SOD) is a mitochondrial enzyme that converts toxic O(2)(-) to H(2)O(2). Hydrogen Peroxide 97-105 superoxide dismutase 2, mitochondrial Mus musculus 0-30 22199367-10 2012 Aged SOD2+/- SMCs had increased mitochondrial superoxide but decreased hydrogen peroxide levels. Hydrogen Peroxide 71-88 superoxide dismutase 2, mitochondrial Mus musculus 5-9 21736939-6 2011 Gene transfer resulting in increased expression of SOD2, but not coexpression of SOD2 and mitochondrial Gpx4, resulted in high levels of H(2)O(2) in the retina. Hydrogen Peroxide 137-145 superoxide dismutase 2, mitochondrial Mus musculus 51-55 20590844-1 2010 Manganese superoxide dismutase (Mn-SOD) is a mitochondrial enzyme that converts toxic O(2)(-) to H(2)O(2). Hydrogen Peroxide 97-105 superoxide dismutase 2, mitochondrial Mus musculus 0-30 20590844-1 2010 Manganese superoxide dismutase (Mn-SOD) is a mitochondrial enzyme that converts toxic O(2)(-) to H(2)O(2). Hydrogen Peroxide 97-105 superoxide dismutase 2, mitochondrial Mus musculus 32-38 20060889-6 2010 The change in the sensitivity of these SOD2-altered HT22 cells was neurotoxicant-specific, because the cytotoxicity of hydrogen peroxide was not altered in these cells. Hydrogen Peroxide 119-136 superoxide dismutase 2, mitochondrial Mus musculus 39-43 20046060-1 2010 Manganese superoxide dismutase (Mn-SOD) is a mitochondrial enzyme that converts toxic O(2)(-) to H(2)O(2). Hydrogen Peroxide 97-105 superoxide dismutase 2, mitochondrial Mus musculus 32-38 19738419-1 2009 Manganese superoxide dismutase (SOD2) is a nuclear encoded and mitochondria localized antioxidant enzyme that converts mitochondria derived superoxide to hydrogen peroxide. Hydrogen Peroxide 154-171 superoxide dismutase 2, mitochondrial Mus musculus 32-36 19628743-8 2009 Administration of plasmids encoding SOD2 or CAT significantly reduced levels of superoxide ion, hydrogen peroxide, and 4-HNE. Hydrogen Peroxide 96-113 superoxide dismutase 2, mitochondrial Mus musculus 36-40 17023572-2 2007 O(2)(-) produced by the mitochondria is converted to hydrogen peroxide by mitochondrial superoxide dismutase (SOD2). Hydrogen Peroxide 53-70 superoxide dismutase 2, mitochondrial Mus musculus 110-114 19549914-5 2009 In other cell types, increasing manganese superoxide dismutase (MnSOD) can increase intracellular H(2)O(2). Hydrogen Peroxide 98-106 superoxide dismutase 2, mitochondrial Mus musculus 32-62 19549914-5 2009 In other cell types, increasing manganese superoxide dismutase (MnSOD) can increase intracellular H(2)O(2). Hydrogen Peroxide 98-106 superoxide dismutase 2, mitochondrial Mus musculus 64-69 19627269-7 2009 These data suggest that specific sites in the PI3K-Akt pathway are more sensitive to increased superoxide levels than to the increased hydrogen peroxide levels generated in Sod2-transgenic myoblasts. Hydrogen Peroxide 135-152 superoxide dismutase 2, mitochondrial Mus musculus 173-177 17316075-5 2007 Furthermore, SCC-VII tumor cells demonstrated increased relative hydrogen peroxide (the product of MnSOD superoxide dismutation)-induced apoptosis in vitro. Hydrogen Peroxide 65-82 superoxide dismutase 2, mitochondrial Mus musculus 99-104 18331617-8 2008 These results support the hypothesis that MnSOD activity regulates a mitochondrial "ROS-switch" favoring a superoxide-signaling regulating proliferation and a hydrogen peroxide-signaling supporting quiescence. Hydrogen Peroxide 159-176 superoxide dismutase 2, mitochondrial Mus musculus 42-47 15224876-6 2004 Semi-quantitative reverse transcriptase polymerase chain reaction was used to observe manganese superoxide dismutase (MnSOD) gene expression of SGCs treated with H2O2 and EGCG. Hydrogen Peroxide 162-166 superoxide dismutase 2, mitochondrial Mus musculus 86-116 16682413-8 2006 In Madin-Darby canine kidney cells, a kidney epithelial cell line, 1 mm H(2)O(2) decreased MnSOD activity, an effect that was potentiated by pretreatment with dihydrotestosterone. Hydrogen Peroxide 72-80 superoxide dismutase 2, mitochondrial Mus musculus 91-96 16139868-3 2005 To understand the molecular mechanisms underlying the increased apoptosis, we compared alphaMUPA and WT mice for parameters associated with SOD2 (MnSOD), a mitochondrial antioxidant enzyme that converts superoxide radicals into H(2)O(2) and is also known to inhibit apoptosis. Hydrogen Peroxide 228-236 superoxide dismutase 2, mitochondrial Mus musculus 140-144 16139868-3 2005 To understand the molecular mechanisms underlying the increased apoptosis, we compared alphaMUPA and WT mice for parameters associated with SOD2 (MnSOD), a mitochondrial antioxidant enzyme that converts superoxide radicals into H(2)O(2) and is also known to inhibit apoptosis. Hydrogen Peroxide 228-236 superoxide dismutase 2, mitochondrial Mus musculus 146-151 16405961-4 2006 Release of hydrogen peroxide from skeletal muscle mitochondria increased 40-50% with age in both wildtype and Sod2(+/-) but was not higher in mitochondria from Sod2(+/-) mice. Hydrogen Peroxide 11-28 superoxide dismutase 2, mitochondrial Mus musculus 110-114 16326710-13 2006 Isolated heart mitochondria from 5-day-old sod2 null animals respiring on the complex II substrate succinate exhibited statistically significant higher levels of mitochondrial O2* (157%, p < 0.01) but significantly less H2O2 (33%, p < 0.001) than wild type littermates. Hydrogen Peroxide 223-227 superoxide dismutase 2, mitochondrial Mus musculus 43-47 16326710-14 2006 Treatment of sod2 nullizygous mice with EUK189 proportionately increased the levels of complex II and H2O2. Hydrogen Peroxide 102-106 superoxide dismutase 2, mitochondrial Mus musculus 13-17 16123448-9 2005 H(2)O(2)-induced apoptotic cell death was both dose and time dependent, and apoptosis in these cells was related to the cellular SOD2 level. Hydrogen Peroxide 0-8 superoxide dismutase 2, mitochondrial Mus musculus 129-133 15642323-6 2004 DNA strand breaks in the epithelium of Sod1 knockouts and Sod2 heterozygotes were much greater than in the corresponding wild-type or in transgenic mice over-expressing the enzymes when the lenses were exposed to H2O2. Hydrogen Peroxide 213-217 superoxide dismutase 2, mitochondrial Mus musculus 58-62 15130276-6 2004 Our data suggest that MnSOD may serve a physiological function of regulating cell cycle progression through its prooxidant activity of generating hydrogen peroxide, resulting in coordination of mitochondrial redox state and cellular proliferation. Hydrogen Peroxide 146-163 superoxide dismutase 2, mitochondrial Mus musculus 22-27 15224876-6 2004 Semi-quantitative reverse transcriptase polymerase chain reaction was used to observe manganese superoxide dismutase (MnSOD) gene expression of SGCs treated with H2O2 and EGCG. Hydrogen Peroxide 162-166 superoxide dismutase 2, mitochondrial Mus musculus 118-123 15224876-8 2004 MnSOD gene expression was upregulated with increasing H2O2 concentration in cultured SGCs, while this upregulation was suppressed by EGCG. Hydrogen Peroxide 54-58 superoxide dismutase 2, mitochondrial Mus musculus 0-5 14975446-10 2004 Since HSP25 overexpression reduced reactive oxygen species (ROS), increased manganese superoxide dismutase (MnSOD) gene expression, and increased enzyme activity, involvement of MnSOD in HSP25-mediated attenuation of H2O2-mediated ERK1/2 activation and cell death was examined. Hydrogen Peroxide 217-221 superoxide dismutase 2, mitochondrial Mus musculus 178-183 15075214-7 2004 In contrast, the data obtained suggest that the increase in hydroxyl radical concentration in the extracellular space of muscles from wild-type mice after the contraction protocol most likely results from degradation of hydrogen peroxide generated by MnSOD activity. Hydrogen Peroxide 220-237 superoxide dismutase 2, mitochondrial Mus musculus 251-256 12538496-0 2003 Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis. Hydrogen Peroxide 112-129 superoxide dismutase 2, mitochondrial Mus musculus 9-13 12538496-7 2003 The Sod2-dependent increases in AP-1 and SP-1 DNA-binding activity, MMP-1 promoter activity, general MMP expression, and collagen degradation can be reversed by the hydrogen peroxide-detoxifying enzyme, catalase. Hydrogen Peroxide 165-182 superoxide dismutase 2, mitochondrial Mus musculus 4-8 12176043-1 2002 Manganese superoxide dismutase (MnSOD) is the enzyme that converts toxic O(2)(-) to H(2)O(2) in mitochondria. Hydrogen Peroxide 84-92 superoxide dismutase 2, mitochondrial Mus musculus 0-30 12176043-1 2002 Manganese superoxide dismutase (MnSOD) is the enzyme that converts toxic O(2)(-) to H(2)O(2) in mitochondria. Hydrogen Peroxide 84-92 superoxide dismutase 2, mitochondrial Mus musculus 32-37 11297530-3 2001 Sod2-dependent increases in the steady-state levels of H(2)O(2) led to ERK1/2 activation and subsequent downstream transcriptional increases in matrix metalloproteinase-1 (MMP-1) expression, which were reversed by expression of the H(2)O(2)-detoxifying enzyme, catalase. Hydrogen Peroxide 55-63 superoxide dismutase 2, mitochondrial Mus musculus 0-4 11297530-3 2001 Sod2-dependent increases in the steady-state levels of H(2)O(2) led to ERK1/2 activation and subsequent downstream transcriptional increases in matrix metalloproteinase-1 (MMP-1) expression, which were reversed by expression of the H(2)O(2)-detoxifying enzyme, catalase. Hydrogen Peroxide 232-240 superoxide dismutase 2, mitochondrial Mus musculus 0-4 8790408-1 1996 Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide. Hydrogen Peroxide 73-90 superoxide dismutase 2, mitochondrial Mus musculus 0-30 8790408-1 1996 Manganese superoxide dismutase (SOD2) converts superoxide to oxygen plus hydrogen peroxide and serves as the primary defense against mitochondrial superoxide. Hydrogen Peroxide 73-90 superoxide dismutase 2, mitochondrial Mus musculus 32-36 35346819-7 2022 The data indicate that mitochondrial oxidative stress, in particular elevated superoxide levels and decreased hydrogen peroxide levels, induces telomere erosion in the ASMCs of the Sod2+/- mice. Hydrogen Peroxide 110-127 superoxide dismutase 2, mitochondrial Mus musculus 181-185 35581738-3 2022 The mitochondrial antioxidant enzyme, superoxide dismutase 2 (SOD2), converts superoxide radicals into less reactive H2 O2 . Hydrogen Peroxide 117-122 superoxide dismutase 2, mitochondrial Mus musculus 38-60 35581738-3 2022 The mitochondrial antioxidant enzyme, superoxide dismutase 2 (SOD2), converts superoxide radicals into less reactive H2 O2 . Hydrogen Peroxide 117-122 superoxide dismutase 2, mitochondrial Mus musculus 62-66