PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27161231-4 2016 For instance, the second messenger diacylglycerol, store-depletion, the plant extract hyperforin or H2O2 have all been shown to trigger the opening of TRPC6 channels. Hydrogen Peroxide 100-104 transient receptor potential cation channel subfamily C member 6 Homo sapiens 151-156 32686475-3 2020 Here we demonstrate that the SASP regulation is linked to shifts in intracellular Ca2+ homeostasis and strategies which rescue redox-dependent calcium entry including enzymatic H2O2 scavenging, TRP modulation, or mTOR inhibition block SASP and TRPC6 gene expression. Hydrogen Peroxide 177-181 transient receptor potential cation channel subfamily C member 6 Homo sapiens 244-249 32139669-4 2020 In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line). Hydrogen Peroxide 151-155 transient receptor potential cation channel subfamily C member 6 Homo sapiens 28-33 32139669-4 2020 In vitro, both knockdown of TRPC6 expression with shRNA and TRPC6 blockage markedly attenuated the release of cytokines IL-6 and IL-8 induced by O3 or H2O2 in 16HBE cells (human bronchial epithelial cell line). Hydrogen Peroxide 151-155 transient receptor potential cation channel subfamily C member 6 Homo sapiens 60-65 32139669-5 2020 Treatment with O3 or H2O2 enhanced TRPC6 protein expression in vivo and vitro. Hydrogen Peroxide 21-25 transient receptor potential cation channel subfamily C member 6 Homo sapiens 35-40 32139669-6 2020 We also observed that TRPC6-dependent increase of intracellular Ca2+ concentration ([Ca2+]i) was triggered by H2O2, which consisted of the release from intracellular calcium store and the influx of extracellular Ca2+ and could be further strengthened by 6-h O3 exposure in both 16HBE cells and HBEpiCs (primary human bronchial epithelial cells). Hydrogen Peroxide 110-114 transient receptor potential cation channel subfamily C member 6 Homo sapiens 22-27 25896763-8 2015 H2O2 treatment, which results in oxidative stress, also increased TRPC6 expression and Ca(2+) influx. Hydrogen Peroxide 0-4 transient receptor potential cation channel subfamily C member 6 Homo sapiens 66-71 23499875-4 2013 Single-channel data from cell-attached, patch-clamp experiments showed that both high glucose and H2O2 activated the TRPC6 channel in control podocytes, but not in TRPC6 knockdown podocytes. Hydrogen Peroxide 98-102 transient receptor potential cation channel subfamily C member 6 Homo sapiens 117-122 25601712-6 2015 In parallel, acute ethanol in the presence of H2O2, but neither ethanol nor H2O2 alone, stimulated transient receptor potential canonical 6 (TRPC6) channels and caused TRPC6-dependent elevation of intracellular Ca2+. Hydrogen Peroxide 46-50 transient receptor potential cation channel subfamily C member 6 Homo sapiens 141-146 25601712-6 2015 In parallel, acute ethanol in the presence of H2O2, but neither ethanol nor H2O2 alone, stimulated transient receptor potential canonical 6 (TRPC6) channels and caused TRPC6-dependent elevation of intracellular Ca2+. Hydrogen Peroxide 46-50 transient receptor potential cation channel subfamily C member 6 Homo sapiens 168-173 25601712-7 2015 These data suggest that exogenous H2O2 does not induce oxidative stress due to rapid degradation to produce O2 in the podocytes, but the oxygenated podocytes become sensitive to acute ethanol challenge and undergo apoptosis via a TRPC6-dependent elevation of intracellular Ca2+. Hydrogen Peroxide 34-38 transient receptor potential cation channel subfamily C member 6 Homo sapiens 230-235 23499875-5 2013 Confocal microscopy showed that high glucose elevated ROS in podocytes and that H2O2 reduced the membrane potential of podocytes and elevated intracellular Ca(2+) via activation of TRPC6. Hydrogen Peroxide 80-84 transient receptor potential cation channel subfamily C member 6 Homo sapiens 181-186 23499875-6 2013 Since intracellular Ca(2+) overload induces apoptosis, H2O2-induced apoptosis may result from TRPC6-mediated elevation of intracellular Ca(2+). Hydrogen Peroxide 55-59 transient receptor potential cation channel subfamily C member 6 Homo sapiens 94-99 20501650-2 2010 In TRPC6-expressing HEK293T cells, H(2)O(2) significantly stimulated Ca(2+) entry in a dose-dependent manner. Hydrogen Peroxide 35-43 transient receptor potential cation channel subfamily C member 6 Homo sapiens 3-8 23525112-2 2013 In cultured human mesangial cells, H2O2 and TNF-alpha inhibited TRPC6 mRNA expression in a time-dependent manner. Hydrogen Peroxide 35-39 transient receptor potential cation channel subfamily C member 6 Homo sapiens 64-69 23525112-3 2013 Inhibition of NF-kappaB reversed both H2O2- and phorbol 12-myristate 13-acetate (PMA)-induced decrease in TRPC6 protein expression. Hydrogen Peroxide 38-42 transient receptor potential cation channel subfamily C member 6 Homo sapiens 106-111 23525112-9 2013 Furthermore, specific knockdown of p65, but not p50, prevented an H2O2 inhibitory effect on TRPC6 protein expression, suggesting p65 as a predominant NF-kappaB subunit repressing TRPC6. Hydrogen Peroxide 66-70 transient receptor potential cation channel subfamily C member 6 Homo sapiens 92-97 23525112-9 2013 Furthermore, specific knockdown of p65, but not p50, prevented an H2O2 inhibitory effect on TRPC6 protein expression, suggesting p65 as a predominant NF-kappaB subunit repressing TRPC6. Hydrogen Peroxide 66-70 transient receptor potential cation channel subfamily C member 6 Homo sapiens 179-184 23525112-12 2013 Consistently, knockdown of HDAC2 by siRNA or inhibition of HDAC with trichostatin A prevented a H2O2-induced decrease in TRPC6 mRNA and protein expressions, respectively. Hydrogen Peroxide 96-100 transient receptor potential cation channel subfamily C member 6 Homo sapiens 121-126 20501650-8 2010 Furthermore, both N-ethylmaleimide- and H(2)O(2)-induced TRPC6 activations were only observed in the cell-attached patches but not in the inside-out patches. Hydrogen Peroxide 40-48 transient receptor potential cation channel subfamily C member 6 Homo sapiens 57-62 20501650-13 2010 These data indicate that H(2)O(2) activates TRPC6 channels via modification of thiol groups of intracellular proteins. Hydrogen Peroxide 25-33 transient receptor potential cation channel subfamily C member 6 Homo sapiens 44-49 23570668-6 2013 Exogenous treatment with H2O2 mimicked the high glucose response, resulting in an increase in TRPC6 expression and Ca(2+) influx. Hydrogen Peroxide 25-29 transient receptor potential cation channel subfamily C member 6 Homo sapiens 94-99 18436303-7 2008 TRPC1, TRPC6 and Orai1 knock-out by siRNA resulted in the inhibition of Ca(2+) influx and H(2)O(2) production in response to fMLF and thapsigargin while suppression of TRPC3 had no effect on thapsigargin induced-SOCE. Hydrogen Peroxide 90-98 transient receptor potential cation channel subfamily C member 6 Homo sapiens 7-12