PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15576431-5 2005 Treatment of primary cultures with adenovirus expressing PKG-1alpha mimicked NO-induced inhibition of insulin-elicited hydrogen peroxide elevation and cell motility, whereas treatment with the pharmacological PKG inhibitor Rp-8-bromo-3",5"-cyclic monophosphorothioate (Rp-8-Br-cGMPS) rescued the stimulatory effects of insulin that were suppressed by NO donor. Hydrogen Peroxide 119-136 protein kinase cGMP-dependent 1 Homo sapiens 57-60 21316056-7 2011 Impairment of the NO/cGMP/PKG signalling is reproduced in VSMC from LZR by hydrogen peroxide and reverted in VSMC from OZR by antioxidants. Hydrogen Peroxide 75-92 protein kinase cGMP-dependent 1 Homo sapiens 26-29 21479273-7 2011 Moreover, PKG stimulation of Kir6.2/SUR2A channels in intact cells was abrogated by ROS/H(2)O(2) scavenging, antagonism of calmodulin, and blockade of calcium/calmodulin-dependent protein kinase II (CaMKII), respectively. Hydrogen Peroxide 88-96 protein kinase cGMP-dependent 1 Homo sapiens 10-13 16339778-11 2006 These data suggest that cGMP decreased HPAEC basal permeability by a PKG(I)-independent process, whereas the ability of cGMP to prevent H(2)O(2)-induced barrier dysfunction was predominantly mediated by PKG(I) through a Ca(2+)-independent mechanism. Hydrogen Peroxide 136-144 protein kinase cGMP-dependent 1 Homo sapiens 203-206 9865501-5 1998 CONCLUSIONS: These data demonstrate that NO/ H2O2 promotes neutrophil-endothelial adhesion through PKG, PKC, calcium, and K+ channels, but not PKA or tyrosine kinase. Hydrogen Peroxide 45-49 protein kinase cGMP-dependent 1 Homo sapiens 99-102 11781812-6 2001 This effect of H2O2 reversed within 120 minutes of removal of H2O2 and was blocked by the mean arterial pressure (MAP) kinase inhibitor, PD98059 and by chelating cytoplasmic Ca2+ but not PKC or PKG inhibition. Hydrogen Peroxide 15-19 protein kinase cGMP-dependent 1 Homo sapiens 194-197 30206122-6 2018 PKG Ialpha C42S and a truncation construct that does not contain Cys-42 (Delta53) were both constitutively activated by H2O2 In contrast, oxidation of PKG Ialpha C117S maintained its cGMP-dependent activation characteristics, although oxidized PKG Ialpha C195S did not. Hydrogen Peroxide 120-124 protein kinase cGMP-dependent 1 Homo sapiens 0-3 30206122-5 2018 Using an in vitro assay, we observed that oxidation with hydrogen peroxide (H2O2) resulted in constitutive, cGMP-independent activation of PKG Ialpha. Hydrogen Peroxide 57-74 protein kinase cGMP-dependent 1 Homo sapiens 139-142 30585261-13 2018 These data suggest that the NO suppresses H2O2-induced SK-N-MC cell apoptosis by suppressing apoptosis signal mediating the interaction between 14-3-3beta and Bad phosphorylation via PKG/PI3K/Akt. Hydrogen Peroxide 42-46 protein kinase cGMP-dependent 1 Homo sapiens 183-186 30206122-8 2018 Application of WT PKG Ialpha activated by either cGMP or H2O2 increased the open probabilities of the channel. Hydrogen Peroxide 57-61 protein kinase cGMP-dependent 1 Homo sapiens 18-21 30206122-5 2018 Using an in vitro assay, we observed that oxidation with hydrogen peroxide (H2O2) resulted in constitutive, cGMP-independent activation of PKG Ialpha. Hydrogen Peroxide 76-80 protein kinase cGMP-dependent 1 Homo sapiens 139-142 25904916-9 2015 The cGMP/PKG-evoked increase in KCa3.1 current in intact MLS-9 microglia was mediated by ROS, mimicked by applying hydrogen peroxide (H2O2), inhibited by a ROS scavenger (MGP), and prevented by a selective CaMKII inhibitor (mAIP). Hydrogen Peroxide 115-132 protein kinase cGMP-dependent 1 Homo sapiens 9-12 25904916-9 2015 The cGMP/PKG-evoked increase in KCa3.1 current in intact MLS-9 microglia was mediated by ROS, mimicked by applying hydrogen peroxide (H2O2), inhibited by a ROS scavenger (MGP), and prevented by a selective CaMKII inhibitor (mAIP). Hydrogen Peroxide 134-138 protein kinase cGMP-dependent 1 Homo sapiens 9-12 24277866-10 2014 Taken together, these findings suggest that NO modulates ventricular sarcK(ATP) channels via a novel sGC-cGMP-PKG-ROS(H2O2)-ERK1/2-calmodulin-CaMKII (delta isoform in particular) signalling cascade, which heightens K(ATP) channel activity by destabilizing the long closed states while facilitating closed-to-open state transitions. Hydrogen Peroxide 118-122 protein kinase cGMP-dependent 1 Homo sapiens 110-113 22158710-3 2012 An important mode of action of H(2)O(2) involves the oxidation of cysteine residues in its target proteins, including protein kinase G (PKG)-Ialpha, thereby modulating their activities. Hydrogen Peroxide 31-39 protein kinase cGMP-dependent 1 Homo sapiens 136-139 22158710-7 2012 The PKG inhibitor Rp-8-Br-PET-cGMP also markedly inhibited flow- and H(2)O(2)-induced dilation, whereas the soluble guanylate cyclase inhibitor ODQ had no effect. Hydrogen Peroxide 69-77 protein kinase cGMP-dependent 1 Homo sapiens 4-7 22158710-8 2012 Treatment of coronary smooth muscle cells (SMCs) with H(2)O(2) elicited dose-dependent, reversible dimerization of PKG-Ialpha, and induced its translocation to the plasma membrane. Hydrogen Peroxide 54-62 protein kinase cGMP-dependent 1 Homo sapiens 115-118 22158710-10 2012 Addition of H(2)O(2) into the bath solution significantly increased the probability of BK(Ca) single-channel openings recorded from cell-attached patches, an effect that was blocked by the PKG-Ialpha inhibitor DT-2. Hydrogen Peroxide 12-20 protein kinase cGMP-dependent 1 Homo sapiens 189-192 22498562-7 2012 In isolated porcine coronary arteries, H(2)O(2) increased the dimers of total PKG I in a concentration-dependent manner, but had no effect on dimerization of PKG Ibeta. Hydrogen Peroxide 39-47 protein kinase cGMP-dependent 1 Homo sapiens 78-81