PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34859377-11 2021 RESULTS: We found that H2O2 treatment significantly decreased cell viability and the level of SOD, increased the levels of ROS and MDA, and upregulated the expression of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, in H9c2 cells. Hydrogen Peroxide 23-27 interleukin 6 Rattus norvegicus 215-219 35584953-10 2022 The expression levels of p-JAK2, p-STAT3, p-AKT, GP130, and IL-6 were significantly elevated in H2O2-treated astrocytes. Hydrogen Peroxide 96-100 interleukin 6 Rattus norvegicus 60-64 28605990-10 2018 miR-25 protected PC-12 cells against H2O2-induced oxidative damage, as evidenced by significant suppression in cell apoptosis, increase in cell viability, decrease in the level of ROS, HIF-alpha and gammaH2A, and decrease in inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and MCP-1). Hydrogen Peroxide 37-41 interleukin 6 Rattus norvegicus 270-274 34997457-0 2022 Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes. Hydrogen Peroxide 104-108 interleukin 6 Rattus norvegicus 117-121 34997457-12 2022 Finally, the NRROS stable clones attenuated the H2O2-induced ROS generation and expression of IL-6 through suppressing the Nox-2 activity. Hydrogen Peroxide 48-52 interleukin 6 Rattus norvegicus 94-98 32833882-4 2020 METHODS: The cell viability, neurite growth, NF-kappa B, TNFalpha and IL-6 production from hydrogen peroxide-treated PC12 cells were analyzed. Hydrogen Peroxide 91-108 interleukin 6 Rattus norvegicus 70-74 32526337-8 2020 In addition, Kuanxiong aerosol suppressed the hypoxia, LPS, and hydrogen peroxide (H2O2)-induced injuries of H9c2 cardiomyocytes through the regulation of HIF1A, suppressed expression of IL6 and TNF, and antioxidant property. Hydrogen Peroxide 64-81 interleukin 6 Rattus norvegicus 187-190 32526337-8 2020 In addition, Kuanxiong aerosol suppressed the hypoxia, LPS, and hydrogen peroxide (H2O2)-induced injuries of H9c2 cardiomyocytes through the regulation of HIF1A, suppressed expression of IL6 and TNF, and antioxidant property. Hydrogen Peroxide 83-87 interleukin 6 Rattus norvegicus 187-190 27430346-10 2016 Pre-treatment with cannabidiol suppressed the promotion of COX-2, iNOS, IL-1beta and IL-6 expression in the nucleus pulposus cells following H2O2 exposure. Hydrogen Peroxide 141-145 interleukin 6 Rattus norvegicus 85-89 28123508-4 2017 In addition, 10 and 100 nM aloperine significantly inhibited H2O2-induced tumor necrosis factor-alpha and interleukin-6 activities, and significantly increased the H2O2-reduced superoxide dismutase and glutathione peroxidase activities in nucleus pulposus cells (all P<0.01). Hydrogen Peroxide 61-65 interleukin 6 Rattus norvegicus 106-119 29695641-5 2018 H2O2 mediated oxidative stress in 2G11 cells, a rat MPC clone previously established in our laboratory, successfully induced senescence, as shown by the upregulation of p21 and SASP factors, including IL-6. Hydrogen Peroxide 0-4 interleukin 6 Rattus norvegicus 201-205 26330101-7 2015 We found that H2O2 stimulated the production of IL-6, IL-1beta, TNF-alpha and NO, which could be reduced by pretreatment with FA through inhibiting the p-NF-kappaB as well as the iNOS expression. Hydrogen Peroxide 14-18 interleukin 6 Rattus norvegicus 48-52 22431190-9 2012 CONCLUSION: Our results provide direct evidence that prohibitin is a protective factor of IL-6 preconditioning in H(2)O(2)-induced neonatal rat ventricular cardiomyocytes death. Hydrogen Peroxide 114-122 interleukin 6 Rattus norvegicus 90-94 22431190-0 2012 Interleukin 6 protects H(2)O(2)-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation. Hydrogen Peroxide 23-31 interleukin 6 Rattus norvegicus 0-13 22431190-5 2012 RESULTS: IL-6 preconditioning protected cardiomyocytes against H(2)O(2)-induced cell death. Hydrogen Peroxide 63-71 interleukin 6 Rattus norvegicus 9-13 25849615-7 2015 Treatment of TG cultures with H2O2 significantly up-regulated mRNA and protein levels of cytokine/chemokine such as interleukin 6 (IL-6) and chemokine (C-X-C motif) ligand 2 (CXCL2). Hydrogen Peroxide 30-34 interleukin 6 Rattus norvegicus 116-129 25849615-7 2015 Treatment of TG cultures with H2O2 significantly up-regulated mRNA and protein levels of cytokine/chemokine such as interleukin 6 (IL-6) and chemokine (C-X-C motif) ligand 2 (CXCL2). Hydrogen Peroxide 30-34 interleukin 6 Rattus norvegicus 131-135 17277164-3 2007 We previously demonstrated that hydrogen peroxide (H(2)O(2)) promotes IL-4 and IL-6 mRNA production and potentates FcepsilonRI-induced cytokine release in rat basophilic leukemia RBL-2H3 cells. Hydrogen Peroxide 32-49 interleukin 6 Rattus norvegicus 79-83 18846383-3 2009 Muscular oxidative stress and inflammation induced by H2O2 or MS were assessed by measurements of isoprostanes and IL-6 levels. Hydrogen Peroxide 54-58 interleukin 6 Rattus norvegicus 115-119 18846383-6 2009 H2O2 injection and MS elicited significant and similar increases in isoprostanes and IL-6. Hydrogen Peroxide 0-4 interleukin 6 Rattus norvegicus 85-89 12884291-3 2003 Like IgE stimulation, H(2)O(2) up-regulates IL-4 and IL-6 gene expression and cytokine secretion, shows a little effect on IL-5 but does not induce IL-10 gene expression. Hydrogen Peroxide 22-30 interleukin 6 Rattus norvegicus 53-57 8684537-5 1996 H2O2 enhanced the mitogenic effects of IL-6 and PDGF, 3H-TdR increasing by 52 +/- 12.1% (p < 0.01) and 100 +/- 21% (p < 0.001), respectively. Hydrogen Peroxide 0-4 interleukin 6 Rattus norvegicus 39-43 12884291-6 2003 Conditional inactivation of APE/Ref-1 expression abolishes H(2)O(2)-induced IL-4 and IL-6 gene expression but does not affect that induced by FcepsilonRI stimulation. Hydrogen Peroxide 59-67 interleukin 6 Rattus norvegicus 85-89 8287668-8 1993 The mitogenic effect of interleukin-6 was enhanced by 10(-6) mol/l H2O2 [49.9 (77.7, 12.3)%] (P < 0.01), whereas the addition of 10(-6) mol/l H2O2 to platelet-derived growth factor resulted in a summated increase in [3H]thymidine incorporation of 82.7 (113, 57.4)% (P < 0.001). Hydrogen Peroxide 67-71 interleukin 6 Rattus norvegicus 24-37 8287668-8 1993 The mitogenic effect of interleukin-6 was enhanced by 10(-6) mol/l H2O2 [49.9 (77.7, 12.3)%] (P < 0.01), whereas the addition of 10(-6) mol/l H2O2 to platelet-derived growth factor resulted in a summated increase in [3H]thymidine incorporation of 82.7 (113, 57.4)% (P < 0.001). Hydrogen Peroxide 145-149 interleukin 6 Rattus norvegicus 24-37