PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23526214-7 2013 In addition, MIF-silenced (short, interfering RNA) human lung endothelial cells failed to express Nrf2 after oxidative (H2O2) challenge, an effect reversed by recombinant MIF administration. Hydrogen Peroxide 120-124 macrophage migration inhibitory factor Homo sapiens 13-16 24916123-7 2014 Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates. Hydrogen Peroxide 43-47 macrophage migration inhibitory factor Homo sapiens 28-31 24916123-7 2014 Near complete inhibition of MIF by the MPO/H2O2/epicatechin system was achieved at equimolar concentrations of epicatechin and MIF, even in the presence of other MPO substrates. Hydrogen Peroxide 43-47 macrophage migration inhibitory factor Homo sapiens 127-130 19428548-9 2009 Treatment with H(2)O(2) decreased the amount of intracellular MIF protein and increased MIF concentration in the culture supernatant. Hydrogen Peroxide 15-23 macrophage migration inhibitory factor Homo sapiens 62-65 19428548-9 2009 Treatment with H(2)O(2) decreased the amount of intracellular MIF protein and increased MIF concentration in the culture supernatant. Hydrogen Peroxide 15-23 macrophage migration inhibitory factor Homo sapiens 88-91 19428548-10 2009 N-acetylcysteine, an antioxidant precursor of glutathione, inhibited the parthenolide-induced and H(2)O(2)-induced secretion of MIF. Hydrogen Peroxide 98-106 macrophage migration inhibitory factor Homo sapiens 128-131 16133150-6 2005 Exposure of cultured human MPhi to oxLDL, C6-ceramide, and tumor necrosis factor-alpha or H2O2 resulted in a significant increase of the apoptosis rate as well as of the MIF protein expression. Hydrogen Peroxide 90-94 macrophage migration inhibitory factor Homo sapiens 170-173 11738060-7 2001 H(2)O(2)-induced MIF production increased in a time- and dose-dependent manner and was completely abolished in the presence of catalase. Hydrogen Peroxide 0-8 macrophage migration inhibitory factor Homo sapiens 17-20 12349949-4 2002 On the other hand, higher concentrations of H2O2 (0.6-1.2 mM) caused an increase of MIF secretion into the culture medium irrespective of LPS-stimulation; with 1.2 mM H2O2-stimulation for 20 h, it was increased to 40-fold as compared with the nonstimulated cells. Hydrogen Peroxide 44-48 macrophage migration inhibitory factor Homo sapiens 84-87 12349949-4 2002 On the other hand, higher concentrations of H2O2 (0.6-1.2 mM) caused an increase of MIF secretion into the culture medium irrespective of LPS-stimulation; with 1.2 mM H2O2-stimulation for 20 h, it was increased to 40-fold as compared with the nonstimulated cells. Hydrogen Peroxide 167-171 macrophage migration inhibitory factor Homo sapiens 84-87 12349949-8 2002 From analysis of trypan blue exclusion, formazan formation, morphological changes, and intracellular MIF content by Western blotting, we found that MIF secretion by H2O2 seemed to be mainly due to cell death and subsequent leakage of intracellular MIF. Hydrogen Peroxide 165-169 macrophage migration inhibitory factor Homo sapiens 101-104 12349949-8 2002 From analysis of trypan blue exclusion, formazan formation, morphological changes, and intracellular MIF content by Western blotting, we found that MIF secretion by H2O2 seemed to be mainly due to cell death and subsequent leakage of intracellular MIF. Hydrogen Peroxide 165-169 macrophage migration inhibitory factor Homo sapiens 148-151 12349949-8 2002 From analysis of trypan blue exclusion, formazan formation, morphological changes, and intracellular MIF content by Western blotting, we found that MIF secretion by H2O2 seemed to be mainly due to cell death and subsequent leakage of intracellular MIF. Hydrogen Peroxide 165-169 macrophage migration inhibitory factor Homo sapiens 148-151 12349949-0 2002 Secretion of macrophage migration inhibitory factor differs from interleukin-6 in hydrogen peroxide- and LPS-stimulated human fibroblasts. Hydrogen Peroxide 82-99 macrophage migration inhibitory factor Homo sapiens 13-51 11738060-9 2001 The H(2)O(2)-induced MIF production was completely inhibited by the protein kinase C (PKC) inhibitor GF109203X, partially inhibited by the tyrosine kinase inhibitor herbimycin A, and uninhibited by calcium chelation or phorbol ester-sensitive PKC down-regulation. Hydrogen Peroxide 4-12 macrophage migration inhibitory factor Homo sapiens 21-24 11738060-10 2001 This suggests that H(2)O(2)-induced MIF production is mediated by an atypical PKC isoform. Hydrogen Peroxide 19-27 macrophage migration inhibitory factor Homo sapiens 36-39 28906008-6 2017 Analysis of a cytokine array revealed that H2 O2 specifically increased the release of macrophage migration inhibitory factor (MIF) from RPE cells. Hydrogen Peroxide 43-48 macrophage migration inhibitory factor Homo sapiens 87-125 9688536-8 1998 The favored use of GSH and dihydrolipoamide indicated that MIF may be involved in the regulation of cellular redox processes and was supported further by the finding that MIF expression by the cell lines COS-1 and RAW 264.7 was significantly induced upon treatment with the oxidant hydrogen peroxide. Hydrogen Peroxide 282-299 macrophage migration inhibitory factor Homo sapiens 59-62 9688536-8 1998 The favored use of GSH and dihydrolipoamide indicated that MIF may be involved in the regulation of cellular redox processes and was supported further by the finding that MIF expression by the cell lines COS-1 and RAW 264.7 was significantly induced upon treatment with the oxidant hydrogen peroxide. Hydrogen Peroxide 282-299 macrophage migration inhibitory factor Homo sapiens 171-174 6206183-4 1984 Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study. Hydrogen Peroxide 62-66 macrophage migration inhibitory factor Homo sapiens 48-51 28906008-6 2017 Analysis of a cytokine array revealed that H2 O2 specifically increased the release of macrophage migration inhibitory factor (MIF) from RPE cells. Hydrogen Peroxide 43-48 macrophage migration inhibitory factor Homo sapiens 127-130 28906008-7 2017 Reverse transcription-polymerase chain reaction and immunoblot analyses showed that H2 O2 increased the expression of MIF in RPE cells. Hydrogen Peroxide 84-89 macrophage migration inhibitory factor Homo sapiens 118-121 26310191-6 2016 Intracellular MIF accumulation preserved the intracellular ability of MIF to reduce oxidative stress as shown by hydrogen peroxide and aconitase activity measurements. Hydrogen Peroxide 113-130 macrophage migration inhibitory factor Homo sapiens 14-17 26310191-6 2016 Intracellular MIF accumulation preserved the intracellular ability of MIF to reduce oxidative stress as shown by hydrogen peroxide and aconitase activity measurements. Hydrogen Peroxide 113-130 macrophage migration inhibitory factor Homo sapiens 70-73