PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16380078-5 2006 Exposure of platelets to LDL or H2O2 led to phosphorylation of p38MAPK, its upstream regulator MAP kinase kinase 3/6 (MKK 3/6), and its downstream target heat shock protein 27 (HSP27), and this effect was abrogated in SKF86002-pretreated platelets. Hydrogen Peroxide 32-36 mitogen-activated protein kinase kinase 3 Homo sapiens 95-116 16380078-5 2006 Exposure of platelets to LDL or H2O2 led to phosphorylation of p38MAPK, its upstream regulator MAP kinase kinase 3/6 (MKK 3/6), and its downstream target heat shock protein 27 (HSP27), and this effect was abrogated in SKF86002-pretreated platelets. Hydrogen Peroxide 32-36 mitogen-activated protein kinase kinase 3 Homo sapiens 118-125 10856288-3 2000 U937 human lymphoid cells treated with low dose (0.02 mm) H(2)O(2) rapidly caused p38 MAPK cascade activation detectable by phosphorylation of MKK3/6, p38 MAPK, activating transcription factor-2, and cAMP-responsive element-binding protein, leaving the JNK and NF-kappaB cascades unaffected. Hydrogen Peroxide 58-66 mitogen-activated protein kinase kinase 3 Homo sapiens 143-149