PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16184770-0	2005	Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells.	Hydrogen Peroxide	104-121	diablo, IAP-binding mitochondrial protein	Mus musculus	49-53	
20890773-4	2011	An antisense phosphorothioate oligonucleotide against Bcl-2 caused selective inhibition of Bcl-2 protein expression induced by HSP70 and significantly attenuated HSP70-mediated cell protection against H(2)O(2)-induced release of Smac and apoptosis.	Hydrogen Peroxide	201-209	diablo, IAP-binding mitochondrial protein	Mus musculus	229-233	
16184770-10	2005	H2O2 can induce the release of Smac/DIABLO from mitochondria and apoptosis in cardiomyocytes and C2C12 myogenic cells.	Hydrogen Peroxide	0-4	diablo, IAP-binding mitochondrial protein	Mus musculus	31-35	
16184770-10	2005	H2O2 can induce the release of Smac/DIABLO from mitochondria and apoptosis in cardiomyocytes and C2C12 myogenic cells.	Hydrogen Peroxide	0-4	diablo, IAP-binding mitochondrial protein	Mus musculus	36-42	
16184770-11	2005	Heat shock pretreatment protects the cells against H2O2-induced apoptosis, and its mechanism appears to involve the inhibition of Smac release from mitochondria.	Hydrogen Peroxide	51-55	diablo, IAP-binding mitochondrial protein	Mus musculus	130-134	
20890773-1	2011	We have previously shown that heat shock protein 70 (HSP70) markedly inhibits H(2)O(2)-induced apoptosis in mouse C2C12 myogenic cells by reducing the release of Smac.	Hydrogen Peroxide	78-86	diablo, IAP-binding mitochondrial protein	Mus musculus	162-166	
16184770-0	2005	Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells.	Hydrogen Peroxide	104-121	diablo, IAP-binding mitochondrial protein	Mus musculus	54-60	
16085184-11	2005	These data demonstrate that H(2)O(2) could result in apoptosis of C2C12 myogenic cells, and that release of Smac/DIABLO from mitochondria to cytoplasm and the subsequent activation of caspase-9 and caspase-3 played important roles in H(2)O(2)-induced apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	234-242	diablo, IAP-binding mitochondrial protein	Mus musculus	108-112	
16085184-11	2005	These data demonstrate that H(2)O(2) could result in apoptosis of C2C12 myogenic cells, and that release of Smac/DIABLO from mitochondria to cytoplasm and the subsequent activation of caspase-9 and caspase-3 played important roles in H(2)O(2)-induced apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	234-242	diablo, IAP-binding mitochondrial protein	Mus musculus	113-119	
16085184-0	2005	Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	23-40	diablo, IAP-binding mitochondrial protein	Mus musculus	8-12	
16085184-0	2005	Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	23-40	diablo, IAP-binding mitochondrial protein	Mus musculus	13-19	
29949402-9	2018	Moreover, the cytoplasmic translocation of the proapoptotic mitochondrial proteins Omi/HtrA2 and Smac/DIABLO in response to H2O2 was reduced in neutrophils from Olfm4-deficient mice compared with neutrophils from wild-type mice.	Hydrogen Peroxide	124-128	diablo, IAP-binding mitochondrial protein	Mus musculus	97-101	
29949402-9	2018	Moreover, the cytoplasmic translocation of the proapoptotic mitochondrial proteins Omi/HtrA2 and Smac/DIABLO in response to H2O2 was reduced in neutrophils from Olfm4-deficient mice compared with neutrophils from wild-type mice.	Hydrogen Peroxide	124-128	diablo, IAP-binding mitochondrial protein	Mus musculus	102-108	
15871184-1	2005	OBJECTIVE: To observe whether HSP70 could protect against H2O2-induced apoptosis in C2C12 myogenic cells by inhibiting Smac release from the mitochondria.	Hydrogen Peroxide	58-62	diablo, IAP-binding mitochondrial protein	Mus musculus	119-123	
15871184-7	2005	RESULTS: H2O2 ( 0.5 mmol/L ) activated caspase-3, caspase-9 8 h after the treatment and specific morphological changes of apoptosis 12 h after the treatment, and overexpression of Smac significantly promoted H2O2-induced activation of caspase-3, caspase-9 and apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	9-13	diablo, IAP-binding mitochondrial protein	Mus musculus	180-184	
15871184-7	2005	RESULTS: H2O2 ( 0.5 mmol/L ) activated caspase-3, caspase-9 8 h after the treatment and specific morphological changes of apoptosis 12 h after the treatment, and overexpression of Smac significantly promoted H2O2-induced activation of caspase-3, caspase-9 and apoptosis in C2C12 myogenic cells.	Hydrogen Peroxide	208-212	diablo, IAP-binding mitochondrial protein	Mus musculus	180-184	
15871184-9	2005	HSP70 could inhibit the release of Smac from the mitochondria to the cytoplasm 2 h after the treatment by H2O2.	Hydrogen Peroxide	106-110	diablo, IAP-binding mitochondrial protein	Mus musculus	35-39