PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15976330-7 2005 In vitro study on endothelial cells indicated that dominant-negative ASK1 significantly attenuated hydrogen peroxide-induced VEGF and MCP-1 production. Hydrogen Peroxide 99-116 mitogen-activated protein kinase kinase kinase 5 Mus musculus 69-73 30351993-10 2019 Inhibiting Prx1/2 promoted neuronal apoptosis by increasing the hydrogen peroxide (H2O2) levels via the apoptosis signal-regulating kinase 1/p38 pathway. Hydrogen Peroxide 83-87 mitogen-activated protein kinase kinase kinase 5 Mus musculus 104-140 22167179-6 2012 More interestingly, H(2)O(2)- and TNF-alpha-induced apoptosis in TAK1-deficient mouse embryo fibroblast cells were dramatically enhanced by overexpression of ASK1, whereas the apoptosis was markedly inhibited by the overexpression of TAK1. Hydrogen Peroxide 20-28 mitogen-activated protein kinase kinase kinase 5 Mus musculus 158-162 19766627-7 2009 The anti-IgM-induced late-phase H2O2 production, loss of DeltaPsim, and increase in the sub-G1 fraction were all reduced substantially in WEHI-231 cells overexpressing a dominant-negative form of ASK1, compared with control vector alone, but enhanced substantially in cells overexpressing a constitutively active form of ASK1. Hydrogen Peroxide 32-36 mitogen-activated protein kinase kinase kinase 5 Mus musculus 196-200 19766627-9 2009 Taken together, these results suggest that mIg engagement induces H2O2 production leading to activation of ASK1-JNK1 pathway, creating a feedback amplification loop of ROS-ASK/JNK that leads to loss of DeltaPsim and finally apoptosis. Hydrogen Peroxide 66-70 mitogen-activated protein kinase kinase kinase 5 Mus musculus 107-111 18948261-8 2008 MPK38 also stimulated H(2)O(2)-mediated apoptosis by enhancing the ASK1 activity through Thr(838) phosphorylation. Hydrogen Peroxide 22-30 mitogen-activated protein kinase kinase kinase 5 Mus musculus 67-71 18339707-3 2008 H(2)O(2) exposure rapidly induced apoptosis, which was associated with sustained activation of apoptosis signal-regulating kinase-1 and stress-activated protein kinases, such as p38 MAPK and c-Jun N-terminal kinase. Hydrogen Peroxide 0-8 mitogen-activated protein kinase kinase kinase 5 Mus musculus 95-131 25298527-9 2014 Angiotensin II and H2O2, but not IL-1 or lipopolysaccharide, induced p38 activation and upregulation of transforming growth factor-beta1, platelet-derived growth factor-B, and monocyte chemoattractant protein-1 production was suppressed in Ask1(-/-) tubular epithelial cells. Hydrogen Peroxide 19-23 mitogen-activated protein kinase kinase kinase 5 Mus musculus 240-244 23742763-0 2013 An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells. Hydrogen Peroxide 40-57 mitogen-activated protein kinase kinase kinase 5 Mus musculus 3-7 23742763-4 2013 This study tested the hypothesis that hydrogen peroxide (H2O2), which produces ROS, induces apoptosis in the NG108-15 neuronal cell line via activation of either TAK1 or the related kinase ASK1 (MAP3K5). Hydrogen Peroxide 38-55 mitogen-activated protein kinase kinase kinase 5 Mus musculus 189-193 23742763-4 2013 This study tested the hypothesis that hydrogen peroxide (H2O2), which produces ROS, induces apoptosis in the NG108-15 neuronal cell line via activation of either TAK1 or the related kinase ASK1 (MAP3K5). Hydrogen Peroxide 38-55 mitogen-activated protein kinase kinase kinase 5 Mus musculus 195-201 23742763-4 2013 This study tested the hypothesis that hydrogen peroxide (H2O2), which produces ROS, induces apoptosis in the NG108-15 neuronal cell line via activation of either TAK1 or the related kinase ASK1 (MAP3K5). Hydrogen Peroxide 57-61 mitogen-activated protein kinase kinase kinase 5 Mus musculus 189-193 23742763-4 2013 This study tested the hypothesis that hydrogen peroxide (H2O2), which produces ROS, induces apoptosis in the NG108-15 neuronal cell line via activation of either TAK1 or the related kinase ASK1 (MAP3K5). Hydrogen Peroxide 57-61 mitogen-activated protein kinase kinase kinase 5 Mus musculus 195-201 23102700-6 2012 Moreover, KLHDC10 was required for H(2)O(2)-induced sustained activation of ASK1 and cell death in Neuro2A cells. Hydrogen Peroxide 35-43 mitogen-activated protein kinase kinase kinase 5 Mus musculus 76-80 20157567-6 2009 In these studies we demonstrate that dermal fibroblasts from these long-lived mice exhibit (a) higher levels of (SH)(2)Trx-ASK1 that correlate with their resistance to ROS generated by inhibitors of electron transport chain complexes CI (rotenone), CII (3-nitropropionic acid), CIII, (antimycin A), and H(2)O(2)-mediated activation of p38 MAPK, and (b) maintain their in vivo resistance to ROS generated by 3NPA. Hydrogen Peroxide 303-311 mitogen-activated protein kinase kinase kinase 5 Mus musculus 123-127 16400028-7 2006 Furthermore, cultured RGCs from ASK1 KO mice were resistant to H(2)O(2)-induced apoptosis. Hydrogen Peroxide 63-71 mitogen-activated protein kinase kinase kinase 5 Mus musculus 32-36 11266364-3 2001 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide 203-211 mitogen-activated protein kinase kinase kinase 5 Mus musculus 30-34 15953587-6 2005 ASK1(-/-) cardiomyocytes were more resistant to H(2)O(2)- or Ca(2+)-induced apoptotic and non-apoptotic cell death compared with wild-type cells. Hydrogen Peroxide 48-56 mitogen-activated protein kinase kinase kinase 5 Mus musculus 0-4 14668338-3 2004 Exposure of L929 cells to interferon-gamma resulted in the endogenous production of NO and in inhibition of the activation of ASK1 by hydrogen peroxide. Hydrogen Peroxide 134-151 mitogen-activated protein kinase kinase kinase 5 Mus musculus 126-130 12391142-3 2002 Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). Hydrogen Peroxide 103-111 mitogen-activated protein kinase kinase kinase 5 Mus musculus 134-170 12391142-3 2002 Prior exposure of NIH 3T3 cells to mild heat shock (43 degrees C for 20 min) resulted in inhibition of H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). Hydrogen Peroxide 103-111 mitogen-activated protein kinase kinase kinase 5 Mus musculus 172-176 12391142-4 2002 Overexpression of Hsp72 also inhibited H(2)O(2)-induced activation of ASK1 as well as that of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. Hydrogen Peroxide 39-47 mitogen-activated protein kinase kinase kinase 5 Mus musculus 70-74 12391142-8 2002 Hsp72 antisense oligonucleotides prevented the inhibitory effects of mild heat shock on H(2)O(2)-induced ASK1 activation and apoptosis. Hydrogen Peroxide 88-96 mitogen-activated protein kinase kinase kinase 5 Mus musculus 105-109 11266364-1 2001 Apoptosis signal-regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H(2)O(2), and activates c-Jun NH(2)-terminal kinase (JNK) and p38. Hydrogen Peroxide 159-167 mitogen-activated protein kinase kinase kinase 5 Mus musculus 0-42 11266364-3 2001 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide 53-61 mitogen-activated protein kinase kinase kinase 5 Mus musculus 30-34 11266364-3 2001 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide 53-61 mitogen-activated protein kinase kinase kinase 5 Mus musculus 119-123 11266364-3 2001 Here we show that by deleting ASK1 in mice, TNF- and H(2)O(2)-induced sustained activations of JNK and p38 are lost in ASK1(-/-) embryonic fibroblasts, and that ASK1(-/-) cells are resistant to TNF- and H(2)O(2)-induced apoptosis. Hydrogen Peroxide 53-61 mitogen-activated protein kinase kinase kinase 5 Mus musculus 119-123