PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25722428-9 2015 Our findings demonstrate that freshly isolated, adipose SVF cells promote vasomotor relaxation in vasoactive arteries via a hydrogen peroxide-dependent mechanism that required CD11b(+) cells (most likely macrophages). Hydrogen Peroxide 124-141 integrin subunit alpha M Homo sapiens 176-181 25825709-5 2015 Specifically, chemotaxis occurs when alpha-syn binds to integrin CD11b, leading to H2O2 production by NADPH oxidase. Hydrogen Peroxide 83-87 integrin subunit alpha M Homo sapiens 65-70 23470120-6 2013 However, pre-treatment with the MAC1/CD11b inhibitor antibody blocked microglial H2 O2 production in response to DEP. Hydrogen Peroxide 81-86 integrin subunit alpha M Homo sapiens 32-36 23470120-6 2013 However, pre-treatment with the MAC1/CD11b inhibitor antibody blocked microglial H2 O2 production in response to DEP. Hydrogen Peroxide 81-86 integrin subunit alpha M Homo sapiens 37-42 23470120-8 2013 These findings support that DEP may activate microglia through multiple mechanisms, where scavenger receptors regulate internalization of DEP and the MAC1 receptor is mandatory for both DEP-induced microglial H2 O2 production and loss of DA neuron function. Hydrogen Peroxide 209-214 integrin subunit alpha M Homo sapiens 150-154 11106946-10 2000 Finally, H2O2 enhanced the expression of both CD11b and CD18 on EOS. Hydrogen Peroxide 9-13 integrin subunit alpha M Homo sapiens 46-51 22156198-5 2012 Local release of hydrogen peroxide from the neutrophils into the immunological synapse between the neutrophils and T cells mediated the suppression of T cell proliferation and required neutrophil expression of the integrin Mac-1 (alphaMbeta2). Hydrogen Peroxide 17-34 integrin subunit alpha M Homo sapiens 223-228 20815781-2 2010 Hydrogen peroxide (15 muM) and taurine chloramine (200 muM) induced HL 60 differentiation, which was detected by CD11b expression and superoxide production. Hydrogen Peroxide 0-17 integrin subunit alpha M Homo sapiens 113-118 18590811-8 2008 Complete inhibition of LPS-stimulated expression of CD11b by catalase, induction of CD11b expression by H2O2 alone, and inhibition of superoxide-stimulated CD11b expression by catalase suggest that H2O2, but not superoxide, is in fact involved in the expression of CD11b. Hydrogen Peroxide 104-108 integrin subunit alpha M Homo sapiens 84-89 18590811-8 2008 Complete inhibition of LPS-stimulated expression of CD11b by catalase, induction of CD11b expression by H2O2 alone, and inhibition of superoxide-stimulated CD11b expression by catalase suggest that H2O2, but not superoxide, is in fact involved in the expression of CD11b. Hydrogen Peroxide 104-108 integrin subunit alpha M Homo sapiens 84-89 18590811-8 2008 Complete inhibition of LPS-stimulated expression of CD11b by catalase, induction of CD11b expression by H2O2 alone, and inhibition of superoxide-stimulated CD11b expression by catalase suggest that H2O2, but not superoxide, is in fact involved in the expression of CD11b. Hydrogen Peroxide 104-108 integrin subunit alpha M Homo sapiens 84-89 16912650-6 2006 Zymosan particles are rich in beta-glucans and lectin structures that are known to trigger H2O2 production via two major non-toll-like receptor pathogen recognition receptors, comprising the lectin-binding site in the alpha-chain (CD11b) of the complement receptor type 3 and the more recently identified nonclassical C-type lectin, dectin-1. Hydrogen Peroxide 91-95 integrin subunit alpha M Homo sapiens 231-236 12685652-7 2003 Flow cytometric analysis of viable cells revealed that the number of CD11b+H2O2+ cells were significantly higher (31.8%, P < 0.001) in UV-irradiated skin in comparison with non-UV-exposed skin (0.4%). Hydrogen Peroxide 75-79 integrin subunit alpha M Homo sapiens 69-74 12685652-10 2003 Analytical data revealed that CD11b+ cell population from UV-irradiated skin resulted in significantly higher production of total H2O2 in both epidermis and dermis (87-89%, P < 0.0001) in comparison with CD11b- cell population (11-13% of total H2O2). Hydrogen Peroxide 130-134 integrin subunit alpha M Homo sapiens 30-35 12685652-10 2003 Analytical data revealed that CD11b+ cell population from UV-irradiated skin resulted in significantly higher production of total H2O2 in both epidermis and dermis (87-89%, P < 0.0001) in comparison with CD11b- cell population (11-13% of total H2O2). Hydrogen Peroxide 247-251 integrin subunit alpha M Homo sapiens 30-35 11418682-5 2001 Moreover, exogenous hydrogen peroxide was effective to increase neutrophil CD11b expression in a protein-dependent way. Hydrogen Peroxide 20-37 integrin subunit alpha M Homo sapiens 75-80 9551717-8 1998 and H2O2, respectively, also abolished Mac-1 upregulation and neutrophil adhesion. Hydrogen Peroxide 4-8 integrin subunit alpha M Homo sapiens 39-44 10556796-3 1999 Exogenously added H(2)O(2) induced CD11b/CD18-dependent neutrophil adhesion and expression of an integrin activation neoepitope recognized by monoclonal antibody (mAb) clone 24. Hydrogen Peroxide 18-26 integrin subunit alpha M Homo sapiens 35-40 8703375-4 1996 PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression. Hydrogen Peroxide 170-187 integrin subunit alpha M Homo sapiens 205-210 8959153-9 1996 Pretreatment with CD11b/CD18 monoclonal antibodies inhibited TNF-alpha-induced H2O2. Hydrogen Peroxide 79-83 integrin subunit alpha M Homo sapiens 18-23 7929363-10 1994 Third, the CD11b I domain fusion protein blocks the inhibition of certain neutrophil functions by rNIF, including adhesion of neutrophils to human endothelial cell monolayers and adhesion-dependent release of hydrogen peroxide from neutrophils. Hydrogen Peroxide 209-226 integrin subunit alpha M Homo sapiens 11-16 1719092-3 1991 Using specific mAb, we showed in this in vitro study that the CD18 beta 2-chain and the CD11b alpha M-chain of the CD11/CD18 integrin heterodimer have a major role in both TNF-alpha-induced neutrophil-mediated detachment of human umbilical vein endothelial cells and H2O2 release by TNF-alpha-activated human neutrophils. Hydrogen Peroxide 267-271 integrin subunit alpha M Homo sapiens 88-93 8004151-1 1993 There is evidence for a tumor necrosis factor alpha (TNF alpha)-initiated and CD11b/CD18-dependent burst of superoxide anion (O2-) and hydrogen peroxide production by human polymorphonuclear leukocytes which are adherent to surfaces bearing a variety of proteins. Hydrogen Peroxide 135-152 integrin subunit alpha M Homo sapiens 78-83 7913925-7 1994 Decreased CD11b/CD18 expression reduced PMN functional capability, as the binding of its ligand (erythrocytes opsonized with the 3rd component of complement Cbi) and intracellular H2O2 production were reduced. Hydrogen Peroxide 180-184 integrin subunit alpha M Homo sapiens 10-15 1719092-5 1991 mAb 904, directed against the bacterial LPS binding region of CD11b, reduced endothelial cell detachment for about 40% and neutrophil H2O2 release for more than 50%, demonstrating that CD11b/CD18 is engaged in TNF-induced neutrophil activation. Hydrogen Peroxide 134-138 integrin subunit alpha M Homo sapiens 185-190 2181020-0 1990 Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. Hydrogen Peroxide 48-65 integrin subunit alpha M Homo sapiens 0-5 2181020-0 1990 Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. Hydrogen Peroxide 48-65 integrin subunit alpha M Homo sapiens 7-12 2181020-7 1990 mAb reactive with CD18 and CD11b were equally effective in markedly inhibiting the adhesion of normal human neutrophils to these surfaces and markedly inhibited the production of H2O2. Hydrogen Peroxide 179-183 integrin subunit alpha M Homo sapiens 27-32 2181020-8 1990 A mAb reactive with CD18 blocked adhesion of stimulated canine neutrophils, and mAb directed against both CD18 and CD11b blocked H2O2 production by canine neutrophils on KLH and endothelium. Hydrogen Peroxide 129-133 integrin subunit alpha M Homo sapiens 115-120 2181020-10 1990 These results indicate that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors. Hydrogen Peroxide 78-82 integrin subunit alpha M Homo sapiens 28-33 2181020-10 1990 These results indicate that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors. Hydrogen Peroxide 78-82 integrin subunit alpha M Homo sapiens 35-40 2904811-0 1988 H2O2 activates CD11b/CD18-dependent cell adhesion. Hydrogen Peroxide 0-4 integrin subunit alpha M Homo sapiens 15-20 2904811-3 1988 The response to H2O2 closely resembled the adhesive response of U-937 cells to phorbol esters in its time dependency, requirement for extracellular Mg2+ and inhibition by cytochalasin B as well as inhibition by monoclonal antibodies against the leucocyte adhesion molecules CD11b and CD18. Hydrogen Peroxide 16-20 integrin subunit alpha M Homo sapiens 274-279