PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22219646-8 2011 Pretreatment with PF attenuated H2O2-induced p38MAPK and extracellular signal regulated kinase (ERK) phosphorylation in human RPE cells, which contributed to cell viability in ARPE-19 cells. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 1 Homo sapiens 57-94 22219646-8 2011 Pretreatment with PF attenuated H2O2-induced p38MAPK and extracellular signal regulated kinase (ERK) phosphorylation in human RPE cells, which contributed to cell viability in ARPE-19 cells. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 1 Homo sapiens 96-99 21031020-10 2010 The p38 inhibitor, but not the ERK or JNK inhibitor, completely abolished H(2)O(2)-induced expression of IL-6 by RPE cells. Hydrogen Peroxide 74-82 mitogen-activated protein kinase 1 Homo sapiens 4-7 21053344-0 2010 Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation. Hydrogen Peroxide 20-37 mitogen-activated protein kinase 1 Homo sapiens 129-132 21053344-5 2010 These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs. Hydrogen Peroxide 17-25 mitogen-activated protein kinase 1 Homo sapiens 165-168 21053344-5 2010 These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs. Hydrogen Peroxide 123-131 mitogen-activated protein kinase 1 Homo sapiens 165-168 21053344-5 2010 These effects of H(2)O(2) were suppressed by pretreatment of the cells with selenite (0.1-1 microM) for 24 h. In addition, H(2)O(2) activated the phosphorylation of ERK1/2 and inhibition of H(2)O(2)-activated ERK signaling by MEK inhibitor PD98059 blocked the effect of H(2)O(2) on osteoblastic differentiation of VSMCs. Hydrogen Peroxide 123-131 mitogen-activated protein kinase 1 Homo sapiens 165-168 21053344-8 2010 These results suggested that selenite suppressed H(2)O(2)-enhanced osteoblastic differentiation and calcification of VSMCs through inhibiting oxidative stress and ERK activation, indicating a potential preventive role for selenium in vascular calcification. Hydrogen Peroxide 49-57 mitogen-activated protein kinase 1 Homo sapiens 163-166 20854900-12 2010 These results, for the first time, reveal that DEHP induces apoptosis in hepatocytes via the activation of the ERK/NF-kappaB signaling pathway, in which calcium ions and hydrogen peroxide act as the pivotal mediators of the apoptotic signaling. Hydrogen Peroxide 170-187 mitogen-activated protein kinase 1 Homo sapiens 111-114 20665666-0 2010 Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. Hydrogen Peroxide 47-64 mitogen-activated protein kinase 1 Homo sapiens 172-175 20665666-14 2010 H(2)O(2) activated p38 that directed the above two pathways in the regulation of early apoptosis of MSCs while JNK was involved in the late apoptosis of MSCs. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 19-22 21031020-11 2010 The p38 inhibitor also abolished the increase of NF-kappaB in nuclear extracts in cells treated with H(2)O(2). Hydrogen Peroxide 101-109 mitogen-activated protein kinase 1 Homo sapiens 4-7 19741209-8 2010 Inhibition of the NADPH oxidase complex decreased PDGF-induced MAPK1/MAPK3 activation, whereas exogenous hydrogen peroxide induced MAPK1/MAPK3 activation. Hydrogen Peroxide 105-122 mitogen-activated protein kinase 1 Homo sapiens 131-136 20145959-5 2010 Thereafter, we have found that H2O2 increased p38 kinase activity and both HSP70 and HSP27 expression. Hydrogen Peroxide 31-35 mitogen-activated protein kinase 1 Homo sapiens 46-49 20610539-0 2010 Hydrogen peroxide mediates EGF-induced down-regulation of E-cadherin expression via p38 MAPK and snail in human ovarian cancer cells. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 84-87 20370564-3 2010 Cell treatment with H(2)O(2) (0.5 mM) resulted in a time- and dose-dependent response of HOX-1 and COX-2 mRNA and protein levels, with ERK1/2, p38-MAPK and MSK1 found to mediate these effects. Hydrogen Peroxide 20-28 mitogen-activated protein kinase 1 Homo sapiens 143-146 19998339-8 2010 Exogenous addition of H(2)O(2) was sufficient to activate ERK in a dose-dependent profile. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 1 Homo sapiens 58-61 19998339-9 2010 Reactive oxygen species scavengers of H(2)O(2) significantly inhibited hypoxia-induced ERK or HIF-1 activation and sequential expression of MGr1-Ag/37LRP. Hydrogen Peroxide 38-46 mitogen-activated protein kinase 1 Homo sapiens 87-90 20623534-7 2010 Cultures exposed to H(2)O(2) caused the activation of MAPKs (ERK1/2, JNK and p38-MAPK), whereas inhibition of MAPKs diminished cell swelling induced by 10 and 25 microM H(2)O(2). Hydrogen Peroxide 20-28 mitogen-activated protein kinase 1 Homo sapiens 77-80 20302854-6 2010 MPA also reduced the H(2)O(2)-induced phosphorylation of p38 MAP (mitogen-activated protein) kinase, the extracellular-signal regulated kinase 1/2 (ERK1/2), Akt kinase and the transcription factor CREB (cyclic AMP response element binding protein). Hydrogen Peroxide 21-29 mitogen-activated protein kinase 1 Homo sapiens 105-146 19508320-6 2009 Phosphorylation state of the kinases Akt, GSK-3beta, mTOR and ERK1/ERK2 of H(2)O(2)-treated HK-2 cells was slightly altered in the presence of erythropoietin at concentration of 100 U/ml, but was significantly less in the presence of erythropoietin at a concentration of 400 U/ml. Hydrogen Peroxide 75-83 mitogen-activated protein kinase 1 Homo sapiens 67-71 20025928-5 2010 Previously we found that H(2)O(2) triggers a series of events including over-activation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and intracellular Ca(2+) accumulation via voltage-gated Ca(2+) channels and ionotropic glutamate receptors, resulting in neuronal cell death (Numakawa et al. Hydrogen Peroxide 25-33 mitogen-activated protein kinase 1 Homo sapiens 168-171 19699794-8 2010 In addition, H(2)O(2)-induced cell death was prevented by PD98059, SB203580, and calphostin C, which are MEK, p38 and PKC inhibitors, respectively. Hydrogen Peroxide 13-21 mitogen-activated protein kinase 1 Homo sapiens 110-113 18633031-0 2008 Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway. Hydrogen Peroxide 41-58 mitogen-activated protein kinase 1 Homo sapiens 95-133 19223550-7 2009 These data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 1 Homo sapiens 29-32 18997418-2 2008 Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H(2)O(2), both being inhibited by ERK and JNK inhibitors. Hydrogen Peroxide 96-104 mitogen-activated protein kinase 1 Homo sapiens 130-133 18633031-9 2008 CONCLUSIONS: These findings demonstrate that propofol protects hepatic L02 cells from H2O2-induced apoptosis, partly through activating the MEK-ERK pathway and further suppressing Bad and Bax expression. Hydrogen Peroxide 86-90 mitogen-activated protein kinase 1 Homo sapiens 144-147 19424603-4 2009 Ultraviolet radiation (UVB) and H2O2, two major factors causing RPE cell damage, induced AQP1 downregulation which was mediated by MEK/ERK activation. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 1 Homo sapiens 135-138 19655415-6 2009 Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. Hydrogen Peroxide 209-213 mitogen-activated protein kinase 1 Homo sapiens 163-166 20150959-6 2009 The iron chelator o-phenanthroline effectively inhibited H(2)O(2)-induced ERK2 activation. Hydrogen Peroxide 57-65 mitogen-activated protein kinase 1 Homo sapiens 74-78 18762777-10 2008 Kallistatin promoted survival of cardiomyocytes subjected to H(2)O(2) treatment, and inhibited H(2)O(2)-induced Akt and ERK phosphorylation, as well as NF-kappaB activation. Hydrogen Peroxide 95-103 mitogen-activated protein kinase 1 Homo sapiens 120-123 18974961-13 2008 These results indicate that H(2)O(2) acts as an inducer of IL-8 secretion via activation of ERK, p38, and JNK in PDL cells. Hydrogen Peroxide 28-36 mitogen-activated protein kinase 1 Homo sapiens 92-95 18702304-7 2008 We also investigated the role of reactive oxygen species (ROS) involved in HIF-1 and VEGF expression Exogenous addition of H2O2 was sufficient to activate Akt and ERK, scavengers of H2O2 significantly inhibited hypoxia-induced Akt and ERK, and subsequent HIF-lax expression and transcriptional activity. Hydrogen Peroxide 123-127 mitogen-activated protein kinase 1 Homo sapiens 163-166 17922126-13 2008 Treatment with a non-thiol antioxidant agent, catalase, completely abrogated H(2)O(2)-induced JNK and ERK phosphorylation, but a thiol antioxidant, L: -cystein, had no effect on phosphorylation of them. Hydrogen Peroxide 77-85 mitogen-activated protein kinase 1 Homo sapiens 102-105 18339970-2 2008 In this study, we examined the role of the extracellular signaling-regulated kinase (ERK) pathway in H2O2-induced necrosis of renal proximal tubular cells (RPTC) in primary culture. Hydrogen Peroxide 101-105 mitogen-activated protein kinase 1 Homo sapiens 43-83 18339970-2 2008 In this study, we examined the role of the extracellular signaling-regulated kinase (ERK) pathway in H2O2-induced necrosis of renal proximal tubular cells (RPTC) in primary culture. Hydrogen Peroxide 101-105 mitogen-activated protein kinase 1 Homo sapiens 85-88 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 1 Homo sapiens 222-225 17922126-6 2008 By Western blot analysis, VK3 or H(2)O(2) was shown to induce rapid phosphorylation of extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNKs). Hydrogen Peroxide 33-41 mitogen-activated protein kinase 1 Homo sapiens 87-124 17922126-6 2008 By Western blot analysis, VK3 or H(2)O(2) was shown to induce rapid phosphorylation of extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNKs). Hydrogen Peroxide 33-41 mitogen-activated protein kinase 1 Homo sapiens 126-129 17922126-7 2008 H(2)O(2)-induced phosphorylation of ERK and JNK was almost complete inhibited by more than 100-muM genistein. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 36-39 17922126-10 2008 H(2)O(2)-induced JNK phosphorylation and ERK phosphorylation were inhibited by staurosporine, protein kinase C (PKC) inhibitor. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 41-44 18357586-3 2008 In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 1 Homo sapiens 72-75 18702304-7 2008 We also investigated the role of reactive oxygen species (ROS) involved in HIF-1 and VEGF expression Exogenous addition of H2O2 was sufficient to activate Akt and ERK, scavengers of H2O2 significantly inhibited hypoxia-induced Akt and ERK, and subsequent HIF-lax expression and transcriptional activity. Hydrogen Peroxide 123-127 mitogen-activated protein kinase 1 Homo sapiens 235-238 18702304-7 2008 We also investigated the role of reactive oxygen species (ROS) involved in HIF-1 and VEGF expression Exogenous addition of H2O2 was sufficient to activate Akt and ERK, scavengers of H2O2 significantly inhibited hypoxia-induced Akt and ERK, and subsequent HIF-lax expression and transcriptional activity. Hydrogen Peroxide 182-186 mitogen-activated protein kinase 1 Homo sapiens 163-166 18702304-7 2008 We also investigated the role of reactive oxygen species (ROS) involved in HIF-1 and VEGF expression Exogenous addition of H2O2 was sufficient to activate Akt and ERK, scavengers of H2O2 significantly inhibited hypoxia-induced Akt and ERK, and subsequent HIF-lax expression and transcriptional activity. Hydrogen Peroxide 182-186 mitogen-activated protein kinase 1 Homo sapiens 235-238 18292183-2 2008 We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble proteins (p40 and p75) on the hydrogen peroxide-induced disruption of tight junctions and barrier function in Caco-2 cell monolayers. Hydrogen Peroxide 101-118 mitogen-activated protein kinase 1 Homo sapiens 81-84 18263590-11 2008 Hydrogen peroxide and ethanol enhanced FGF2-stimulated pGSK3beta(Tyr-216), ERK/pGSK3beta(Tyr-216) association, and cytoplasmic retention of pERK1/2. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 75-78 18292183-3 2008 Pretreatment of cell monolayers with p40 or p75 attenuated the hydrogen peroxide-induced decrease in transepithelial resistance and increase in inulin permeability in a time- and dose-dependent manner. Hydrogen Peroxide 63-80 mitogen-activated protein kinase 1 Homo sapiens 37-40 18292183-4 2008 p40 and p75 also prevented hydrogen peroxide-induced redistribution of occludin, ZO-1, E-cadherin, and beta-catenin from the intercellular junctions and their dissociation from the detergent-insoluble fractions. Hydrogen Peroxide 27-44 mitogen-activated protein kinase 1 Homo sapiens 0-3 18292183-6 2008 The attenuation of hydrogen peroxide-induced inulin permeability and redistribution of tight junction proteins by p40 and p75 was abrogated by Ro-32-0432, a PKC inhibitor. Hydrogen Peroxide 19-36 mitogen-activated protein kinase 1 Homo sapiens 114-117 18292183-8 2008 U0126 (a MAP kinase inhibitor) attenuated the p40- and p75-mediated reduction of hydrogen peroxide-induced tight junction disruption and inulin permeability. Hydrogen Peroxide 81-98 mitogen-activated protein kinase 1 Homo sapiens 46-49 16885155-0 2007 ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Hydrogen Peroxide 13-30 mitogen-activated protein kinase 1 Homo sapiens 0-3 17895359-5 2007 We identified, for the first time, death-associated protein kinase 1 (DAP kinase 1) as the kinase that phosphorylates tropomyosin-1 in response to ERK activation by hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 165-182 mitogen-activated protein kinase 1 Homo sapiens 147-150 16963224-0 2007 PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2. Hydrogen Peroxide 84-88 mitogen-activated protein kinase 1 Homo sapiens 54-57 16963224-12 2007 This phosphorylation is critical in H(2)O(2) induced ERK activation as reconstitution with ShcA Ser29A failed to rescue ERK activation of ShcA-/- MEFs, while ShcA could. Hydrogen Peroxide 36-44 mitogen-activated protein kinase 1 Homo sapiens 53-56 16963224-13 2007 In line with this conclusion, inhibition of PKC delta with inhibitors is able to diminish H(2)O(2) induced ERK activation in MEFs. Hydrogen Peroxide 90-98 mitogen-activated protein kinase 1 Homo sapiens 107-110 18164958-4 2008 Pretreatment with the MEK-ERK inhibitor (PD98059) reversed these effects of HP. Hydrogen Peroxide 76-78 mitogen-activated protein kinase 1 Homo sapiens 26-29 17960092-11 2007 In parallel, H2O2-induced the activation of ERK1/2, p38 and JNK in keratinocytes could be inhibited by ECG. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 1 Homo sapiens 52-55 16885155-2 2007 The present studies examined the role of the extracellular signal-regulated kinase (ERK) pathway in H(2)O(2)-induced renal proximal tubular cells (RPTC) apoptosis. Hydrogen Peroxide 100-108 mitogen-activated protein kinase 1 Homo sapiens 45-82 16885155-2 2007 The present studies examined the role of the extracellular signal-regulated kinase (ERK) pathway in H(2)O(2)-induced renal proximal tubular cells (RPTC) apoptosis. Hydrogen Peroxide 100-108 mitogen-activated protein kinase 1 Homo sapiens 84-87 16940294-5 2006 Using a combination of Western blot analyses, as well as genetic and pharmacological inhibitors, we found that activation of FGFR by FGF2 in LNCaP cells leads to NAD(P)H oxidase-dependent hydrogen peroxide production, phosphorylation of ERK1/2 and p38, activation of AP-1, increased expression and secretion of HARP, and, finally, increased cell proliferation and migration. Hydrogen Peroxide 188-205 mitogen-activated protein kinase 1 Homo sapiens 248-251 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 103-149 17406055-3 2007 Hydrogen peroxide (H2O2), a ROS, has been shown to activate several signaling protein kinases, such as extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (PKB) in different cell types, notably in vascular smooth muscle cells. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 1 Homo sapiens 103-149 17030072-5 2007 We determined: phosphorylation of Janus kinase (JAK) 1 and -2, signal transducer and activator of transcription (STAT)3 and -5, extracellular signal-regulated kinase (ERK)1/2 and p38 by Western blot; H2O2 concentration by a colorimetric method; MMP-1 mRNA levels and stability by Northern blot; MMP-1 promoter activity as well as pro-MMP-1 by ELISA; and active MMP-1 by fluorescence. Hydrogen Peroxide 200-204 mitogen-activated protein kinase 1 Homo sapiens 179-182 17030072-7 2007 The repression was mediated by JAK/STAT pathway in synergism with JAK-mediated H2O2-dependent ERK1/2 and p38 pathways. Hydrogen Peroxide 79-83 mitogen-activated protein kinase 1 Homo sapiens 105-108 17030072-10 2007 CONCLUSIONS: Leptin represses MMP-1 gene expression via the synergistic actions of the JAK/STAT pathway and JAK-mediated H2O2-dependent ERK1/2 and p38 pathways. Hydrogen Peroxide 121-125 mitogen-activated protein kinase 1 Homo sapiens 147-150 16806820-4 2006 H(2)O(2) induced a strong activation of ERKs, JNKs and p38-MAPK in a time- and dose-dependent profile. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 55-58 16996477-4 2006 Blocking H2O2 signaling through ERK1/2 and p38 pathways resulted in a complete inhibition of leptin or menadione-induced alpha1(I) collagen mRNA. Hydrogen Peroxide 9-13 mitogen-activated protein kinase 1 Homo sapiens 43-46 16855386-8 2006 Pharmacological and molecular inhibition indicated that CaM-KII was participating in hydrogen peroxide-induced ERK phosphorylation in breast cancer cells indicating a potential mechanism by which this sensitization occurs. Hydrogen Peroxide 85-102 mitogen-activated protein kinase 1 Homo sapiens 111-114 16814101-2 2006 In primary proximal tubular epithelial cells exposed to hydrogen peroxide (H2O2), both the selective cPLA2 inhibitors and the cPLA2 antisense oligonucleotides significantly attenuated H2O2-induced arachidonic acid liberation and activation of p38(SAPK), ERK1/2, and Akt1. Hydrogen Peroxide 184-188 mitogen-activated protein kinase 1 Homo sapiens 243-246 16814101-5 2006 We observed that inhibition of EGFR kinase activity with AG1478 significantly attenuated H2O2-induced p38(SAPK) and ERK1/2 activation, but did not inhibit Akt1 activation. Hydrogen Peroxide 89-93 mitogen-activated protein kinase 1 Homo sapiens 102-105 15979845-0 2006 Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1. Hydrogen Peroxide 15-19 mitogen-activated protein kinase 1 Homo sapiens 29-32 16814101-6 2006 Furthermore, it seems that p38(SAPK) is upstream of ERK1/2 and Akt1, since a p38(SAPK) inhibitor SB203580 significantly blocked H2O2-induced activation of ERK1/2 and Akt1. Hydrogen Peroxide 128-132 mitogen-activated protein kinase 1 Homo sapiens 27-30 16814101-6 2006 Furthermore, it seems that p38(SAPK) is upstream of ERK1/2 and Akt1, since a p38(SAPK) inhibitor SB203580 significantly blocked H2O2-induced activation of ERK1/2 and Akt1. Hydrogen Peroxide 128-132 mitogen-activated protein kinase 1 Homo sapiens 77-80 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 63-80 mitogen-activated protein kinase 1 Homo sapiens 141-186 16998541-3 2006 Previous work from our laboratory has indicated that exogenous hydrogen peroxide (H2O2) activates several signaling protein kinases, such as extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase B (PKB) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 82-86 mitogen-activated protein kinase 1 Homo sapiens 141-186 16650413-0 2006 HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis-- involvement of ERK pathway. Hydrogen Peroxide 26-43 mitogen-activated protein kinase 1 Homo sapiens 91-94 16632120-9 2006 It was observed that H2O2-induced phosphorylation of ERK1/2, JNK, and p38 was decreased by these antioxidants. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 1 Homo sapiens 70-73 16540400-8 2006 H2O2 and NO* induced P-Tyr even in the presence of ERK pathway inhibitors, indicating that ROS also act downstream of this pathway. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 51-54 16448461-6 2006 Up-regulation of leptin receptor and activation of JAK1 and 2 were not affected by DLPC+SAMe, whereas phosphorylation of ERK1/2 and p38 was blocked by DLPC+SAMe or catalase, suggesting an H2O2-dependent mechanism. Hydrogen Peroxide 188-192 mitogen-activated protein kinase 1 Homo sapiens 132-135 15979845-8 2006 Taken together, these results suggest that activation of H2O2-mediated ERK signaling pathway is required for p21WAF1/Cip1 expression by TGF-beta1 and led us to propose a cooperative model whereby TGF-beta1-induced receptor activation stimulates not only a Smad pathway but also a parallel H2O2-mediated ERK pathway that acts as a key determinant for association between Smads and Sp1 transcription factor. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 303-306 15979845-8 2006 Taken together, these results suggest that activation of H2O2-mediated ERK signaling pathway is required for p21WAF1/Cip1 expression by TGF-beta1 and led us to propose a cooperative model whereby TGF-beta1-induced receptor activation stimulates not only a Smad pathway but also a parallel H2O2-mediated ERK pathway that acts as a key determinant for association between Smads and Sp1 transcription factor. Hydrogen Peroxide 289-293 mitogen-activated protein kinase 1 Homo sapiens 71-74 16724983-10 2006 Furthermore, H(2)O(2)-induced phosphorylation of ERK and JNK was also reduced by VEGF (100 ng/mL). Hydrogen Peroxide 13-21 mitogen-activated protein kinase 1 Homo sapiens 49-52 16651638-4 2006 ERK activation was also selectively attenuated by chain-breaking antioxidants and by vitamin E targeted to mitochondria, suggesting that transduction of the mitochondrial hydrogen peroxide signal is mediated by a lipid peroxidation product. Hydrogen Peroxide 171-188 mitogen-activated protein kinase 1 Homo sapiens 0-3 16483932-5 2006 Exposure to H2O2 enhances c-Myc recruitment to gamma-GCS regulatory regions through ERK-dependent phosphorylation. Hydrogen Peroxide 12-16 mitogen-activated protein kinase 1 Homo sapiens 84-87 15979845-2 2006 In this study, we investigated a possible role of hydrogen peroxide (H2O2)-ERK pathway in TGF-beta1 induction of p21WAF1/Cip1 in human keratinocytes HaCaT cells. Hydrogen Peroxide 50-67 mitogen-activated protein kinase 1 Homo sapiens 75-78 15979845-2 2006 In this study, we investigated a possible role of hydrogen peroxide (H2O2)-ERK pathway in TGF-beta1 induction of p21WAF1/Cip1 in human keratinocytes HaCaT cells. Hydrogen Peroxide 69-73 mitogen-activated protein kinase 1 Homo sapiens 75-78 15979845-4 2006 ERK activation by TGF-beta1 was significantly attenuated by treatment with N-acetyl-l-cysteine or catalase, indicating that reactive oxygen species (ROS) generated by TGF-beta1, mainly H2O2, stimulates ERK signaling pathway to induce the p21WAF1/Cip1 expression. Hydrogen Peroxide 185-189 mitogen-activated protein kinase 1 Homo sapiens 0-3 15979845-8 2006 Taken together, these results suggest that activation of H2O2-mediated ERK signaling pathway is required for p21WAF1/Cip1 expression by TGF-beta1 and led us to propose a cooperative model whereby TGF-beta1-induced receptor activation stimulates not only a Smad pathway but also a parallel H2O2-mediated ERK pathway that acts as a key determinant for association between Smads and Sp1 transcription factor. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 71-74 16134968-10 2006 Therefore the present study shows that ERK interacts with the C-terminal region of occludin and mediates the prevention of H2O2-induced disruption of TJs by EGF. Hydrogen Peroxide 123-127 mitogen-activated protein kinase 1 Homo sapiens 39-42 16151051-3 2006 H2O2 initiated an influx of extracellular Ca2+ that was required for phosphorylation of both ERK and CREB in C10 lung epithelial cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 93-96 16151051-4 2006 H2O2-mediated CREB phosphorylation was sensitive to MEK inhibition, suggesting that crosstalk between Ca2+, ERK, and CREB signaling pathways contributes to the oxidant-induced response. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 108-111 15958730-6 2005 Acute treatment with H(2)O(2) activated multiple signaling pathways, including the mitogen-activated protein kinases (MAPK) members (MAPK3/1-ERK2/1, MAPK8/9-JNK1/2, and MAPK11-p38(mapk)) and the c-src tyrosine kinase (CSK). Hydrogen Peroxide 21-29 mitogen-activated protein kinase 1 Homo sapiens 176-179 16125295-7 2005 H2O2 treatment caused a transient activation of extracellular signal-regulated kinase (ERK), followed by sustained activation. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 48-85 16125295-7 2005 H2O2 treatment caused a transient activation of extracellular signal-regulated kinase (ERK), followed by sustained activation. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 87-90 16125295-8 2005 Cell death induced by H2O2 was prevented by PD98059, an inhibitor of ERK upstream kinase MEK1/2. Hydrogen Peroxide 22-26 mitogen-activated protein kinase 1 Homo sapiens 69-72 16125295-9 2005 But H2O2 induced a transient activation of p38 and c-Jun N-terminal kinase (JNK) without sustained activation and inhibitors of these kinses were not effective in preventing the cell death. Hydrogen Peroxide 4-8 mitogen-activated protein kinase 1 Homo sapiens 43-46 16125295-11 2005 The ERK activation and cell death induced by H2O2 were not dependent on the phosphorylation of epidermal growth factor receptor. Hydrogen Peroxide 45-49 mitogen-activated protein kinase 1 Homo sapiens 4-7 16125295-12 2005 Taken together, these findings suggest that the ERK signaling pathway plays an active role in mediating H2O2-induced apoptosis of osteoblasts and functions upstream of mitochondria-dependent pathway to initiate the apoptotic signal. Hydrogen Peroxide 104-108 mitogen-activated protein kinase 1 Homo sapiens 48-51 16356139-8 2005 Zinc deficiency-induced increases in cellular H(2)O(2) can trigger the activation of JNK and p38, leading to AP-1 activation, events that are not involved in zinc deficiency-induced apoptosis. Hydrogen Peroxide 46-54 mitogen-activated protein kinase 1 Homo sapiens 93-96 16173077-1 2006 Leptin, a liver profibrogenic cytokine, induces oxidative stress in hepatic stellate cells (HSCs), with increased formation of the oxidant H2O2, which signals through p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways, stimulating tissue inhibitor of metalloproteinase-1 production. Hydrogen Peroxide 139-143 mitogen-activated protein kinase 1 Homo sapiens 167-170 16173077-1 2006 Leptin, a liver profibrogenic cytokine, induces oxidative stress in hepatic stellate cells (HSCs), with increased formation of the oxidant H2O2, which signals through p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways, stimulating tissue inhibitor of metalloproteinase-1 production. Hydrogen Peroxide 139-143 mitogen-activated protein kinase 1 Homo sapiens 175-216 16173077-6 2006 ERK1/2 and p38 were activated, and the activation was blocked by catalase, consistent with an H2O2-dependent mechanism. Hydrogen Peroxide 94-98 mitogen-activated protein kinase 1 Homo sapiens 11-14 15801906-4 2005 At 200 microM H2O2, which caused activation of the MAP (mitogen-activated protein) kinase ERK (extracellular-signal-regulated kinase), growth arrest and apoptosis, relatively few changes were seen. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 1 Homo sapiens 90-93 15801906-4 2005 At 200 microM H2O2, which caused activation of the MAP (mitogen-activated protein) kinase ERK (extracellular-signal-regulated kinase), growth arrest and apoptosis, relatively few changes were seen. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 1 Homo sapiens 95-132 15618436-2 2005 Fibroblast growth factor-10 (FGF-10), an alveolar epithelial type II cell mitogen that is required for the lung development, prevents H(2)O(2)-induced AEC DNA damage by a mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)-dependent mechanism. Hydrogen Peroxide 134-142 mitogen-activated protein kinase 1 Homo sapiens 250-253 15961886-9 2005 H2O2, derived in part from NADPH and CYP2E1, activated ERK1/2 and p38. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 66-69 14962831-4 2004 In addition, pretreatment of cells with the protein phosphatase 2A (PP2A) inhibitors okadaic acid and fostriecin increased basal and H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 133-141 mitogen-activated protein kinase 1 Homo sapiens 153-156 15650391-6 2005 H2O2-induced AT II cell proliferation was preceded by activation of the mitogen-activated protein kinase ERK (extracellular signal-regulated kinase). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 105-108 15328380-8 2005 Also, H(2)O(2)-induced ERK activation was attenuated by a receptor tyrosine kinase inhibitor, tyrphostin 51, but not by down-regulation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate or by a PKC inhibitor, GF109203X [3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride]. Hydrogen Peroxide 6-14 mitogen-activated protein kinase 1 Homo sapiens 23-26 15328380-9 2005 Growth factor receptor antagonist suramin pretreatment inhibited H(2)O(2)-induced ERK activation, highlighting a role for growth factor receptors in this activation. Hydrogen Peroxide 65-73 mitogen-activated protein kinase 1 Homo sapiens 82-85 15328380-10 2005 Furthermore, the ERK activation by H(2)O(2) was blocked by pretreatment with either N-acetyl-cysteine, o-phenanthroline, or mannitol indicating that metal-catalyzed free radical formation may mediate the initiation of signal transduction by H(2)O(2). Hydrogen Peroxide 35-43 mitogen-activated protein kinase 1 Homo sapiens 17-20 15550066-7 2004 RESULTS: IL-1beta, TNFalpha and H(2)O(2) stimulated the phosphorylation of ERK, p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls. Hydrogen Peroxide 32-40 mitogen-activated protein kinase 1 Homo sapiens 75-78 15550066-7 2004 RESULTS: IL-1beta, TNFalpha and H(2)O(2) stimulated the phosphorylation of ERK, p38 and JNK, while the total amounts of proteins of the respective MAPKs were virtually the same compared with those in the unstimulated controls. Hydrogen Peroxide 32-40 mitogen-activated protein kinase 1 Homo sapiens 80-83 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 82-90 mitogen-activated protein kinase 1 Homo sapiens 35-38 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 82-90 mitogen-activated protein kinase 1 Homo sapiens 102-105 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 82-90 mitogen-activated protein kinase 1 Homo sapiens 206-209 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 186-194 mitogen-activated protein kinase 1 Homo sapiens 35-38 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. Hydrogen Peroxide 186-194 mitogen-activated protein kinase 1 Homo sapiens 148-151 15895830-0 2005 Role of ERK in hydrogen peroxide-induced cell death of human glioma cells. Hydrogen Peroxide 15-32 mitogen-activated protein kinase 1 Homo sapiens 8-11 15895830-4 2005 The present study was undertaken to examine the role of ERK activation in H2O2-induced cell death of human glioma (A172) cells. Hydrogen Peroxide 74-78 mitogen-activated protein kinase 1 Homo sapiens 56-59 15895830-6 2005 H2O2 treatment caused marked sustained activation of ERK. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 53-56 15895830-7 2005 The ERK activation and cell death induced by H2O2 was prevented by catalase, the hydrogen peroxide scavenger, and U0126, an inhibitor of ERK upstream kinase MEK1/2. Hydrogen Peroxide 45-49 mitogen-activated protein kinase 1 Homo sapiens 4-7 15895830-7 2005 The ERK activation and cell death induced by H2O2 was prevented by catalase, the hydrogen peroxide scavenger, and U0126, an inhibitor of ERK upstream kinase MEK1/2. Hydrogen Peroxide 45-49 mitogen-activated protein kinase 1 Homo sapiens 137-140 15895830-7 2005 The ERK activation and cell death induced by H2O2 was prevented by catalase, the hydrogen peroxide scavenger, and U0126, an inhibitor of ERK upstream kinase MEK1/2. Hydrogen Peroxide 81-98 mitogen-activated protein kinase 1 Homo sapiens 4-7 15895830-9 2005 The ERK activation and cell death caused by H2O2 was inhibited by antioxidants (N-acetylcysteine and trolox), Ras inhibitor, and suramin. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 1 Homo sapiens 4-7 15895830-11 2005 Taken together, these findings suggest that growth factor receptor/Ras/MEK/ERK signaling pathway plays an active role in mediating H2O2-induced apoptosis of human glioma cells and functions upstream of mitochondria-dependent pathway to initiate the apoptotic signal. Hydrogen Peroxide 131-135 mitogen-activated protein kinase 1 Homo sapiens 75-78 15650391-6 2005 H2O2-induced AT II cell proliferation was preceded by activation of the mitogen-activated protein kinase ERK (extracellular signal-regulated kinase). Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 110-147 15650391-7 2005 Inhibition of ERK and p38 activation prevented H2O2-induced proliferation. Hydrogen Peroxide 47-51 mitogen-activated protein kinase 1 Homo sapiens 14-17 15328380-10 2005 Furthermore, the ERK activation by H(2)O(2) was blocked by pretreatment with either N-acetyl-cysteine, o-phenanthroline, or mannitol indicating that metal-catalyzed free radical formation may mediate the initiation of signal transduction by H(2)O(2). Hydrogen Peroxide 241-249 mitogen-activated protein kinase 1 Homo sapiens 17-20 15205451-11 2004 IL-1beta reproduces these changes, possibly by production of H(2)O(2) via sequential activation of MAPKs (ERK1/ERK2) and cPLA(2). Hydrogen Peroxide 61-69 mitogen-activated protein kinase 1 Homo sapiens 111-115 14962831-6 2004 Finally, H(2)O(2)-induced apoptosis was attenuated by p38 MAPK or PP2A inhibition, whereas it was enhanced by MEK inhibition. Hydrogen Peroxide 9-17 mitogen-activated protein kinase 1 Homo sapiens 54-57 14962831-7 2004 Thus the present study demonstrated that p38 MAPK activation decreases H(2)O(2)-induced ERK activation through a PP2A-dependent mechanism in cardiac ventricular myocytes. Hydrogen Peroxide 71-79 mitogen-activated protein kinase 1 Homo sapiens 41-44 14962831-7 2004 Thus the present study demonstrated that p38 MAPK activation decreases H(2)O(2)-induced ERK activation through a PP2A-dependent mechanism in cardiac ventricular myocytes. Hydrogen Peroxide 71-79 mitogen-activated protein kinase 1 Homo sapiens 88-91 15003539-3 2004 We demonstrate that brief H2O2 exposure results in transient phosphorylations of p38 and ERK which peaked by 15 min. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 1 Homo sapiens 89-92 15025937-0 2004 Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cells. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 1 Homo sapiens 95-98 15025937-1 2004 We have shown earlier that extracellular signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B (PKB), two key mediators of growth-promoting and proliferative responses, are activated by hydrogen peroxide (H(2)O(2)) in A10 vascular smooth muscle cells (VSMC). Hydrogen Peroxide 195-212 mitogen-activated protein kinase 1 Homo sapiens 27-73 15025937-4 2004 BAPTA-AM and EGTA, chelators of intracellular and extracellular Ca(2+), respectively, inhibited H(2)O(2)-stimulated ERK1/2, p38 MAPK, and PKB phosphorylation. Hydrogen Peroxide 96-104 mitogen-activated protein kinase 1 Homo sapiens 124-127 15023565-9 2004 CONCLUSIONS: These data demonstrated that LDL stimulates SMCs to induce IL-8 production in dose- and time-dependent manners at the transcription level and that the LDL signaling in hAoSMCs is conveyed via the generation of H2O2, the phosphorylation of p38 MAPK, the activation of AP-1, and the participation of NF-kappaB. Hydrogen Peroxide 223-227 mitogen-activated protein kinase 1 Homo sapiens 252-255 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 131-168 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 170-173 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 19-27 mitogen-activated protein kinase 1 Homo sapiens 131-168 15020252-1 2004 Hydrogen peroxide (H(2)O(2)) induces apoptosis of mesangial cells via c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) and extracellular signal-regulated kinase (ERK)-AP-1 pathways. Hydrogen Peroxide 19-27 mitogen-activated protein kinase 1 Homo sapiens 170-173 15003539-8 2004 In conclusion, primary adult cardiac fibroblasts exposed to brief H2O2 exhibit an altered phenotype characterized by reduced migration and apoptosis and increased necrosis resulting, in part, from the differential effects of p38 and ERK signaling. Hydrogen Peroxide 66-70 mitogen-activated protein kinase 1 Homo sapiens 233-236 14757132-7 2004 Ebselen inhibited H(2)O(2)-induced p38 MAP kinase, but not JNK or ERK1/2 activation. Hydrogen Peroxide 18-26 mitogen-activated protein kinase 1 Homo sapiens 35-38 14625304-9 2004 ERK1/2 MAPK and p38 were activated, which was prevented by catalase, indicating an H2O2-dependent mechanism. Hydrogen Peroxide 83-87 mitogen-activated protein kinase 1 Homo sapiens 16-19 14625304-15 2004 This process appears to be mediated by the JAK/STAT pathway via the leptin receptor long form and the H2O2-dependent p38 and ERK1/2 pathways via activated JAK. Hydrogen Peroxide 102-106 mitogen-activated protein kinase 1 Homo sapiens 117-120 14757132-6 2004 Moreover, it was observed that H(2)O(2) significantly stimulated activation of mitogen-activated protein (MAP) kinases, i.e., p38 MAP kinase, c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK1/2). Hydrogen Peroxide 31-39 mitogen-activated protein kinase 1 Homo sapiens 126-129 14757132-9 2004 These findings suggest that ebselen attenuates H(2)O(2)-induced endothelial cell death through the inhibition of signaling pathways mediated by p38 MAP kinase, caspase-3, and cytochrome c release. Hydrogen Peroxide 47-55 mitogen-activated protein kinase 1 Homo sapiens 144-147 12676358-7 2003 Finally, transient expression of kinase-negative PKCalpha eliminated the 8-OH-DPAT-evoked block on the H(2)O(2)-triggered caspase-3 stimulation, establishing PKCalpha as a link between ERK and caspase-3 (5-HT(1A)-R-->PLC-->ERK1/2-->PKCalpha-->caspase-3). Hydrogen Peroxide 103-111 mitogen-activated protein kinase 1 Homo sapiens 185-188 15709700-9 2004 We present novel results from our laboratory showing ERK-mediated CREB activation by hydrogen peroxide. Hydrogen Peroxide 85-102 mitogen-activated protein kinase 1 Homo sapiens 53-56 14649717-6 2003 ACM derived from astrocytes exposed to H2O2 lost the activities to stimulate ERK phosphorylation and protect against neuronal injury. Hydrogen Peroxide 39-43 mitogen-activated protein kinase 1 Homo sapiens 77-80 12899942-0 2003 T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation. Hydrogen Peroxide 41-58 mitogen-activated protein kinase 1 Homo sapiens 72-75 12899942-3 2003 TcR cross-linking of primary human T blasts and Jurkat human T cells rapidly activated the ERK, JNK, p38 and Akt kinases within minutes, and was temporally associated with TcR-stimulated production of hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 201-218 mitogen-activated protein kinase 1 Homo sapiens 91-94 12899942-4 2003 TcR-induced activation of ERK was selectively augmented and sustained in the presence of pharmacologic antioxidants that can quench or inhibit H(2)O(2) production (NAC, MnTBAP and Ebselen, but not DPI), while activation of JNK and Akt were largely unaffected. Hydrogen Peroxide 143-151 mitogen-activated protein kinase 1 Homo sapiens 26-29 12899942-6 2003 Molecular targeting of H(2)O(2) by overexpression of peroxiredoxin II, a thioredoxin dependent peroxidase, also increased and sustained ERK and MEK activation upon TcR cross-linking. Hydrogen Peroxide 23-31 mitogen-activated protein kinase 1 Homo sapiens 136-139 12899942-8 2003 Thus, the data suggest that TcR-stimulated production of hydrogen peroxide negatively feeds back to dampen antigen-stimulated ERK activation and this redox-dependent regulation may serve to modulate key steps in TcR signaling. Hydrogen Peroxide 57-74 mitogen-activated protein kinase 1 Homo sapiens 126-129 12847121-3 2003 p43-ERK activation by H(2)O(2) was inhibited by PD98059 but not by SB203580. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 1 Homo sapiens 4-7 12868492-4 2003 Furthermore, extracellular signal-regulated kinase (ERK), a prominent member of the mitogen-activated protein kinase (MAPK) family, was found to be activated by treatment with both UVB and H2O2. Hydrogen Peroxide 189-193 mitogen-activated protein kinase 1 Homo sapiens 13-50 12868492-4 2003 Furthermore, extracellular signal-regulated kinase (ERK), a prominent member of the mitogen-activated protein kinase (MAPK) family, was found to be activated by treatment with both UVB and H2O2. Hydrogen Peroxide 189-193 mitogen-activated protein kinase 1 Homo sapiens 52-55 12868492-4 2003 Furthermore, extracellular signal-regulated kinase (ERK), a prominent member of the mitogen-activated protein kinase (MAPK) family, was found to be activated by treatment with both UVB and H2O2. Hydrogen Peroxide 189-193 mitogen-activated protein kinase 1 Homo sapiens 118-122 12868492-5 2003 Inhibition of ERK phosphorylation by pre-treatment with PD98059 resulted in enhanced apoptosis after H2O2-exposure. Hydrogen Peroxide 101-105 mitogen-activated protein kinase 1 Homo sapiens 14-17 12868492-10 2003 Moreover, activation of ERK only blocks H2O2-dependent apoptosis but has no impact on UVB-induced apoptosis. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 24-27 12444151-6 2002 Exogenous H(2)O(2) induced Erk activation in human monocytes, which was suppressed by exogenous catalase. Hydrogen Peroxide 10-18 mitogen-activated protein kinase 1 Homo sapiens 27-30 12592389-8 2003 Cells treated with H(2)O(2) result in an increase in phospho-ERK. Hydrogen Peroxide 19-27 mitogen-activated protein kinase 1 Homo sapiens 61-64 12604218-9 2003 Under oxidative stress generated by hydrogen peroxide, the major signaling pathway mediating the up-regulation of AR expression was demonstrated to be the epidermal growth factor receptor-ERK pathway. Hydrogen Peroxide 36-53 mitogen-activated protein kinase 1 Homo sapiens 188-191 12655182-8 2003 Interestingly, this induction of apoptosis was also prevented by SB203580, suggesting that p38 is involved in an apoptotic pathway induced by H(2)O (2) as well as in a survival pathway evoked by FSH in granulosa cells. Hydrogen Peroxide 142-151 mitogen-activated protein kinase 1 Homo sapiens 91-94 14501030-5 2003 H2O2- induced phosphorylation (activation) of p42/p44(ERK) and p38 within 10 min of 200 microM H2O2 exposure. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 54-57 14501030-5 2003 H2O2- induced phosphorylation (activation) of p42/p44(ERK) and p38 within 10 min of 200 microM H2O2 exposure. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 1 Homo sapiens 54-57 14501030-7 2003 Inhibiting ERKs with PD98059 attenuated H2O2-induced AP-1 activation but did not affect H2O2-induced p70S6K1 activation or cardiomyocyte enlargement as measured by increases in cell volume and protein content. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 11-15 12361705-7 2002 PKB and extracellular signal-regulated kinase (ERK) were both rapidly and transiently activated by 10 microM H2O2, but the activities of p38 MAPK and JNK were not changed. Hydrogen Peroxide 109-113 mitogen-activated protein kinase 1 Homo sapiens 8-45 12485891-0 2002 Vanadate inhibition of protein tyrosine phosphatases mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages. Hydrogen Peroxide 60-77 mitogen-activated protein kinase 1 Homo sapiens 103-106 12361705-7 2002 PKB and extracellular signal-regulated kinase (ERK) were both rapidly and transiently activated by 10 microM H2O2, but the activities of p38 MAPK and JNK were not changed. Hydrogen Peroxide 109-113 mitogen-activated protein kinase 1 Homo sapiens 47-50 12374624-0 2002 Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. Hydrogen Peroxide 22-30 mitogen-activated protein kinase 1 Homo sapiens 68-72 12374624-4 2002 Stimulation of Jurkat T cells with H(2)O(2) induces the phosphorylation of ERK, p38, and JNK members of MAPK family. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 1 Homo sapiens 75-78 12374624-4 2002 Stimulation of Jurkat T cells with H(2)O(2) induces the phosphorylation of ERK, p38, and JNK members of MAPK family. Hydrogen Peroxide 35-43 mitogen-activated protein kinase 1 Homo sapiens 104-108 12374624-7 2002 Transfection with wtHePTP inhibited H(2)O(2)-induced ERK and p38 phosphorylation without inhibiting JNK phosphorylation. Hydrogen Peroxide 36-44 mitogen-activated protein kinase 1 Homo sapiens 53-56 12374624-8 2002 The Src-family kinase inhibitor, PP2, inhibited the H(2)O(2)-induced phosphorylation of ERK, p38, and JNK. Hydrogen Peroxide 52-60 mitogen-activated protein kinase 1 Homo sapiens 88-91 12374624-6 2002 Transfection of cells with wtSHP-1 decreased H(2)O(2)-induced ERK and JNK phosphorylation without affecting p38 phosphorylation. Hydrogen Peroxide 45-53 mitogen-activated protein kinase 1 Homo sapiens 62-65 12374624-9 2002 The phospholipase C (PLC) inhibitor, U73122, or the protein kinase C (PKC) inhibitor, Ro-31-8425, blocked H(2)O(2)-induced ERK phosphorylation, whereas the same treatment did not inhibit p38 or JNK phosphorylation. Hydrogen Peroxide 106-114 mitogen-activated protein kinase 1 Homo sapiens 123-126 11769330-13 2001 These data therefore suggest that the toxic effects of beta-amyloid involve the generation of hydrogen peroxide, leading to the activation of p38 and the down-regulation of ERK. Hydrogen Peroxide 94-111 mitogen-activated protein kinase 1 Homo sapiens 173-176 12374624-10 2002 Taken together, these results suggest that inhibition of PTPs by H(2)O(2) contributes to the induction of distinct MAPK activation profiles via differential signaling pathways. Hydrogen Peroxide 65-73 mitogen-activated protein kinase 1 Homo sapiens 115-119 12060808-0 2002 The spin trapping agent PBN stimulates H2 O2 -induced Erk and Src kinase activity in human neuroblastoma cells. Hydrogen Peroxide 39-44 mitogen-activated protein kinase 1 Homo sapiens 54-57 12060808-4 2002 In SH-SY5Y human neuroblastoma cells, H2O2 induced activation of Erk and Src kinases was markedly potentiated by treatment with PBN. Hydrogen Peroxide 38-42 mitogen-activated protein kinase 1 Homo sapiens 65-68 12060808-5 2002 The potentiation by PBN of the Erk and Src kinase activation by H2O2 required extracellular Ca2+ and appeared dependent on voltage sensitive Ca2+ channels. Hydrogen Peroxide 64-68 mitogen-activated protein kinase 1 Homo sapiens 31-34 12060808-7 2002 Our results suggest that PBN might have a protective effect on cells by potentiating the anti-apoptotic Erk and Src kinase pathways responding to H2O2, an effect apparently distinct from its ability to trap oxygen free radicals. Hydrogen Peroxide 146-150 mitogen-activated protein kinase 1 Homo sapiens 104-107 11790785-4 2002 In 293(PED) cells, decreased apoptosis induced by anisomycin and H(2)O(2) was also accompanied by block of JNK1/2 and p38 phosphorylations, respectively. Hydrogen Peroxide 65-73 mitogen-activated protein kinase 1 Homo sapiens 118-121 11781366-5 2002 Anti-CD3 induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2 required hydrogen peroxide generation but was unaffected by superoxide anion. Hydrogen Peroxide 92-109 mitogen-activated protein kinase 1 Homo sapiens 36-82 11601887-6 2001 Using the same in vitro system, when these cells were pretreated with EGCG or with the known antioxidant ascorbic acid (as positive control), H(2)O(2)-induced phosphorylation of ERK1/2, JNK, and p38 was found to be significantly inhibited. Hydrogen Peroxide 142-150 mitogen-activated protein kinase 1 Homo sapiens 195-198 11595755-5 2001 Western blot analysis and immunocytochemistry revealed that H2O2 treatment elicited the phosphorylation and nuclear translocation of ERK 1/2 and p38 MAP kinases. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 1 Homo sapiens 145-148 11595755-6 2001 Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 1 Homo sapiens 27-30 11595755-6 2001 Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 1 Homo sapiens 16-19 10965882-7 2000 In this regard, H2O2 and a membrane permeable thiol-oxidizing agent, diamide, stimulated protein tyrosine phosphorylation of p120 and p70, and ERK activation in VSMCs. Hydrogen Peroxide 16-20 mitogen-activated protein kinase 1 Homo sapiens 143-146 11162642-4 2001 Moreover, H(2)O(2) stimulates EGF receptor tyrosine phosphorylation and EGF receptor inhibitors attenuated H(2)O(2)-induced ERK activation. Hydrogen Peroxide 107-115 mitogen-activated protein kinase 1 Homo sapiens 124-127 11135060-0 2001 Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase. Hydrogen Peroxide 66-70 mitogen-activated protein kinase 1 Homo sapiens 17-20 11495722-1 2001 In Jurkat T lymphocytes, hydrogen peroxide (H(2)O(2)) potentiates the phosphorylation level of extracellular signal-regulated kinase 1 and 2 (ERK1/2) caused by T cell receptor (TCR) stimulation with anti-CD3 and anti-CD28 or anti-CD3 alone. Hydrogen Peroxide 25-42 mitogen-activated protein kinase 1 Homo sapiens 95-140 11495722-1 2001 In Jurkat T lymphocytes, hydrogen peroxide (H(2)O(2)) potentiates the phosphorylation level of extracellular signal-regulated kinase 1 and 2 (ERK1/2) caused by T cell receptor (TCR) stimulation with anti-CD3 and anti-CD28 or anti-CD3 alone. Hydrogen Peroxide 44-52 mitogen-activated protein kinase 1 Homo sapiens 95-140 10993784-2 2000 The purpose of this study was to determine whether mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) 1 and ERK2, or protein kinase C (PKC) activation is required for H(2)O(2)-induced contraction. Hydrogen Peroxide 201-209 mitogen-activated protein kinase 1 Homo sapiens 92-137 10993784-2 2000 The purpose of this study was to determine whether mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) 1 and ERK2, or protein kinase C (PKC) activation is required for H(2)O(2)-induced contraction. Hydrogen Peroxide 201-209 mitogen-activated protein kinase 1 Homo sapiens 142-146 10972672-10 2000 Consistently, transfection with dominant-negative mutants of ERK1 and ERK2 or a dominant-negative mutant of JNK inhibited H2O2-induced apoptosis. Hydrogen Peroxide 122-126 mitogen-activated protein kinase 1 Homo sapiens 70-74 10972672-13 2000 CONCLUSIONS: These results suggested that (1) activation of JNK and ERKs, but not p38 kinase, is required for the H2O2-induced apoptosis; and (2) suppression of the JNK-c-Jun/AP-1 pathway and the ERK-c-Fos/AP-1 pathway is involved in the anti-apoptotic effect of quercetin. Hydrogen Peroxide 114-118 mitogen-activated protein kinase 1 Homo sapiens 68-71 10898713-3 2000 We report that H(2)O(2) exposure caused an increase in endothelial solute permeability in a time-dependent manner through extracellularly regulated kinase 1 and 2 (ERK1/ERK2) signal pathways. Hydrogen Peroxide 15-23 mitogen-activated protein kinase 1 Homo sapiens 169-173 10900173-7 2000 Myxothiazol, an inhibitor of complex III of the mitochondrial electron transport chain, also inhibited ERK MAPK activation by hydrogen peroxide, but not by 12- O -tetradecanoylphorbol-13-acetate (TPA) or hyperosmotic shock. Hydrogen Peroxide 126-143 mitogen-activated protein kinase 1 Homo sapiens 103-106 10900173-7 2000 Myxothiazol, an inhibitor of complex III of the mitochondrial electron transport chain, also inhibited ERK MAPK activation by hydrogen peroxide, but not by 12- O -tetradecanoylphorbol-13-acetate (TPA) or hyperosmotic shock. Hydrogen Peroxide 126-143 mitogen-activated protein kinase 1 Homo sapiens 107-111 10900173-9 2000 A variety of inhibitors which act at different levels of the mitochondrial electron transport chain (rotenone, theonyltrifluoroacetone, antimycin A, cyanide) also inhibited activation of the ERK MAPKs by hydrogen peroxide but not TPA or hyperosmotic shock. Hydrogen Peroxide 204-221 mitogen-activated protein kinase 1 Homo sapiens 191-194 10900173-10 2000 These studies suggest a novel mechanism of regulation of the ERK MAPK pathway and oxidative stress signalling by hydrogen peroxide. Hydrogen Peroxide 113-130 mitogen-activated protein kinase 1 Homo sapiens 61-64 10900173-10 2000 These studies suggest a novel mechanism of regulation of the ERK MAPK pathway and oxidative stress signalling by hydrogen peroxide. Hydrogen Peroxide 113-130 mitogen-activated protein kinase 1 Homo sapiens 65-69 10898713-8 2000 These data strongly suggest that H(2)O(2)-mediated increased endothelial solute permeability involves the loss of endothelial tight junction integrity through increased ERK1/ERK2 activation. Hydrogen Peroxide 33-41 mitogen-activated protein kinase 1 Homo sapiens 174-178 10722699-7 2000 Consistent with our hypothesis, exogenous H(2)O(2)-mediated repression of alpha-ENaC GRE activity is partially blocked by either a specific inhibitor for extracellular signal-regulated kinase (ERK) pathway activation, U0126, or dominant negative ERK, suggesting that, in part, activated ERK may mediate the repressive effects of H(2)O(2) on alpha-ENaC expression. Hydrogen Peroxide 42-50 mitogen-activated protein kinase 1 Homo sapiens 154-191 10828072-7 2000 PD098059, a specific inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase inhibited ERK activities but had no significant effect on eIF4E phosphorylation induced by H(2)O(2). Hydrogen Peroxide 216-224 mitogen-activated protein kinase 1 Homo sapiens 68-72 10828072-8 2000 Similarly, SB203580, a specific inhibitor of p38 MAPK, although inhibiting H(2)O(2)-induced p38 MAPK activity, had no effect on H(2)O(2)-induced eIF4E phosphorylation. Hydrogen Peroxide 75-83 mitogen-activated protein kinase 1 Homo sapiens 92-95 10777699-0 2000 Monoamine oxidase B induces ERK-dependent cell mitogenesis by hydrogen peroxide generation. Hydrogen Peroxide 62-79 mitogen-activated protein kinase 1 Homo sapiens 28-31 10722699-7 2000 Consistent with our hypothesis, exogenous H(2)O(2)-mediated repression of alpha-ENaC GRE activity is partially blocked by either a specific inhibitor for extracellular signal-regulated kinase (ERK) pathway activation, U0126, or dominant negative ERK, suggesting that, in part, activated ERK may mediate the repressive effects of H(2)O(2) on alpha-ENaC expression. Hydrogen Peroxide 42-50 mitogen-activated protein kinase 1 Homo sapiens 193-196 10722699-7 2000 Consistent with our hypothesis, exogenous H(2)O(2)-mediated repression of alpha-ENaC GRE activity is partially blocked by either a specific inhibitor for extracellular signal-regulated kinase (ERK) pathway activation, U0126, or dominant negative ERK, suggesting that, in part, activated ERK may mediate the repressive effects of H(2)O(2) on alpha-ENaC expression. Hydrogen Peroxide 42-50 mitogen-activated protein kinase 1 Homo sapiens 246-249 10722699-7 2000 Consistent with our hypothesis, exogenous H(2)O(2)-mediated repression of alpha-ENaC GRE activity is partially blocked by either a specific inhibitor for extracellular signal-regulated kinase (ERK) pathway activation, U0126, or dominant negative ERK, suggesting that, in part, activated ERK may mediate the repressive effects of H(2)O(2) on alpha-ENaC expression. Hydrogen Peroxide 42-50 mitogen-activated protein kinase 1 Homo sapiens 246-249 10233767-2 1999 Here we demonstrate that physiologic doses of ultraviolet B and hydrogen peroxide stimulate activation of two related but distinct mitogen-activated protein kinase pathways: extracellular regulated kinase 1 and 2 (ERK1/2), as well as p38, the mammalian homolog of HOG1 in yeast which is a major kinase for a recently identified stress-induced signaling pathway. Hydrogen Peroxide 64-81 mitogen-activated protein kinase 1 Homo sapiens 234-237 10629214-0 2000 Hydrogen peroxide inhibition of nuclear protein import is mediated by the mitogen-activated protein kinase, ERK2. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 108-112 10629214-9 2000 Western blotting revealed that H(2)O(2) activated ERK2. Hydrogen Peroxide 31-39 mitogen-activated protein kinase 1 Homo sapiens 50-54 10543994-4 1999 The activity of ERK was transiently upregulated (15-60 min) in response to hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 75-92 mitogen-activated protein kinase 1 Homo sapiens 16-19 10543994-6 1999 Inhibition of the transient ERK activation by MEK inhibitor PD098059 attenuated the H(2)O(2)-induced apoptosis. Hydrogen Peroxide 84-92 mitogen-activated protein kinase 1 Homo sapiens 28-31 10543994-8 1999 Consistently, transfection with dominant-negative mutants of ERK1 and ERK2 inhibited H(2)O(2)-induced apoptosis, whereas it facilitated apoptosis of unstimulated cells. Hydrogen Peroxide 85-93 mitogen-activated protein kinase 1 Homo sapiens 70-74 10233767-5 1999 Ascorbic acid strongly blocks ERK1/2 and p38 activation by ultraviolet B and hydrogen peroxide whereas pyrrolidine dithiocarbamate and butyl hydroxyanisole are less effective. Hydrogen Peroxide 77-94 mitogen-activated protein kinase 1 Homo sapiens 41-44 9698606-3 1998 In the present study, we investigated the effects and mechanisms of H2O2 on activation of ERK1 and ERK2 in pulmonary arterial smooth muscle cells (PASMC). Hydrogen Peroxide 68-72 mitogen-activated protein kinase 1 Homo sapiens 99-103 9856964-13 1998 Moreover, H2O2 production emerges as a critical intermediary event in the oleic acid-mediated mitogenic signaling pathway between the activation of PKC and ERK. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 1 Homo sapiens 156-159 9832563-3 1998 Here we show that the concomitant activation of the extracellular signal-regulated kinase (ERK) MAP kinase pathway by H2O2 accomplishes an essential survival function during this process. Hydrogen Peroxide 118-122 mitogen-activated protein kinase 1 Homo sapiens 52-89 9832563-3 1998 Here we show that the concomitant activation of the extracellular signal-regulated kinase (ERK) MAP kinase pathway by H2O2 accomplishes an essential survival function during this process. Hydrogen Peroxide 118-122 mitogen-activated protein kinase 1 Homo sapiens 91-94 9832563-10 1998 In contrast, in fibroblasts that expressed wild-type HSP27 to a level similar to that found in endothelial cells, H2O2 induced accumulation of F-actin and caused bleb formation when the ERK pathway was inhibited. Hydrogen Peroxide 114-118 mitogen-activated protein kinase 1 Homo sapiens 186-189 9722530-5 1998 Hydrogen peroxide treatment of AGS-B cells increased the phosphorylation and kinase activity of ERK-1 and ERK-2, but did not affect Jun kinase tyrosine phosphorylation or kinase activity. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 106-111 9698606-5 1998 Western blot analysis done with phospho-specific mitogen-activated protein (MAP) kinase antibodies demonstrated that H2O2 stimulated the phosphorylation of p42, p44, p46, and p38 MAP kinases. Hydrogen Peroxide 117-121 mitogen-activated protein kinase 1 Homo sapiens 175-178 9698606-8 1998 Furthermore, stimulation of ERK1 and ERK2 activity by H2O2 was partly attenuated by genistein, a tyrosine kinase inhibitor. Hydrogen Peroxide 54-58 mitogen-activated protein kinase 1 Homo sapiens 37-41 9698606-9 1998 Taken together, these data suggest that H2O2 activates ERK1, ERK2, p46 JNK, and p38 MAP kinases in PASMC. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 61-65 9698606-9 1998 Taken together, these data suggest that H2O2 activates ERK1, ERK2, p46 JNK, and p38 MAP kinases in PASMC. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 80-83 9657968-3 1998 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 145-149 9657968-3 1998 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 163-208 9657968-3 1998 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 210-213 9657968-3 1998 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 287-290 9657968-4 1998 This H2O2-induced apoptosis was markedly enhanced when ERK2 activation was selectively inhibited by PD098059. Hydrogen Peroxide 5-9 mitogen-activated protein kinase 1 Homo sapiens 55-59 9657968-7 1998 Because NF-kappaB activation by H2O2 is potentially related to both the ERK and JNK/SAPK signalling pathways, we examined the effects of inhibiting the activation of NF-kappaB; this interference had no effect on the cellular response to H2O2. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 1 Homo sapiens 72-75 9657968-10 1998 Bcl-2 acts independently and downstream of ERK and JNK/SAPK to enhance the survival of H2O2-treated cells. Hydrogen Peroxide 87-91 mitogen-activated protein kinase 1 Homo sapiens 43-46 9553143-4 1998 In this study P116, a ZAP-70-negative Jurkat T cell line, was used to investigate the role of ZAP-70 in mediating activation of Erk in response to H2O2. Hydrogen Peroxide 147-151 mitogen-activated protein kinase 1 Homo sapiens 128-131 9572294-6 1998 H2O2 alone strongly enhanced the levels of immunodetectable activated mitogen-activated protein kinase (activated MAP kinases ERK1 and ERK2) in a Ca2+-dependent manner and this effect was additive with increases in the levels of activated MAP kinase evoked by glutamate. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 135-139 9553143-5 1998 Consistent with the hypothesis that ZAP-70 is required for activation of Erk in response to an oxidative stimulus, Erk1 and Erk2 could be rapidly activated in Jurkat cells but not in P116 cells upon addition of H2O2. Hydrogen Peroxide 211-215 mitogen-activated protein kinase 1 Homo sapiens 73-76 9553143-5 1998 Consistent with the hypothesis that ZAP-70 is required for activation of Erk in response to an oxidative stimulus, Erk1 and Erk2 could be rapidly activated in Jurkat cells but not in P116 cells upon addition of H2O2. Hydrogen Peroxide 211-215 mitogen-activated protein kinase 1 Homo sapiens 124-128 9553143-6 1998 P116 cells became competent for H2O2-induced Erk activation upon stable transfection with wild-type ZAP-70. Hydrogen Peroxide 32-36 mitogen-activated protein kinase 1 Homo sapiens 45-48 9553143-7 1998 An in vivo ZAP-70 substrate, SLP-76, implicated in Erk activation, also became rapidly tyrosine-phosphorylated in Jurkat cells, but not in P116 cells, upon treatment with H2O2. Hydrogen Peroxide 171-175 mitogen-activated protein kinase 1 Homo sapiens 51-54 9553143-8 1998 Surprisingly, although ZAP-70 was required for H2O2-mediated Erk activation, Erk activation in response to T cell antigen receptor engagement did not require ZAP-70. Hydrogen Peroxide 47-51 mitogen-activated protein kinase 1 Homo sapiens 61-64 9553143-9 1998 In addition to demonstrating a requirement for ZAP-70 in H2O2-stimulated Erk activation, these results provide the first evidence for the existence of a ZAP-70-independent pathway for Erk activation in T cells. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 73-76 35218032-6 2022 Furthermore, preincubation with Orz reduced H2 O2 -mediated the proapoptotic protein of Bak expression and the phosphorylation of ASK1, p38, JNK, and ERK, and increased the anti-apoptotic protein of Bcl-xl expression and anti-oxidative stress proteins of Nrf2 and HO-1 expression. Hydrogen Peroxide 44-49 mitogen-activated protein kinase 1 Homo sapiens 150-153 9360968-10 1997 Modulation of intracellular H2O2 levels by direct addition of catalase or pretreatment with a catalase inhibitor, aminotriazole, also affected BHA- and tBHQ-stimulated ERK2 activity but not JNK1, indicating the involvement of oxidative stress in the ERK2 activation by these two compounds. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 1 Homo sapiens 168-172 9360968-10 1997 Modulation of intracellular H2O2 levels by direct addition of catalase or pretreatment with a catalase inhibitor, aminotriazole, also affected BHA- and tBHQ-stimulated ERK2 activity but not JNK1, indicating the involvement of oxidative stress in the ERK2 activation by these two compounds. Hydrogen Peroxide 28-32 mitogen-activated protein kinase 1 Homo sapiens 250-254 9119028-2 1997 Recently, H2O2 has been reported to stimulate the activity of the mitogen-activated protein kinases (MAPKs) ERK and JNK, and the expression of the proto-oncogenes c-fos and c-jun. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 1 Homo sapiens 108-111 9119028-4 1997 The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. Hydrogen Peroxide 80-84 mitogen-activated protein kinase 1 Homo sapiens 115-118 9119028-4 1997 The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 1 Homo sapiens 115-118 9119028-8 1997 Moreover, the stimulation by H2O2 of ERK and JNK was decreased by phospholipase A2 activity inhibitors. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 37-40 9119028-12 1997 Although ERK was strongly and durably stimulated by 200 microM H2O2 in astrocytes, at the same extent as by mitogenic growth factors, basal thymidine incorporation rate was decreased by more than 80% after 12-15 h. Moreover, the stimulation of thymidine incorporation induced by basic fibroblast growth factor was transiently abolished by H2O2. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 1 Homo sapiens 9-12 9119028-12 1997 Although ERK was strongly and durably stimulated by 200 microM H2O2 in astrocytes, at the same extent as by mitogenic growth factors, basal thymidine incorporation rate was decreased by more than 80% after 12-15 h. Moreover, the stimulation of thymidine incorporation induced by basic fibroblast growth factor was transiently abolished by H2O2. Hydrogen Peroxide 339-343 mitogen-activated protein kinase 1 Homo sapiens 9-12 9119028-13 1997 Furthermore, H2O2 likely induced the expression of CL100/PAC1/MKP-1, a dual specificity phosphatase which has been implicated in ERK and JNK inactivation in the nucleus. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 1 Homo sapiens 129-132 9119028-15 1997 These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. Hydrogen Peroxide 169-173 mitogen-activated protein kinase 1 Homo sapiens 116-119 34744744-11 2021 H2O2 treatment could partially restore the expression levels of CXCL14 and p-ERK in HCT116/shCXCL14 cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 77-80 34203307-10 2021 Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-kappaB (NF-kappaB) activation, thereby preventing H2O2-induced neurotoxicity. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 1 Homo sapiens 182-185 33807495-5 2021 In line with the previous results in fission yeast, the phosphorylation of the MAPKs ERK and p38 increased substantially more with the combination treatment than by H2O2 or phenothiazines, whereas INR119 alone did not affect phosphorylation. Hydrogen Peroxide 165-169 mitogen-activated protein kinase 1 Homo sapiens 85-88 34284139-4 2021 IGFBP3 knockdown in MESCs committed to H2O2-induced senescence led to partial abrogation of p21/Rb axis, to elevated ERK phosphorylation and to increase in SA-beta-gal activity. Hydrogen Peroxide 39-43 mitogen-activated protein kinase 1 Homo sapiens 117-120 33901243-0 2021 Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and beta-amyloid-induced cell injury via ERK pathway. Hydrogen Peroxide 97-114 mitogen-activated protein kinase 1 Homo sapiens 156-159 32645628-5 2020 Western blot analysis showed that DL0410 increased the H2O2-triggered down-regulated TrkB, ERK and CREB phosphorylation and the expression of BDNF. Hydrogen Peroxide 55-59 mitogen-activated protein kinase 1 Homo sapiens 91-94 33045879-11 2021 Altogether, our results illustrated that hydrogen peroxide-mediated endothelial cell damage could be attenuated by liraglutide through modulation of the MAPK/ERK signaling pathway. Hydrogen Peroxide 41-58 mitogen-activated protein kinase 1 Homo sapiens 158-161 32881386-3 2020 Here, I show that SHIP2 inhibition in cervical cancer cell lines alters H2 O2 -mediated AKT and MAPK/ERK pathway activation. Hydrogen Peroxide 72-77 mitogen-activated protein kinase 1 Homo sapiens 101-104 33270331-7 2021 Furthermore, the UVB/H2 O2 -induced excessive production of reactive oxygen species, degradation of collagen, activation of MAPKs, including P38, ERK, and JNK, and premature senescence were remarkably attenuated by F-FEJS in dermal fibroblast cells. Hydrogen Peroxide 21-26 mitogen-activated protein kinase 1 Homo sapiens 146-149 33111210-9 2021 Additionally, Akt and ERK were activated with different kinetics after H2O2 exposure, and Akt activity inhibition attenuated SA-beta-gal activity augmentation. Hydrogen Peroxide 71-75 mitogen-activated protein kinase 1 Homo sapiens 22-25 32833955-11 2020 In vitro studies demonstrated that increased ROS generation induced by H2O2 resulted in decreased E-cadherin expression levels in 16HBE cells, which was attenuated by inhibition of ERK signaling. Hydrogen Peroxide 71-75 mitogen-activated protein kinase 1 Homo sapiens 181-184 32833955-12 2020 Moreover, the H2O2-induced downregulation of E-cadherin expression, increased ROS generation, and ERK activation in 16HBE cells were restored by treatment with QXT water or ethanol extract. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 1 Homo sapiens 98-101 32139669-7 2020 Moreover, we confirmed that the activation of MAPK signals (ERK1/2, p38, JNK) was required for the inflammatory response induced by O3 or H2O2 while only the phosphorylation of ERK pathway was diminished in the TRPC6-knockdown situation. Hydrogen Peroxide 138-142 mitogen-activated protein kinase 1 Homo sapiens 68-71 32552665-9 2020 Moreover, p-p-38, p-ERK, and p-JNK were up-regulated in H2O2-treated HLE-B3 cells, and overexpression of miR-182-5p reversed the effects of H2O2 on HLE-B3 cells. Hydrogen Peroxide 56-60 mitogen-activated protein kinase 1 Homo sapiens 20-23 31159593-13 2019 In conclusion, our study reveals that APS alleviates H2O2-triggered oxidative injury in HUVECs via elevating the expression of KLF2 via the MEK/ERK pathway. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 1 Homo sapiens 144-147 28342871-9 2019 We found that the oxidative stress induced by H2O2 increased the apoptosis and subsequently the calcification in the cartilage endplate cells through the ROS/p38/ERK/p65 pathway. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 1 Homo sapiens 162-165 31070932-3 2019 We previously showed that H2O2 inhibits Ca2+-dependent Cl- secretion across intestinal epithelial cells (IECs) via a phosphatidylinositol 3-kinase (PI3K)- and extracellular signal-regulated kinase (ERK)-dependent mechanism that occurs, at least in part, through inhibition of the basolateral Na+-K+-2Cl- cotransporter NKCC1. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 1 Homo sapiens 159-196 31070932-3 2019 We previously showed that H2O2 inhibits Ca2+-dependent Cl- secretion across intestinal epithelial cells (IECs) via a phosphatidylinositol 3-kinase (PI3K)- and extracellular signal-regulated kinase (ERK)-dependent mechanism that occurs, at least in part, through inhibition of the basolateral Na+-K+-2Cl- cotransporter NKCC1. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 1 Homo sapiens 198-201 31070932-9 2019 These data identify a key role for AMPK-NKCC1 interaction as a point of convergence for suppression of colonic epithelial ion transport by inflammatory reactive oxygen species.NEW & NOTEWORTHY H2O2 inhibition of intestinal epithelial Ca2+-dependent Cl- secretion involves recruitment of AMP-activated protein kinase (AMPK) downstream of ERK and phosphatidylinositol 3-kinase signaling pathways, physical interaction of AMPK with the Na+-K+-2Cl- cotransporter NKCC1, and AMPK-dependent suppression of NKCC1-mediated electrolyte influx without causing NKCC1 internalization. Hydrogen Peroxide 193-197 mitogen-activated protein kinase 1 Homo sapiens 337-340 31121283-6 2019 Co-immunoprecipitation experiments revealed that ShcD mainly interacts with ERK in B16 and MM138 melanoma cells under both hydrogen peroxide-untreated and -treated conditions. Hydrogen Peroxide 123-140 mitogen-activated protein kinase 1 Homo sapiens 76-79 31185752-8 2019 Inhibition of either p38 or ERK up-regulated the apoptosis induction in EcI- and H2O2-cotreated cells. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 28-31 31121283-12 2019 The ShcD/ERK interaction promoted anti-survival signalling upon exposure to hydrogen peroxide, while U0126 treatment reduced death signalling. Hydrogen Peroxide 76-93 mitogen-activated protein kinase 1 Homo sapiens 9-12 30954555-0 2019 Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer. Hydrogen Peroxide 154-171 mitogen-activated protein kinase 1 Homo sapiens 89-93 30954555-0 2019 Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer. Hydrogen Peroxide 154-171 mitogen-activated protein kinase 1 Homo sapiens 115-118 31081068-10 2019 Phosphorylation levels of the key kinases in the mTOR and MEK/ERK pathways were enhanced by lncRNA ANRIL via down-regulating miR-7 in H2O2-treated TM cells. Hydrogen Peroxide 134-138 mitogen-activated protein kinase 1 Homo sapiens 62-65 30979953-7 2019 GB treatment resulted in activation of Lyn, Akt, and ERK1/2, suggesting that GB is able to mitigate the H2O2-induced oxidative stress via activation of both the Lyn/PI3K/Akt and ERK/MAPK pathways. Hydrogen Peroxide 104-108 mitogen-activated protein kinase 1 Homo sapiens 53-56 30284230-9 2019 Hydrogen peroxide significantly induced the elevation of FUNDC1, a mitophagic factor, in a time- and dose-dependent manner in laryngeal cancer cells, which was dependent on ERK signal activation. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 173-176 30970524-14 2019 CONCLUSIONS: These data demonstrated that ARB protected RGCs against oxidative injury induced by H2O2 through blocking MEK/ERK and p38MAPK signaling pathways by up-regulation of miR-29a. Hydrogen Peroxide 97-101 mitogen-activated protein kinase 1 Homo sapiens 123-126 29324335-4 2018 In particular, four compounds were found to protect SH-SY5Y cells from H2O2-induced toxicity by increasing Bcl-2/Bax ratio, regulating PI3-K/Akt cascade and inhibiting the ERK pathway. Hydrogen Peroxide 71-75 mitogen-activated protein kinase 1 Homo sapiens 172-175 30818884-14 2019 Similarly, the ERK inhibitor U0126 inhibited HAS-2 in Pm-ME/H2O2-treated HaCaT cells. Hydrogen Peroxide 60-64 mitogen-activated protein kinase 1 Homo sapiens 15-18 30662622-0 2018 CXCL16 is activated by p-JNK and is involved in H2O2-induced HK-2 cell injury via p-ERK signaling. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 1 Homo sapiens 84-87 30662622-9 2018 Additionally, rh CXCL16 treatment led to effects like those of H2O2 treatment in HK-2 cells, with symptoms being effectively improved by CXCR6 siRNA and the ERK inhibitor (PD98059). Hydrogen Peroxide 63-67 mitogen-activated protein kinase 1 Homo sapiens 157-160 30186615-5 2018 In this study, we examined the influence of CAM against H2O2-induced activities of cellular antioxidant enzymes and phosphorylated extracellular signal regulatory kinase (p-ERK) using SAECs, the main cells involved in chronic airway inflammatory diseases. Hydrogen Peroxide 56-60 mitogen-activated protein kinase 1 Homo sapiens 173-176 29849919-6 2018 As well, in vitro study showed that p-CA also suppressed H2O2-induced phosphorylation of p-38, ERK, and JNK in HLE cells. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 95-98 29471244-11 2018 SIGNIFICANCE: DAs provided cytoprotective effects against H2O2-induced cytotoxicity by activation of the Nrf2/ARE/HO-1 pathway via phosphorylation of AMPKalpha and ERK. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 1 Homo sapiens 164-167 30839497-7 2019 In detail, it showed that H2O2 induced a transient activation of Mitogen-activated protein kinases members ERK1/2 and p38, whereas induced a sustained activation of c-Jun N-terminal kinase (JNK), which play dominant roles in triggering apoptosis. Hydrogen Peroxide 26-30 mitogen-activated protein kinase 1 Homo sapiens 118-121 29615910-7 2018 Human umbilical vein endothelial cell (HUVEC) neovascularization induced by conditioned medium (CM) from H2O2-stimulated RPE cells was attenuated by treatment with Kin, VEGF antagonist, NF-kappaB, Erk-MAPK, and p38-MAPK inhibitors. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 1 Homo sapiens 197-200 29615910-7 2018 Human umbilical vein endothelial cell (HUVEC) neovascularization induced by conditioned medium (CM) from H2O2-stimulated RPE cells was attenuated by treatment with Kin, VEGF antagonist, NF-kappaB, Erk-MAPK, and p38-MAPK inhibitors. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 1 Homo sapiens 201-205 29615910-7 2018 Human umbilical vein endothelial cell (HUVEC) neovascularization induced by conditioned medium (CM) from H2O2-stimulated RPE cells was attenuated by treatment with Kin, VEGF antagonist, NF-kappaB, Erk-MAPK, and p38-MAPK inhibitors. Hydrogen Peroxide 105-109 mitogen-activated protein kinase 1 Homo sapiens 215-219 29615910-8 2018 Additionally, H2O2-activated phosphorylated expression of IkappaBalpha, p65, Erk, and p38 in RPE cells was inhibited by treatment with Kin. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 1 Homo sapiens 77-80 29615910-10 2018 This could be ascribed to the inhibition of Erk/p38/NF-kappaB signaling by Kin that contributed to the resulting decreased VEGF expression in H2O2-treated RPE cells. Hydrogen Peroxide 142-146 mitogen-activated protein kinase 1 Homo sapiens 44-47 29084209-5 2018 In human colorectal carcinoma (HCT116) cells treated with H2O2, extracellular signal-regulated kinases 1 and 2 (ERK1/2) were activated and MLK3 exhibited reduced electrophoretic mobility (shift) in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), which was eliminated by phosphatase treatment. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 1 Homo sapiens 64-110 28843779-5 2017 We report that ERK is actively and directly oxidized by signal-generated H2O2 during proliferative signaling, and that ERK oxidation occurs downstream of a variety of receptor classes tested in four cell lines. Hydrogen Peroxide 73-77 mitogen-activated protein kinase 1 Homo sapiens 15-18 29222974-8 2018 We also demonstrated that cytosolic hydrogen peroxide, formed by O2- dismutation, act as an intracellular messenger to specifically activate the Trk/Ras/ERK signaling pathway. Hydrogen Peroxide 36-53 mitogen-activated protein kinase 1 Homo sapiens 153-156 28532624-8 2017 AG-related compounds also inhibited the H2O2-induced activation of ERK, and subsequent secretion of CXCL8 mediated by TRPM2-dependent and -independent mechanisms. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 67-70 28849063-0 2017 Hydrogen peroxide promotes the expression of angiopoietin like 4 in RAW264.7 macrophages via MAPK pathways. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 93-97 28849063-6 2017 Mitogen-activated protein kinase (MAPK) pathways were implicated in the secretion of ANGPTL4 regulated by H2O2, and specific inhibitors of MAPK1 (also known as ERK) and p38 MAPK significantly decreased H2O2 induced ANGPTL4 protein expression. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 1 Homo sapiens 34-38 28849063-6 2017 Mitogen-activated protein kinase (MAPK) pathways were implicated in the secretion of ANGPTL4 regulated by H2O2, and specific inhibitors of MAPK1 (also known as ERK) and p38 MAPK significantly decreased H2O2 induced ANGPTL4 protein expression. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 1 Homo sapiens 160-163 28849063-6 2017 Mitogen-activated protein kinase (MAPK) pathways were implicated in the secretion of ANGPTL4 regulated by H2O2, and specific inhibitors of MAPK1 (also known as ERK) and p38 MAPK significantly decreased H2O2 induced ANGPTL4 protein expression. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 1 Homo sapiens 34-38 28849063-6 2017 Mitogen-activated protein kinase (MAPK) pathways were implicated in the secretion of ANGPTL4 regulated by H2O2, and specific inhibitors of MAPK1 (also known as ERK) and p38 MAPK significantly decreased H2O2 induced ANGPTL4 protein expression. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 1 Homo sapiens 139-144 28849063-6 2017 Mitogen-activated protein kinase (MAPK) pathways were implicated in the secretion of ANGPTL4 regulated by H2O2, and specific inhibitors of MAPK1 (also known as ERK) and p38 MAPK significantly decreased H2O2 induced ANGPTL4 protein expression. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 1 Homo sapiens 160-163 28849063-7 2017 Accordingly, it was demonstrated that ANGPTL4 expression was regulated by H2O2 via ERK and p38 MAPK, but not the MAPK8 (also known as JNK) pathway. Hydrogen Peroxide 74-78 mitogen-activated protein kinase 1 Homo sapiens 83-86 27412761-0 2017 Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3beta and the ERK Pathway. Hydrogen Peroxide 27-31 mitogen-activated protein kinase 1 Homo sapiens 104-107 27412761-3 2017 H2O2 exposure led to the increased activities of glycogen synthase kinase 3beta (GSK3beta) and extracellular signal-regulated kinase (ERK) in SH-SY5Y cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 95-132 27412761-3 2017 H2O2 exposure led to the increased activities of glycogen synthase kinase 3beta (GSK3beta) and extracellular signal-regulated kinase (ERK) in SH-SY5Y cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 134-137 27412761-4 2017 Indirubin-3-oxime treatment significantly reversed the altered activity of both the PI3-K/Akt/GSK3beta cascade and the ERK pathway induced by H2O2. Hydrogen Peroxide 142-146 mitogen-activated protein kinase 1 Homo sapiens 119-122 28532624-6 2017 METHODS: The effects of AG-related compounds on H2O2-induced changes in intracellular Ca2+ concentrations, extracellular signal-regulated kinase (ERK) activation, and CXCL8 secretion were assessed using U937 cells. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 1 Homo sapiens 107-144 28532624-9 2017 CONCLUSION: Our results show that AG-related compounds inhibit H2O2-induced CXCL8 secretion following ERK activation, which is mediated by TRPM2-dependent and -independent mechanisms in U937 cells. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 1 Homo sapiens 102-105 28469544-0 2017 Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway. Hydrogen Peroxide 21-25 mitogen-activated protein kinase 1 Homo sapiens 122-125 27357344-6 2017 In osteoblastic MC3T3-E1 and MG-63 cells, H2 O2 triggered p38, JNK, ERK and p66Shc phosphorylation, and cell apoptosis. Hydrogen Peroxide 42-47 mitogen-activated protein kinase 1 Homo sapiens 68-71 27357344-8 2017 H2 O2 -induced p38 and ERK phosphorylation and apoptosis were both decreased by pre-treatment with specific kinase inhibitors or PTHrP (1-37) in both osteoblastic cell types. Hydrogen Peroxide 0-5 mitogen-activated protein kinase 1 Homo sapiens 23-26 28469544-5 2017 H2O2 treatment led to the reduced activity of phosphoinositide 3-kinase (PI3-K)/Akt cascade and the increased activity of extracellular signal-regulated kinase (ERK) pathway in SH-SY5Y cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 122-159 28469544-5 2017 H2O2 treatment led to the reduced activity of phosphoinositide 3-kinase (PI3-K)/Akt cascade and the increased activity of extracellular signal-regulated kinase (ERK) pathway in SH-SY5Y cells. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 161-164 28469544-6 2017 Moreover, fucoxanthin significantly restored the altered activities of PI3-K/Akt and ERK pathways induced by H2O2. Hydrogen Peroxide 109-113 mitogen-activated protein kinase 1 Homo sapiens 85-88 28469544-9 2017 Conclusions: Our data strongly revealed that fucoxanthin protected against H2O2-induced neurotoxicity via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway, providing support for the use of fucoxanthin to treat neurodegenerative disorders induced by oxidative stress. Hydrogen Peroxide 75-79 mitogen-activated protein kinase 1 Homo sapiens 171-174 28314256-4 2017 Pharmacological inhibition of MEK/ERK signaling partly reversed the effects of H2O2 Conclusion: H2O2 enhances TGFbeta-mediated EMT via SMAD and MEK/ERK signaling. Hydrogen Peroxide 96-100 mitogen-activated protein kinase 1 Homo sapiens 148-151 27754784-6 2016 The addition of 10 nM 3alpha-diol, which did not itself activate ERK, significantly inhibited ERK phosphorylation induced by DHT, epidermal growth factor, or H2O2, but not acetylcholine. Hydrogen Peroxide 158-162 mitogen-activated protein kinase 1 Homo sapiens 94-97 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Hydrogen Peroxide 154-158 mitogen-activated protein kinase 1 Homo sapiens 99-136 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Hydrogen Peroxide 154-158 mitogen-activated protein kinase 1 Homo sapiens 138-141 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Hydrogen Peroxide 220-224 mitogen-activated protein kinase 1 Homo sapiens 99-136 28338196-4 2017 The expression of the epidermal growth factor receptor (EGFR) and its downstream signaling pathway extracellular signal-regulated kinase (ERK) protein in H2O2 was detected by Western blot method; moreover, the effect of H2O2 on intracellular reactive oxygen species (ROS) in AGS cells was observed under the fluorescence microscope and quantitative analysis by flow cytometry. Hydrogen Peroxide 220-224 mitogen-activated protein kinase 1 Homo sapiens 138-141 28338196-7 2017 The Western blot results showed that after 48 hours of low concentration of H2O2 treatment of AGS cells, the EGFR protein levels and ERK protein phosphorylation levels increased significantly (p<0.05). Hydrogen Peroxide 76-80 mitogen-activated protein kinase 1 Homo sapiens 133-136 28338196-10 2017 CONCLUSIONS: Low concentration of H2O2 can significantly promote the proliferation of AGS cells by activating EGFR/ERK signaling pathway. Hydrogen Peroxide 34-38 mitogen-activated protein kinase 1 Homo sapiens 115-118 27914828-9 2017 Further studies showed that OL also inhibited H2O2-induced P38 and JNK phosphorylation but enhanced ERK1/2 phosphorylation in a dose-dependent manner. Hydrogen Peroxide 46-50 mitogen-activated protein kinase 1 Homo sapiens 59-62 27754784-5 2016 In SH-SY5Y cells, ERK phosphorylation was induced by 10 nM DHT, epidermal growth factor, hydrogen peroxide (H2O2), and acetylcholine. Hydrogen Peroxide 89-106 mitogen-activated protein kinase 1 Homo sapiens 18-21 27754784-5 2016 In SH-SY5Y cells, ERK phosphorylation was induced by 10 nM DHT, epidermal growth factor, hydrogen peroxide (H2O2), and acetylcholine. Hydrogen Peroxide 108-112 mitogen-activated protein kinase 1 Homo sapiens 18-21 28314256-3 2017 RESULTS: Hydrogen peroxide (H2O2, 250 muM) enhanced TGFbeta-mediated EMT, as evidenced by increased expression of EMT-associated transcription factors, which was accompanied by increased nuclear localization of phosphorylated SMAD family member 2 (SMAD2) and up-regulation of the TGFbeta signaling pathway components mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK). Hydrogen Peroxide 9-26 mitogen-activated protein kinase 1 Homo sapiens 402-405 28314256-3 2017 RESULTS: Hydrogen peroxide (H2O2, 250 muM) enhanced TGFbeta-mediated EMT, as evidenced by increased expression of EMT-associated transcription factors, which was accompanied by increased nuclear localization of phosphorylated SMAD family member 2 (SMAD2) and up-regulation of the TGFbeta signaling pathway components mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK). Hydrogen Peroxide 28-32 mitogen-activated protein kinase 1 Homo sapiens 402-405 28314256-4 2017 Pharmacological inhibition of MEK/ERK signaling partly reversed the effects of H2O2 Conclusion: H2O2 enhances TGFbeta-mediated EMT via SMAD and MEK/ERK signaling. Hydrogen Peroxide 79-83 mitogen-activated protein kinase 1 Homo sapiens 34-37 28314256-4 2017 Pharmacological inhibition of MEK/ERK signaling partly reversed the effects of H2O2 Conclusion: H2O2 enhances TGFbeta-mediated EMT via SMAD and MEK/ERK signaling. Hydrogen Peroxide 79-83 mitogen-activated protein kinase 1 Homo sapiens 148-151 28314256-4 2017 Pharmacological inhibition of MEK/ERK signaling partly reversed the effects of H2O2 Conclusion: H2O2 enhances TGFbeta-mediated EMT via SMAD and MEK/ERK signaling. Hydrogen Peroxide 96-100 mitogen-activated protein kinase 1 Homo sapiens 34-37 27372058-0 2016 Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling. Hydrogen Peroxide 65-82 mitogen-activated protein kinase 1 Homo sapiens 130-133 27637085-0 2016 Dual oxidase 2 and pancreatic adenocarcinoma: IFN-gamma-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1alpha and VEGF-A. Hydrogen Peroxide 106-110 mitogen-activated protein kinase 1 Homo sapiens 120-123 27572503-0 2016 Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-kappaB pathway. Hydrogen Peroxide 18-22 mitogen-activated protein kinase 1 Homo sapiens 104-107 27572503-13 2016 In addition, the H2O2-induced elevation of p-ERK and p-NF-kappaB in BxPC-3 and Panc-1 cells were reduced by curcumin, NAC and PD 98059 (an ERK inhibitor). Hydrogen Peroxide 17-21 mitogen-activated protein kinase 1 Homo sapiens 45-48 27372058-7 2016 Taken together, these results suggest that Artemisinin is a potential protectant with the pro-survival effects against H2O2 insult through activation of the ERK/CREB pathway. Hydrogen Peroxide 119-123 mitogen-activated protein kinase 1 Homo sapiens 157-160 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 202-205 27659916-3 2016 In this study, we showed that H2O2 reduced BIS mobility on SDS-polyacrylamide gels in a time-dependent manner via the activation of extracellular signaling-regulated kinase (ERK). Hydrogen Peroxide 30-34 mitogen-activated protein kinase 1 Homo sapiens 132-172 27659916-3 2016 In this study, we showed that H2O2 reduced BIS mobility on SDS-polyacrylamide gels in a time-dependent manner via the activation of extracellular signaling-regulated kinase (ERK). Hydrogen Peroxide 30-34 mitogen-activated protein kinase 1 Homo sapiens 174-177 27351826-9 2016 On the other hand, low doses of PAF or H2O2 induced phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and NF-kappaB activation, However, PAF or H2O2 at high doses did not produce changes in NF-kappaB activation levels. Hydrogen Peroxide 39-43 mitogen-activated protein kinase 1 Homo sapiens 71-117 28598074-5 2016 RESULTS: Compared with the control group,H2O2 not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1beta in human lung epithelial cells A549 (P<0.05),while SF group showed no statistic significance of those indicators above (P>0.05). Hydrogen Peroxide 41-45 mitogen-activated protein kinase 1 Homo sapiens 166-169 28598074-5 2016 RESULTS: Compared with the control group,H2O2 not only increased the mRNA and protein expression levels of caspase-1 and NALP3 and the protein expression levels of p-ERK/ERK, but also enhanced the secretion of IL-1beta in human lung epithelial cells A549 (P<0.05),while SF group showed no statistic significance of those indicators above (P>0.05). Hydrogen Peroxide 41-45 mitogen-activated protein kinase 1 Homo sapiens 170-173 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 206-209 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 202-205 28598074-6 2016 The Z-VAD group, the PD98059 group and the SF+H2O2 group resisted the effects of H2O2 on A549 cells by decreasing the mRNA and protein expressions of caspase-1 and NALP3,and the protein expression of p-ERK/ERK, as well as reducing the secretion of IL-1beta(P<0.05),when compared with the H2O2 group. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 206-209 27051648-13 2016 Moreover, it activated ERK and restored cell viability which was decreased by hydrogen peroxide. Hydrogen Peroxide 78-95 mitogen-activated protein kinase 1 Homo sapiens 23-26 27346674-7 2016 Results from VRK3-deficient neurons were further confirmed the role of VRK3 phosphorylation in H2O2-evoked ERK regulation. Hydrogen Peroxide 95-99 mitogen-activated protein kinase 1 Homo sapiens 107-110 26095111-10 2016 It was found that WEHDW reversed H2O2-induced activation of MEK/ERK pathway and H2O2-induced inhibition of P13-K/AKT/GSK3beta pathway in LO2 cells. Hydrogen Peroxide 33-37 mitogen-activated protein kinase 1 Homo sapiens 64-67 26789270-8 2016 Tbeta4 peptide inhibited the effects of H2O2 on the activation of ERK and JNK MAPK, and NF-kappaB in PDLCs. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 66-69 26789270-8 2016 Tbeta4 peptide inhibited the effects of H2O2 on the activation of ERK and JNK MAPK, and NF-kappaB in PDLCs. Hydrogen Peroxide 40-44 mitogen-activated protein kinase 1 Homo sapiens 78-82 25921766-9 2015 GGA also blocked the H2O2-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). Hydrogen Peroxide 21-25 mitogen-activated protein kinase 1 Homo sapiens 53-94 26542288-12 2015 Finally, the induction of LPL production and activity by H2O2 was abolished by BA, inhibition of PKC or ERK or depletion c-Fos, respectively. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 104-107 26234813-2 2015 Previous studies have reported that H2O2 leads to phosphorylation of extracellular signal-regulated kinase (ERK), one of the MAPKs in endothelial cells. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 1 Homo sapiens 69-106 26234813-2 2015 Previous studies have reported that H2O2 leads to phosphorylation of extracellular signal-regulated kinase (ERK), one of the MAPKs in endothelial cells. Hydrogen Peroxide 36-40 mitogen-activated protein kinase 1 Homo sapiens 108-111 26234813-3 2015 The current study shows that H2O2 suppressed ERK1/2 activation and phosphorylation at specific concentrations and times in human umbilical vein endothelial cells but not in immortalized mouse aortic endothelial cells or human astrocytoma cell line CRT-MG. Phosphorylation of other MAPK family members (i.e., p38 and JNK) was not suppressed by H2O2. Hydrogen Peroxide 29-33 mitogen-activated protein kinase 1 Homo sapiens 308-311 26710786-3 2015 The mechanism of hydrogen peroxide apoptotic action includes launching signaling pathways that involve protein kinases PI3K, p38MAPK, JNK and ERK. Hydrogen Peroxide 17-34 mitogen-activated protein kinase 1 Homo sapiens 142-145 26439801-0 2015 Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer. Hydrogen Peroxide 0-17 mitogen-activated protein kinase 1 Homo sapiens 71-74 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 1 Homo sapiens 188-191 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 1 Homo sapiens 200-204 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 1 Homo sapiens 188-191 26439801-3 2015 Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-kappaB and AP-1, in a time-dependent manner. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 1 Homo sapiens 200-204 26439801-4 2015 The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 98059 (ERK inhibitor), SB 203580 (p38 MAPK inhibitor), polyethylene glycol-conjugated catalase (PEG-CAT), or the siRNA specific to SOD2. Hydrogen Peroxide 77-81 mitogen-activated protein kinase 1 Homo sapiens 82-86 26439801-4 2015 The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 98059 (ERK inhibitor), SB 203580 (p38 MAPK inhibitor), polyethylene glycol-conjugated catalase (PEG-CAT), or the siRNA specific to SOD2. Hydrogen Peroxide 77-81 mitogen-activated protein kinase 1 Homo sapiens 160-163 26439801-7 2015 Taken together, our results demonstrate that hyperglycemia enhances cell invasive ability through the SOD2/H2O2/MAPK axis in human pancreatic cancer. Hydrogen Peroxide 107-111 mitogen-activated protein kinase 1 Homo sapiens 112-116 26439801-8 2015 Thus, SOD2/H2O2/MAPK axis may represent a promising therapeutic target for pancreatic cancer patients combined with diabetes mellitus. Hydrogen Peroxide 11-15 mitogen-activated protein kinase 1 Homo sapiens 16-20 26047336-6 2015 Further analysis revealed that UII increased the production of hydrogen sulfide (H2S) and the level of cystathionine-gamma-lyase (CSE) by activating the ERK signaling in H2O2-treated-cardiomyocytes. Hydrogen Peroxide 170-174 mitogen-activated protein kinase 1 Homo sapiens 153-156 26047336-7 2015 Si-CSE or ERK inhibitor not only greatly inhibited the increase in CSE level or the phosphorylation of ERK induced by UII but also reversed anti-apoptosis of UII in H2O2-treated-cadiomyocytes. Hydrogen Peroxide 165-169 mitogen-activated protein kinase 1 Homo sapiens 10-13 26047336-7 2015 Si-CSE or ERK inhibitor not only greatly inhibited the increase in CSE level or the phosphorylation of ERK induced by UII but also reversed anti-apoptosis of UII in H2O2-treated-cadiomyocytes. Hydrogen Peroxide 165-169 mitogen-activated protein kinase 1 Homo sapiens 103-106 25825208-0 2015 Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-kappaB axis. Hydrogen Peroxide 117-121 mitogen-activated protein kinase 1 Homo sapiens 122-125 25831202-7 2015 Inhibition of ERK by its inhibitor U0126 or by its specific small interfering RNA (siRNA) blocked the CaA-induced improvement in cell viability and the protective effects against H2O2-mediated DNA damage. Hydrogen Peroxide 179-183 mitogen-activated protein kinase 1 Homo sapiens 14-17 25683165-4 2015 Transforming growth factor-beta1/H2O2/HOCl could upregulate SIRT6 expression in HCC cells by inducing the sustained activation of ERK and Smad pathways. Hydrogen Peroxide 33-37 mitogen-activated protein kinase 1 Homo sapiens 130-133 25825208-11 2015 Blocking the H2O2/ERK/NF-kappaB axis might be a novel strategy for the treatment of this severe malignancy. Hydrogen Peroxide 13-17 mitogen-activated protein kinase 1 Homo sapiens 18-21 26064424-5 2015 Moreover, RNSP significantly attenuated the H2O2-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase 1/2 (ERK 1/2) in SH-SY5Y cells. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 1 Homo sapiens 124-165 25128742-6 2014 Immunofluorescence and Western blot analyses demonstrated that H2O2 treatment up-regulated SIRT1, phosphorylated-JNK (p-JNK), p-p38MAPK, and p-ERK expression. Hydrogen Peroxide 63-67 mitogen-activated protein kinase 1 Homo sapiens 143-146 25078118-5 2014 However, only p38 activation depended both on hydrogen peroxide production and on PARP1 activation as the hydrogen peroxide decomposing enzyme catalase, the PARP inhibitor PJ34, and the silencing of PARP1 suppressed p38 activation. Hydrogen Peroxide 46-63 mitogen-activated protein kinase 1 Homo sapiens 14-17 24440775-9 2014 Together, our results suggest that AB and BH restore the H2O2-inhibited viability and proliferation of NSCs by inhibiting oxidative stress and by activating the PI3K and ERK pathways. Hydrogen Peroxide 57-61 mitogen-activated protein kinase 1 Homo sapiens 170-173 25078118-5 2014 However, only p38 activation depended both on hydrogen peroxide production and on PARP1 activation as the hydrogen peroxide decomposing enzyme catalase, the PARP inhibitor PJ34, and the silencing of PARP1 suppressed p38 activation. Hydrogen Peroxide 106-123 mitogen-activated protein kinase 1 Homo sapiens 14-17 25078118-5 2014 However, only p38 activation depended both on hydrogen peroxide production and on PARP1 activation as the hydrogen peroxide decomposing enzyme catalase, the PARP inhibitor PJ34, and the silencing of PARP1 suppressed p38 activation. Hydrogen Peroxide 106-123 mitogen-activated protein kinase 1 Homo sapiens 216-219 25078118-7 2014 Metabolic collapse appears to be central in the hydrogen peroxide-PARP1-p38 pathway as silencing PARP1 or inhibition of p38 prevented differentiation-associated loss of cellular NAD, inhibition of mitochondrial respiration, and glycolytic activity. Hydrogen Peroxide 48-65 mitogen-activated protein kinase 1 Homo sapiens 72-75 25078118-7 2014 Metabolic collapse appears to be central in the hydrogen peroxide-PARP1-p38 pathway as silencing PARP1 or inhibition of p38 prevented differentiation-associated loss of cellular NAD, inhibition of mitochondrial respiration, and glycolytic activity. Hydrogen Peroxide 48-65 mitogen-activated protein kinase 1 Homo sapiens 120-123 25078118-10 2014 In summary, hydrogen peroxide-induced PARP1 activation leads to p38 activation and this pathway is required both for the successful completion of the differentiation process and for the associated cell death. Hydrogen Peroxide 12-29 mitogen-activated protein kinase 1 Homo sapiens 64-67 24577881-7 2014 RESULTS: H2 O2 and ONOO(-) inhibited ERK pathway signaling in T cells by inhibiting the upstream regulator protein kinase Cdelta, decreased DNMT-1 levels, and caused demethylation and overexpression of genes previously shown to be suppressed by DNA methylation in T cells from patients with active lupus. Hydrogen Peroxide 9-14 mitogen-activated protein kinase 1 Homo sapiens 37-40 24912447-0 2014 Activated delta-opioid receptors inhibit hydrogen peroxide-induced apoptosis in liver cancer cells through the PKC/ERK signaling pathway. Hydrogen Peroxide 41-58 mitogen-activated protein kinase 1 Homo sapiens 115-118 25069610-11 2014 H2O2-upregulated phosphorylation of JNK and p38 MAPK was dampened by adding astragalin to epithelial cells, while this compound enhanced epithelial activation of Akt and ERK. Hydrogen Peroxide 0-4 mitogen-activated protein kinase 1 Homo sapiens 170-173 23815460-9 2014 Inhibition of SDF-1 and MCP-1 blocked the H2 O2 -induced activation of Akt, p38, ERK and NF-kB. Hydrogen Peroxide 42-47 mitogen-activated protein kinase 1 Homo sapiens 81-84 24632723-6 2014 In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK). Hydrogen Peroxide 50-54 mitogen-activated protein kinase 1 Homo sapiens 248-283 24632723-6 2014 In contrast, siRNA targeting of SHP-2 facilitated H2O2-mediated interaction between caveolin-1 and CSK and enhanced Src phosphorylation at Tyr 530, leading to subsequent decrease in Src downstream signaling, such as focal adhesion kinase (FAK) and extracellular signal-related kinase (ERK). Hydrogen Peroxide 50-54 mitogen-activated protein kinase 1 Homo sapiens 285-288 24871786-0 2014 Transient receptor potential melastatin 7 (TRPM7) contributes to H2O2-induced cardiac fibrosis via mediating Ca(2+) influx and extracellular signal-regulated kinase 1/2 (ERK1/2) activation in cardiac fibroblasts. Hydrogen Peroxide 65-69 mitogen-activated protein kinase 1 Homo sapiens 127-168 24586933-7 2014 ROS-generating myeloid cells and exogenous H2O2 triggered PARP 1-dependent accumulation of poly ADP-ribose (PAR), which was prevented by ERK pathway inhibitors. Hydrogen Peroxide 43-47 mitogen-activated protein kinase 1 Homo sapiens 137-140 24140706-6 2014 Antioxidant EUK-8, a synthetic catalytic superoxide and hydrogen peroxide scavenger, significantly decreases ATG-mediated p38 activation and apoptosis. Hydrogen Peroxide 56-73 mitogen-activated protein kinase 1 Homo sapiens 122-125 24871786-7 2014 Furthermore, we found that H2O2-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2) decreased in TRPM7-shRNA cells and Ca(2+)-free culture media. Hydrogen Peroxide 27-31 mitogen-activated protein kinase 1 Homo sapiens 55-96 24058693-0 2013 Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide. Hydrogen Peroxide 111-128 mitogen-activated protein kinase 1 Homo sapiens 21-25 23805040-9 2013 Both doses of H2O2 activated Akt, ERK1/2, and p38 in TM cells at 20 min after treatment, but not JNK or NFkB until 1 h after treatment. Hydrogen Peroxide 14-18 mitogen-activated protein kinase 1 Homo sapiens 46-49 23624332-7 2013 The use of pharmacological inhibitors as well as knockdown of ILK with small interfering RNA (siRNA) demonstrated the implication of a PI3K/ILK/AKT/ERK MAPK signaling pathway axis in the H2O2-induced TGF-beta1 overexpression. Hydrogen Peroxide 187-191 mitogen-activated protein kinase 1 Homo sapiens 148-151 23624332-7 2013 The use of pharmacological inhibitors as well as knockdown of ILK with small interfering RNA (siRNA) demonstrated the implication of a PI3K/ILK/AKT/ERK MAPK signaling pathway axis in the H2O2-induced TGF-beta1 overexpression. Hydrogen Peroxide 187-191 mitogen-activated protein kinase 1 Homo sapiens 152-156 24058693-4 2013 Here, we investigated the initial contribution of S6K1/MAPK signaling pathways in the cell response to oxidative stress produced by hydrogen peroxide (H2O2). Hydrogen Peroxide 132-149 mitogen-activated protein kinase 1 Homo sapiens 55-59 24058693-4 2013 Here, we investigated the initial contribution of S6K1/MAPK signaling pathways in the cell response to oxidative stress produced by hydrogen peroxide (H2O2). Hydrogen Peroxide 151-155 mitogen-activated protein kinase 1 Homo sapiens 55-59 23805040-10 2013 Inhibitors of PI3K, ERK1/2, and p38 suppressed recovery from the morphologic changes induced by 600 muM H2O2. Hydrogen Peroxide 104-108 mitogen-activated protein kinase 1 Homo sapiens 32-35 23805040-12 2013 CONCLUSIONS: In TM cells, the PI3K-Akt, ERK, and p38 signaling pathways are primary oxidative stress response pathways involved in the mechanism of recovery from cellular morphologic changes induced by H2O2 treatment accompanied by actin cytoskeletal changes. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 1 Homo sapiens 40-43 23805040-12 2013 CONCLUSIONS: In TM cells, the PI3K-Akt, ERK, and p38 signaling pathways are primary oxidative stress response pathways involved in the mechanism of recovery from cellular morphologic changes induced by H2O2 treatment accompanied by actin cytoskeletal changes. Hydrogen Peroxide 202-206 mitogen-activated protein kinase 1 Homo sapiens 49-52 23478801-10 2013 Overexpression of Ngb suppressed serum- and H2O2-stimulated Erk activation in HepG2 cells. Hydrogen Peroxide 44-48 mitogen-activated protein kinase 1 Homo sapiens 60-63 23261939-9 2013 The phosphorylation of Akt and ERK after exposure to H2O2 or MPP(+) was also inhibited in PINK1 P209A mutant cells compared with empty-vector-transfected cells. Hydrogen Peroxide 53-57 mitogen-activated protein kinase 1 Homo sapiens 31-34 23247634-0 2013 Vitamin D protects human endothelial cells from H2O2 oxidant injury through the Mek/Erk-Sirt1 axis activation. Hydrogen Peroxide 48-52 mitogen-activated protein kinase 1 Homo sapiens 84-87 23569422-0 2013 Propofol-induced protection of SH-SY5Y cells against hydrogen peroxide is associated with the HO-1 via the ERK pathway. Hydrogen Peroxide 53-70 mitogen-activated protein kinase 1 Homo sapiens 107-110 22246135-6 2012 Our results demonstrated that flavonoid baicalein protected against H(2)O(2)-induced cell death by inhibition of JNK/ERK pathways activation and other key molecules in apoptotic pathways, including blockage of Bax and caspase-9 activation, induction of Bcl-2 expression and prevention of cell death. Hydrogen Peroxide 68-76 mitogen-activated protein kinase 1 Homo sapiens 117-120 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Hydrogen Peroxide 18-27 mitogen-activated protein kinase 1 Homo sapiens 71-74 22507555-7 2012 Melatonin blocked H(2) O(2) -induced phosphorylation of PI3K/Akt, p38, ERK, JNK, and MAPK, as well as activation of NF-kappaB, which was reversed by sirtinol and SIRT1 siRNA. Hydrogen Peroxide 18-27 mitogen-activated protein kinase 1 Homo sapiens 85-89 22683469-8 2012 We further demonstrated that the H(2)O(2)-induced increase in PLGF mRNA levels partially relies on p38 MAPK, JNK and ERK1/2 pathways. Hydrogen Peroxide 33-41 mitogen-activated protein kinase 1 Homo sapiens 99-102 24008236-10 2013 CONCLUSION: H2O2-mediated phosphorylation of eNOS Thr(495) is mediated by ROCK and ERK activity, but not by PKC, and is uncoupled from mitochondrial ROS signaling. Hydrogen Peroxide 12-16 mitogen-activated protein kinase 1 Homo sapiens 83-86 22342995-4 2012 Consistent with these observations, the apoptotic pathway activated upon H2O2 treatment relies upon Trx1 oxidation, and is mediated by the p38(MAPK)/p53 signaling axis. Hydrogen Peroxide 73-77 mitogen-activated protein kinase 1 Homo sapiens 139-142 22082048-6 2012 DPI also inhibited H2O2-induced ERK (extracellular-signal-regulated kinase) activation, as detected by Western blotting. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 1 Homo sapiens 32-35 22082048-6 2012 DPI also inhibited H2O2-induced ERK (extracellular-signal-regulated kinase) activation, as detected by Western blotting. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 1 Homo sapiens 37-74 22082048-7 2012 Furthermore, PD98059, the inhibitor of the ERK pathway, inhibited the differentiation of HL-60 cells induced by H2O2. Hydrogen Peroxide 112-116 mitogen-activated protein kinase 1 Homo sapiens 43-46 22082048-8 2012 This shows that H2O2 can activate NADPH oxidase, leading to O2 - production, followed by ERK activation and ultimately resulting in the differentiation of HL-60 cells. Hydrogen Peroxide 16-20 mitogen-activated protein kinase 1 Homo sapiens 89-92 23243457-6 2012 Conversely, ERK inhibitor PD98059 promoted the intercellular communication in H(2)O(2)-treated HaCaT cells. Hydrogen Peroxide 78-86 mitogen-activated protein kinase 1 Homo sapiens 12-15 23243457-8 2012 Overall, these findings support the scientific evidences that melatonin facilitates gap junctional intercellular communication in H(2)O(2)-treated HaCaT keratinocyte cells via inhibition of connexin 26/43 and ERK as a potent chemopreventive agent. Hydrogen Peroxide 130-138 mitogen-activated protein kinase 1 Homo sapiens 209-212 21946416-10 2012 However, only inhibition of ERK reduced the ability of PEDF to protect neurons from H2O2-induced Bcl-2 decrease and neuronal death. Hydrogen Peroxide 84-88 mitogen-activated protein kinase 1 Homo sapiens 28-31 21918362-9 2011 Lastly, H2O2 induced extracellular signal-regulated kinase (ERK) activation in astrocytes through caveolin-1. Hydrogen Peroxide 8-12 mitogen-activated protein kinase 1 Homo sapiens 21-58 21918362-9 2011 Lastly, H2O2 induced extracellular signal-regulated kinase (ERK) activation in astrocytes through caveolin-1. Hydrogen Peroxide 8-12 mitogen-activated protein kinase 1 Homo sapiens 60-63 21865167-10 2011 H(2)O(2)- and LPS-induced TACE activity up-regulation were effectively abolished by a variety of selective p38 MAPK inhibitors. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 111-115 21750116-8 2011 H(2)O(2)-induced increase in luciferase activity in FLO cells was significantly decreased by knockdown of extracellular signal-regulated kinase 2 (ERK2) mitogen-activated protein kinase (MAPK). Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 106-145 21750116-8 2011 H(2)O(2)-induced increase in luciferase activity in FLO cells was significantly decreased by knockdown of extracellular signal-regulated kinase 2 (ERK2) mitogen-activated protein kinase (MAPK). Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 147-151 21750116-11 2011 Likewise, H(2)O(2)-induced increase in NOX5-S expression was significantly decreased by ERK2 siRNA in FLO and OE33 cells. Hydrogen Peroxide 10-18 mitogen-activated protein kinase 1 Homo sapiens 88-92 21750116-13 2011 H(2)O(2)-induced increase in cell proliferation may depend on sequential activation of ERK2 MAPK, NF-kappaB1 p50, and NOX5-S. Hydrogen Peroxide 0-8 mitogen-activated protein kinase 1 Homo sapiens 87-91 21699973-5 2011 The p38 MAPK was also found to be phosphorylated upon treatment with H(2)O(2) but it was not required for H(2)O(2)-induced migration or proliferation. Hydrogen Peroxide 69-77 mitogen-activated protein kinase 1 Homo sapiens 4-7 21557328-3 2011 TGFalpha-dependent ERK oscillations mediated through the epidermal growth factor receptor (EGFR) are inhibited by low dose X-irradiation (10 cGy) and low concentrations of hydrogen peroxide (0.32-3.26 microM H(2)O(2)) used as a model reactive oxygen species (ROS). Hydrogen Peroxide 172-189 mitogen-activated protein kinase 1 Homo sapiens 19-22 21689633-0 2011 Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap1-Nrf2-ARE signaling pathway. Hydrogen Peroxide 22-39 mitogen-activated protein kinase 1 Homo sapiens 68-72 21467197-0 2011 Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Hydrogen Peroxide 17-34 mitogen-activated protein kinase 1 Homo sapiens 88-91 21467197-6 2011 Both ERK and p38MAPK were activated (peaked at 8 h in ERK and 1 h in p38MAPK) by H2O2 treatment, whereas c-Jun N-terminal kinase and Akt were not. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 5-8 21467197-6 2011 Both ERK and p38MAPK were activated (peaked at 8 h in ERK and 1 h in p38MAPK) by H2O2 treatment, whereas c-Jun N-terminal kinase and Akt were not. Hydrogen Peroxide 81-85 mitogen-activated protein kinase 1 Homo sapiens 54-57 21467197-8 2011 Next, we tried to elucidate the role of ERK and p38MAPK activation in H2O2-induced apoptotic cell death of oligodendrocytes using pharmacological inhibitors. Hydrogen Peroxide 70-74 mitogen-activated protein kinase 1 Homo sapiens 40-43 21467197-10 2011 These results thus indicate that ghrelin inhibits H2O2 -induced oligodendrocytes cell death in part by increasing ERK activation and decreasing p38MAPK activation, and ghrelin may represent a potential therapeutic agent for protecting oligodendrocytes in central nervous system injuries. Hydrogen Peroxide 50-54 mitogen-activated protein kinase 1 Homo sapiens 114-117 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. Hydrogen Peroxide 112-120 mitogen-activated protein kinase 1 Homo sapiens 67-104 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. Hydrogen Peroxide 112-120 mitogen-activated protein kinase 1 Homo sapiens 106-109 21630016-3 2011 When young HDFs were treated with PD98059, a specific inhibitor of extracellular signal-regulated kinase (ERK), H(2)O(2)-induced apoptosis was blocked, whereas staurosporine-induced apoptosis was inhibited by treatment with SB203580, a specific inhibitor of p38. Hydrogen Peroxide 112-120 mitogen-activated protein kinase 1 Homo sapiens 258-261 21630016-7 2011 Moreover, the nuclear translocation of activated ERK1/2 and p38 in response to H(2)O(2) or staurosporine was significantly compromised in senescent HDFs, compared with young cells. Hydrogen Peroxide 79-87 mitogen-activated protein kinase 1 Homo sapiens 60-63 21566137-6 2011 Disruption of barrier function by H(2)O(2) + NHS rapidly increased Ras expression and Erk and Src phosphorylation, but had no effect on P38 phosphorylation. Hydrogen Peroxide 34-44 mitogen-activated protein kinase 1 Homo sapiens 86-89 21315693-5 2011 Increased activation of extracellular signal-regulated kinase (ERK) and decreased activation of glycogen synthase kinase (GSK) 3beta were observed after H2O2 exposure, and B12H reversed the altered activation of GSK3beta, but not that of ERK. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 1 Homo sapiens 24-61 21315693-5 2011 Increased activation of extracellular signal-regulated kinase (ERK) and decreased activation of glycogen synthase kinase (GSK) 3beta were observed after H2O2 exposure, and B12H reversed the altered activation of GSK3beta, but not that of ERK. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 1 Homo sapiens 63-66 21315693-5 2011 Increased activation of extracellular signal-regulated kinase (ERK) and decreased activation of glycogen synthase kinase (GSK) 3beta were observed after H2O2 exposure, and B12H reversed the altered activation of GSK3beta, but not that of ERK. Hydrogen Peroxide 153-157 mitogen-activated protein kinase 1 Homo sapiens 238-241 21497337-11 2011 Finally, we confirmed these results further by demonstrating that melatonin prevention of H2O2-induced DNA fragmentation is dependent on both MT1 receptor and ERK signaling. Hydrogen Peroxide 90-94 mitogen-activated protein kinase 1 Homo sapiens 159-162 21344509-2 2011 The goal of this study was to investigate the role of the ERK pathway in mediating apoptotic signals induced by oncogenic H-Ras, FK228 treatment, and exogenous H(2) O(2) treatment to increase Nox-1 elevation, leading to production of intracellular reactive oxygen species (ROS) for inducing apoptosis in human bladder cancer J82 cells. Hydrogen Peroxide 160-169 mitogen-activated protein kinase 1 Homo sapiens 58-61 21397862-6 2011 A high ratio of O(2)(-):H(2)O(2) oxidizes/activates Src, triggering the PI3K/PKBalpha and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. Hydrogen Peroxide 24-32 mitogen-activated protein kinase 1 Homo sapiens 90-93 21344509-0 2011 Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the ERK pathway in selective induction of human urinary bladder cancer J82 cell death. Hydrogen Peroxide 38-42 mitogen-activated protein kinase 1 Homo sapiens 71-74 21241762-8 2011 Furthermore, pretreatment with loganin significantly attenuated the H(2)O(2)-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). Hydrogen Peroxide 68-76 mitogen-activated protein kinase 1 Homo sapiens 135-138 21241762-8 2011 Furthermore, pretreatment with loganin significantly attenuated the H(2)O(2)-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 (ERK 1/2). Hydrogen Peroxide 68-76 mitogen-activated protein kinase 1 Homo sapiens 184-225 21814482-5 2011 DMA pretreatment suppressed activation of H2O2-mediated MAPK pathways and cell invasion. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 1 Homo sapiens 56-60 20961289-4 2011 EGF (epidermal growth factor) potentiated H2O2-induced tight junction disruption in under-differentiated cell monolayers, which was attenuated by the MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] inhibitor U0126. Hydrogen Peroxide 42-46 mitogen-activated protein kinase 1 Homo sapiens 195-198 20961289-8 2011 EGF prevented both H2O2-induced association of PP2A (protein phosphatase 2A), and loss of association of PKCzeta (protein kinase Czeta), with occludin by an ERK-dependent mechanism in differentiated cell monolayers, but not in under-differentiated cell monolayers. Hydrogen Peroxide 19-23 mitogen-activated protein kinase 1 Homo sapiens 157-160 21814482-0 2011 Dimerumic acid inhibits SW620 cell invasion by attenuating H2O2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Hydrogen Peroxide 59-63 mitogen-activated protein kinase 1 Homo sapiens 108-111 21814482-4 2011 Our results showed that increased MMP-7 expression due to H2O2 exposure was mediated by activation of mitogen-activated protein kinases (MAPKs) such as Jun N-terminal kinase (JNK), extracellular-regulated kinase (ERK), and p38 kinase. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 1 Homo sapiens 181-211 21241762-0 2011 Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Hydrogen Peroxide 25-42 mitogen-activated protein kinase 1 Homo sapiens 99-102 22146720-9 2011 Taken together, these results indicate that mangiferin attenuated H(2)O(2)-induced MMP-1 activation via inhibition of ERK and JNK pathway and AP-1. Hydrogen Peroxide 66-74 mitogen-activated protein kinase 1 Homo sapiens 118-121 21814482-4 2011 Our results showed that increased MMP-7 expression due to H2O2 exposure was mediated by activation of mitogen-activated protein kinases (MAPKs) such as Jun N-terminal kinase (JNK), extracellular-regulated kinase (ERK), and p38 kinase. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 1 Homo sapiens 213-216 21814482-6 2011 Moreover, H2O2-triggered MMP-7 production was demonstrated via JNK/c-Jun and ERK/c-Fos activation in an activating protein 1 (AP-1)-dependent manner. Hydrogen Peroxide 10-14 mitogen-activated protein kinase 1 Homo sapiens 77-80 21814482-7 2011 Taken together, these results suggest that DMA suppresses H2O2-induced cell invasion by inhibiting AP-1-mediated MMP-7 gene transcription via the JNK/c-Jun and ERK/c-Fos signaling pathways in SW620 human colon cancer cells. Hydrogen Peroxide 58-62 mitogen-activated protein kinase 1 Homo sapiens 160-163