PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32942847-7 2020 Moreover, in vitro experiments demonstrated that pretreatment of H2O2-treated NIH/3T3 cells with KF-8 significantly mitigated the NF-kappaB signaling and attenuated the Nrf2 nuclear transport (both p < 0.05). Hydrogen Peroxide 65-69 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 130-139 35091064-7 2022 The mechanistic effect of HMGB2 was studied in the 661w cell line treated with H2O2, showing that exogenous recombinant HMGB2 protein reduced the expressions of the antioxidant protein nuclear erythroid factor 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1), and induced NF-kappaB/NLRP3 signaling pathway. Hydrogen Peroxide 79-83 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 299-308 30818058-5 2019 Also, Tat-CIAPIN1 protein enhances cell survival via the regulation of Akt, MAPK, NF-kappaB and apoptotic signaling pathways in the H2O2 treated cells. Hydrogen Peroxide 132-136 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 82-91 30196988-8 2018 Nuclear translocation of NF-kappaB was inhibited possibly as a result of enhanced levels of hydrogen peroxide (H2O2) and nitric oxide (NO) in HEMA-exposed cells. Hydrogen Peroxide 92-109 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 25-34 30411846-11 2019 CO reduces the NF-kappaB-mediated transcription of BACE1 induced by the cholesterol oxidation product 27-hydroxycholesterol or hydrogen peroxide. Hydrogen Peroxide 127-144 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-24 30196988-8 2018 Nuclear translocation of NF-kappaB was inhibited possibly as a result of enhanced levels of hydrogen peroxide (H2O2) and nitric oxide (NO) in HEMA-exposed cells. Hydrogen Peroxide 111-115 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 25-34 28115850-9 2017 TLR4/NF-kappaB and Nrf2 pathways were upregulated with high-fat diet intake in mice, resulting in reduction of superoxide dismutase activity and increase in superoxide radical, H2O2, malondialdehyde, XO, XDH, and XO/XDH ratio. Hydrogen Peroxide 177-181 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 5-14 28222108-14 2017 Proteasome inhibition by H2O2 causes p62-NFkappaB signaling as antioxidant pre-treatment reversed p62 expression and p65 phosphorylation when RPE was challenged by H2O2 but not when by Lactacystin. Hydrogen Peroxide 25-29 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 41-49 28222108-14 2017 Proteasome inhibition by H2O2 causes p62-NFkappaB signaling as antioxidant pre-treatment reversed p62 expression and p65 phosphorylation when RPE was challenged by H2O2 but not when by Lactacystin. Hydrogen Peroxide 164-168 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 41-49 28960786-7 2018 Pharmacological inhibition of NF-kappaB signalling attenuated the increase in CXCL1 gene expression induced by palmitate and hydrogen peroxide. Hydrogen Peroxide 125-142 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 30-39 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 38-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 59-72 27412767-2 2016 In agreement, we hereby demonstrate that, in adrenocortical Y1 cells, HO-1 induction correlates with a significant prevention of the generation of reactive oxygen species induced by H2O2/Fe(2+) ACTH/cAMP-dependent activation of redox-imbalanced related factors such as NRF2 or NFkappaB and the participation of MAPKs in this mechanism was, however, discarded based on results with specific inhibitors and reporter plasmids. Hydrogen Peroxide 182-186 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 277-285 26718031-0 2016 Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-kappaB. Hydrogen Peroxide 47-51 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 119-128 26718031-14 2016 Taken together, the findings of this study indicate that crocin prevented H2O2-induced damage to RGCs through the mitochondrial pathway and activation of NF-kappaB. Hydrogen Peroxide 74-78 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 154-163 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 38-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-126 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 38-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-126 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 202-207 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 59-72 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 202-207 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-126 25331559-3 2015 Microglia exposed to steady fluxes of H2 O2 showed altered NF-kappaB p50 protein-protein interactions, decreased NF-kappaB p50 DNA binding, and augmented late-stage TNFalpha expression, indicating that H2 O2 impairs NF-kappaB p50 function and prolongs amplified M1 activation. Hydrogen Peroxide 202-207 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-126 18620044-8 2008 Our data suggest that H(2)O(2) modulates IKK-dependent NF-kappaB activation by promoting the redox-sensitive activation of the PI3K/PTEN/Akt and NIK/IKK pathways. Hydrogen Peroxide 22-30 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 55-64 25714462-3 2015 Depletion of Nck prevented oxidative stress induced by exogenous hydrogen peroxide or hypoxia/reoxygenation injury from activating NF-kappaB in endothelial cells, increasing the abundance of the proinflammatory molecules ICAM-1 (intracellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) and recruiting leukocytes. Hydrogen Peroxide 65-82 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 131-140 24627968-12 2014 CONCLUSIONS AND IMPLICATIONS: H2O2 stimulated UCB-MSCs motility by increasing MMP12-dependent degradation of COL-5 and FN through the activation of NF-kappaB and glycogen synthase kinase-3beta/beta-catenin, which is critical for providing a suitable microenvironment for MSCs transplantation and re-epithelialization of skin wounds in mice. Hydrogen Peroxide 30-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 148-192 24572641-10 2014 In this study, Western Blot assay showed that HEB could inhibit the activation of NF-kappaB signal pathway stimulated by H2O2 in mouse spleen cells through suppressing NF-kappaB (p65) translocation into nucleus and NF-kappa-B inhibitor (IkappaB) degradation in cytoplasm. Hydrogen Peroxide 121-125 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 82-91 24572641-10 2014 In this study, Western Blot assay showed that HEB could inhibit the activation of NF-kappaB signal pathway stimulated by H2O2 in mouse spleen cells through suppressing NF-kappaB (p65) translocation into nucleus and NF-kappa-B inhibitor (IkappaB) degradation in cytoplasm. Hydrogen Peroxide 121-125 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 168-177 24572641-10 2014 In this study, Western Blot assay showed that HEB could inhibit the activation of NF-kappaB signal pathway stimulated by H2O2 in mouse spleen cells through suppressing NF-kappaB (p65) translocation into nucleus and NF-kappa-B inhibitor (IkappaB) degradation in cytoplasm. Hydrogen Peroxide 121-125 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 215-225 24333630-5 2014 H2O2 activated NFkappaB and its translocation into the nucleus of L6 muscle cells suggesting that NFkappaB mediates the H2O2-induced overexpression of ICAM-1. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-23 24333630-5 2014 H2O2 activated NFkappaB and its translocation into the nucleus of L6 muscle cells suggesting that NFkappaB mediates the H2O2-induced overexpression of ICAM-1. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 98-106 24333630-5 2014 H2O2 activated NFkappaB and its translocation into the nucleus of L6 muscle cells suggesting that NFkappaB mediates the H2O2-induced overexpression of ICAM-1. Hydrogen Peroxide 120-124 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 15-23 24333630-5 2014 H2O2 activated NFkappaB and its translocation into the nucleus of L6 muscle cells suggesting that NFkappaB mediates the H2O2-induced overexpression of ICAM-1. Hydrogen Peroxide 120-124 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 98-106 21831045-11 2012 The results reflect that intracellular production of H2O2 in oxidative tumour micro-environment regulates NF-kappaB activation. Hydrogen Peroxide 53-57 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-115 21599461-3 2011 The effects of H(2)O(2) exposure on lymphocytes may be partly mediated by oxidative modulation of the NFkappaB signal transduction pathway, which also plays a role in Ig heavy chain (Igh) gene expression. Hydrogen Peroxide 15-23 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 102-110 21599461-6 2011 Furthermore, suppressive H(2)O(2) concentrations increased protein levels of the p50 NFkappaB sub-unit, IkappaBalpha, and an IkappaBalpha immunoreactive band which was previously characterized as an IkappaBalpha cleavage product exhibiting stronger inhibitory function than native IkappaBalpha. Hydrogen Peroxide 25-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 85-93 18620044-0 2008 The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation. Hydrogen Peroxide 211-219 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 50-59 24825375-7 2014 The findings of the study indicate that the mRNA expression of TNF-alpha and NF-kappaB are significantly (p < 0.05) increased in H2O2-induced C2C12 cells, whereas a significant decrease (p < 0.05) in these mRNA expressions are observed when pretreated with T.peptide or MPG peptide. Hydrogen Peroxide 132-136 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-86 21919816-7 2012 The results showed that H2O2 or t-PA alone caused a significant increase in NF-kappaB translocation to the nucleus, whereas the combination of t-PA and H2O2 increased the translocation of NF-kappaB to an even greater extent. Hydrogen Peroxide 24-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 76-85 21919816-7 2012 The results showed that H2O2 or t-PA alone caused a significant increase in NF-kappaB translocation to the nucleus, whereas the combination of t-PA and H2O2 increased the translocation of NF-kappaB to an even greater extent. Hydrogen Peroxide 24-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 188-197 21919816-7 2012 The results showed that H2O2 or t-PA alone caused a significant increase in NF-kappaB translocation to the nucleus, whereas the combination of t-PA and H2O2 increased the translocation of NF-kappaB to an even greater extent. Hydrogen Peroxide 152-156 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 188-197 20569277-4 2010 Exposure of cells to hydrogen peroxide 24 hrs after the curcumin treatment decreased caspase-12 activation, total protein oxidation and translocation of NF-kappaB to the nucleus, compared with untreated cells. Hydrogen Peroxide 21-38 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 153-162 18716444-8 2008 H2O2 also increased the phosphorylation of p38 MAPK, SAPK/JNK and nuclear factor kappa B (NF-kappaB), but DHT blocked these effects. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 66-88 18716444-8 2008 H2O2 also increased the phosphorylation of p38 MAPK, SAPK/JNK and nuclear factor kappa B (NF-kappaB), but DHT blocked these effects. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 90-99 18716444-11 2008 In conclusion, DHT may partially prevent H2O2-induced cell injury through inhibition of ROS and ROS-induced activation of p38 MAPK, SAPK/JNK and NF-kappaB in mouse ES cells. Hydrogen Peroxide 41-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 145-154 18620044-9 2008 These findings further provide new insights into the pathophysiological role of intracellular H(2)O(2) in the NF-kappaB signal pathway and inflammatory process. Hydrogen Peroxide 94-102 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 110-119 18754865-0 2008 Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis. Hydrogen Peroxide 0-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 42-48 18754865-8 2008 These findings indicate for the first time that NF-kappaB, a key agent regulating the expression of various molecules involved in tumor metastasis, is activated in both liver and tumor cells during the initial stages of tumor metastasis through a hydrogen peroxide mediated pathway. Hydrogen Peroxide 247-264 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 48-57 18330893-12 2008 Catalase inhibited the effect of H2O2 on MAPKs and NF-kappaB. Hydrogen Peroxide 33-37 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 51-60 18330893-11 2008 H2O2 also increased the level of p38 MAPK, JNK/SAPK, and NF-kappaB phosphorylation, which were inhibited by the DHT pretreatment. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 57-66 18330893-13 2008 However, the flutamide treatment abolished the inhibitory effects of DHT on the H2O2-induced increase in the levels of p38 MAPK, JNK/SAPK, and NF-kappaB phosphorylation. Hydrogen Peroxide 80-84 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 143-152 18330893-16 2008 In conclusion, DHT prevents the H2O2-induced apoptotic cell death of mouse ES cells through the activation of catalase and the downregulation of p38 MAPK, JNK/SAPK, and NF-kappaB via the androgen receptor. Hydrogen Peroxide 32-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 169-178 17977619-4 2008 In the cells treated with H(2)O(2), significant increases in the immunoreactivities of DJ-1 and nuclear factor-kappaB (NF-kappaB) subunits (p65 and p50) were observed in the nuclear fraction. Hydrogen Peroxide 26-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 148-151 17640975-8 2007 In vitro, isolated liver macrophages showed increased DNA binding activity of NF-kappaB and inflammatory cytokine production after hydrogen peroxide treatment; both increases were inhibited significantly by the NF-kappaB decoy. Hydrogen Peroxide 131-148 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 78-87 17640975-8 2007 In vitro, isolated liver macrophages showed increased DNA binding activity of NF-kappaB and inflammatory cytokine production after hydrogen peroxide treatment; both increases were inhibited significantly by the NF-kappaB decoy. Hydrogen Peroxide 131-148 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 211-220 17975303-10 2007 In conclusion, H(2)O(2) increases the 2-DG uptake via MAPKs, cPLA(2), and NF-kappaB signaling pathways in mouse ES cells. Hydrogen Peroxide 15-23 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 74-83 17392377-4 2007 Exposure of bone marrow or peritoneal neutrophils to H(2)O(2) was associated with reduced nuclear translocation of NF-kappaB and decreased production of the NF-kappaB-dependent cytokines TNF-alpha and macrophage inhibitory protein-2. Hydrogen Peroxide 53-61 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 115-124 17392377-4 2007 Exposure of bone marrow or peritoneal neutrophils to H(2)O(2) was associated with reduced nuclear translocation of NF-kappaB and decreased production of the NF-kappaB-dependent cytokines TNF-alpha and macrophage inhibitory protein-2. Hydrogen Peroxide 53-61 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 157-166 17499901-0 2007 Dexamethasone protects RAW264.7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear factor-kappa B (NF-kappaB) activity. Hydrogen Peroxide 88-92 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 158-180 17499901-0 2007 Dexamethasone protects RAW264.7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear factor-kappa B (NF-kappaB) activity. Hydrogen Peroxide 88-92 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 182-191 17975303-0 2007 Hydrogen peroxide increases [3H]-2-deoxyglucose uptake via MAPKs, cPLA2, and NF-kappaB signaling pathways in mouse embryonic stem cells. Hydrogen Peroxide 0-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 77-86 17392377-0 2007 Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Hydrogen Peroxide 12-29 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 41-50 16094314-13 2006 We suggest that SOD1 deficiency impairs H2O2-mediated activation of NF-kappaB, decreasing death-promoting signals, and leading to better outcome. Hydrogen Peroxide 40-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 14656721-10 2004 This inhibition of nuclear accumulation of NF-kappaB by H2O2 was not caused by an impaired capacity of LPS to stimulate the IKK pathway or to direct oxidative effects on NF-kappaB but rather reflected diminished degradation of IkappaB-alpha. Hydrogen Peroxide 56-60 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 43-52 16249388-4 2006 Although nuclear expression of both p50 and p65 NF-kappaB increased on H2O2 exposure, nuclear c-rel level was inhibited. Hydrogen Peroxide 71-75 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 36-39 15746559-9 2005 These data show that activation of NF-kappaB mediates H2O2-induced necrotic injury, but inhibits apoptotic cell death in renal collecting duct cells, and that Bcl-2 selectively protects apoptotic cell death in M-1 cells. Hydrogen Peroxide 54-58 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 35-44 14656721-0 2004 Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Hydrogen Peroxide 58-62 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 94-103 14656721-8 2004 Exposure of LPS- or TNF-alpha-stimulated neutrophils to H2O2 decreased nuclear translocation of NF-kappaB. Hydrogen Peroxide 56-60 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 96-105 14656721-10 2004 This inhibition of nuclear accumulation of NF-kappaB by H2O2 was not caused by an impaired capacity of LPS to stimulate the IKK pathway or to direct oxidative effects on NF-kappaB but rather reflected diminished degradation of IkappaB-alpha. Hydrogen Peroxide 56-60 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 170-179 12532330-0 2003 Raf-independent and MEKK1-dependent activation of NF-kappaB by hydrogen peroxide in 70Z/3 pre-B lymphocyte tumor cells. Hydrogen Peroxide 63-80 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 50-59 12626583-8 2003 Furthermore, H(2)O(2) inhibition by catalase attenuated the acute WT PMN recruitment and the induction of NF-kappa B and TNF-alpha much more than integrin (CD18) blockade, indicating a role for the respiratory burst before integrin-dependent accumulation. Hydrogen Peroxide 13-21 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-116 12532330-5 2003 Especially, MEK1 may contribute to H(2)O(2)-induced NF-kappaB activation as shown in the inhibition of NF-kappaB binding activity by the MEK1 inhibitor, PD 98059, and H(2)O(2)-induced MEK1 activation. Hydrogen Peroxide 35-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 52-61 12532330-5 2003 Especially, MEK1 may contribute to H(2)O(2)-induced NF-kappaB activation as shown in the inhibition of NF-kappaB binding activity by the MEK1 inhibitor, PD 98059, and H(2)O(2)-induced MEK1 activation. Hydrogen Peroxide 35-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 103-112 12532330-5 2003 Especially, MEK1 may contribute to H(2)O(2)-induced NF-kappaB activation as shown in the inhibition of NF-kappaB binding activity by the MEK1 inhibitor, PD 98059, and H(2)O(2)-induced MEK1 activation. Hydrogen Peroxide 167-175 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 52-61 12532330-5 2003 Especially, MEK1 may contribute to H(2)O(2)-induced NF-kappaB activation as shown in the inhibition of NF-kappaB binding activity by the MEK1 inhibitor, PD 98059, and H(2)O(2)-induced MEK1 activation. Hydrogen Peroxide 167-175 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 103-112 12532330-10 2003 Therefore, our data suggest that H(2)O(2) regulates the activity of NF-kappaB by MEK1 activation through MEKK1-dependent but Ras/Raf-independent mechanism. Hydrogen Peroxide 33-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 12453183-5 2002 We further show that the nuclear levels of the redox sensitive transcription factor NF-kappa B is regulated by H2O2 formed by the action of gamma-GT: stimulation and inhibition of gamma-GT affect the levels of NF-kappa B. Hydrogen Peroxide 111-115 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 84-94 12471138-0 2002 Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5"-monophosphate (cAMP)-dependent pathways: involvement of NF-kappa B, activator protein 1, and cAMP response element binding protein. Hydrogen Peroxide 0-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 196-227 12453183-5 2002 We further show that the nuclear levels of the redox sensitive transcription factor NF-kappa B is regulated by H2O2 formed by the action of gamma-GT: stimulation and inhibition of gamma-GT affect the levels of NF-kappa B. Hydrogen Peroxide 111-115 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 210-220 11479295-5 2001 Importantly, in the presence of H(2)O(2), the ability of TNFalpha to induce IKK activity was markedly decreased and resulted in prevention of IkappaBalpha degradation and NF-kappaB activation. Hydrogen Peroxide 32-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 171-180 10092673-6 1999 Partial inhibition of NF-kappaB baseline activity by overexpression of a dominant-negative IkappaBalpha mutant enhanced the toxicity of H2O2 in GT1-7 cells. Hydrogen Peroxide 136-140 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 22-31 10569191-6 1999 Pretreatment of the cells with catalase (H2O2 scavenger) or deferoxamine (*OH scavenger) effectively inhibits NF-kappaB and TNFalpha activation, whereas superoxide dismutase (O2 scavenger) has an opposite effect. Hydrogen Peroxide 41-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 110-119 11587565-9 2001 Exogenous H(2)O(2) induced NF-kappa B activation in macrophages, which was inhibited by catalase and pyrroline dithiocarbamate (PDTC). Hydrogen Peroxide 10-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 27-37 11587565-11 2001 These findings suggest that H(2)O(2) production from LPS-stimulated macrophages participates in the upregulation of iNOS expression via NF-kappa B activation and that NO is a negative feedback inhibitor of iNOS protein expression. Hydrogen Peroxide 28-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 136-146 9657527-7 1998 Catalase 1 kU/ml inhibited NF-kappaB activation by TNF-alpha; exogenous hydrogen peroxide 200 microM activated NF-kappaB and stimulated I-kappaBalpha degradation. Hydrogen Peroxide 72-89 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 111-120 9719433-7 1998 A second phase of nuclear transfer of NF-kappaB was observed at 3 h of cisplatin treatment which was dependent on H2O2 production in cisplatin-treated macrophages. Hydrogen Peroxide 114-118 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 38-47 9466823-0 1998 Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Hydrogen Peroxide 38-55 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 67-77 9466823-1 1998 In macrophages, hydrogen peroxide appears to be a physiological activator of the transcription factor, nuclear factor kappa B (NF-kappa B); however, the molecular basis of H2O2-stimulated NF-kappa B activation is not well defined. Hydrogen Peroxide 16-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 103-125 9466823-1 1998 In macrophages, hydrogen peroxide appears to be a physiological activator of the transcription factor, nuclear factor kappa B (NF-kappa B); however, the molecular basis of H2O2-stimulated NF-kappa B activation is not well defined. Hydrogen Peroxide 16-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 127-137 9466823-1 1998 In macrophages, hydrogen peroxide appears to be a physiological activator of the transcription factor, nuclear factor kappa B (NF-kappa B); however, the molecular basis of H2O2-stimulated NF-kappa B activation is not well defined. Hydrogen Peroxide 172-176 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 103-125 9466823-1 1998 In macrophages, hydrogen peroxide appears to be a physiological activator of the transcription factor, nuclear factor kappa B (NF-kappa B); however, the molecular basis of H2O2-stimulated NF-kappa B activation is not well defined. Hydrogen Peroxide 172-176 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 127-137 9466823-1 1998 In macrophages, hydrogen peroxide appears to be a physiological activator of the transcription factor, nuclear factor kappa B (NF-kappa B); however, the molecular basis of H2O2-stimulated NF-kappa B activation is not well defined. Hydrogen Peroxide 172-176 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 188-198 9466823-4 1998 Although PKC activity was modified by H2O2 with a similar time course as H2O2 activation of NF-kappa B, the H2O2-stimulated increase in NF-kappa B DNA binding and translocation to the nucleus was unaffected by PKC inhibitors. Hydrogen Peroxide 73-77 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 92-102 9466823-4 1998 Although PKC activity was modified by H2O2 with a similar time course as H2O2 activation of NF-kappa B, the H2O2-stimulated increase in NF-kappa B DNA binding and translocation to the nucleus was unaffected by PKC inhibitors. Hydrogen Peroxide 73-77 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 92-102 9430659-3 1998 Here we show that SLs prevented the activation of NF-kappa B by different stimuli such as phorbol esters, tumor necrosis factor-alpha, ligation of the T-cell receptor, and hydrogen peroxide in various cell types. Hydrogen Peroxide 172-189 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 50-60 7982975-6 1994 Although J774 cells responded to exogenously added rTNF-alpha, but not to H2O2, by activation of NF-kappa B, the recombinant TNF-alpha-mediated NF-kappa B activation was enhanced by simultaneous presence of H2O2. Hydrogen Peroxide 207-211 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 97-107 9512778-9 1998 The results indicate that silica-mediated free radical generation via the Fenton or Fenton-like reaction (M(n)+ + H2O2-->M(n + 1)+ + OH- + .OH) and silanol groups on the silica surface play an important role in silica-induced NF-kappa B activation. Hydrogen Peroxide 114-118 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 229-239 8872603-9 1996 Super-shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M1 cells treated with TPA bound to the TRE, and same assays using DNA with the NF-kappa B motif also revealed that the active NF-kappa B protein from M1 cells treated with H2O2 or TPA also bound to the corresponding motif. Hydrogen Peroxide 274-278 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 228-238 8774698-9 1996 Some oxidative reagents (e.g., H2O2) are strong activators of NF-kappa B, and therefore we treated M1 cells with H2O2. Hydrogen Peroxide 31-35 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 62-72 8774698-9 1996 Some oxidative reagents (e.g., H2O2) are strong activators of NF-kappa B, and therefore we treated M1 cells with H2O2. Hydrogen Peroxide 113-117 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 62-72 8774698-11 1996 Super-shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M1 cells treated with LPS and H2O2 bound weakly to the TRE motif, and, in assays with DNA that contained the NF-kappa B motif, nuclear protein from M1 cells treated with H2O2 or LPS bound strongly to the NF-kappa B motif. Hydrogen Peroxide 141-145 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 220-230 8774698-11 1996 Super-shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M1 cells treated with LPS and H2O2 bound weakly to the TRE motif, and, in assays with DNA that contained the NF-kappa B motif, nuclear protein from M1 cells treated with H2O2 or LPS bound strongly to the NF-kappa B motif. Hydrogen Peroxide 141-145 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 315-325 8774698-11 1996 Super-shift assays with DNA that contained the TRE motif revealed that the Fos and Jun proteins from nuclei of M1 cells treated with LPS and H2O2 bound weakly to the TRE motif, and, in assays with DNA that contained the NF-kappa B motif, nuclear protein from M1 cells treated with H2O2 or LPS bound strongly to the NF-kappa B motif. Hydrogen Peroxide 281-285 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 220-230 8774698-12 1996 These results strongly suggest that the HO gene in M1 cells is mainly activated by LPS through oxidative activation of NF-kappa B due to production of H2O2. Hydrogen Peroxide 151-155 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 119-129 7492966-12 1995 We show that binding of a p50/p65 complex to an NF-kappa B consensus sequence is enhanced by H2O2 treatment in NIH3T3 cells. Hydrogen Peroxide 93-97 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 26-29 7492966-12 1995 We show that binding of a p50/p65 complex to an NF-kappa B consensus sequence is enhanced by H2O2 treatment in NIH3T3 cells. Hydrogen Peroxide 93-97 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 48-58 7841193-3 1995 In agreement with earlier studies hydrogen peroxide activated NF kappa B in Jurkat, although only at much higher concentrations (10 mM) than those previously reported. Hydrogen Peroxide 34-51 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 62-72 8666828-5 1996 Two different lines of evidence show that ROIs, in particular H2O2, are second messengers for the anthralin-induced NF-(kappa)B activation. Hydrogen Peroxide 62-66 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-127 8855453-1 1996 H2O2 and other reduced oxygen species have been proposed as activators of the transcription factor, NF Kappa B. Hydrogen Peroxide 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 100-110 8855453-6 1996 Thus, H2O2 was the principal agent of respiratory burst-associated NF kappa B activation. Hydrogen Peroxide 6-10 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 67-77 8855453-8 1996 Exogenous H2O2 added as a bolus > or = 50 microM (> or = 50 nmol/10(6) macrophages) also activated NF kappa B in macrophages. Hydrogen Peroxide 10-14 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 105-115 8855453-10 1996 Thus, relatively little endogenous H2O2 generation was required to produce NF kappa B activation compared to the required amount of exogenous H2O2. Hydrogen Peroxide 35-39 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 75-85 7982975-6 1994 Although J774 cells responded to exogenously added rTNF-alpha, but not to H2O2, by activation of NF-kappa B, the recombinant TNF-alpha-mediated NF-kappa B activation was enhanced by simultaneous presence of H2O2. Hydrogen Peroxide 207-211 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 144-154 7926024-6 1994 (iii) The treatment of cells with low doses of hydrogen peroxide increased the NF kappa B binding activity. Hydrogen Peroxide 47-64 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 79-89 7926024-7 1994 (iv) Expression of a reporter gene in which the chloramphenicol acetyltransferase (CAT) gene was under the control of NF kappa B binding sites was induced by hydrogen peroxide. Hydrogen Peroxide 158-175 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 118-128 34904823-4 2022 Initial priming of microglial cells with LPS following treatment with H2O2 induced NF-kappaB translocation to the nucleus with a robust generation of free radicals that act as signal 2 in augmenting NLRP3 inflammasome assembly and its downstream targets. Hydrogen Peroxide 70-74 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 34537189-7 2022 More importantly, transfection of keratinocytes with dsDNA synergized with TNF-alpha or H2O2 to induce STING-dependent activation of NF-kappaB and subsequent expression of Il1b, Ccl20, and Cxcl10. Hydrogen Peroxide 88-92 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 133-142 8076691-2 1994 In mouse L cells, overexpression of Bcl-2 interfered with the activation of NF-kappa B by H2O2. Hydrogen Peroxide 90-94 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 76-86 34740611-4 2021 Using LPS, TNFalpha, different kinds of viruses, hydrogen peroxide or ultraviolet stimulation, we demonstrate that HDAC5-mediated regulation of NF-kappaB occurs in manners both dependent on and independent of IKK, an upstream kinase in the NF-kappaB signaling pathway. Hydrogen Peroxide 49-66 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 144-153