PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16123043-3 2005 Hydrogen peroxide and pervanadate (PV) treatment stimulates eNOS tyrosine phosphorylation in BAECs. Hydrogen Peroxide 0-17 nitric oxide synthase 3 Bos taurus 60-64 15304367-3 2004 We showed previously for the first time that calcium/calmodulin-dependent protein kinase II (CaMKII) is redox-sensitive in endothelial cells, mediating H(2)O(2) upregulation of endothelial nitric oxide synthase. Hydrogen Peroxide 152-160 nitric oxide synthase 3 Bos taurus 177-210 15242742-0 2004 Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. Hydrogen Peroxide 98-115 nitric oxide synthase 3 Bos taurus 41-74 15242742-1 2004 We have previously shown that hydrogen peroxide (H(2)O(2)) upregulates endothelial nitric oxide synthase (eNOS) expression via a calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated mechanism whereas it also acutely activates eNOS enzyme. Hydrogen Peroxide 30-47 nitric oxide synthase 3 Bos taurus 71-104 15242742-1 2004 We have previously shown that hydrogen peroxide (H(2)O(2)) upregulates endothelial nitric oxide synthase (eNOS) expression via a calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated mechanism whereas it also acutely activates eNOS enzyme. Hydrogen Peroxide 49-57 nitric oxide synthase 3 Bos taurus 71-104 12527803-0 2003 Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Hydrogen Peroxide 208-225 nitric oxide synthase 3 Bos taurus 171-204 10679488-0 2000 Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Hydrogen Peroxide 102-119 nitric oxide synthase 3 Bos taurus 54-87 11597928-0 2001 Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway. Hydrogen Peroxide 40-57 nitric oxide synthase 3 Bos taurus 13-36 11597928-1 2001 We have recently demonstrated that hydrogen peroxide (H(2)O(2)) is an extremely potent stimulus of endothelial NO synthase (eNOS) gene expression. Hydrogen Peroxide 35-52 nitric oxide synthase 3 Bos taurus 99-122 11597928-1 2001 We have recently demonstrated that hydrogen peroxide (H(2)O(2)) is an extremely potent stimulus of endothelial NO synthase (eNOS) gene expression. Hydrogen Peroxide 35-52 nitric oxide synthase 3 Bos taurus 124-128 11597928-3 2001 Induction of eNOS expression by H(2)O(2) was found to be Ca(2+) dependent, inasmuch as it was blocked by BAPTA-AM. Hydrogen Peroxide 32-40 nitric oxide synthase 3 Bos taurus 13-17 10679488-8 2000 Induction of eNOS by H(2)O(2) was not affected by the hydroxyl radical scavenger DMSO, mannitol, or N-tert-butyl-alpha-phenylnitrone, but it was inhibited by the antioxidants N-acetylcysteine, ebselen, and exogenously added catalase. Hydrogen Peroxide 21-29 nitric oxide synthase 3 Bos taurus 13-17 9647467-17 1998 The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation. Hydrogen Peroxide 78-95 nitric oxide synthase 3 Bos taurus 129-133 8910295-3 1996 Treatment of BAEC with hydrogen peroxide and the protein tyrosine phosphatase inhibitor, sodium orthovanadate, increases eNOS tyrosine phosphorylation. Hydrogen Peroxide 23-40 nitric oxide synthase 3 Bos taurus 121-125 20353820-0 2010 A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress. Hydrogen Peroxide 102-106 nitric oxide synthase 3 Bos taurus 42-75 20353820-1 2010 Previous studies have shown that acute increases in oxidative stress induced by the addition of hydrogen peroxide (H(2)O(2)) can increase endothelial nitric oxide synthase (eNOS) catalytic activity via an increase in the phosphorylation of eNOS at serine 1177. Hydrogen Peroxide 96-113 nitric oxide synthase 3 Bos taurus 138-171 20353820-1 2010 Previous studies have shown that acute increases in oxidative stress induced by the addition of hydrogen peroxide (H(2)O(2)) can increase endothelial nitric oxide synthase (eNOS) catalytic activity via an increase in the phosphorylation of eNOS at serine 1177. Hydrogen Peroxide 96-113 nitric oxide synthase 3 Bos taurus 173-177 20353820-1 2010 Previous studies have shown that acute increases in oxidative stress induced by the addition of hydrogen peroxide (H(2)O(2)) can increase endothelial nitric oxide synthase (eNOS) catalytic activity via an increase in the phosphorylation of eNOS at serine 1177. Hydrogen Peroxide 96-113 nitric oxide synthase 3 Bos taurus 240-244 20353820-5 2010 This amplification in NO signaling was found to correlate with an H(2)O(2)-induced increase in eNOS localized to the plasma membrane and an increase in total caveolin-1 protein levels. Hydrogen Peroxide 66-74 nitric oxide synthase 3 Bos taurus 95-99 20353820-11 2010 To our knowledge, this is the first report that H(2)O(2) modulates eNOS activity by altering its subcellular location and that caveolin-1 can play a stimulatory role in NO signaling. Hydrogen Peroxide 48-56 nitric oxide synthase 3 Bos taurus 67-71 17614833-0 2007 The presence of melatonin receptors and inhibitory effect of melatonin on hydrogen peroxide-induced endothelial nitric oxide synthase expression in bovine cerebral blood vessels. Hydrogen Peroxide 74-91 nitric oxide synthase 3 Bos taurus 100-133 17614833-2 2007 Therefore, in the present study, we have identified the existence of melatonin receptors and test the effect of melatonin on hydrogen peroxide-induced endothelial nitric oxide synthase (eNOS) expression in bovine cerebral arteries. Hydrogen Peroxide 125-142 nitric oxide synthase 3 Bos taurus 151-184