PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15653642-7	2005	On treatment of metaphase cells with H2O2, XRCC1 and DNA ligase IIIalpha translocate immediately from the centrosomes to mitotic chromosomes.	Hydrogen Peroxide	37-41	X-ray repair cross complementing 1	Homo sapiens	43-48	
15867196-5	2005	A reduction in XRCC1 protein levels resulted in decreased SSBR capacity as measured by the comet assay and intracellular NAD(P)H levels, hypersensitivity to the cell killing effects of the DNA damaging agents methyl methanesulfonate (MMS), hydrogen peroxide and ionizing radiation and enhanced formation of micronuclei following exposure to MMS.	Hydrogen Peroxide	240-257	X-ray repair cross complementing 1	Homo sapiens	15-20	
29761828-6	2018	The percentages of cells exhibiting micronuclei in the base excision repair- and single strand break repair-deficient XRCC1-/- cells after exposure to H2 O2 , MMC and MMS were all ~5 times higher than those of wild-type cells.	Hydrogen Peroxide	151-156	X-ray repair cross complementing 1	Homo sapiens	118-123	
27268481-0	2016	SNF2H interacts with XRCC1 and is involved in repair of H2O2-induced DNA damage.	Hydrogen Peroxide	56-60	X-ray repair cross complementing 1	Homo sapiens	21-26	
29100039-9	2017	Xrcc1-/- cells are hypersensitive to the DNA-protein cross-link inducing agent camptothecin (CPT) and the DNA oxidative agent H2O2 due in part to compromised PNKP-mediated repair.	Hydrogen Peroxide	126-130	X-ray repair cross complementing 1	Homo sapiens	0-5	
28866241-5	2017	We show that APEH interacts with the amino-terminal domain of XRCC1, and that APEH facilitates both single-strand break repair and cell survival following exposure to H2O2 in human cells.	Hydrogen Peroxide	167-171	X-ray repair cross complementing 1	Homo sapiens	62-67	
27965414-7	2017	Notably, concentrations of PARP inhibitor >1000-fold higher than the IC50 were required to ablate both ADP-ribosylation and XRCC1 chromatin binding following H2O2 treatment.	Hydrogen Peroxide	161-165	X-ray repair cross complementing 1	Homo sapiens	127-132	
27268481-4	2016	The proficiency of repairing H2O2-induced damage was strongly impaired by SNF2H knock-down, and similar impairment was observed with knock-down of both XRCC1 and SNF2H simultaneously, suggesting their role in a common repair pathway.	Hydrogen Peroxide	29-33	X-ray repair cross complementing 1	Homo sapiens	152-157	
20705543-6	2010	RESULTS: XRCC1 knockdown sensitized cells to the clastogenic and cytotoxic effects of oxidants [hydrogen peroxide (H2O2), bleomycin] but not to the nonoxidant paclitaxel.	Hydrogen Peroxide	96-113	X-ray repair cross complementing 1	Homo sapiens	9-14	
20705543-6	2010	RESULTS: XRCC1 knockdown sensitized cells to the clastogenic and cytotoxic effects of oxidants [hydrogen peroxide (H2O2), bleomycin] but not to the nonoxidant paclitaxel.	Hydrogen Peroxide	115-119	X-ray repair cross complementing 1	Homo sapiens	9-14	
26130715-5	2015	We also show that the phosphate-binding pocket is required for EGFP-XRCC1 accumulation at DNA damage induced by UVA laser, H2O2, and at sites of sub-nuclear PCNA foci, suggesting that poly (ADP-ribose) promotes XRCC1 recruitment both at single-strand breaks globally across the genome and at sites of DNA replication stress.	Hydrogen Peroxide	123-127	X-ray repair cross complementing 1	Homo sapiens	63-73	
26130715-5	2015	We also show that the phosphate-binding pocket is required for EGFP-XRCC1 accumulation at DNA damage induced by UVA laser, H2O2, and at sites of sub-nuclear PCNA foci, suggesting that poly (ADP-ribose) promotes XRCC1 recruitment both at single-strand breaks globally across the genome and at sites of DNA replication stress.	Hydrogen Peroxide	123-127	X-ray repair cross complementing 1	Homo sapiens	68-73	
19596613-7	2009	After hydrogen peroxide treatment, hyperphosphorylated XRCC1 appeared in the NM and accordingly, those in the chromatin fraction decreased.	Hydrogen Peroxide	6-23	X-ray repair cross complementing 1	Homo sapiens	55-60