PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26433932-9 2015 Moreover, markers of oxidative stress were increased in vulnerable brain regions of ANPC mice and enhanced beta-CTF/Abeta levels increased susceptibility of N2a-ANPC cells to H2O2-induced toxicity. Hydrogen Peroxide 175-179 amyloid beta (A4) precursor protein Mus musculus 116-121 26581638-5 2016 MTZ prevented DNA fragmentation, CytC release and activation of caspase 9 and caspase 3 induced by Abeta in neuronal and glial cells in culture through the inhibition of mitochondrial hydrogen peroxide production. Hydrogen Peroxide 184-201 amyloid beta (A4) precursor protein Mus musculus 99-104 26104799-12 2015 Moreover, Cu(II)-Abeta induced hydrogen peroxide release, which was not affected by NADPH oxidase inhibitors. Hydrogen Peroxide 31-48 amyloid beta (A4) precursor protein Mus musculus 17-22 21297255-3 2011 In cultured dissociated rat cortical neurons and rat and mouse hippocampal organotypic slices, we apply the assay to measure the production of Abeta in response to treatment with hydrogen peroxide, a known stimulator of Abeta secretion, or human Abeta dimer/trimer (Abetad/t), fractionated from the culture medium of 7PA2 cells. Hydrogen Peroxide 179-196 amyloid beta (A4) precursor protein Mus musculus 143-148 21297255-3 2011 In cultured dissociated rat cortical neurons and rat and mouse hippocampal organotypic slices, we apply the assay to measure the production of Abeta in response to treatment with hydrogen peroxide, a known stimulator of Abeta secretion, or human Abeta dimer/trimer (Abetad/t), fractionated from the culture medium of 7PA2 cells. Hydrogen Peroxide 179-196 amyloid beta (A4) precursor protein Mus musculus 220-225 20164595-4 2010 Here, we observed that the cells bearing high level of Abeta were more vulnerable than the controls to H2O2-induced apoptosis, and this effect of Abeta was associated with decrease of Bcl-2, elevation of Bax and cytosolic cytochrome-c, as well as activation of caspase-3, suggesting that Abeta could potentiate the oxidant-induced cell apoptosis with involvement of mitochondria-caspase-3 pathway. Hydrogen Peroxide 103-107 amyloid beta (A4) precursor protein Mus musculus 55-60 20164595-4 2010 Here, we observed that the cells bearing high level of Abeta were more vulnerable than the controls to H2O2-induced apoptosis, and this effect of Abeta was associated with decrease of Bcl-2, elevation of Bax and cytosolic cytochrome-c, as well as activation of caspase-3, suggesting that Abeta could potentiate the oxidant-induced cell apoptosis with involvement of mitochondria-caspase-3 pathway. Hydrogen Peroxide 103-107 amyloid beta (A4) precursor protein Mus musculus 146-151 20164595-4 2010 Here, we observed that the cells bearing high level of Abeta were more vulnerable than the controls to H2O2-induced apoptosis, and this effect of Abeta was associated with decrease of Bcl-2, elevation of Bax and cytosolic cytochrome-c, as well as activation of caspase-3, suggesting that Abeta could potentiate the oxidant-induced cell apoptosis with involvement of mitochondria-caspase-3 pathway. Hydrogen Peroxide 103-107 amyloid beta (A4) precursor protein Mus musculus 146-151 16127459-3 2005 Abeta binds Cu2+ with very high affinity, forming a redox-active complex that catalyzes H2O2 production from O2 and cholesterol. Hydrogen Peroxide 88-92 amyloid beta (A4) precursor protein Mus musculus 0-5 17886039-2 2007 The role of hydrogen peroxide (H(2)O(2)) in AD is thought to be associated with Abeta (amyloid - beta) damage in cells. Hydrogen Peroxide 12-29 amyloid beta (A4) precursor protein Mus musculus 80-101 16551656-6 2006 Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice. Hydrogen Peroxide 0-17 amyloid beta (A4) precursor protein Mus musculus 174-179 16551656-6 2006 Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice. Hydrogen Peroxide 0-17 amyloid beta (A4) precursor protein Mus musculus 220-225 16551656-6 2006 Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice. Hydrogen Peroxide 267-284 amyloid beta (A4) precursor protein Mus musculus 174-179 16551656-6 2006 Hydrogen peroxide levels were found to be significantly increased in Tg2576 mice when compared with age-matched WT littermates and directly correlated with levels of soluble Abeta in Tg2576 mice, suggesting that soluble Abeta may be responsible for the production of hydrogen peroxide in AD progression in Tg2576 mice. Hydrogen Peroxide 267-284 amyloid beta (A4) precursor protein Mus musculus 220-225 21207670-3 2003 RESULTS: Concentration-dependent toxicity was induced with H2O2 treatment for 24 h. The neurotoxicity of H2O2 was increased by about 10 times with cotreatment neurons with amyloid beta-protein fragment 25-35 (Abeta(25-35)). Hydrogen Peroxide 105-109 amyloid beta (A4) precursor protein Mus musculus 209-214 32434556-5 2020 Reducing Abeta and tau levels by combination of exercise and 40-Hz light flickering improves Ca2+ homeostasis and reactive oxygen species such as H2O2 in mitochondria and apoptosis including bax, bcl-2, cytochrome c, and cleaved caspase-3 and cell death, cell differentiation, and neurogenesis in the 3xTg-AD model of the hippocampus, resulting in improving cognitive impairment such as spatial learning, memory and long term memory. Hydrogen Peroxide 146-150 amyloid beta (A4) precursor protein Mus musculus 9-14 12215434-2 2002 Copper and iron levels both show marked increases with age and may adversely interact with the amyloid-beta (Abeta) peptide causing its aggregation and the production of neurotoxic hydrogen peroxide (H(2)O(2)), contributing to the pathogenesis of AD. Hydrogen Peroxide 181-198 amyloid beta (A4) precursor protein Mus musculus 109-114