PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28765965-6 2017 SMP30 mRNA expression levels were significantly downregulated following exposure to 75 and 100 microM H2O2, and the protein expression levels in the same groups were decreased by >6-fold compared with the control untreated cells. Hydrogen Peroxide 102-106 regucalcin Homo sapiens 0-5 32679123-5 2020 The treatment of nifedipine dose-dependently suppressed H2O2-induced senescence by reducing Ca2+ entry, autophagy impairment and mTOR signaling, and this suppression was found to be related to senescence-associated beta-galactosidase (SA-beta-gal) activity and the expressions of senescence marker protein 30 (SMP30), p53, and p21. Hydrogen Peroxide 56-60 regucalcin Homo sapiens 280-308 32679123-5 2020 The treatment of nifedipine dose-dependently suppressed H2O2-induced senescence by reducing Ca2+ entry, autophagy impairment and mTOR signaling, and this suppression was found to be related to senescence-associated beta-galactosidase (SA-beta-gal) activity and the expressions of senescence marker protein 30 (SMP30), p53, and p21. Hydrogen Peroxide 56-60 regucalcin Homo sapiens 310-315 31908576-5 2020 In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways. Hydrogen Peroxide 19-36 regucalcin Homo sapiens 209-214 28765965-8 2017 These results suggest that, in the early stage of senescence induced by H2O2-mediated chronic oxidative stress, there may be no significant change in SMP30 expression, but when the oxidative stress increases and senescence is aggravated, SMP30 may be significantly downregulated in the senescent HLECs. Hydrogen Peroxide 72-76 regucalcin Homo sapiens 238-243