PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31908576-5	2020	In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways.	Hydrogen Peroxide	19-36	regucalcin	Homo sapiens	209-214	
32679123-5	2020	The treatment of nifedipine dose-dependently suppressed H2O2-induced senescence by reducing Ca2+ entry, autophagy impairment and mTOR signaling, and this suppression was found to be related to senescence-associated beta-galactosidase (SA-beta-gal) activity and the expressions of senescence marker protein 30 (SMP30), p53, and p21.	Hydrogen Peroxide	56-60	regucalcin	Homo sapiens	280-308	
32679123-5	2020	The treatment of nifedipine dose-dependently suppressed H2O2-induced senescence by reducing Ca2+ entry, autophagy impairment and mTOR signaling, and this suppression was found to be related to senescence-associated beta-galactosidase (SA-beta-gal) activity and the expressions of senescence marker protein 30 (SMP30), p53, and p21.	Hydrogen Peroxide	56-60	regucalcin	Homo sapiens	310-315	
28765965-6	2017	SMP30 mRNA expression levels were significantly downregulated following exposure to 75 and 100 microM H2O2, and the protein expression levels in the same groups were decreased by >6-fold compared with the control untreated cells.	Hydrogen Peroxide	102-106	regucalcin	Homo sapiens	0-5	
28765965-8	2017	These results suggest that, in the early stage of senescence induced by H2O2-mediated chronic oxidative stress, there may be no significant change in SMP30 expression, but when the oxidative stress increases and senescence is aggravated, SMP30 may be significantly downregulated in the senescent HLECs.	Hydrogen Peroxide	72-76	regucalcin	Homo sapiens	238-243