PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19933270-6 2010 Exposure to H(2)O(2) resulted in oxidative modification of cysteine residues in beta-TrCP. Hydrogen Peroxide 12-20 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 80-89 19933270-8 2010 These findings suggest that the anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP). Hydrogen Peroxide 61-69 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 243-252 19933270-0 2010 Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. Hydrogen Peroxide 71-88 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 18-27 18575781-5 2008 beta-TrCP, the F-box protein component of SCF ubiquitin ligase, interacted with RCAN1 in response to H2O2 stimulation. Hydrogen Peroxide 101-105 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 0-9 18575781-8 2008 In addition, knockdown of beta-TrCP by siRNA abolished the H2O2-induced decrease in RCAN1 in HEK293T cells. Hydrogen Peroxide 59-63 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 26-35 18575781-12 2008 These results suggest that H2O2 induces SCF beta-TrCP-mediated ubiquitination of RCAN1, leading to a decrease in the protein level of RCAN1. Hydrogen Peroxide 27-31 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 44-53