PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset
33674382-4 2021 Here, we show that the kinematic properties of postactivated piscine spermatozoa are regulated through a conserved trafficking mechanism whereby a peroxiporin ortholog of mammalian aquaporin-8 (Aqp8bb) is inserted into the inner mitochondrial membrane to facilitate H2O2 efflux in order to maintain ATP production. Hydrogen Peroxide 266-270 aquaporin 8 Homo sapiens 181-192
17105724-6 2007 Expression of human AQP8 and plant Arabidopsis TIP1;1 and TIP1;2 in yeast decreased growth and survival in the presence of H2O2. Hydrogen Peroxide 123-127 aquaporin 8 Homo sapiens 20-24
34087390-6 2021 AQP8 seems to have a fundamental role in regulating the elimination of hydrogen peroxide, the most abundant reactive oxygen species (ROS), and therefore in the response to oxidative stress. Hydrogen Peroxide 71-88 aquaporin 8 Homo sapiens 0-4
29317238-3 2018 Aquaporin 8 (AQP8) is a diffusion facilitator of H2O2 and glutathione peroxidase (Gpx) is a H2O2 scavenging enzyme. Hydrogen Peroxide 49-53 aquaporin 8 Homo sapiens 0-11
32063362-4 2020 Human lens epithelial cells expressing AQP1, AQP5 and AQP8, when treated with 50 muM HgCl2 water channel inhibitor showed a significant reduction in H2O2 transport. Hydrogen Peroxide 149-153 aquaporin 8 Homo sapiens 54-58
31586057-3 2019 This probe is able to detect nanomolar fluctuations of intracellular H2O2 caused by extracellular peroxides; expression of human aquaporin 8 channels H2O2 entry into fission yeast decreasing membrane gradients. Hydrogen Peroxide 69-73 aquaporin 8 Homo sapiens 129-140
31586057-3 2019 This probe is able to detect nanomolar fluctuations of intracellular H2O2 caused by extracellular peroxides; expression of human aquaporin 8 channels H2O2 entry into fission yeast decreasing membrane gradients. Hydrogen Peroxide 150-154 aquaporin 8 Homo sapiens 129-140
30581529-4 2018 Recent evidence show that many tumour cell types express elevated level of aquaporin isoforms, and we previously demonstrated that aquaporin-8 acts as H2O2 transport facilitator across the plasma membrane of B1647 cells, a model of acute myeloid human leukemia. Hydrogen Peroxide 151-155 aquaporin 8 Homo sapiens 131-142
30581529-5 2018 Thus, the control of AQP8-mediated H2O2 transport could be a novel strategy to regulate cell signalling and survival. Hydrogen Peroxide 35-39 aquaporin 8 Homo sapiens 21-25
30581529-6 2018 To this purpose, we evaluated whether sulforaphane could somehow affect aquaporin-8-mediated H2O2 transport and/or Nox-mediated H2O2 production in B1647 cell line. Hydrogen Peroxide 93-97 aquaporin 8 Homo sapiens 72-83
29732408-2 2018 We reported previously that aquaporin-8 (AQP8) transports H2O2 across the plasma membrane and is reversibly gated during cell stress, modulating signal strength and duration. Hydrogen Peroxide 58-62 aquaporin 8 Homo sapiens 28-39
29732408-2 2018 We reported previously that aquaporin-8 (AQP8) transports H2O2 across the plasma membrane and is reversibly gated during cell stress, modulating signal strength and duration. Hydrogen Peroxide 58-62 aquaporin 8 Homo sapiens 41-45
29732408-7 2018 We propose that H2O2 molecules transported through AQP8 sulfenylate C53, making it susceptible to H2S produced by CBS. Hydrogen Peroxide 16-20 aquaporin 8 Homo sapiens 51-55
29317238-3 2018 Aquaporin 8 (AQP8) is a diffusion facilitator of H2O2 and glutathione peroxidase (Gpx) is a H2O2 scavenging enzyme. Hydrogen Peroxide 49-53 aquaporin 8 Homo sapiens 13-17
29317238-3 2018 Aquaporin 8 (AQP8) is a diffusion facilitator of H2O2 and glutathione peroxidase (Gpx) is a H2O2 scavenging enzyme. Hydrogen Peroxide 92-96 aquaporin 8 Homo sapiens 0-11
29317238-3 2018 Aquaporin 8 (AQP8) is a diffusion facilitator of H2O2 and glutathione peroxidase (Gpx) is a H2O2 scavenging enzyme. Hydrogen Peroxide 92-96 aquaporin 8 Homo sapiens 13-17
29317238-11 2018 After supplementation, a decrease in AQP8 in LECs may inhibit the influx of H2O2 from the aqueous humor in males. Hydrogen Peroxide 76-80 aquaporin 8 Homo sapiens 37-41
29317238-12 2018 In females however, the correlation between AQP8 and Gpx in LECs may indicate an increase in Gpx activity following the influx of H2O2 from the aqueous humor and further scavenging of H2O2. Hydrogen Peroxide 130-134 aquaporin 8 Homo sapiens 44-48
29317238-12 2018 In females however, the correlation between AQP8 and Gpx in LECs may indicate an increase in Gpx activity following the influx of H2O2 from the aqueous humor and further scavenging of H2O2. Hydrogen Peroxide 184-188 aquaporin 8 Homo sapiens 44-48
26972385-1 2016 UNLABELLED: Aquaporin-8 (AQP8) allows the bidirectional transport of water and hydrogen peroxide across biological membranes. Hydrogen Peroxide 79-96 aquaporin 8 Homo sapiens 12-23
29454339-3 2018 AQP8 conducts water, ammonia, urea, glycerol and H2O2 through various membranes of animal cells. Hydrogen Peroxide 49-53 aquaporin 8 Homo sapiens 0-4
28322010-1 2017 Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Hydrogen Peroxide 208-225 aquaporin 8 Homo sapiens 25-36
31988920-1 2017 Purpose/Aim: Aquaporin 8 (AQP8) is a diffusion facilitator of hydrogen peroxide (H2O2) through cell membranes. Hydrogen Peroxide 62-79 aquaporin 8 Homo sapiens 13-24
31988920-1 2017 Purpose/Aim: Aquaporin 8 (AQP8) is a diffusion facilitator of hydrogen peroxide (H2O2) through cell membranes. Hydrogen Peroxide 62-79 aquaporin 8 Homo sapiens 26-30
27862460-0 2017 Intracellular cysteine oxidation is modulated by aquaporin-8-mediated hydrogen peroxide channeling in leukaemia cells. Hydrogen Peroxide 70-87 aquaporin 8 Homo sapiens 49-60
27862460-4 2017 As Aquaporin-8 (AQP8) has been demonstrated to funnel Nox-produced H2 O2 across the plasma membrane, this study aims to elucidate the role of AQP8 in the redox signaling occurring in human leukaemia B1647 cells that constitutively produce VEGF. Hydrogen Peroxide 67-72 aquaporin 8 Homo sapiens 3-14
27862460-4 2017 As Aquaporin-8 (AQP8) has been demonstrated to funnel Nox-produced H2 O2 across the plasma membrane, this study aims to elucidate the role of AQP8 in the redox signaling occurring in human leukaemia B1647 cells that constitutively produce VEGF. Hydrogen Peroxide 67-72 aquaporin 8 Homo sapiens 16-20
27862460-5 2017 AQP8 overexpression or silencing resulted in the modulation of VEGF ability of increasing or decreasing, respectively, H2 O2 intracellular level. Hydrogen Peroxide 119-124 aquaporin 8 Homo sapiens 0-4
26972385-1 2016 UNLABELLED: Aquaporin-8 (AQP8) allows the bidirectional transport of water and hydrogen peroxide across biological membranes. Hydrogen Peroxide 79-96 aquaporin 8 Homo sapiens 25-29
26972385-4 2016 AIMS: In this study, we investigated whether and how the transport of H2O2 through plasma membrane AQP8 is regulated, particularly during cell stress. Hydrogen Peroxide 70-74 aquaporin 8 Homo sapiens 99-103
26972385-5 2016 RESULTS: We show that diverse cellular stress conditions, including heat, hypoxia, and ER stress, reversibly inhibit the permeability of AQP8 to H2O2 and water. Hydrogen Peroxide 145-149 aquaporin 8 Homo sapiens 137-141
26972385-10 2016 INNOVATION AND CONCLUSION: The control of AQP8-mediated H2O2 transport provides a novel mechanism to regulate cell signaling and survival during stress. Hydrogen Peroxide 56-60 aquaporin 8 Homo sapiens 42-46
26837049-2 2016 Some AQPs including AQP3 and AQP8 have been recently found to transport hydrogen peroxide (H2O2). Hydrogen Peroxide 72-89 aquaporin 8 Homo sapiens 29-33
26837049-2 2016 Some AQPs including AQP3 and AQP8 have been recently found to transport hydrogen peroxide (H2O2). Hydrogen Peroxide 91-95 aquaporin 8 Homo sapiens 29-33
24440277-6 2014 Furthermore, AQP8 overexpression or silencing resulted to modulate VEGF capacity of triggering an H2O2 intracellular level increase or decrease, respectively. Hydrogen Peroxide 98-102 aquaporin 8 Homo sapiens 13-17
24440277-7 2014 Finally, we report that AQP8 is capable of increasing H2O2-induced phosphorylation of both PI3K and p38 MAPK and that AQP8 expression affected positively cell proliferation. Hydrogen Peroxide 54-58 aquaporin 8 Homo sapiens 24-28
24440277-8 2014 Taken together, the results here reported indicate that AQP8 is able to modulate H2O2 transport through the plasma membrane affecting redox signalling linked to leukaemia cell proliferation. Hydrogen Peroxide 81-85 aquaporin 8 Homo sapiens 56-60
20724658-4 2010 Molecular imaging with Peroxy Yellow 1 Methyl-Ester (PY1-ME), a new chemoselective fluorescent indicator for H(2)O(2), directly demonstrates that aquaporin isoforms AQP3 and AQP8, but not AQP1, can promote uptake of H(2)O(2) specifically through membranes in mammalian cells. Hydrogen Peroxide 216-224 aquaporin 8 Homo sapiens 174-178
25586329-0 2015 Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility. Hydrogen Peroxide 35-52 aquaporin 8 Homo sapiens 14-25
25586329-4 2015 Here, we show that a marine teleost orthologue of human aquaporin-8, termed Aqp8b, is rapidly phosphorylated and inserted into the inner mitochondrial membrane of SW-activated spermatozoa, where it facilitates H2O2 efflux from this compartment. Hydrogen Peroxide 210-214 aquaporin 8 Homo sapiens 56-67
23541115-3 2013 Silencing aquaporin-8 (AQP8), but not AQP3 or AQP4, inhibited H2O2 entry into HeLa cells. Hydrogen Peroxide 62-66 aquaporin 8 Homo sapiens 10-21
23541115-3 2013 Silencing aquaporin-8 (AQP8), but not AQP3 or AQP4, inhibited H2O2 entry into HeLa cells. Hydrogen Peroxide 62-66 aquaporin 8 Homo sapiens 23-27
23541115-4 2013 Re-expression of AQP8 with silencing-resistant vectors rescued H2O2 transport, whereas a C173A-AQP8 mutant failed to do so. Hydrogen Peroxide 63-67 aquaporin 8 Homo sapiens 17-21
23541115-5 2013 Lowering AQP8 levels affected H2O2 entry into the endoplasmic reticulum, but not into mitochondria. Hydrogen Peroxide 30-34 aquaporin 8 Homo sapiens 9-13
23541115-6 2013 AQP8 silencing also inhibited the H2O2 spikes and phosphorylation of downstream proteins induced by epidermal growth factor. Hydrogen Peroxide 34-38 aquaporin 8 Homo sapiens 0-4
22192778-3 2012 The constriction region of the pore determining the solute specificity deviates in AQP8 making it permeable to both ammonia and H(2)O(2) in addition to water. Hydrogen Peroxide 128-136 aquaporin 8 Homo sapiens 83-87