PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18941904-5 2009 Our findings demonstrate that H(2)O(2)-enhanced osteoblastic differentiation and apoptosis are responsible for the increased calcification in rat CVCs, and LaCl(3) can counteract these effects by suppressing the activation of JNK (JNK2, but not JNK1) and p38 MAPK signaling pathway. Hydrogen Peroxide 30-38 mitogen activated protein kinase 14 Rattus norvegicus 255-258 19222219-0 2009 Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. Hydrogen Peroxide 127-144 mitogen activated protein kinase 14 Rattus norvegicus 28-31 18951527-9 2009 Both OGD/recovery and H(2)O(2) increased the phosphorylated p38 MAPK level, which was inhibited by caffeic acid and the ROS scavenger edaravone, but not by MK886 or zileuton. Hydrogen Peroxide 22-30 mitogen activated protein kinase 14 Rattus norvegicus 60-63 19059215-0 2009 PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells. Hydrogen Peroxide 13-17 mitogen activated protein kinase 14 Rattus norvegicus 54-57 19059215-5 2009 We also found that overexpression of wild type PKD1 attenuated H(2)O(2)-induced phosphorylation of p38 MAPK and its upstream activator, MAPK kinase (MKK) 3/6, whereas the phosphorylation was increased by PKD1 siRNA or kinase-dead PKD1. Hydrogen Peroxide 63-71 mitogen activated protein kinase 14 Rattus norvegicus 99-102 17965278-7 2008 The greatest difference between H(2)O(2) and CCPA was in the Triton-insoluble membrane fraction, where H(2)O(2) increased p38 and p42 activation and CCPA reduced MAPK activation. Hydrogen Peroxide 103-111 mitogen activated protein kinase 14 Rattus norvegicus 122-125 18420382-4 2008 Thus, in H9c2 cells treated with H2O2 the mechanism regulating alphaB-crystallin phosphorylation was found to involve p38-MAPK/MSK1 as well as intracellular free calcium levels. Hydrogen Peroxide 33-37 mitogen activated protein kinase 14 Rattus norvegicus 118-121 18410586-5 2008 It was found that melatonin strongly attenuated H(2)O(2)-induced activation of the ERK1/2 and p38 MAP kinases, as well as several of their downstream targets. Hydrogen Peroxide 48-56 mitogen activated protein kinase 14 Rattus norvegicus 94-97 18272186-0 2008 Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. Hydrogen Peroxide 43-60 mitogen activated protein kinase 14 Rattus norvegicus 107-110 18272186-8 2008 Furthermore, H(2)O(2)-induced rapid and significant phosphorylation of c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), and both of these effects were attenuated by CPF or procyanidin B2 treatment. Hydrogen Peroxide 13-21 mitogen activated protein kinase 14 Rattus norvegicus 113-116 18272186-9 2008 These results suggest that the protective effects of CPF and procyanidin B2 against H(2)O(2)-induced apoptosis involve inhibiting the downregulation of Bcl-X(L) and Bcl-2 expression through blocking the activation of JNK and p38 MAPK. Hydrogen Peroxide 84-92 mitogen activated protein kinase 14 Rattus norvegicus 225-228 17965278-5 2008 CCPA and H(2)O(2) activated p38 MAPK and p44/p42 ERKs in cytosolic fractions. Hydrogen Peroxide 9-17 mitogen activated protein kinase 14 Rattus norvegicus 28-31 17965278-7 2008 The greatest difference between H(2)O(2) and CCPA was in the Triton-insoluble membrane fraction, where H(2)O(2) increased p38 and p42 activation and CCPA reduced MAPK activation. Hydrogen Peroxide 32-40 mitogen activated protein kinase 14 Rattus norvegicus 122-125 18668153-0 2008 Involvement of ERK1/2 and p38 MAPK in up-regulation of 14-3-3 protein induced by hydrogen peroxide preconditioning in PC12 cells. Hydrogen Peroxide 81-98 mitogen activated protein kinase 14 Rattus norvegicus 26-29 18410586-7 2008 Upregulation of ERK1/2, p38, and Akt signaling by H(2)O(2) was accompanied by activation of Ras, an effect that was blocked by melatonin. Hydrogen Peroxide 50-58 mitogen activated protein kinase 14 Rattus norvegicus 24-27 17003231-0 2007 Cyclooxygenase, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase MAPK, Rho kinase, and Src mediate hydrogen peroxide-induced contraction of rat thoracic aorta and vena cava. Hydrogen Peroxide 133-150 mitogen activated protein kinase 14 Rattus norvegicus 16-19 17164397-8 2007 Since H(2)O(2) has also been demonstrated to activate mitogen-activated protein kinase, P38, and ERK (3), we examined the role of P38 and ERK in mediating the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 6-14 mitogen activated protein kinase 14 Rattus norvegicus 88-91 17164397-10 2007 However, combined use of ERK, P38, and PTK inhibitors completely abolished the effect of H(2)O(2) on SK channels. Hydrogen Peroxide 89-97 mitogen activated protein kinase 14 Rattus norvegicus 30-33 17513494-5 2007 We hypothesized that H(2)O(2) causes the activation of p38 MAPK which initiates translocation of heat shock protein 25/27 (HSP25/27) to the myofilament Z disk. Hydrogen Peroxide 21-29 mitogen activated protein kinase 14 Rattus norvegicus 55-58 17640472-7 2007 Propofol inhibited the H2O2-induced p38 MAP kinase, but not c-Jun N-terminal kinase or extracellular signal-regulated kinase 1 and 2 activations. Hydrogen Peroxide 23-27 mitogen activated protein kinase 14 Rattus norvegicus 36-39 17640472-8 2007 CONCLUSION: Propofol might attenuate H2O2-induced PC12 cell death through the inhibition of signaling pathways mediated by the p38 MAP kinase. Hydrogen Peroxide 37-41 mitogen activated protein kinase 14 Rattus norvegicus 127-130 17164397-12 2007 We conclude that addition of H(2)O(2) inhibited SK channels by stimulating PTK activity, P38, and ERK in the CCD and that H(2)O(2) enhances the internalization of the SK channels. Hydrogen Peroxide 29-37 mitogen activated protein kinase 14 Rattus norvegicus 89-92 17003231-8 2007 Our data suggest that, in rat thoracic aorta and vena cava, a COX-derived metabolite is one important mediator of H2O2 contraction, possibly via rho kinase activation, and that H2O2-induced contraction via p38 and Erk MAPK probably occurs independently of TXA2 receptor activation. Hydrogen Peroxide 177-181 mitogen activated protein kinase 14 Rattus norvegicus 206-209 16351573-11 2006 Our results indicate that p38 kinase-mediated Ser158 phosphorylation is essential for augmentation of the DNA binding and transactivation potential of HNF4alpha in the presence of IL-1beta+H2O2. Hydrogen Peroxide 189-193 mitogen activated protein kinase 14 Rattus norvegicus 26-29 16531007-0 2006 Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Hydrogen Peroxide 50-54 mitogen activated protein kinase 14 Rattus norvegicus 24-27 16531007-4 2006 Inhibition of JNKs, p38-MAPK and MSK1 pathways, by pharmacological inhibitors, reduced HOX-1 mRNA levels in H2O2-treated H9c2 cells. Hydrogen Peroxide 108-112 mitogen activated protein kinase 14 Rattus norvegicus 20-23 16531007-6 2006 H2O2-induced MSK1 phosphorylation was completely abrogated in the presence of the selective p38-MAPK inhibitor SB203580. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 92-95 16208142-7 2005 RESULTS: H(2)O(2) stimulated phosphorylation of ERK1/2 and p38MAP kinase in a time-dependent manner. Hydrogen Peroxide 9-17 mitogen activated protein kinase 14 Rattus norvegicus 59-62 16362428-7 2006 It was also observed in PC12 cells that H2O2 stimulated phosphorylation of mitogen-activated protein (MAP) kinases, i.e., extracellular signal-regulated kinase1/2 (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 MAP kinase. Hydrogen Peroxide 40-44 mitogen activated protein kinase 14 Rattus norvegicus 209-212 16362428-8 2006 Pramipexole inhibited H2O2-induced JNK and p38 MAP kinase, but not ERK1/2 phosphorylation. Hydrogen Peroxide 22-26 mitogen activated protein kinase 14 Rattus norvegicus 43-57 16208142-11 2005 CONCLUSION: These data indicate that H(2)O(2) increases ERK1/2 and p38MAP kinase activation through tyrosine kinase-dependent, PKC-independent mechanisms. Hydrogen Peroxide 37-45 mitogen activated protein kinase 14 Rattus norvegicus 67-70 16208142-13 2005 Our findings identify an important role for tyrosine kinases, but not PKC, in H(2)O(2)-induced phosphorylation of ERK1/2 and p38MAP kinase in VSMC. Hydrogen Peroxide 78-86 mitogen activated protein kinase 14 Rattus norvegicus 125-138 15659805-3 2004 Recently, we reported that p38 mitogen-activated protein kinase (MAPK) is also involved in the inhibition of GJIC by hydrogen peroxide in WB-F344 rat liver epithelial cells (WB cells). Hydrogen Peroxide 117-134 mitogen activated protein kinase 14 Rattus norvegicus 27-63 16046474-6 2005 Western blot analysis suggests that H2O2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H2O2 treatment. Hydrogen Peroxide 36-40 mitogen activated protein kinase 14 Rattus norvegicus 78-114 16046474-6 2005 Western blot analysis suggests that H2O2 triggered the phosphorylation of the p38 mitogen-activated protein kinase (MAPK), and that SB203580, a specific inhibitor of p38 MAPK, suppressed the changes in membrane phase properties and cytoskeleton resulting from H2O2 treatment. Hydrogen Peroxide 260-264 mitogen activated protein kinase 14 Rattus norvegicus 78-114 15228596-8 2004 In contrast, inhibitors of both p38 and MEK reduced H(2)O(2)-induced death most significantly in oligodendrocytes. Hydrogen Peroxide 52-60 mitogen activated protein kinase 14 Rattus norvegicus 32-35 15239099-8 2004 Accordingly, p38 inhibitor SB202190 or N-acetyl-cysteine prevented H(2)O(2) inhibitory effects on proliferation. Hydrogen Peroxide 67-75 mitogen activated protein kinase 14 Rattus norvegicus 13-16 14556849-7 2003 V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase (AG1478) or p38 MAPK (SB203580). Hydrogen Peroxide 136-140 mitogen activated protein kinase 14 Rattus norvegicus 95-98 15059639-4 2004 H(2)O(2) induced phosphorylation of extracellular signal-regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase and consequently activated activator protein 1 (AP-1). Hydrogen Peroxide 0-8 mitogen activated protein kinase 14 Rattus norvegicus 75-89 14556849-7 2003 V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase (AG1478) or p38 MAPK (SB203580). Hydrogen Peroxide 16-20 mitogen activated protein kinase 14 Rattus norvegicus 95-98 15156562-7 2004 H(2)O(2)-induced apoptosis was preceded by rapid activation of all three classes of mitogen-activated protein kinases (MAPKs): ERK, JNK, and p38. Hydrogen Peroxide 0-8 mitogen activated protein kinase 14 Rattus norvegicus 141-144 14556849-7 2003 V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase (AG1478) or p38 MAPK (SB203580). Hydrogen Peroxide 136-140 mitogen activated protein kinase 14 Rattus norvegicus 269-272 14556849-7 2003 V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase (AG1478) or p38 MAPK (SB203580). Hydrogen Peroxide 136-140 mitogen activated protein kinase 14 Rattus norvegicus 95-98 14556849-7 2003 V2O5 suppressed H2O2 for as long as 24 h. Differences in the temporal activation of STAT-1 and p38 MAPK were observed following V2O5 or H2O2 treatment, and STAT-1 activation by V2O5 or H2O2 was attenuated by an inhibitor of the EGF receptor tyrosine kinase (AG1478) or p38 MAPK (SB203580). Hydrogen Peroxide 136-140 mitogen activated protein kinase 14 Rattus norvegicus 269-272 12704812-0 2003 Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. Hydrogen Peroxide 79-83 mitogen activated protein kinase 14 Rattus norvegicus 128-131 12788379-8 2003 An apoptotic concentration of H(2)O(2) (100 microM) activated JNK, p38 kinase and Akt, and further activated ERK1/2. Hydrogen Peroxide 30-38 mitogen activated protein kinase 14 Rattus norvegicus 67-70 12704812-12 2003 These data suggest that H(2)O(2) and NO act synergistically to induce neuronal death through apoptosis in which activation of p38 MAPK and caspase-3 is involved. Hydrogen Peroxide 24-32 mitogen activated protein kinase 14 Rattus norvegicus 126-129 12540778-10 2003 In contrast, H(2)O(2) resistance was abolished by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, but induced when p38 MAPK was directly activated by anisomycin. Hydrogen Peroxide 13-21 mitogen activated protein kinase 14 Rattus norvegicus 54-90 12540778-10 2003 In contrast, H(2)O(2) resistance was abolished by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, but induced when p38 MAPK was directly activated by anisomycin. Hydrogen Peroxide 13-21 mitogen activated protein kinase 14 Rattus norvegicus 92-100 12540778-10 2003 In contrast, H(2)O(2) resistance was abolished by the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580, but induced when p38 MAPK was directly activated by anisomycin. Hydrogen Peroxide 13-21 mitogen activated protein kinase 14 Rattus norvegicus 139-147 12540778-12 2003 Activation of p38 MAPK and preservation of the intracellular GSH/oxidized glutathione (GSSG) redox system, but not adenosine A2a receptor stimulation, seems to be pivotal for the development of H(2)O(2) resistance in preconditioned livers. Hydrogen Peroxide 194-202 mitogen activated protein kinase 14 Rattus norvegicus 14-22 12397078-7 2002 p38 kinase phosphorylation is blocked in L9 cells, indicating that high hydroperoxide levels are needed for the activation of p38 kinase. Hydrogen Peroxide 72-85 mitogen activated protein kinase 14 Rattus norvegicus 0-3 12397078-7 2002 p38 kinase phosphorylation is blocked in L9 cells, indicating that high hydroperoxide levels are needed for the activation of p38 kinase. Hydrogen Peroxide 72-85 mitogen activated protein kinase 14 Rattus norvegicus 126-129 12397078-8 2002 Thus, intracellular hydroperoxide levels participate in regulating p38 kinase phosphorylation, which in turn controls the activation of acetyltransferase and thus the synthesis of PAF. Hydrogen Peroxide 20-33 mitogen activated protein kinase 14 Rattus norvegicus 67-70 11447348-6 2001 To our knowledge, this study is the first demonstration that both ERK1/2 and p38 MAP kinase are involved in the PLD2 activation in PC12 cells exposed to H2O2. Hydrogen Peroxide 153-157 mitogen activated protein kinase 14 Rattus norvegicus 77-80 12130563-7 2002 Hydrogen peroxide (>/=10(-5) M) also stimulated p38 MAPK phosphorylation, ANG secretion, and ANG mRNA gene expression, but its stimulatory effect was blocked by catalase and SB 203580. Hydrogen Peroxide 0-17 mitogen activated protein kinase 14 Rattus norvegicus 51-54 11832430-5 2002 The release of arachidonic acid induced by PDGF together with H(2)O(2) was inhibited partially by an inhibitor of ERK or p38 MAP kinase and completely when the two inhibitors were combined; the inhibitory pattern was similar to that for the phosphorylation of cPLA(2). Hydrogen Peroxide 62-70 mitogen activated protein kinase 14 Rattus norvegicus 121-135 11827698-5 2002 ERK and p38 MAPK activities were both increased by 100 microM H(2)O(2) (peak at 6 min); the ERK kinase inhibitor PD98059 (10 microM), but not the p38 MAPK inhibitor SB203580 (1 microM), inhibited the H(2)O(2)-induced increase in DeltaJ(H). Hydrogen Peroxide 62-70 mitogen activated protein kinase 14 Rattus norvegicus 8-16 11827698-5 2002 ERK and p38 MAPK activities were both increased by 100 microM H(2)O(2) (peak at 6 min); the ERK kinase inhibitor PD98059 (10 microM), but not the p38 MAPK inhibitor SB203580 (1 microM), inhibited the H(2)O(2)-induced increase in DeltaJ(H). Hydrogen Peroxide 200-208 mitogen activated protein kinase 14 Rattus norvegicus 8-16 11447348-3 2001 Furthermore, H2O2-induced PLD activation was partially inhibited by either MEK1 inhibitor (PD98059) or p38 MAP kinase inhibitor (SB203580), but a combination of both inhibitors resulted in nearly 80% suppression. Hydrogen Peroxide 13-17 mitogen activated protein kinase 14 Rattus norvegicus 103-106 12145102-4 2002 2: Our findings showed that hydrogen peroxide (H(2)O(2)) stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 in PC12 cells, which is a model of catecholamine-containing neurons. Hydrogen Peroxide 28-45 mitogen activated protein kinase 14 Rattus norvegicus 186-189 12145102-4 2002 2: Our findings showed that hydrogen peroxide (H(2)O(2)) stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 in PC12 cells, which is a model of catecholamine-containing neurons. Hydrogen Peroxide 47-55 mitogen activated protein kinase 14 Rattus norvegicus 186-189 12145102-5 2002 3: H(2)O(2)-induced JNK activation was inhibited by ebselen, whereas ERK1/2 and p38 activation by H(2)O(2) were not affected by ebselen. Hydrogen Peroxide 98-106 mitogen activated protein kinase 14 Rattus norvegicus 80-83 12117774-0 2002 The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Hydrogen Peroxide 171-188 mitogen activated protein kinase 14 Rattus norvegicus 24-27 12117774-4 2002 Moreover, H(2)O(2) activated p38 kinase, extracellular signal-regulated protein kinases (ERK)1/2 and c-Jun N-terminal kinase (JNK) in WB cells. Hydrogen Peroxide 10-18 mitogen activated protein kinase 14 Rattus norvegicus 29-32 11600417-4 2001 H(2)O(2) caused a concentration- and time-dependent activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), p38, and c-Jun NH(2)-terminal kinase (JNK) mitogen-activated protein (MAP) kinases in adult rat ventricular myocytes. Hydrogen Peroxide 0-8 mitogen activated protein kinase 14 Rattus norvegicus 123-126 11600417-5 2001 H(2)O(2) (50 microM) caused transient activation of ERK1/2 and p38 MAP kinase that was detected as early as 5 min, was maximal at 20 min (9.6 +/- 1.2- and 9.0 +/- 1.6-fold, respectively, vs. control), and returned to baseline at 60 min. Hydrogen Peroxide 0-8 mitogen activated protein kinase 14 Rattus norvegicus 63-66 14715469-6 2001 Exposure of the cells to H2O2 led to transient activation of both c-Jun N-terminal kinase (JNK) and p38 kinase but has no effect on extracellular regulated kinase (ERK) activity. Hydrogen Peroxide 25-29 mitogen activated protein kinase 14 Rattus norvegicus 100-103 11440832-9 2001 Inhibition of p38 MAP kinase by SB203580 also partially suppressed the H2O2-initiated AR induction. Hydrogen Peroxide 71-75 mitogen activated protein kinase 14 Rattus norvegicus 14-17 10651889-6 2000 The data described indicate that IL-1beta and H2O2 increase the activity of two stress-activated mitogen-activated protein kinases, c-Jun NH2-terminal kinase (JNK) and p38 in vitro, while age-related increases in both kinases were observed. Hydrogen Peroxide 46-50 mitogen activated protein kinase 14 Rattus norvegicus 168-171 11228094-8 2001 Although H2O2 activates both p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK), IGF-1 inhibited only JNK activation. Hydrogen Peroxide 9-13 mitogen activated protein kinase 14 Rattus norvegicus 29-65 10652023-5 2000 In control glomeruli, a free radical stress, H2O2, activated p38MAPK and increased Hsp25 in a concentration-dependent manner. Hydrogen Peroxide 45-49 mitogen activated protein kinase 14 Rattus norvegicus 61-68 10220113-2 1999 In the present study, we show that interleukin 1beta (IL1beta), H2O2, and sorbitol-induced hyperosmolarity mediate a 5- to 10-fold increase in phosphorylation (activation) of the p38 protein kinase in rat primary glial cells as measured by analyses of Western blots using an antibody directed against the dually phosphorylated (active) p38. Hydrogen Peroxide 64-68 mitogen activated protein kinase 14 Rattus norvegicus 179-182 10629859-3 1999 Treatment of the rat neonatal myocytes with H2O2 resulted in activation of mitogen-activated protein kinases (MAPKs) such as extracellular signal regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK) and p38. Hydrogen Peroxide 44-48 mitogen activated protein kinase 14 Rattus norvegicus 206-209 10629859-6 1999 In contrast with H2O2-induced activation of ERK, the activation of ERK induced by phorbol ester PMA and the activation of JNK and p38 induced by H2O2 were not affected by expression of GRK2-ct, indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit. Hydrogen Peroxide 145-149 mitogen activated protein kinase 14 Rattus norvegicus 130-133 10588574-3 1999 Pretreatment with H2O2 did not alter phosphorylation of ERK1/2 induced by either growth factor, but increased the phosphorylation of p38 kinase induced by treatment with NGF or EGF alone. Hydrogen Peroxide 18-22 mitogen activated protein kinase 14 Rattus norvegicus 133-136 10220113-2 1999 In the present study, we show that interleukin 1beta (IL1beta), H2O2, and sorbitol-induced hyperosmolarity mediate a 5- to 10-fold increase in phosphorylation (activation) of the p38 protein kinase in rat primary glial cells as measured by analyses of Western blots using an antibody directed against the dually phosphorylated (active) p38. Hydrogen Peroxide 64-68 mitogen activated protein kinase 14 Rattus norvegicus 336-339 10220113-7 1999 These data suggest that ROS, particularly H2O2, are used as second messenger substances that activate p38 in part via the transient inactivation of regulatory protein phosphatases. Hydrogen Peroxide 42-46 mitogen activated protein kinase 14 Rattus norvegicus 102-105 9769235-3 1998 Relatively low concentrations of menadione (10 micrometer) or H2O2 (250 micrometer) caused maximal DNA fragmentation and caspase activation, both markers for apoptotic cell death, and preferential activation of the c-Jun NH 2-terminal kinase (JNK) and p38 MAPK pathways. Hydrogen Peroxide 62-66 mitogen activated protein kinase 14 Rattus norvegicus 252-255 9677316-6 1998 p38-MAPK was activated by 0.1 mM H2O2 as shown by an increase in its phosphorylation. Hydrogen Peroxide 33-37 mitogen activated protein kinase 14 Rattus norvegicus 0-3 9677316-9 1998 As with p38-MAPK, MAPKAPK2 was rapidly activated (maximal within 5 min) by 0.1 mM H2O2. Hydrogen Peroxide 82-86 mitogen activated protein kinase 14 Rattus norvegicus 8-11 9516415-5 1998 H2O2 activated both SAPKs/JNKs and p38-MAPK. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 35-43 9706151-0 1998 Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism. Hydrogen Peroxide 0-17 mitogen activated protein kinase 14 Rattus norvegicus 83-86 9706151-2 1998 We hypothesized that hydrogen peroxide (H2O2) induces myocardial dysfunction and cardiomyocyte death via P38 mitogen-activated protein kinase (MAPK)-mediated myocardial tumor necrosis factor (TNF) production. Hydrogen Peroxide 21-38 mitogen activated protein kinase 14 Rattus norvegicus 105-141 9706151-2 1998 We hypothesized that hydrogen peroxide (H2O2) induces myocardial dysfunction and cardiomyocyte death via P38 mitogen-activated protein kinase (MAPK)-mediated myocardial tumor necrosis factor (TNF) production. Hydrogen Peroxide 40-44 mitogen activated protein kinase 14 Rattus norvegicus 105-141 9516415-7 1998 Whereas activation of p38-MAPK by H2O2 was comparable to that of ischemia and ischemia/reperfusion, activation of the SAPKs/JNKs was less than that of ischemia/reperfusion. Hydrogen Peroxide 34-38 mitogen activated protein kinase 14 Rattus norvegicus 22-25 9516415-9 1998 MAPK-activated protein kinase 2 (MAPKAPK2), a downstream substrate of p38-MAPKs, was activated by H2O2 to a similar extent as with ischemia or ischemia/reperfusion. Hydrogen Peroxide 98-102 mitogen activated protein kinase 14 Rattus norvegicus 70-73 29273374-7 2018 The role of P38 mitogen-activated protein kinase (P38 MAPK) signaling was examined using the P38 MAPK agonist U46619 and inhibitor SB203580 in H2O2 and GSH-treated cells. Hydrogen Peroxide 143-147 mitogen activated protein kinase 14 Rattus norvegicus 50-58 35496304-8 2022 The phosphorylation of ERK, JNK, and p38 was attenuated by MA in IRI-induced kidney injury and H2O2-stimulated NRK52 cells. Hydrogen Peroxide 95-99 mitogen activated protein kinase 14 Rattus norvegicus 37-40 30058479-0 2020 Vitamin K2 protects PC12 cells against Abeta (1-42) and H2O2-induced apoptosis via p38 MAP kinase pathway. Hydrogen Peroxide 56-60 mitogen activated protein kinase 14 Rattus norvegicus 83-86 9281447-9 1997 Moreover, exposure of H9c2 cells to H2O2-induced oxidative stress or PMA rapidly activated cellular p38 MAP kinase as detected by the induced protein phosphorylation of the kinase. Hydrogen Peroxide 36-40 mitogen activated protein kinase 14 Rattus norvegicus 100-103 8626753-5 1996 H2O2 activated ERK2 in several cell types and also moderately activated (3-5-fold) both c-Jun N-terminal kinase and p38/RK/CSBP. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 116-119 8626753-5 1996 H2O2 activated ERK2 in several cell types and also moderately activated (3-5-fold) both c-Jun N-terminal kinase and p38/RK/CSBP. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 123-127 30510405-9 2018 Under the stimulation of H2O2, MAPKs (ERK, JNK, and p38), AKT, and Src signaling proteins in PC12 cells were activated in a time-dependent manner. Hydrogen Peroxide 25-29 mitogen activated protein kinase 14 Rattus norvegicus 52-55 30059683-5 2018 Exposure of PC12 cells to 150 muM H2O2 or 20 muM Abeta1-42 down-regulated anti-apoptotic protein expression (Bcl-2), up-regulated pro-apoptotic protein expression (Bax, cytochrome C, and cleaved caspase-3), increased JNK and p38 MAPK phosphorylation and finally caused significant cell death. Hydrogen Peroxide 34-38 mitogen activated protein kinase 14 Rattus norvegicus 225-228 30059683-7 2018 Among the selective inhibitors of MAPKs, the JNK inhibitor (SP600125) and p38 MAPK inhibitor (SB203580) showed steady preventive effect against H2O2 or Abeta1-42-induced apoptosis. Hydrogen Peroxide 144-148 mitogen activated protein kinase 14 Rattus norvegicus 74-77 29273374-10 2018 RESULTS: Pretreatment with GSH attenuates the activation of NF-kappaB and P38 MAPK signaling pathways by H2O2. Hydrogen Peroxide 105-109 mitogen activated protein kinase 14 Rattus norvegicus 74-82 29273374-14 2018 CONCLUSIONS: GSH appears to ameliorate oxidative injury in intestinal epithelial cells by attenuating H2O2-mediated activation of NF-kappaB and P38 MAPK signaling pathways that regulate intestinal inflammation and apoptosis. Hydrogen Peroxide 102-106 mitogen activated protein kinase 14 Rattus norvegicus 144-152 28447781-4 2017 Western blot analysis showed that artemisinin upregulated the phosphorylation of p38 and extracellular signal-regulated kinases1/2 (ERK1/2) and reversed the inhibitory effect of H2O2 on the phosphorylation of these two kinases. Hydrogen Peroxide 178-182 mitogen activated protein kinase 14 Rattus norvegicus 81-84 27409597-7 2016 In addition, CS treatment attenuated the cell injury by H2O2 through the inhibition of phosphorylation of p38 and the extracellular signal-regulated kinase (ERK). Hydrogen Peroxide 56-60 mitogen activated protein kinase 14 Rattus norvegicus 106-109 27593219-11 2016 Exposure to H2O2 also significantly increased the phosphorylation of p38, JNK and ERK in the H9c2 cells. Hydrogen Peroxide 12-16 mitogen activated protein kinase 14 Rattus norvegicus 69-72 27588145-9 2016 The present study demonstrated that daphnetin attenuated hydrogen peroxide (H2O2)-induced apoptosis in a concentration-dependent manner, reduced the cleavage of poly ADP ribose polymerase and caspase 3, and inhibited the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK) in H2O2-induced PC12 cells. Hydrogen Peroxide 57-74 mitogen activated protein kinase 14 Rattus norvegicus 240-243 27588145-9 2016 The present study demonstrated that daphnetin attenuated hydrogen peroxide (H2O2)-induced apoptosis in a concentration-dependent manner, reduced the cleavage of poly ADP ribose polymerase and caspase 3, and inhibited the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK) in H2O2-induced PC12 cells. Hydrogen Peroxide 76-80 mitogen activated protein kinase 14 Rattus norvegicus 240-243 28099940-9 2017 This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3beta and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Hydrogen Peroxide 57-61 mitogen activated protein kinase 14 Rattus norvegicus 148-184 26961382-7 2016 More importantly, SSD effectively blocked H2O2-induced phosphorylation of extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK), and specific inhibitors of ERK, JNK, and p38-reduced OS injury and apoptosis, suggesting that SSD reduces OS injury and apoptosis via MAPK signalling pathways. Hydrogen Peroxide 42-46 mitogen activated protein kinase 14 Rattus norvegicus 147-183 26961382-7 2016 More importantly, SSD effectively blocked H2O2-induced phosphorylation of extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK), and specific inhibitors of ERK, JNK, and p38-reduced OS injury and apoptosis, suggesting that SSD reduces OS injury and apoptosis via MAPK signalling pathways. Hydrogen Peroxide 42-46 mitogen activated protein kinase 14 Rattus norvegicus 185-192 26961382-7 2016 More importantly, SSD effectively blocked H2O2-induced phosphorylation of extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK), and specific inhibitors of ERK, JNK, and p38-reduced OS injury and apoptosis, suggesting that SSD reduces OS injury and apoptosis via MAPK signalling pathways. Hydrogen Peroxide 42-46 mitogen activated protein kinase 14 Rattus norvegicus 147-150 27507201-9 2016 Co-incubation of Akt inhibitor or p38 inhibitor partly attenuated the protection of SMXZF against H2O2-injured PC12 cells. Hydrogen Peroxide 98-102 mitogen activated protein kinase 14 Rattus norvegicus 34-37 26176363-7 2015 Furthermore, inhibition of JNK and p38 mitogen-activated protein kinases (MAPKs) were observed after mGluR4 activation, and as paralleling control, JNK-specific inhibitor SP600125 and p38-specific inhibitor SB203580 significantly rescued the H2O2-mediated NSC apoptosis and cleavage of procaspase-3. Hydrogen Peroxide 242-246 mitogen activated protein kinase 14 Rattus norvegicus 35-38 26310779-17 2015 Of note, the increase in the levels of phosphorylated extracellular signal-regulated kinase (ERK) and phosphorylated p38 which occurred in response to exposure to H2O2 was inhibited by treatment with SK. Hydrogen Peroxide 163-167 mitogen activated protein kinase 14 Rattus norvegicus 117-120 25989822-9 2015 Furthermore, hydrogen peroxide (H2 O2 )-derived oxidative stress activated p38 MAPK, and induced apoptosis in NRK-52E cells; knockdown of Prx1 sensitized both events in NRK-52E cells, and overexpression of Prx1 diminished the apoptosis and the phosphorylation of p38 CONCLUSION: Downregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Hydrogen Peroxide 13-30 mitogen activated protein kinase 14 Rattus norvegicus 75-78 25989822-9 2015 Furthermore, hydrogen peroxide (H2 O2 )-derived oxidative stress activated p38 MAPK, and induced apoptosis in NRK-52E cells; knockdown of Prx1 sensitized both events in NRK-52E cells, and overexpression of Prx1 diminished the apoptosis and the phosphorylation of p38 CONCLUSION: Downregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Hydrogen Peroxide 13-30 mitogen activated protein kinase 14 Rattus norvegicus 263-266 25989822-9 2015 Furthermore, hydrogen peroxide (H2 O2 )-derived oxidative stress activated p38 MAPK, and induced apoptosis in NRK-52E cells; knockdown of Prx1 sensitized both events in NRK-52E cells, and overexpression of Prx1 diminished the apoptosis and the phosphorylation of p38 CONCLUSION: Downregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Hydrogen Peroxide 32-37 mitogen activated protein kinase 14 Rattus norvegicus 75-78 25989822-9 2015 Furthermore, hydrogen peroxide (H2 O2 )-derived oxidative stress activated p38 MAPK, and induced apoptosis in NRK-52E cells; knockdown of Prx1 sensitized both events in NRK-52E cells, and overexpression of Prx1 diminished the apoptosis and the phosphorylation of p38 CONCLUSION: Downregulation of Prx1 occurred in renal tubular epithelial cells of UUO rats and patients with obstructive nephropathy. Hydrogen Peroxide 32-37 mitogen activated protein kinase 14 Rattus norvegicus 263-266 25989822-10 2015 Prx1 may alleviate the pathogenesis by inhibiting H2 O2 -induced apoptosis via inhibiting the p38 MAPK pathway. Hydrogen Peroxide 50-55 mitogen activated protein kinase 14 Rattus norvegicus 94-97 24607510-10 2014 Furthermore, rhamnetin recovered the H2O2-induced decrease in phosphorylation of Akt/GSK-3beta and MAPKs (ERK1/2, p38 MAPK, and JNK) and pretreatment with their inhibitors, attenuating the rhamnetin-induced cytoprotective effect. Hydrogen Peroxide 37-41 mitogen activated protein kinase 14 Rattus norvegicus 114-117 25280787-9 2014 H2O2 at toxic levels activated p38 mitogen-activated protein kinases (MAPK) and p53 pathways and increased DNA double strand breaks (DSBs) in microglia, whereas the rescue exerted by sublytic SNAP against toxic H2O2 occurred via the activation of both Akt and extracellular-signal-regulated kinase (ERK) cascades and decreased DNA DSBs. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 31-34 25203460-8 2015 Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death. Hydrogen Peroxide 21-26 mitogen activated protein kinase 14 Rattus norvegicus 63-66 23751595-6 2014 However, H2O2-induced increments in p38 phosphorylation and cardiac cell apoptosis were largely enhanced by TAK1 overexpression, whereas the similar transfection did not affect the ROS generation in the cardiomyocytes. Hydrogen Peroxide 9-13 mitogen activated protein kinase 14 Rattus norvegicus 36-39 23751595-7 2014 Moreover, inhibition of H2O2-increased ROS generation, p38 phosphorylation, and cardiomyocytes apoptosis by overexpression of HSP70 tended to disappear when the cells were cotransfected with TAK1. Hydrogen Peroxide 24-28 mitogen activated protein kinase 14 Rattus norvegicus 55-58 22144097-4 2012 Ampelopsin was able to prevent the activation of p38 induced by H2O2. Hydrogen Peroxide 64-68 mitogen activated protein kinase 14 Rattus norvegicus 49-52 22537597-11 2012 Thus, resveratrol protected H(2)O(2)-treated H9c2 cells by upregulating autophagy via the p38 MAPK pathway. Hydrogen Peroxide 28-36 mitogen activated protein kinase 14 Rattus norvegicus 90-93 21486680-6 2011 Intracellular H(2)O(2) thus produced now activates the p38-JNK and p53-mediated pathways. Hydrogen Peroxide 14-22 mitogen activated protein kinase 14 Rattus norvegicus 55-58 21126185-0 2011 Adventitia-derived hydrogen peroxide impairs relaxation of the rat carotid artery via smooth muscle cell p38 mitogen-activated protein kinase. Hydrogen Peroxide 19-36 mitogen activated protein kinase 14 Rattus norvegicus 105-108 21126185-2 2011 Based on robust adventitial ROS generation and effects on MAPK involvement in vascular dysfunction, we hypothesized that adventitia-derived ROS hydrogen peroxide (H(2)O(2)) impairs vascular relaxation through activation of medial smooth muscle p38 MAPK. Hydrogen Peroxide 144-161 mitogen activated protein kinase 14 Rattus norvegicus 244-247 21478407-0 2011 H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation. Hydrogen Peroxide 0-4 mitogen activated protein kinase 14 Rattus norvegicus 56-59 21478407-7 2011 Specific inhibitors of phosphatidylinositol 3-kinase/Akt and p38 MAPK activation partially reduced the cardioprotection elicited by H(2)O(2) preconditioning and the induction and activity of phase II enzymes. Hydrogen Peroxide 132-140 mitogen activated protein kinase 14 Rattus norvegicus 61-64 21300357-5 2011 Pull-down assay or Western blot analysis revealed that pre-administration of 10(-8)mol/L E(2) significantly reduced the H(2)O(2)-induced activation of oncogene Ras, as well as activity of p16 and p38 MAPK, and expression of PRAK, p53, p21 and p-Rb. Hydrogen Peroxide 120-128 mitogen activated protein kinase 14 Rattus norvegicus 196-199 20493825-4 2010 The stimulatory effect of H2O2 on the exchanger activity was blocked by SP600125 (JNK inhibitor), but not by U0126 (MEK1/2 inhibitor) or SB203580 (p38 inhibitor) in both cell lines. Hydrogen Peroxide 26-30 mitogen activated protein kinase 14 Rattus norvegicus 147-150 19386027-8 2009 Both menadione and hydrogen peroxide activated Jun N-terminal kinase (JNK) and p38. Hydrogen Peroxide 19-36 mitogen activated protein kinase 14 Rattus norvegicus 79-82 21236269-8 2011 We observed that H(2)O(2) activated the JNK/p38 mitogen-activated protein kinase (MAPK) and induced PC12 cells apoptosis in a concentration-dependent manner. Hydrogen Peroxide 17-25 mitogen activated protein kinase 14 Rattus norvegicus 44-80