PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32267715-5 2020 Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases. Hydrogen Peroxide 82-99 aquaporin 3 (Gill blood group) Homo sapiens 121-132 33161251-8 2020 Furthermore, sSeP showed a protective effect against H2O2-induced cytotoxicity in cultured human epidermal keratinocytes (HaCaT) cells probably by increasing aquaporin-3 expression and attenuating the phosphorylation of p38 MAPK. Hydrogen Peroxide 53-57 aquaporin 3 (Gill blood group) Homo sapiens 158-169 33017631-9 2020 Further, we observed that aquaporin (AQP) 3, 5, and 8 bind nicotinamide-adenine dinucleotide phosphate oxidase 2 and regulate the permeability of extracellular H2O2, thereby contributing to ferroptosis. Hydrogen Peroxide 160-164 aquaporin 3 (Gill blood group) Homo sapiens 26-43 33120979-5 2020 This mechanism seems to be enhanced by manuka honey"s ability to maintain high H2O2 permeability through aquaporin-3. Hydrogen Peroxide 79-83 aquaporin 3 (Gill blood group) Homo sapiens 105-116 32267715-5 2020 Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases. Hydrogen Peroxide 82-99 aquaporin 3 (Gill blood group) Homo sapiens 134-138 32171979-9 2020 The pathway ends when aquaporin-3 channels H2O2 across the plasma membrane to inactivate PTEN. Hydrogen Peroxide 43-47 aquaporin 3 (Gill blood group) Homo sapiens 22-33 31277235-4 2019 AQP3 and AQP5 are strongly expressed in cancer tissues and AQP3-mediated H2O2 transport has been related to breast cancer cell migration, but studies with human AQP5 are lacking. Hydrogen Peroxide 73-77 aquaporin 3 (Gill blood group) Homo sapiens 0-4 32309744-13 2020 Increased extracellular H2O2 concentration induced by quercetin under oxidative stress was related to the inhibition of AQP3 and upregulation of NOX1/2, which may contribute to the observed protective effects of quercetin. Hydrogen Peroxide 24-28 aquaporin 3 (Gill blood group) Homo sapiens 120-124 31379986-10 2019 The AQP3 gene expression was stimulated by H2O2 treatment in hormone-positive and HER2NEU cells, together with Nrf2 expression, but was downregulated in triple-negative cells that showed instead upregulation of AQP1 and AQP5. Hydrogen Peroxide 43-47 aquaporin 3 (Gill blood group) Homo sapiens 4-8 31277235-4 2019 AQP3 and AQP5 are strongly expressed in cancer tissues and AQP3-mediated H2O2 transport has been related to breast cancer cell migration, but studies with human AQP5 are lacking. Hydrogen Peroxide 73-77 aquaporin 3 (Gill blood group) Homo sapiens 59-63 33811845-2 2021 Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Hydrogen Peroxide 44-48 aquaporin 3 (Gill blood group) Homo sapiens 0-11 26896765-3 2016 AQP3 knockdown suppressed the transport into the cells of extracellular H2O2 produced in response to EGF in A431 and H1666 cells. Hydrogen Peroxide 72-76 aquaporin 3 (Gill blood group) Homo sapiens 0-4 26830227-0 2016 Aquaporin-3 Controls Breast Cancer Cell Migration by Regulating Hydrogen Peroxide Transport and Its Downstream Cell Signaling. Hydrogen Peroxide 64-81 aquaporin 3 (Gill blood group) Homo sapiens 0-11 26830227-3 2016 Here, we show that the water/glycerol channel protein aquaporin-3 (AQP3) is required for CXCL12/CXCR4-dependent breast cancer cell migration through a mechanism involving its hydrogen peroxide (H2O2) transport function. Hydrogen Peroxide 175-192 aquaporin 3 (Gill blood group) Homo sapiens 54-65 26830227-3 2016 Here, we show that the water/glycerol channel protein aquaporin-3 (AQP3) is required for CXCL12/CXCR4-dependent breast cancer cell migration through a mechanism involving its hydrogen peroxide (H2O2) transport function. Hydrogen Peroxide 175-192 aquaporin 3 (Gill blood group) Homo sapiens 67-71 26830227-3 2016 Here, we show that the water/glycerol channel protein aquaporin-3 (AQP3) is required for CXCL12/CXCR4-dependent breast cancer cell migration through a mechanism involving its hydrogen peroxide (H2O2) transport function. Hydrogen Peroxide 194-198 aquaporin 3 (Gill blood group) Homo sapiens 54-65 30754672-0 2019 Honey-Mediated Wound Healing: H2O2 Entry through AQP3 Determines Extracellular Ca2+ Influx. Hydrogen Peroxide 30-34 aquaporin 3 (Gill blood group) Homo sapiens 49-53 30754672-4 2019 We observed that this extracellularly released H2O2 could pass across the plasma membrane through a specific aquaporin (i.e., AQP3). Hydrogen Peroxide 47-51 aquaporin 3 (Gill blood group) Homo sapiens 126-130 26837049-2 2016 Some AQPs including AQP3 and AQP8 have been recently found to transport hydrogen peroxide (H2O2). Hydrogen Peroxide 72-89 aquaporin 3 (Gill blood group) Homo sapiens 20-24 26837049-2 2016 Some AQPs including AQP3 and AQP8 have been recently found to transport hydrogen peroxide (H2O2). Hydrogen Peroxide 91-95 aquaporin 3 (Gill blood group) Homo sapiens 20-24 26830227-3 2016 Here, we show that the water/glycerol channel protein aquaporin-3 (AQP3) is required for CXCL12/CXCR4-dependent breast cancer cell migration through a mechanism involving its hydrogen peroxide (H2O2) transport function. Hydrogen Peroxide 194-198 aquaporin 3 (Gill blood group) Homo sapiens 67-71 26830227-4 2016 Extracellular H2O2, produced by CXCL12-activated membrane NADPH oxidase 2 (Nox2), was transported into breast cancer cells via AQP3. Hydrogen Peroxide 14-18 aquaporin 3 (Gill blood group) Homo sapiens 127-131 26830227-5 2016 Transient H2O2 accumulation was observed around the membrane during CXCL12-induced migration, which may be facilitated by the association of AQP3 with Nox2. Hydrogen Peroxide 10-14 aquaporin 3 (Gill blood group) Homo sapiens 141-145 26830227-8 2016 The expression level of AQP3 in breast cancer cells was related to their migration ability both in vitro and in vivo through CXCL12/CXCR4- or H2O2-dependent pathways. Hydrogen Peroxide 142-146 aquaporin 3 (Gill blood group) Homo sapiens 24-28 26830227-10 2016 These findings underscore the importance of AQP3-transported H2O2 in CXCL12/CXCR4-dependent signaling and migration in breast cancer cells and suggest that AQP3 has potential as a therapeutic target for breast cancer. Hydrogen Peroxide 61-65 aquaporin 3 (Gill blood group) Homo sapiens 44-48 26830227-10 2016 These findings underscore the importance of AQP3-transported H2O2 in CXCL12/CXCR4-dependent signaling and migration in breast cancer cells and suggest that AQP3 has potential as a therapeutic target for breast cancer. Hydrogen Peroxide 61-65 aquaporin 3 (Gill blood group) Homo sapiens 156-160 20724658-0 2010 Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Hydrogen Peroxide 21-38 aquaporin 3 (Gill blood group) Homo sapiens 0-11 20724658-3 2010 Here we report that the water channel Aquaporin-3 (AQP3) can facilitate the uptake of H(2)O(2) into mammalian cells and mediate downstream intracellular signaling. Hydrogen Peroxide 86-94 aquaporin 3 (Gill blood group) Homo sapiens 38-49 20724658-3 2010 Here we report that the water channel Aquaporin-3 (AQP3) can facilitate the uptake of H(2)O(2) into mammalian cells and mediate downstream intracellular signaling. Hydrogen Peroxide 86-94 aquaporin 3 (Gill blood group) Homo sapiens 51-55 20724658-4 2010 Molecular imaging with Peroxy Yellow 1 Methyl-Ester (PY1-ME), a new chemoselective fluorescent indicator for H(2)O(2), directly demonstrates that aquaporin isoforms AQP3 and AQP8, but not AQP1, can promote uptake of H(2)O(2) specifically through membranes in mammalian cells. Hydrogen Peroxide 109-117 aquaporin 3 (Gill blood group) Homo sapiens 165-169 20724658-5 2010 Moreover, we show that intracellular H(2)O(2) accumulation can be modulated up or down based on endogenous AQP3 expression, which in turn can influence downstream cell signaling cascades. Hydrogen Peroxide 37-45 aquaporin 3 (Gill blood group) Homo sapiens 107-111 33811845-2 2021 Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Hydrogen Peroxide 44-48 aquaporin 3 (Gill blood group) Homo sapiens 13-17 34091997-0 2021 AQP3-mediated H2 O2 uptake inhibits LUAD autophagy by inactivating PTEN. Hydrogen Peroxide 14-19 aquaporin 3 (Gill blood group) Homo sapiens 0-4 34091997-3 2021 In current study, we newly identified the aquaporin 3 (AQP3) as a LUAD oncogenic factor with capacity to transport exogenous hydrogen peroxide (H2 O2 ) and increase intracellular ROS levels. Hydrogen Peroxide 125-142 aquaporin 3 (Gill blood group) Homo sapiens 42-53 34091997-3 2021 In current study, we newly identified the aquaporin 3 (AQP3) as a LUAD oncogenic factor with capacity to transport exogenous hydrogen peroxide (H2 O2 ) and increase intracellular ROS levels. Hydrogen Peroxide 125-142 aquaporin 3 (Gill blood group) Homo sapiens 55-59 34091997-3 2021 In current study, we newly identified the aquaporin 3 (AQP3) as a LUAD oncogenic factor with capacity to transport exogenous hydrogen peroxide (H2 O2 ) and increase intracellular ROS levels. Hydrogen Peroxide 144-149 aquaporin 3 (Gill blood group) Homo sapiens 42-53 34091997-3 2021 In current study, we newly identified the aquaporin 3 (AQP3) as a LUAD oncogenic factor with capacity to transport exogenous hydrogen peroxide (H2 O2 ) and increase intracellular ROS levels. Hydrogen Peroxide 144-149 aquaporin 3 (Gill blood group) Homo sapiens 55-59 34091997-4 2021 Subsequently, we demonstrated that AQP3 was necessary for the facilitated diffusion of exogenous H2 O2 in LUAD cells and that the AQP3-dependent transport of H2 O2 accelerated cell growth and inhibited rapamycin-induced autophagy. Hydrogen Peroxide 97-102 aquaporin 3 (Gill blood group) Homo sapiens 35-39 34091997-4 2021 Subsequently, we demonstrated that AQP3 was necessary for the facilitated diffusion of exogenous H2 O2 in LUAD cells and that the AQP3-dependent transport of H2 O2 accelerated cell growth and inhibited rapamycin-induced autophagy. Hydrogen Peroxide 158-163 aquaporin 3 (Gill blood group) Homo sapiens 35-39 34091997-4 2021 Subsequently, we demonstrated that AQP3 was necessary for the facilitated diffusion of exogenous H2 O2 in LUAD cells and that the AQP3-dependent transport of H2 O2 accelerated cell growth and inhibited rapamycin-induced autophagy. Hydrogen Peroxide 158-163 aquaporin 3 (Gill blood group) Homo sapiens 130-134 34091997-5 2021 Mechanistically, AQP3-mediated H2 O2 uptake increased intracellular ROS levels to inactivate PTEN and activate the AKT/mTOR pathway subsequently inhibit autophagy and 1promote proliferation in LUAD cells. Hydrogen Peroxide 31-36 aquaporin 3 (Gill blood group) Homo sapiens 17-21 34145535-6 2021 mRNA expression (aquaporin-1 and aquaporin-3) and hyaluronan secretion associated with skin moisturization were reduced by H2O2 treatment, whereas MSC-Ex reversed these effects. Hydrogen Peroxide 123-127 aquaporin 3 (Gill blood group) Homo sapiens 33-44