PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35506157-5	2022	Moreover, GAA also suppressed H2O2 induced major matrix degrading proteases (MMP-3, MMP-13, ADAMTS4 and ADAMTS5) associated with NP degradation.	Hydrogen Peroxide	30-34	matrix metallopeptidase 13	Homo sapiens	84-90	
31383789-6	2019	Chondrocytes were treated with Dex alone or in combination with H2O2 Treatment with Dex alone decreased mRNA expression of COL2A1 and increased that of MMP-3 and MMP-13, thus contributing to cartilage degeneration.	Hydrogen Peroxide	64-68	matrix metallopeptidase 13	Homo sapiens	162-168	
32305648-11	2020	Significant SPD tuning of the H2O2-dependent induction of degradative (MMP-13) inflammatory (iNOS, COX-2) and hypertrophy markers (Runx 2 and VEGF) was revealed by Real Time PCR and pointed at the SPD ability of reducing NF-kappaB activation through autophagy induction.	Hydrogen Peroxide	30-34	matrix metallopeptidase 13	Homo sapiens	71-77	
32995615-8	2020	In addition, the gene expression of pro-inflammatory MMPs arose significantly in BJ fibroblasts after oxidative stress induction using 200 muM H2O2, in which the expression for MMP1, MMP3, and MMP13 increased by 7.10, 38.96, and 2.69 times, respectively.	Hydrogen Peroxide	143-147	matrix metallopeptidase 13	Homo sapiens	193-198	
32995615-10	2020	In conclusion, CME showed favorable antiaging activities in H2O2-treated human BJ fibroblasts as confirmed by the low levels of gene expression of MPP1, MMP3, and MMP13 after treatment with CME.	Hydrogen Peroxide	60-64	matrix metallopeptidase 13	Homo sapiens	163-168	
31213768-16	2019	MMP-2 and MMP-13 expression increased with H2O2, but doxycycline inhibited MMP-2 up-regulation/activation.	Hydrogen Peroxide	43-47	matrix metallopeptidase 13	Homo sapiens	10-16	
28153003-13	2017	In RT-qPCR results, aucubin could maintain ACAN and COL2A1 gene expressions, and prevent IL6 and MMP13 gene up-regulation induced by H2O2 and compression stimulations.	Hydrogen Peroxide	133-137	matrix metallopeptidase 13	Homo sapiens	97-102	
21863215-8	2011	In vitro, acetaldehyde, H2O2, as well as 2-AG and THC, alone or in combination with acetaldehyde, induced CB1 mRNA expression, whereas CB1 blockage with SR141716 dose-dependently inhibited HSC proliferation and downregulated mRNA expression of fibrosis-mediated genes PCalpha1(I), TIMP-1 and MMP-13.	Hydrogen Peroxide	24-28	matrix metallopeptidase 13	Homo sapiens	292-298	
30071128-7	2018	Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin-6 (Il6), were downregulated in the H2 O2 group with AP, demonstrating a decrease in the progression of OA.	Hydrogen Peroxide	166-171	matrix metallopeptidase 13	Homo sapiens	30-56	
30071128-7	2018	Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin-6 (Il6), were downregulated in the H2 O2 group with AP, demonstrating a decrease in the progression of OA.	Hydrogen Peroxide	166-171	matrix metallopeptidase 13	Homo sapiens	58-63