PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34043997-1 2021 H2O2 is endogenously generated and its removal in the matrix of skeletal muscle mitochondria (SMM) is dependent on NADPH likely provided by NAD(P)+ transhydrogenase (NNT) and isocitrate dehydrogenase (IDH2). Hydrogen Peroxide 0-4 isocitrate dehydrogenase 2 (NADP+), mitochondrial Mus musculus 201-205 30508699-6 2019 MitoQ almost completely neutralized the H2O2-induced ototoxicity, as the survival rate of Idh2-/- hair cells were restored to normal levels. Hydrogen Peroxide 40-44 isocitrate dehydrogenase 2 (NADP+), mitochondrial Mus musculus 90-94 27821630-8 2017 In cultured mouse kidney proximal tubule cells, Idh2 gene downregulation enhanced the mitochondrial damage and apoptosis induced by treatment with hydrogen peroxide. Hydrogen Peroxide 147-164 isocitrate dehydrogenase 2 (NADP+), mitochondrial Mus musculus 48-52 26589116-6 2015 IDH2-mediated conversion of isocitrate to alpha-ketoglutarate leads to the generation of NADPH, which is critical to buffering the H2O2 produced by the respiratory chain. Hydrogen Peroxide 131-135 isocitrate dehydrogenase 2 (NADP+), mitochondrial Mus musculus 0-4