PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34043997-4	2021	Further comparisons between SMM from both Nnt mouse genotypes revealed that the NADPH supplied by NNT supports up to 600 pmol/mg/min of H2O2 removal under selected conditions.	Hydrogen Peroxide	136-140	nicotinamide nucleotide transhydrogenase	Mus musculus	98-101	
34043997-0	2021	NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria.	Hydrogen Peroxide	71-75	nicotinamide nucleotide transhydrogenase	Mus musculus	63-66	
34043997-5	2021	Surprisingly, SMM from Nnt-/- mice removed exogenous H2O2 at wild-type levels and exhibited a maintained or even decreased net emission of endogenous H2O2 when substrates that support Krebs cycle reactions were present (e.g., pyruvate plus malate or palmitoylcarnitine plus malate).	Hydrogen Peroxide	53-57	nicotinamide nucleotide transhydrogenase	Mus musculus	23-26	
34043997-5	2021	Surprisingly, SMM from Nnt-/- mice removed exogenous H2O2 at wild-type levels and exhibited a maintained or even decreased net emission of endogenous H2O2 when substrates that support Krebs cycle reactions were present (e.g., pyruvate plus malate or palmitoylcarnitine plus malate).	Hydrogen Peroxide	150-154	nicotinamide nucleotide transhydrogenase	Mus musculus	23-26	
34043997-7	2021	Importantly, respiratory rates were similar between SMM from both Nnt genotypes despite differing NNT contributions to H2O2 removal and their implications for an evolving concept in the literature are discussed.	Hydrogen Peroxide	119-123	nicotinamide nucleotide transhydrogenase	Mus musculus	98-101	
34043997-8	2021	We concluded that NNT is capable of meaningfully sustaining NADPH-dependent H2O2 removal in intact SMM.	Hydrogen Peroxide	76-80	nicotinamide nucleotide transhydrogenase	Mus musculus	18-21	
34043997-9	2021	Nonetheless, if the available substrates favor non-NNT sources of NADPH, the H2O2 removal by SMM is maintained in Nnt-/- mice SMM.	Hydrogen Peroxide	77-81	nicotinamide nucleotide transhydrogenase	Mus musculus	114-117	
30281804-5	2018	In the absence of NNT, an increased release of H2 O2 from mitochondria was observed when the metabolism of respiratory substrates occurred with restricted flux through relevant mitochondrial NADPH sources or when respiratory complex I was inhibited.	Hydrogen Peroxide	47-52	nicotinamide nucleotide transhydrogenase	Mus musculus	18-21	
31639438-1	2020	Here, we demonstrate that the upregulation of catalase is required to compensate for the loss of nicotinamide nucleotide transhydrogenase (NNT) to maintain hydrogen peroxide (H2O2) steady-state levels in C57BL/6J liver mitochondria.	Hydrogen Peroxide	156-173	nicotinamide nucleotide transhydrogenase	Mus musculus	97-137	
31639438-1	2020	Here, we demonstrate that the upregulation of catalase is required to compensate for the loss of nicotinamide nucleotide transhydrogenase (NNT) to maintain hydrogen peroxide (H2O2) steady-state levels in C57BL/6J liver mitochondria.	Hydrogen Peroxide	156-173	nicotinamide nucleotide transhydrogenase	Mus musculus	139-142	
30281804-6	2018	In accordance, mitochondria from Nnt-/- brains were unable to sustain NADP in its reduced state when energized in the absence of carbon substrates, an effect aggravated after H2 O2 bolus metabolism.	Hydrogen Peroxide	175-180	nicotinamide nucleotide transhydrogenase	Mus musculus	33-36	
28964917-5	2017	Under a HFD, the aggravated NAFLD phenotype in the Nnt-/- mice was accompanied by an increased H2O2 release rate from mitochondria, decreased aconitase activity (a redox-sensitive mitochondrial enzyme) and higher susceptibility to Ca2+-induced mitochondrial permeability transition.	Hydrogen Peroxide	95-99	nicotinamide nucleotide transhydrogenase	Mus musculus	51-54	
28580284-12	2017	Accordingly, the lack of NNT in J-islets decreased their sensitivity to exogenous H2O2 at non-stimulating glucose.	Hydrogen Peroxide	82-86	nicotinamide nucleotide transhydrogenase	Mus musculus	25-28	
23747984-7	2013	The functional evaluation of respiring mitochondria revealed major redox alterations in B6J-Nnt(MUT) mice, including an absence of transhydrogenation between NAD and NADP, higher rates of H2O2 release, the spontaneous oxidation of NADPH, the poor ability to metabolize organic peroxide, and a higher susceptibility to undergo Ca(2+)-induced mitochondrial permeability transition.	Hydrogen Peroxide	188-192	nicotinamide nucleotide transhydrogenase	Mus musculus	92-95