PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28542134-3 2017 Treatment with hydrogen peroxide enhanced autophagy flux and caused the localization of BECN1 to the mitochondria, whereas these changes were impaired in the absence of CAV1. Hydrogen Peroxide 15-32 beclin 1, autophagy related Mus musculus 88-93 33327462-10 2020 In addition, Tat-p27 significantly increased microtubule-associated protein 1A/1B light chain 3A/3B expression and ameliorated the H2O2 or ischemia-induced increases of p62 and decreases of beclin-1 in the HT22 cells and hippocampus. Hydrogen Peroxide 131-135 beclin 1, autophagy related Mus musculus 190-198 30320895-7 2019 Moreover, elimination of TDP-43 inhibited H2 O2 -triggered autophagy, which appeared as decreased expression of LC3II/I and Beclin-1, along with p62 degradation. Hydrogen Peroxide 42-47 beclin 1, autophagy related Mus musculus 124-132 29479301-5 2018 The overexpression of Homer1a enhanced autophagy after H2O2 treatment, which was confirmed by increased expression of LC3II, Beclin-1, and greater autophagosome formation. Hydrogen Peroxide 55-59 beclin 1, autophagy related Mus musculus 125-133 28450048-11 2017 Our results showed that pretreatment with liraglutide significantly prevented H2O2-induced cell viability decline, mitochondrial morphological deterioration and induction of autophagy, which appeared as increased expression of LC3 II/I and Beclin-1, along with p62 degradation. Hydrogen Peroxide 78-82 beclin 1, autophagy related Mus musculus 240-248 32838711-0 2021 Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy. Hydrogen Peroxide 47-51 beclin 1, autophagy related Mus musculus 81-88 32838711-12 2021 In addition, H2O2 decreased the levels of Beclin1 and Atg5/12/16, which were reversed by rapamycin or melatonin. Hydrogen Peroxide 13-17 beclin 1, autophagy related Mus musculus 42-49 32838711-14 2021

Conclusion: In conclusion, these results demonstrate that melatonin protects HT22 hippocampal neurons from H2O2- induced injury by increasing the levels of the Beclin1 and Atg proteins to activate autophagy. Hydrogen Peroxide 111-115 beclin 1, autophagy related Mus musculus 164-171 28542134-6 2017 Interestingly, the phosphorylation of CAV1 at tyrosine-14 was essential for the interaction with BECN1 and their localization to the mitochondria, and the activation of autophagy in response to hydrogen peroxide. Hydrogen Peroxide 194-211 beclin 1, autophagy related Mus musculus 97-102 27335569-4 2016 Inverted phase contrast microscope images, MTT assay, flow cytometry and western blot results showed that, compared to cells exposed to 100 microM H2O2 alone, cells pretreated with methylprednisolone had a significantly lower percentage of apoptotic cells, maintained a healthy morphology, and showed downregulation of autophagic protein light chain 3B and Beclin-1 protein expression. Hydrogen Peroxide 147-151 beclin 1, autophagy related Mus musculus 357-365 21067284-0 2011 Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Hydrogen Peroxide 0-17 beclin 1, autophagy related Mus musculus 26-34 25895672-8 2015 H2O2 highly enhanced the expression induction of the autophagy-related beclin-1 and light chains 3A/B (LC3A/B) within 4 h and astragalin blocked such induction by H2O2. Hydrogen Peroxide 0-4 beclin 1, autophagy related Mus musculus 71-79 25895672-8 2015 H2O2 highly enhanced the expression induction of the autophagy-related beclin-1 and light chains 3A/B (LC3A/B) within 4 h and astragalin blocked such induction by H2O2. Hydrogen Peroxide 163-167 beclin 1, autophagy related Mus musculus 71-79 21067284-2 2011 Under GSH-depleted conditions, H2O2-induced autophagic cell, characterized by an increased LC3-II/I ratio, a decreased level of p62 and the formation of autophagic vacuoles, was inhibited by bafilomycin A1 and by Atg5 siRNA transfection, whereas the cell death was not inhibited by zVAD-fmk, by PI3K inhibitors or by Beclin 1 siRNA transfection. Hydrogen Peroxide 31-35 beclin 1, autophagy related Mus musculus 317-325 21067284-5 2011 Collectively, these findings demonstrate that H2O2 induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells. Hydrogen Peroxide 46-50 beclin 1, autophagy related Mus musculus 59-67 35227772-11 2022 However, sSTEAP4 inhibited AMPK phosphorylation and Beclin1/LC3 expression under H2O2-deficiency situation, but the results were conversed with H2O2 stimulation. Hydrogen Peroxide 81-85 beclin 1, autophagy related Mus musculus 52-59