PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10190554-10	1999	Intracellular steady-state levels of the mdrl substrate rhodamine 123, determined as parameter of mdr1-type transport activity, indicated that mdr1-dependent efflux was increased in hepatocytes pretreated with H2O2 or aminotriazole and decreased in antioxidant-treated cells.	Hydrogen Peroxide	210-214	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	98-102	
19656260-4	2009	Exposure to hydrogen peroxide (200 microM) resulted in intracellular oxidative stress as detected from higher levels of dichlorofluorescein fluorescence and raised levels of P-gp protein, mdr1a and mdr1b transcripts and, in GPNT cells, increased mdr1a and mdr1b promoter activity.	Hydrogen Peroxide	12-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	174-178	
19656260-4	2009	Exposure to hydrogen peroxide (200 microM) resulted in intracellular oxidative stress as detected from higher levels of dichlorofluorescein fluorescence and raised levels of P-gp protein, mdr1a and mdr1b transcripts and, in GPNT cells, increased mdr1a and mdr1b promoter activity.	Hydrogen Peroxide	12-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	198-203	
19656260-4	2009	Exposure to hydrogen peroxide (200 microM) resulted in intracellular oxidative stress as detected from higher levels of dichlorofluorescein fluorescence and raised levels of P-gp protein, mdr1a and mdr1b transcripts and, in GPNT cells, increased mdr1a and mdr1b promoter activity.	Hydrogen Peroxide	12-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	256-261	
19656260-8	2009	These data suggest that hydrogen peroxide contributes to P-gp up-regulation following hypoxia-reoxygenation but the underlying mechanisms of its actions differ from those occurring after direct hydrogen peroxide application.	Hydrogen Peroxide	24-41	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	57-61	
19656260-8	2009	These data suggest that hydrogen peroxide contributes to P-gp up-regulation following hypoxia-reoxygenation but the underlying mechanisms of its actions differ from those occurring after direct hydrogen peroxide application.	Hydrogen Peroxide	194-211	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	57-61	
14622133-0	2003	Signalling pathways influencing basal and H(2)O(2)-induced P-glycoprotein expression in endothelial cells derived from the blood-brain barrier.	Hydrogen Peroxide	42-50	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	59-73	
14622133-2	2003	Pathways regulating P-gp expression, both basal and hydrogen peroxide (H2O2)-induced, are here examined in primary cultured rat brain endothelial cells.	Hydrogen Peroxide	52-69	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	20-24	
14622133-2	2003	Pathways regulating P-gp expression, both basal and hydrogen peroxide (H2O2)-induced, are here examined in primary cultured rat brain endothelial cells.	Hydrogen Peroxide	71-75	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	20-24	
14622133-9	2003	By depressing NF-kappaB signalling, H2O2 may still augment P-gp expression when ERK1/2, PKC or SAPK are inhibited.	Hydrogen Peroxide	36-40	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	59-63	
11796744-3	2002	H(2)O(2) up to 500 microm applied to cell monolayers caused a concentration-dependent increase in expression of P-glycoprotein (Pgp) but not of multidrug resistance-associated protein (Mrp1).	Hydrogen Peroxide	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	112-126	
11796744-3	2002	H(2)O(2) up to 500 microm applied to cell monolayers caused a concentration-dependent increase in expression of P-glycoprotein (Pgp) but not of multidrug resistance-associated protein (Mrp1).	Hydrogen Peroxide	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	128-131	
15177642-2	2004	Hydrogen peroxide and paraquat-induced further upregulation supporting that oxidative stress mediated mechanisms are involved in the regulation of MDR1b in rat lung.	Hydrogen Peroxide	0-17	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	147-152	
10190554-5	1999	Addition of H2O2 to the culture medium resulted in a significant increase in mdrlb mRNA and P-glycoprotein after 3 days of culture, with maximal (approximately 2-fold) induction being observed with 0.5-1 mM H2O2.	Hydrogen Peroxide	12-16	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	92-106	
10190554-10	1999	Intracellular steady-state levels of the mdrl substrate rhodamine 123, determined as parameter of mdr1-type transport activity, indicated that mdr1-dependent efflux was increased in hepatocytes pretreated with H2O2 or aminotriazole and decreased in antioxidant-treated cells.	Hydrogen Peroxide	210-214	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	143-147