PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22883016-3	2012	E2F-1/PAC1-mediated induction of apoptotic cell death in response to H2O2 were examined by trypan blue exclusion and the expression levels of related target factors detected by Western blot.	Hydrogen Peroxide	69-73	E2F transcription factor 1	Homo sapiens	0-5	
30571557-5	2019	Overexpression of E2F1/2/3a activated DHFR promoter at baseline and alleviated the inhibitory effect of H2O2 on DHFR promoter activity.	Hydrogen Peroxide	104-108	E2F transcription factor 1	Homo sapiens	18-24	
30571557-6	2019	H2O2 treatment diminished mRNA and protein expression of E2F1/2/3a, whereas overexpression of E2F isoforms increased DHFR protein levels.	Hydrogen Peroxide	0-4	E2F transcription factor 1	Homo sapiens	57-63	
30571557-7	2019	Chromatin immunoprecipitation assay indicated direct binding of E2F1/2/3a to the DHFR promoter, which was weakened by H2O2.	Hydrogen Peroxide	118-122	E2F transcription factor 1	Homo sapiens	64-70	
30571557-11	2019	In summary, endothelial DHFR is downregulated by H2O2 transcriptionally via an E2F-dependent mechanism, and that specifically targeting E2F1/2/3a to restore DHFR and eNOS function may serve as a novel therapeutic option for the treatment of hypertension.	Hydrogen Peroxide	49-53	E2F transcription factor 1	Homo sapiens	136-142	
19760704-1	2009	The intramolecular trans-halophosphanylation of 2-(aminophosphanyl)phenylacetylenes mediated by PBr3 followed by the oxidation with H2O2, produces 3-bromobenzo[b]phosphole oxide derivatives.	Hydrogen Peroxide	132-136	E2F transcription factor 1	Homo sapiens	96-100	
32910941-3	2020	Here, we established an RPE model of H2O2-induced oxidative stress and found that Sirtuin 1 (Sirt1)-mediated deacetylation of E2F transcription factor 1 (E2F1) was required for oxidation resistance in RPE cells.	Hydrogen Peroxide	37-41	E2F transcription factor 1	Homo sapiens	126-152	
32910941-3	2020	Here, we established an RPE model of H2O2-induced oxidative stress and found that Sirtuin 1 (Sirt1)-mediated deacetylation of E2F transcription factor 1 (E2F1) was required for oxidation resistance in RPE cells.	Hydrogen Peroxide	37-41	E2F transcription factor 1	Homo sapiens	154-158	
33093269-8	2020	In conclusion, our results point to the obvious protective effect of TSG on HUVECs injury induced by H2O2, and the mechanism may through miR16/ATF6/ E2F1 signaling pathway.	Hydrogen Peroxide	101-105	E2F transcription factor 1	Homo sapiens	149-153