PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29197562-8	2018	Thus, we propose that the main pathway affecting the overall age-related cellular stress network in the rat blood would entail NADPH-related oxidative stress (involving H2O2) triggering GADD153 activation leading to SP induction which in-turn affects other cell signals.	Hydrogen Peroxide	169-173	DNA-damage inducible transcript 3	Rattus norvegicus	186-193	
30060293-7	2018	The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H2O2-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and beta-catenin and activated ERK phosphorylation.	Hydrogen Peroxide	188-192	DNA-damage inducible transcript 3	Rattus norvegicus	236-240	
29599827-8	2018	The assays showed that after sevoflurane pretreatment the H9c2 cell viability was significantly increased, whereas the H2O2-induced apoptosis, intracellular Ca2+ concentration, mRNA expression of GRP78, and the protein expression of GRP78, CHOP and caspase-12 were all reduced.	Hydrogen Peroxide	119-123	DNA-damage inducible transcript 3	Rattus norvegicus	240-244	
24612558-8	2014	RESULTS: MiRNAs belonging to the miR-30 family including miR-30a, b, c, d and e were all downregulated in ER stress induced by H2O2 in cardiovascular cells NRVCs and RAVSMCs, along with the upregulation of GRP78, cleaved ATF6, CHOP, and cleaved caspase-12.	Hydrogen Peroxide	127-131	DNA-damage inducible transcript 3	Rattus norvegicus	227-231	
24867233-7	2014	Finally, we demonstrated that NRG-1 alleviated ER stress and decreased CHOP and GRP78 protein levels in NRCMs treated by H2 O2 .	Hydrogen Peroxide	121-126	DNA-damage inducible transcript 3	Rattus norvegicus	71-75	
9356315-0	1997	NR8383 alveolar macrophage toxic growth arrest by hydrogen peroxide is associated with induction of growth-arrest and DNA damage-inducible genes GADD45 and GADD153.	Hydrogen Peroxide	50-67	DNA-damage inducible transcript 3	Rattus norvegicus	156-163	
20109102-4	2010	In vitro experiments using PC12 cells revealed that 6-OHDA or hydrogen peroxide could induce the elevation of Grp58 and CHOP.	Hydrogen Peroxide	62-79	DNA-damage inducible transcript 3	Rattus norvegicus	120-124	
20109102-5	2010	6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA.	Hydrogen Peroxide	83-100	DNA-damage inducible transcript 3	Rattus norvegicus	47-51	
20109102-5	2010	6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA.	Hydrogen Peroxide	83-100	DNA-damage inducible transcript 3	Rattus norvegicus	161-165	
20109102-5	2010	6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA.	Hydrogen Peroxide	186-203	DNA-damage inducible transcript 3	Rattus norvegicus	47-51	
20804591-9	2010	Furthermore, taurine was also found to suppress up-regulation of GRP78, GADD153/CHOP and Bim induced by H2O2, suggesting that taurine may also exert a protective function against oxidative stress by reducing the ER stress.	Hydrogen Peroxide	104-108	DNA-damage inducible transcript 3	Rattus norvegicus	72-79	
20804591-9	2010	Furthermore, taurine was also found to suppress up-regulation of GRP78, GADD153/CHOP and Bim induced by H2O2, suggesting that taurine may also exert a protective function against oxidative stress by reducing the ER stress.	Hydrogen Peroxide	104-108	DNA-damage inducible transcript 3	Rattus norvegicus	80-84	
20109102-5	2010	6-OHDA could induce the elevation of Grp58 and CHOP in the presence of catalase, a hydrogen peroxide-removing enzyme, suggesting that the elevation of Grp58 and CHOP are induced by both hydrogen peroxide and p-quinone generated by 6-OHDA.	Hydrogen Peroxide	186-203	DNA-damage inducible transcript 3	Rattus norvegicus	161-165	
9356315-5	1997	Genes known to be coordinatively regulated in response to growth arrest and DNA damage, GADD45 and GADD153, were induced compared to the housekeeping gene beta-ACTIN by equitoxic doses of hydrogen peroxide and mercaptosuccinate.	Hydrogen Peroxide	188-205	DNA-damage inducible transcript 3	Rattus norvegicus	99-106