PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20419599-4 2010 TRPA1 is targeted by a series of byproducts of oxidative and nitrative stress, including acrolein, 4-hydroxy-2-nonenal and hydrogen peroxide. Hydrogen Peroxide 123-140 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-5 23918657-0 2013 Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents. Hydrogen Peroxide 63-80 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-38 23918657-3 2013 The aim of this study was to evaluate the role of transient receptor potential ankyrin 1 (TRPA-1) and TRPA-1 stimulants, such as H2 O2 , in a rodent model of MSU-induced inflammation. Hydrogen Peroxide 129-134 transient receptor potential cation channel subfamily A member 1 Homo sapiens 102-108 23918657-8 2013 H2 O2 , but not MSU, directly stimulated sensory neurons through the activation of TRPA-1. Hydrogen Peroxide 0-5 transient receptor potential cation channel subfamily A member 1 Homo sapiens 83-89 24961969-6 2014 In addition to TRPM2, TRPC5, TRPV1, and TRPA1 are also activated by H2O2 via modification of cysteine (Cys) free sulfhydryl groups. Hydrogen Peroxide 68-72 transient receptor potential cation channel subfamily A member 1 Homo sapiens 40-45 22843691-6 2012 The induced TRPA1 channels, which were intrinsically activated by endogenous hydrogen peroxide and Zn(2+), suppressed secretion of interleukin-6 and interleukin-8. Hydrogen Peroxide 77-94 transient receptor potential cation channel subfamily A member 1 Homo sapiens 12-17 34831352-6 2021 Hydrogen peroxide (H2O2) evoked a TRPA1-dependent calcium response in two distinct melanoma cell lines (SK-MEL-28 and WM266-4). Hydrogen Peroxide 0-17 transient receptor potential cation channel subfamily A member 1 Homo sapiens 34-39 18814910-6 2009 Since extracellular application of hydrogen peroxide mimicked the effect of UVA irradiation and since dithiothreitol partly reversed the activation by UVA exposure, we conclude that reactive oxygen species may mediate the light-induced activation of TRPA1. Hydrogen Peroxide 35-52 transient receptor potential cation channel subfamily A member 1 Homo sapiens 250-255 18814910-7 2009 Accordingly, hydrogen peroxide induced a TRPA1 activation with a membrane-delimited mode of action that was attenuated by dithiothreitol. Hydrogen Peroxide 13-30 transient receptor potential cation channel subfamily A member 1 Homo sapiens 41-46 18814910-8 2009 Intracellular but not extracellular application of FeSO(4), which catalyses the formation of highly reactive hydroxyl radicals potentiated the hydrogen peroxide-stimulated TRPA1 activation. Hydrogen Peroxide 143-160 transient receptor potential cation channel subfamily A member 1 Homo sapiens 172-177 18814910-9 2009 We conclude that, via generation of reactive oxygen species, light-induced TRPA1 activation provides an additional mode of activation, which renders TRPA1 a likely molecular candidate in processes leading to painful or burning sensations during photodynamic therapy or upon local application of hydrogen peroxide. Hydrogen Peroxide 295-312 transient receptor potential cation channel subfamily A member 1 Homo sapiens 75-80 18814910-9 2009 We conclude that, via generation of reactive oxygen species, light-induced TRPA1 activation provides an additional mode of activation, which renders TRPA1 a likely molecular candidate in processes leading to painful or burning sensations during photodynamic therapy or upon local application of hydrogen peroxide. Hydrogen Peroxide 295-312 transient receptor potential cation channel subfamily A member 1 Homo sapiens 149-154 18568080-5 2008 The identification of TRPA1 activation by toxicants from cigarette smoke and polluted air, such as crotonaldehyde, acrolein, and oxidizing agents such as hydrogen peroxide, is an important finding. Hydrogen Peroxide 154-171 transient receptor potential cation channel subfamily A member 1 Homo sapiens 22-27 34831352-6 2021 Hydrogen peroxide (H2O2) evoked a TRPA1-dependent calcium response in two distinct melanoma cell lines (SK-MEL-28 and WM266-4). Hydrogen Peroxide 19-23 transient receptor potential cation channel subfamily A member 1 Homo sapiens 34-39 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 13-17 transient receptor potential cation channel subfamily A member 1 Homo sapiens 28-33 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 13-17 transient receptor potential cation channel subfamily A member 1 Homo sapiens 83-88 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 13-17 transient receptor potential cation channel subfamily A member 1 Homo sapiens 113-118 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 44-48 transient receptor potential cation channel subfamily A member 1 Homo sapiens 28-33 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 44-48 transient receptor potential cation channel subfamily A member 1 Homo sapiens 83-88 34831352-7 2021 Furthermore, H2O2 induced a TRPA1-dependent H2O2 release that was prevented by the TRPA1 antagonist, A967079, or Trpa1 gene silencing (siRNA). Hydrogen Peroxide 44-48 transient receptor potential cation channel subfamily A member 1 Homo sapiens 113-118 33786825-7 2021 TRPA1 over-expression or activation induced HLMF apoptosis, and TRPA1 activation by H2 O2 induced necrosis. Hydrogen Peroxide 84-89 transient receptor potential cation channel subfamily A member 1 Homo sapiens 64-69 34539837-12 2021 Pre-treatment with 18beta-GA obviously reduced Bad, Bax, cleaved-caspase3, cleaved-caspase 7, TRPA1 and TRPV1 levels and p38 MAPK phosphorylation after H2O2 treatment and increased Bcl-2 and Bcl-xl levels. Hydrogen Peroxide 152-156 transient receptor potential cation channel subfamily A member 1 Homo sapiens 94-99 33786825-9 2021 Lentiviral vector mediated TRPA1 expression was also found to induce sensitivity to H2 O2 induced cell death in a TRPA1-negative HEK293T cell line. Hydrogen Peroxide 84-89 transient receptor potential cation channel subfamily A member 1 Homo sapiens 27-32 33786825-9 2021 Lentiviral vector mediated TRPA1 expression was also found to induce sensitivity to H2 O2 induced cell death in a TRPA1-negative HEK293T cell line. Hydrogen Peroxide 84-89 transient receptor potential cation channel subfamily A member 1 Homo sapiens 114-119 33786825-10 2021 CONCLUSION AND IMPLICATIONS: TGFbeta1 induces resistance of HLMFs to TRPA1 agonist- and H2 O2 -mediated cell death via downregulation of TRPA1. Hydrogen Peroxide 88-93 transient receptor potential cation channel subfamily A member 1 Homo sapiens 137-142 27238971-6 2016 Regarding TRPV1 and TRPA1, none of the three compounds tested affected H2O2-induced TRPV1 activation; however, AG555 and AG556 reduced H2O2-induced TRPA1 activation more than AG490. Hydrogen Peroxide 135-139 transient receptor potential cation channel subfamily A member 1 Homo sapiens 148-153 31805147-4 2019 We found that chemicals known to activate TRPA1 (allyl isothiocyanate (AITC) and hydrogen peroxide) and TRPV (capsaicin and anandamide) in other systems induce scrunching in the planarian species Dugesia japonica and, except for anandamide, in Schmidtea mediterranea. Hydrogen Peroxide 81-98 transient receptor potential cation channel subfamily A member 1 Homo sapiens 42-47 30990108-8 2019 ET-1 sensitized TRPA1 activated by endogenous agonist H2O2. Hydrogen Peroxide 54-58 transient receptor potential cation channel subfamily A member 1 Homo sapiens 16-21 31682917-4 2020 For example, TRPM2, TRPC5, TRPV1, and TRPA1 are known as redox sensors activated by hydrogen peroxide (H2O2), nitric oxide (NO), and electrophiles. Hydrogen Peroxide 84-101 transient receptor potential cation channel subfamily A member 1 Homo sapiens 38-43 30914247-10 2019 Surprisingly, both TRPA1 and TRPV1 were activated by H2O2 when expressed in HEK293. Hydrogen Peroxide 53-57 transient receptor potential cation channel subfamily A member 1 Homo sapiens 19-24 29184198-5 2017 Instead, our data suggest that TRPA1 activation is mediated by H2O2 and reactive oxygen species, early markers of tissue damage rapidly produced as a result of heat exposure. Hydrogen Peroxide 63-67 transient receptor potential cation channel subfamily A member 1 Homo sapiens 31-36 29163216-7 2017 Oxaliplatin also induced the rapid generation of hydrogen peroxide, and the resultant Ca2+ influx was prevented in the presence of glutathione and in cysteine-mutated hTRPA1 (Cys641Ser)-expressing cells, whereas proline-mutated hTRPA1 (Pro394Ala)-expressing cells showed similar whole-cell currents and Ca2+ influx. Hydrogen Peroxide 49-66 transient receptor potential cation channel subfamily A member 1 Homo sapiens 167-173 27628562-3 2016 We show that inhibiting hydroxylation of a proline residue within the N-terminal ankyrin repeat of human TRPA1 by mutation or using a prolyl hydroxylase (PHD) inhibitor potentiates the cold sensitivity of TRPA1 in the presence of hydrogen peroxide. Hydrogen Peroxide 230-247 transient receptor potential cation channel subfamily A member 1 Homo sapiens 105-110 27628562-3 2016 We show that inhibiting hydroxylation of a proline residue within the N-terminal ankyrin repeat of human TRPA1 by mutation or using a prolyl hydroxylase (PHD) inhibitor potentiates the cold sensitivity of TRPA1 in the presence of hydrogen peroxide. Hydrogen Peroxide 230-247 transient receptor potential cation channel subfamily A member 1 Homo sapiens 205-210 27238971-7 2016 Thus, we herein identified AG555 and AG556 as new compounds that exert stronger inhibitory effects on H2O2-induced TRPM2 and TRPA1 activation than AG490. Hydrogen Peroxide 102-106 transient receptor potential cation channel subfamily A member 1 Homo sapiens 125-130 26983498-6 2016 In human TRPA1-expressing cells as well as cultured mouse dorsal root ganglion neurons, the H2O2-evoked TRPA1 response was significantly increased by pretreatment with hypoxia (80 mmHg) for 30 min. Hydrogen Peroxide 92-96 transient receptor potential cation channel subfamily A member 1 Homo sapiens 9-14 25564678-8 2015 NOX-induced activation of TRPA1 sparklets and vasodilation required generation of hydrogen peroxide and lipid-peroxidizing hydroxyl radicals as intermediates. Hydrogen Peroxide 82-99 transient receptor potential cation channel subfamily A member 1 Homo sapiens 26-31 25179574-12 2014 Although transient receptor potential ankyrin 1 (TRPA1) channel is also activated by H2O2, the H2O2-induced Ca(2+) entry through TRPA1 was only slightly delayed by AG490. Hydrogen Peroxide 85-89 transient receptor potential cation channel subfamily A member 1 Homo sapiens 9-47 25179574-12 2014 Although transient receptor potential ankyrin 1 (TRPA1) channel is also activated by H2O2, the H2O2-induced Ca(2+) entry through TRPA1 was only slightly delayed by AG490. Hydrogen Peroxide 85-89 transient receptor potential cation channel subfamily A member 1 Homo sapiens 49-54 25179574-12 2014 Although transient receptor potential ankyrin 1 (TRPA1) channel is also activated by H2O2, the H2O2-induced Ca(2+) entry through TRPA1 was only slightly delayed by AG490. Hydrogen Peroxide 95-99 transient receptor potential cation channel subfamily A member 1 Homo sapiens 9-47 25179574-12 2014 Although transient receptor potential ankyrin 1 (TRPA1) channel is also activated by H2O2, the H2O2-induced Ca(2+) entry through TRPA1 was only slightly delayed by AG490. Hydrogen Peroxide 95-99 transient receptor potential cation channel subfamily A member 1 Homo sapiens 49-54 25179574-12 2014 Although transient receptor potential ankyrin 1 (TRPA1) channel is also activated by H2O2, the H2O2-induced Ca(2+) entry through TRPA1 was only slightly delayed by AG490. Hydrogen Peroxide 95-99 transient receptor potential cation channel subfamily A member 1 Homo sapiens 129-134