PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33242093-0	2021	1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway.	Hydrogen Peroxide	52-56	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	98-102	
35439699-5	2022	The PKR-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 alpha(eIF2alpha) signaling branch was specifically activated and tightly regulated in senescent BMSCs induced by hydrogen peroxide (H2O2).	Hydrogen Peroxide	193-210	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	4-41	
35439699-5	2022	The PKR-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 alpha(eIF2alpha) signaling branch was specifically activated and tightly regulated in senescent BMSCs induced by hydrogen peroxide (H2O2).	Hydrogen Peroxide	193-210	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	43-47	
35439699-5	2022	The PKR-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 alpha(eIF2alpha) signaling branch was specifically activated and tightly regulated in senescent BMSCs induced by hydrogen peroxide (H2O2).	Hydrogen Peroxide	212-216	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	4-41	
35439699-5	2022	The PKR-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor 2 alpha(eIF2alpha) signaling branch was specifically activated and tightly regulated in senescent BMSCs induced by hydrogen peroxide (H2O2).	Hydrogen Peroxide	212-216	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	43-47	
33242093-6	2021	H2O2 activated the phosphorylation of PERK, upregulated the activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP) expression, and subsequently initiated cell apoptosis, which were significantly reversed by 1,25-(OH)2D3 pretreatment.	Hydrogen Peroxide	0-4	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	38-42	
33242093-7	2021	In addition, GSK2606414, a specific inhibitor of PERK, suppressed PERK phosphorylation and reduced the expressions of ATF4 and CHOP, leading to a significant decrease in beta cell apoptosis induced by H2O2.	Hydrogen Peroxide	201-205	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	49-53	
32039224-5	2020	This study using mouse kidney epithelial cells (TCMK-1) revealed that the level of CHOP (a key marker of ERS), PERK, and JNK (regulators of CHOP) was gradually increased by the prolonged time of hydrogen peroxide (H2O2) stimulation.	Hydrogen Peroxide	195-212	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	111-115	
31445205-0	2019	Free fatty acid-induced H2O2 activates TRPM2 to aggravate endothelial insulin resistance via Ca2+-dependent PERK/ATF4/TRB3 cascade in obese mice.	Hydrogen Peroxide	24-28	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	108-112