PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17392377-0 2007 Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Hydrogen Peroxide 12-29 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 63-76 21599461-6 2011 Furthermore, suppressive H(2)O(2) concentrations increased protein levels of the p50 NFkappaB sub-unit, IkappaBalpha, and an IkappaBalpha immunoreactive band which was previously characterized as an IkappaBalpha cleavage product exhibiting stronger inhibitory function than native IkappaBalpha. Hydrogen Peroxide 25-33 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 104-116 21599461-6 2011 Furthermore, suppressive H(2)O(2) concentrations increased protein levels of the p50 NFkappaB sub-unit, IkappaBalpha, and an IkappaBalpha immunoreactive band which was previously characterized as an IkappaBalpha cleavage product exhibiting stronger inhibitory function than native IkappaBalpha. Hydrogen Peroxide 25-33 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 125-137 21599461-6 2011 Furthermore, suppressive H(2)O(2) concentrations increased protein levels of the p50 NFkappaB sub-unit, IkappaBalpha, and an IkappaBalpha immunoreactive band which was previously characterized as an IkappaBalpha cleavage product exhibiting stronger inhibitory function than native IkappaBalpha. Hydrogen Peroxide 25-33 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 125-137 21599461-6 2011 Furthermore, suppressive H(2)O(2) concentrations increased protein levels of the p50 NFkappaB sub-unit, IkappaBalpha, and an IkappaBalpha immunoreactive band which was previously characterized as an IkappaBalpha cleavage product exhibiting stronger inhibitory function than native IkappaBalpha. Hydrogen Peroxide 25-33 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 125-137 19933270-0 2010 Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. Hydrogen Peroxide 71-88 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 38-52 30634242-5 2011 Furthermore, curcumin could block H2O2-mediated degradation of the protein IkappaBalpha and subsequent activation of nuclear factor kappaB, thus inhibiting the expression of its target gene cyclooxygenase 2. Hydrogen Peroxide 34-38 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 75-87 19933270-8 2010 These findings suggest that the anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF(beta-TrCP). Hydrogen Peroxide 61-69 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 162-176 15746559-5 2005 Overexpression of I-kappaBalpha and Bcl-2 did not affect cisplatin-induced necrotic cell death, but overexpression of I-kappaBalpha significantly decreased H2O2-induced cell death. Hydrogen Peroxide 156-160 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 118-131 16544977-10 2006 mIkappaBalpha-mediated inhibition of NF-kappaB activation sensitized HuH7 cells to H2O2-induced inhibition of cell growth, and further promoted cell death. Hydrogen Peroxide 83-87 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 0-13 16544977-11 2006 Addition of H2O2 (200-500 microM) to control or mIkappaBalpha-infected HuH7 cells enhanced caspase-3 activity and cleavage. Hydrogen Peroxide 12-16 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 48-61 9657527-7 1998 Catalase 1 kU/ml inhibited NF-kappaB activation by TNF-alpha; exogenous hydrogen peroxide 200 microM activated NF-kappaB and stimulated I-kappaBalpha degradation. Hydrogen Peroxide 72-89 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 136-149 11479295-5 2001 Importantly, in the presence of H(2)O(2), the ability of TNFalpha to induce IKK activity was markedly decreased and resulted in prevention of IkappaBalpha degradation and NF-kappaB activation. Hydrogen Peroxide 32-40 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 142-154 10092673-6 1999 Partial inhibition of NF-kappaB baseline activity by overexpression of a dominant-negative IkappaBalpha mutant enhanced the toxicity of H2O2 in GT1-7 cells. Hydrogen Peroxide 136-140 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 91-103 14656721-10 2004 This inhibition of nuclear accumulation of NF-kappaB by H2O2 was not caused by an impaired capacity of LPS to stimulate the IKK pathway or to direct oxidative effects on NF-kappaB but rather reflected diminished degradation of IkappaB-alpha. Hydrogen Peroxide 56-60 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 227-240 29156799-13 2017 Mechanistically, AA attenuated I/R or LPS/H2O2-induced ROS production and phosphorylation level of JNK, p38 MAPK and IkappaBalpha but not ERK, a mechanism dependent on PPARgamma. Hydrogen Peroxide 42-46 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 117-129 28223539-10 2017 Furthermore, H2O2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol. Hydrogen Peroxide 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 69-81