PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12214088-6	2000	However, the H2O2-treated cells also manifested increased expression of growth and sprouting molecules, including GAP-43, nitric oxide synthase 3, neuronal thread protein (NTP; approximately 17 kD and approximately 21 kD forms), proliferating cell nuclear antigen, and phospho-Erk MAPK, and normal levels of the AD-associated approximately 41 kD NTP species, cyclin dependent kinase 5 (cdk-5), and phospho-tau.	Hydrogen Peroxide	13-17	cyclin dependent kinase 5	Homo sapiens	359-384	
23646926-8	2013	In addition, we found that there were no obvious changes of Cyclin-dependent kinase 5 (CDK5) expression (responsible for tau phosphorylation) and of p35 cleavage, the regulatory subunit of CDK5 in H2O2-treated HEK293/Tau cells.	Hydrogen Peroxide	197-201	cyclin dependent kinase 5	Homo sapiens	189-193	
21922195-5	2012	Higher basal, IR, and hydrogen peroxide-induced polymer levels were observed in Cdk5(KD) compared to Control cells.	Hydrogen Peroxide	22-39	cyclin dependent kinase 5	Homo sapiens	80-84	
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Hydrogen Peroxide	174-191	cyclin dependent kinase 5	Homo sapiens	10-14	
18490454-6	2008	Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide.	Hydrogen Peroxide	174-191	cyclin dependent kinase 5	Homo sapiens	16-41	
18490454-9	2008	Our results show that c-Abl and Cdk5 cooperatively regulate maximal activation of p53, resulting in neuronal death in response to oxidative stress by hydrogen peroxide.	Hydrogen Peroxide	150-167	cyclin dependent kinase 5	Homo sapiens	32-36	
12214088-6	2000	However, the H2O2-treated cells also manifested increased expression of growth and sprouting molecules, including GAP-43, nitric oxide synthase 3, neuronal thread protein (NTP; approximately 17 kD and approximately 21 kD forms), proliferating cell nuclear antigen, and phospho-Erk MAPK, and normal levels of the AD-associated approximately 41 kD NTP species, cyclin dependent kinase 5 (cdk-5), and phospho-tau.	Hydrogen Peroxide	13-17	cyclin dependent kinase 5	Homo sapiens	386-391	
12214088-7	2000	In addition, the H2O2-treated cells had increased levels of p25, the catalytically active and stable cleavage product of p35, which regulates cdk-5 activity.	Hydrogen Peroxide	17-21	cyclin dependent kinase 5	Homo sapiens	142-147	
26206088-6	2016	Lentiviral transduction assay shows that knockdown of Cdk5 or overexpression of CHIP(S20A), but not CHIP(WT), attenuates tAIF-mediated neuronal cell death induced by hydrogen peroxide.	Hydrogen Peroxide	166-183	cyclin dependent kinase 5	Homo sapiens	54-58