PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33738869-7 2021 CoCl2 , a HIF-1 alpha stabilizer, blunted the effect of hydrogen peroxide. Hydrogen Peroxide 56-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 10-21 31310363-4 2019 The effects of H2 O2 and N-acetylcysteine (NAC) on the levels of HIF1-alpha and HIF2-alpha after overexpression of GPX3 were studied. Hydrogen Peroxide 15-20 hypoxia inducible factor 1 subunit alpha Homo sapiens 65-75 31981961-8 2020 The miR-548a-3p might regulate the cellular response to hydrogen peroxide through HO-1 and HIF-1pathway. Hydrogen Peroxide 56-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 91-96 31524211-2 2019 However, doxorubicin therapy increases the level of reactive oxygen species (ROS) in tumor cells, such as hydrogen peroxide (H2O2), which can stabilize hypoxia-inducible-factor-1alpha (HIF-1alpha). Hydrogen Peroxide 106-123 hypoxia inducible factor 1 subunit alpha Homo sapiens 152-183 31524211-2 2019 However, doxorubicin therapy increases the level of reactive oxygen species (ROS) in tumor cells, such as hydrogen peroxide (H2O2), which can stabilize hypoxia-inducible-factor-1alpha (HIF-1alpha). Hydrogen Peroxide 106-123 hypoxia inducible factor 1 subunit alpha Homo sapiens 185-195 31524211-2 2019 However, doxorubicin therapy increases the level of reactive oxygen species (ROS) in tumor cells, such as hydrogen peroxide (H2O2), which can stabilize hypoxia-inducible-factor-1alpha (HIF-1alpha). Hydrogen Peroxide 125-129 hypoxia inducible factor 1 subunit alpha Homo sapiens 152-183 31524211-2 2019 However, doxorubicin therapy increases the level of reactive oxygen species (ROS) in tumor cells, such as hydrogen peroxide (H2O2), which can stabilize hypoxia-inducible-factor-1alpha (HIF-1alpha). Hydrogen Peroxide 125-129 hypoxia inducible factor 1 subunit alpha Homo sapiens 185-195 32122653-8 2020 In SS B16 melanoma, exogenous non-toxic 100 muM H2O2 super-induces the ratio of tyrosinase to HIF1alpha. Hydrogen Peroxide 48-52 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-103 31310363-12 2019 The addition of H2 O2 increased while NAC reduced the protein levels of HIF1-alpha and HIF2-alpha in the cells overexpressing GPX3. Hydrogen Peroxide 16-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 72-82 30686776-4 2019 Here, we examined the subcellular localization of HIF-1alpha in human cells and identified a small fraction of HIF-1alpha that translocated to the mitochondria after exposure to hypoxia or H2O2 treatment. Hydrogen Peroxide 189-193 hypoxia inducible factor 1 subunit alpha Homo sapiens 111-121 31389949-5 2019 Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated. Hydrogen Peroxide 103-120 hypoxia inducible factor 1 subunit alpha Homo sapiens 180-211 31389949-5 2019 Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated. Hydrogen Peroxide 103-120 hypoxia inducible factor 1 subunit alpha Homo sapiens 213-223 31389949-5 2019 Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated. Hydrogen Peroxide 122-126 hypoxia inducible factor 1 subunit alpha Homo sapiens 180-211 31389949-5 2019 Moreover, FA-BSA-MnO2/DOX/siRNA NPs were also able to generate oxygen (O2) by reaction with endogenous hydrogen peroxide (H2O2) in tumor, thereby down-regulating the expression of hypoxia inducible factor-1alpha (HIF-1alpha), and then the expression of the vascular endothelial growth factor (VEGF) was down-regulated. Hydrogen Peroxide 122-126 hypoxia inducible factor 1 subunit alpha Homo sapiens 213-223 27637085-0 2016 Dual oxidase 2 and pancreatic adenocarcinoma: IFN-gamma-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1alpha and VEGF-A. Hydrogen Peroxide 106-110 hypoxia inducible factor 1 subunit alpha Homo sapiens 152-162 31011561-9 2019 Moreover after exposure to 100 muM H2O2, western blotting analysis showed that cell pretreatment with 20 muM H2O2, decremented Bax/Bcl2 ratio and up-regulated HIF-1alpha and pAkt-1 compared to the control group. Hydrogen Peroxide 35-39 hypoxia inducible factor 1 subunit alpha Homo sapiens 159-169 31011561-9 2019 Moreover after exposure to 100 muM H2O2, western blotting analysis showed that cell pretreatment with 20 muM H2O2, decremented Bax/Bcl2 ratio and up-regulated HIF-1alpha and pAkt-1 compared to the control group. Hydrogen Peroxide 109-113 hypoxia inducible factor 1 subunit alpha Homo sapiens 159-169 29258824-5 2018 Moreover, SNP or H2O2 exposure could further amplify hypoxia-induced nuclear translocation of HIF-1alpha and NF-kappa B. Hydrogen Peroxide 17-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-104 30062712-9 2018 HIF-1alpha, vascular endothelial growth factor-A, and vascular endothelial growth factor receptor-2 were overexpressed more than twofold in silicon-treated HUVECs, under normal and toxic H2 O2 conditions. Hydrogen Peroxide 187-192 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 30247915-6 2018 In particular, we observed that the highly stable mSPAM nanoassembly suppressed HIF1alpha expression by scavenging H2O2 in LPS-induced macrophage cells. Hydrogen Peroxide 115-119 hypoxia inducible factor 1 subunit alpha Homo sapiens 80-89 29396728-4 2018 We hypothesized that pancreatic cancer (PDAC) progression and metastasis could be be targeted by P-AscH- via H2O2-mediated inhibition of HIF-1alpha stabilization. Hydrogen Peroxide 109-113 hypoxia inducible factor 1 subunit alpha Homo sapiens 137-147 29287724-4 2018 Inhibition of PPP by either PARIS overexpression or TKT knock-down elevated the level of H2O2, and diminished NADPH and GSH levels, ultimately triggering the induction of HIF-1alpha, a master activator of glycolysis. Hydrogen Peroxide 89-93 hypoxia inducible factor 1 subunit alpha Homo sapiens 171-181 29138796-5 2018 The protein and gene levels of RelA, RelB, hypoxia-inducible factor-1alpha, tumor necrosis factor-alpha and apoptosis signal-regulating kinase 1 were significantly higher in the hyperoxia and H2O2 groups compared with those in the control group. Hydrogen Peroxide 192-196 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-103 24634836-1 2014 The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-kappaB, NOTCH, SP1 and SCREB-1) are reviewed. Hydrogen Peroxide 35-52 hypoxia inducible factor 1 subunit alpha Homo sapiens 229-234 25433027-8 2015 We then examined the roles of ROS in thGCs: hydrogen peroxide (20 and 50 muM) elevated HIF1A protein as well as the expression of EDN2, implying that induction of HIF1A protein levels is sufficient to stimulate the expression of EDN2 (and VEGF) in normoxia. Hydrogen Peroxide 44-61 hypoxia inducible factor 1 subunit alpha Homo sapiens 87-92 25433027-8 2015 We then examined the roles of ROS in thGCs: hydrogen peroxide (20 and 50 muM) elevated HIF1A protein as well as the expression of EDN2, implying that induction of HIF1A protein levels is sufficient to stimulate the expression of EDN2 (and VEGF) in normoxia. Hydrogen Peroxide 44-61 hypoxia inducible factor 1 subunit alpha Homo sapiens 163-168 25317019-7 2014 HIF-1alpha expression decreased by 10 microM exogenous hydrogen peroxide (H2O2); scavenger of ROS with or without bilirubin in the HK2 cells increased HIF-1alpha concentration more than that in the cells without bilirubin. Hydrogen Peroxide 55-72 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 25317019-7 2014 HIF-1alpha expression decreased by 10 microM exogenous hydrogen peroxide (H2O2); scavenger of ROS with or without bilirubin in the HK2 cells increased HIF-1alpha concentration more than that in the cells without bilirubin. Hydrogen Peroxide 74-78 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 27132006-3 2016 A nano-bioconjugate with hydrazine and a secondary antibody of HIF1alpha (sec-Ab2) attached on AuNPs reveals the immunoreaction at the sensor probe through the catalytic reduction of H2O2 by hydrazine at -0.35V vs. Ag/AgCl. Hydrogen Peroxide 183-187 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-72 25108166-5 2014 In addition, H2O2 increased intracellular levels of HIF-1alpha, Foxo-3a and Notch intracellular domain (NICD). Hydrogen Peroxide 13-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 52-62 24634836-1 2014 The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-kappaB, NOTCH, SP1 and SCREB-1) are reviewed. Hydrogen Peroxide 54-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 229-234 24184535-2 2014 SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of catalase to disproportionate H2O2 to O2, and has obvious effect on the proliferation of HepG-2 cells in 72 h. Moreover, the two nanoparticles show some inhibition on the expression of hypoxia inducible factor (HIF-1alpha), glucose transporter (GLUT1) and the production of lactate in HepG-2 cells. Hydrogen Peroxide 139-143 hypoxia inducible factor 1 subunit alpha Homo sapiens 320-330 22307228-0 2012 Transforming growth factor-beta1 induces glutathione peroxidase-1 and protects from H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway. Hydrogen Peroxide 96-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 163-173 23626851-10 2013 These results indicate that, along with H2O2 generation, downregulation of HIF-1alpha transcription plays a crucial role in growth inhibition of human leukemic cells by high AA. Hydrogen Peroxide 40-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 75-85 22986926-13 2013 Pretreatment with H(2)O(2) significantly inhibited the invasion ability, tube-like formation and HIF1A and ITGAV of TCL1. Hydrogen Peroxide 18-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 97-102 21150341-6 2010 We found that: 1) AAH, HIF-1alpha, and neuronal migration were stimulated by H2O2; 2) si-HIF-1alpha reduced AAH expression and cell motility; 3) si-AAH inhibited Notch and cell migration, but not HIF-1alpha; and 4) si-Notch-1 increased FIH and inhibited HIF-1alpha. Hydrogen Peroxide 77-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 23-33 22223846-4 2012 M2 treatment inhibited the induction of HIF-1alpha by a variety of stimuli including insulin, hypoxia, CoCl(2) and hydrogen peroxide in HCT116 cells, whereas M3 or M4 failed to do so. Hydrogen Peroxide 115-132 hypoxia inducible factor 1 subunit alpha Homo sapiens 40-50 21239473-7 2011 Mechanistic investigations revealed that LOX activated the PI3K (phosphoinositide 3-kinase)-Akt signaling pathway, thereby upregulating HIF-1alpha protein synthesis in a manner requiring LOX-mediated hydrogen peroxide production. Hydrogen Peroxide 200-217 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-146 21150341-6 2010 We found that: 1) AAH, HIF-1alpha, and neuronal migration were stimulated by H2O2; 2) si-HIF-1alpha reduced AAH expression and cell motility; 3) si-AAH inhibited Notch and cell migration, but not HIF-1alpha; and 4) si-Notch-1 increased FIH and inhibited HIF-1alpha. Hydrogen Peroxide 77-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 89-99 22569265-2 2012 Here, we assessed the role of vasohibin on HIF-1alpha expression under oxidative stress induced by hydrogen peroxide (H2O2) in HUVEC. Hydrogen Peroxide 99-116 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-53 22569265-2 2012 Here, we assessed the role of vasohibin on HIF-1alpha expression under oxidative stress induced by hydrogen peroxide (H2O2) in HUVEC. Hydrogen Peroxide 118-122 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-53 22569265-5 2012 Interestingly, vasohibin inhibited cell proliferation through degradation of HIF-1alpha expression during H2O2-pretreatment. Hydrogen Peroxide 106-110 hypoxia inducible factor 1 subunit alpha Homo sapiens 77-87 21103079-10 2010 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. Hydrogen Peroxide 15-32 hypoxia inducible factor 1 subunit alpha Homo sapiens 124-129 21150341-6 2010 We found that: 1) AAH, HIF-1alpha, and neuronal migration were stimulated by H2O2; 2) si-HIF-1alpha reduced AAH expression and cell motility; 3) si-AAH inhibited Notch and cell migration, but not HIF-1alpha; and 4) si-Notch-1 increased FIH and inhibited HIF-1alpha. Hydrogen Peroxide 77-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 89-99 19998339-9 2010 Reactive oxygen species scavengers of H(2)O(2) significantly inhibited hypoxia-induced ERK or HIF-1 activation and sequential expression of MGr1-Ag/37LRP. Hydrogen Peroxide 38-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-99 19789218-11 2009 Oltipraz treatment abrogated insulin-induced H(2)O(2) production, thereby preventing H(2)O(2)-enhanced HIF-1alpha expression and promoting its ubiquitination and degradation. Hydrogen Peroxide 45-53 hypoxia inducible factor 1 subunit alpha Homo sapiens 103-113 19789218-0 2009 Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Hydrogen Peroxide 136-140 hypoxia inducible factor 1 subunit alpha Homo sapiens 46-77 19789218-11 2009 Oltipraz treatment abrogated insulin-induced H(2)O(2) production, thereby preventing H(2)O(2)-enhanced HIF-1alpha expression and promoting its ubiquitination and degradation. Hydrogen Peroxide 85-93 hypoxia inducible factor 1 subunit alpha Homo sapiens 103-113 18258605-5 2008 Here we report that ROS induced by a direct application of H(2)O(2) and menadione to DU145 human prostate carcinoma resulted in accumulation of HIF-1alpha protein by attenuation of its degradation and activation of its transcriptional activity in an AMPK-dependent manner. Hydrogen Peroxide 59-67 hypoxia inducible factor 1 subunit alpha Homo sapiens 144-154 19147752-9 2009 Extracellular treatment with hydrogen peroxide, a ROS mimic, increased PDK2 expression and HIF1alpha expression, and introduction of mitochondria-targeted catalase decreased mitochondrial mutation-mediated PDK2 and HIF1alpha expression and suppressed cell growth. Hydrogen Peroxide 29-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 91-100 19147752-9 2009 Extracellular treatment with hydrogen peroxide, a ROS mimic, increased PDK2 expression and HIF1alpha expression, and introduction of mitochondria-targeted catalase decreased mitochondrial mutation-mediated PDK2 and HIF1alpha expression and suppressed cell growth. Hydrogen Peroxide 29-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 215-224 20022860-9 2009 Factors such as HIF1 alpha that respond both to hypoxia and H2O2 are an especially attractive target for the novel methodology. Hydrogen Peroxide 60-64 hypoxia inducible factor 1 subunit alpha Homo sapiens 16-26 18559422-7 2008 We use the model to demonstrate effects on HIF1alpha expression from combined doses of five potential therapeutically targeted compounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular oxidation-reduction and involved in HIF1alpha hydroxylation. Hydrogen Peroxide 155-172 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-52 18559422-7 2008 We use the model to demonstrate effects on HIF1alpha expression from combined doses of five potential therapeutically targeted compounds (iron, ascorbate, hydrogen peroxide, 2-oxoglutarate, and succinate) influenced by cellular oxidation-reduction and involved in HIF1alpha hydroxylation. Hydrogen Peroxide 155-172 hypoxia inducible factor 1 subunit alpha Homo sapiens 264-273 18559422-9 2008 We also show how tumor cells and cells under ischemic conditions would differentially respond to reactive oxygen species via changes to HIF1alpha expression over the course of hours to days, dependent on extracellular hydrogen peroxide levels and largely independent of initial intracellular levels, during hypoxia. Hydrogen Peroxide 218-235 hypoxia inducible factor 1 subunit alpha Homo sapiens 136-145 18702304-7 2008 We also investigated the role of reactive oxygen species (ROS) involved in HIF-1 and VEGF expression Exogenous addition of H2O2 was sufficient to activate Akt and ERK, scavengers of H2O2 significantly inhibited hypoxia-induced Akt and ERK, and subsequent HIF-lax expression and transcriptional activity. Hydrogen Peroxide 123-127 hypoxia inducible factor 1 subunit alpha Homo sapiens 75-80 17045920-6 2006 The inhibition of H(2)O(2) production by catalase abolished EGF-induced AKT and p70S6K1 activation, and VEGF expression through HIF-1alpha expression. Hydrogen Peroxide 18-26 hypoxia inducible factor 1 subunit alpha Homo sapiens 128-138 17561100-6 2007 Activation of p38 MAPK and HIF-1alpha accumulation were attenuated by N-acetyl-L-cysteine (antioxidant), catalase (hydrogen peroxide scavenger), or a selective p38 MAPK inhibitor (SB203580). Hydrogen Peroxide 115-132 hypoxia inducible factor 1 subunit alpha Homo sapiens 27-37 17562787-7 2007 Exogenous hydrogen peroxide under normoxia prevented hydroxylation of HIF-1alpha protein and stabilized HIF-1alpha protein. Hydrogen Peroxide 10-27 hypoxia inducible factor 1 subunit alpha Homo sapiens 70-80 17562787-7 2007 Exogenous hydrogen peroxide under normoxia prevented hydroxylation of HIF-1alpha protein and stabilized HIF-1alpha protein. Hydrogen Peroxide 10-27 hypoxia inducible factor 1 subunit alpha Homo sapiens 104-114 17942596-7 2008 We show that HIF-1alpha stability is mediated through the Ang II-mediated generation of hydrogen peroxide and a subsequent decrease in ascorbate levels, leading to decreased HIF prolyl-hydroxylase activity and HIF-1alpha stabilization. Hydrogen Peroxide 88-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 13-23 17942596-7 2008 We show that HIF-1alpha stability is mediated through the Ang II-mediated generation of hydrogen peroxide and a subsequent decrease in ascorbate levels, leading to decreased HIF prolyl-hydroxylase activity and HIF-1alpha stabilization. Hydrogen Peroxide 88-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 210-220 16774940-5 2007 H2O2 production is also required for insulin-induced VEGF and HIF-1alpha expression in the cells. Hydrogen Peroxide 0-4 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-72 16774940-7 2007 These results suggest that insulin induced HIF-1alpha and VEGF expression through H2O2 production and p70S6K1 activation in prostate cancer cells. Hydrogen Peroxide 82-86 hypoxia inducible factor 1 subunit alpha Homo sapiens 43-53 17045920-9 2006 This study demonstrates a novel mechanism of EGF-induced VEGF and HIF-1alpha expression through production of H2O2 and activation of AKT and p70S6K1 in human ovarian cancer cells. Hydrogen Peroxide 110-114 hypoxia inducible factor 1 subunit alpha Homo sapiens 66-76 16170370-12 2005 Coexpression of mitochondrial hydrogen peroxide-removing proteins prevented the accumulation of HIF-1alpha protein in cells with high levels of MnSOD; this effect demonstrates that the restabilization of HIF-1alpha observed in high MnSOD overexpressors is probably due to hydrogen peroxide, most likely produced from MnSOD. Hydrogen Peroxide 30-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 16923368-9 2006 H2O2 can inhibit the HIF-1alpha expression but increase the ET-1levels. Hydrogen Peroxide 0-4 hypoxia inducible factor 1 subunit alpha Homo sapiens 21-31 16427606-9 2006 H2O2 treatment decreased the expression levels of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein (C/EBPalpha), but had no effect on HIF-1alpha, whereas hypoxia stabilized HIF-1alpha and decreased expression of C/EBPalpha, but not PPARgamma. Hydrogen Peroxide 0-4 hypoxia inducible factor 1 subunit alpha Homo sapiens 220-230 16489029-5 2006 Exogenous H2O2 stabilizes HIF1-alpha protein. Hydrogen Peroxide 10-14 hypoxia inducible factor 1 subunit alpha Homo sapiens 26-36 16170370-12 2005 Coexpression of mitochondrial hydrogen peroxide-removing proteins prevented the accumulation of HIF-1alpha protein in cells with high levels of MnSOD; this effect demonstrates that the restabilization of HIF-1alpha observed in high MnSOD overexpressors is probably due to hydrogen peroxide, most likely produced from MnSOD. Hydrogen Peroxide 30-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 204-214 16170370-12 2005 Coexpression of mitochondrial hydrogen peroxide-removing proteins prevented the accumulation of HIF-1alpha protein in cells with high levels of MnSOD; this effect demonstrates that the restabilization of HIF-1alpha observed in high MnSOD overexpressors is probably due to hydrogen peroxide, most likely produced from MnSOD. Hydrogen Peroxide 272-289 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 16170370-12 2005 Coexpression of mitochondrial hydrogen peroxide-removing proteins prevented the accumulation of HIF-1alpha protein in cells with high levels of MnSOD; this effect demonstrates that the restabilization of HIF-1alpha observed in high MnSOD overexpressors is probably due to hydrogen peroxide, most likely produced from MnSOD. Hydrogen Peroxide 272-289 hypoxia inducible factor 1 subunit alpha Homo sapiens 204-214 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 0-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-116 15923604-7 2005 Furthermore, the hypoxic activation of p38alpha and HIF-1 was abolished by myxothiazol, a mitochondrial complex III inhibitor, and glutathione peroxidase 1 (GPX1), a scavenger of hydrogen peroxide. Hydrogen Peroxide 179-196 hypoxia inducible factor 1 subunit alpha Homo sapiens 52-57 15987493-7 2005 Both IL-1beta and H2O2 accelerated mRNA and protein levels of HIF-1alpha in cultured chondrocytes. Hydrogen Peroxide 18-22 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-72 14971644-10 2004 The major species of ROS required for the induction of HIF-1 and VEGF is H2O2. Hydrogen Peroxide 73-77 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-60 16115891-8 2005 Exogenous H(2)O(2) abolished PGI(2)- and catalase-induced HIF-1alpha up-regulation, which suggests that degradation of HIF-1alpha under prolonged hypoxia is through a reactive oxygen species-dependent pathway. Hydrogen Peroxide 10-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 58-68 16115891-8 2005 Exogenous H(2)O(2) abolished PGI(2)- and catalase-induced HIF-1alpha up-regulation, which suggests that degradation of HIF-1alpha under prolonged hypoxia is through a reactive oxygen species-dependent pathway. Hydrogen Peroxide 10-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 119-129 15110393-8 2004 This suggests that H2O2 links Nox1 and HIF-1 activation. Hydrogen Peroxide 19-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 39-44 11566189-5 2001 Antioxidants purported as prototypical scavengers of H2O2 and .OH, attenuated TNF-alpha-induced HIF-1alpha activation, and blockading NADPH-oxidase by scavenging O(2-.) Hydrogen Peroxide 53-57 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 0-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-123 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 0-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 146-156 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 19-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-116 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 19-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-123 11169463-1 2001 Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Hydrogen Peroxide 19-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 146-156 34965614-4 2022 Interestingly, the h+ can trigger the decomposition of H2 O2 to generate O2 for alleviating tumor hypoxia, which not only sensitizes photodynamic therapy (PDT) and radiotherapy (RT), but also promotes the tumor-associated macrophages (TAMs) polarization from M2 to M1 phenotype, beneficial to decrease the expression of HIF-1alpha. Hydrogen Peroxide 55-60 hypoxia inducible factor 1 subunit alpha Homo sapiens 320-330 8943284-6 1996 Moreover, short pre-exposure of cells to hydrogen peroxide selectively prevented hypoxia-induced HIF-1 binding via blocking accumulation of HIF-1alpha protein, whereas treatment of hypoxic cell extracts with H2O2 had no effect on HIF-1 binding. Hydrogen Peroxide 41-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 97-102 8943284-6 1996 Moreover, short pre-exposure of cells to hydrogen peroxide selectively prevented hypoxia-induced HIF-1 binding via blocking accumulation of HIF-1alpha protein, whereas treatment of hypoxic cell extracts with H2O2 had no effect on HIF-1 binding. Hydrogen Peroxide 41-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 140-150 8943284-6 1996 Moreover, short pre-exposure of cells to hydrogen peroxide selectively prevented hypoxia-induced HIF-1 binding via blocking accumulation of HIF-1alpha protein, whereas treatment of hypoxic cell extracts with H2O2 had no effect on HIF-1 binding. Hydrogen Peroxide 41-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 140-145 7626069-3 1995 Here, we provide evidence that alteration of cellular redox states by treating cells with H2O2 or dithiothreitol impairs hypoxia signaling mechanisms and the expression of HIF-1 alpha protein in hypoxic cells. Hydrogen Peroxide 90-94 hypoxia inducible factor 1 subunit alpha Homo sapiens 172-183 7626069-4 1995 In addition, HIF-1 DNA-binding activity in vitro is sensitive to oxidizing reagents diamide and H2O2 and the alkylating agent N-ethylmaleimide. Hydrogen Peroxide 96-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 13-18 34742454-2 2022 In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor. Hydrogen Peroxide 169-173 hypoxia inducible factor 1 subunit alpha Homo sapiens 260-270 34742454-2 2022 In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor. Hydrogen Peroxide 322-326 hypoxia inducible factor 1 subunit alpha Homo sapiens 260-270 34836938-4 2021 LOXL2 stabilizes hypoxia-inducible factor 1alpha (HIF1alpha) from prolyl hydroxylase (PHD)-dependent hydroxylation via hydrogen peroxide generation, thereby facilitating the transcription of multiple glycolytic genes. Hydrogen Peroxide 119-136 hypoxia inducible factor 1 subunit alpha Homo sapiens 17-48 34836938-4 2021 LOXL2 stabilizes hypoxia-inducible factor 1alpha (HIF1alpha) from prolyl hydroxylase (PHD)-dependent hydroxylation via hydrogen peroxide generation, thereby facilitating the transcription of multiple glycolytic genes. Hydrogen Peroxide 119-136 hypoxia inducible factor 1 subunit alpha Homo sapiens 50-59 35565979-4 2022 The hybrid nanoparticles utilize the catalytic decomposition of endogenous H2O2 to produce oxygen for the downregulation of the hypoxia-inducible factor 1 subunit alpha (HIF-1alpha) protein, which could reverse the tumor hypoxic microenvironment. Hydrogen Peroxide 75-79 hypoxia inducible factor 1 subunit alpha Homo sapiens 170-180 35401926-8 2022 Furthermore, COS caused significant inactivation of the HIF-1alpha-VEGF pathway in H2O2-stimulated KGN cells. Hydrogen Peroxide 83-87 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-66 35401926-10 2022 Thus, COS protected GCs from H2O2-stimulated oxidative damage and apoptosis by inactivating the HIF-1alpha-VEGF signaling pathway. Hydrogen Peroxide 29-33 hypoxia inducible factor 1 subunit alpha Homo sapiens 96-106 34558885-6 2021 H2O2 and PHD small interfering RNA treatments increased HIF-1alpha and IGFBP-3 protein levels, which were decreased by DATS treatment. Hydrogen Peroxide 0-4 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-66 34204881-7 2021 Additionally, DFO caused accumulation of HIF-1alpha, which may contribute to the survival of H2O2-treated cells. Hydrogen Peroxide 93-97 hypoxia inducible factor 1 subunit alpha Homo sapiens 41-51 35401926-0 2022 Chitosan Oligosaccharides Alleviate H2O2-stimulated Granulosa Cell Damage via HIF-1alpha Signaling Pathway. Hydrogen Peroxide 36-40 hypoxia inducible factor 1 subunit alpha Homo sapiens 78-88 35007563-4 2022 KEY FINDINGS: We reported that senescent ARPE-19 up-regulated VEGF expression under both short-term and prolonged H2O2 treatment, accompanying with increased HIF-1alpha, the key mediator of VEGF. Hydrogen Peroxide 114-118 hypoxia inducible factor 1 subunit alpha Homo sapiens 158-168 35380485-9 2022 HIF-1alpha reduces H2O2-induced apoptosis by upregulating Bcl-2 and Bcl-XL, downregulating Bax, Bak, and caspase-9, stabilizing intracellular ROS levels, and promoting the repair of H2O2-induced DNA damage to reduce apoptosis. Hydrogen Peroxide 182-186 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 35380485-3 2022 The relationship between H2O2 and HIFs is complex, and this study aimed to explore the role of HIF-1alpha in H2O2-induced apoptosis. Hydrogen Peroxide 25-29 hypoxia inducible factor 1 subunit alpha Homo sapiens 95-105 35380485-3 2022 The relationship between H2O2 and HIFs is complex, and this study aimed to explore the role of HIF-1alpha in H2O2-induced apoptosis. Hydrogen Peroxide 109-113 hypoxia inducible factor 1 subunit alpha Homo sapiens 95-105 35380485-9 2022 HIF-1alpha reduces H2O2-induced apoptosis by upregulating Bcl-2 and Bcl-XL, downregulating Bax, Bak, and caspase-9, stabilizing intracellular ROS levels, and promoting the repair of H2O2-induced DNA damage to reduce apoptosis. Hydrogen Peroxide 19-23 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10