PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32012242-0	2020	H2 O2 induces oxidative stress damage through the BMP-6/SMAD/hepcidin axis.	Hydrogen Peroxide	0-5	bone morphogenetic protein 6	Homo sapiens	50-55	
32012242-5	2020	Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 .	Hydrogen Peroxide	51-56	bone morphogenetic protein 6	Homo sapiens	101-129	
32012242-5	2020	Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 .	Hydrogen Peroxide	51-56	bone morphogenetic protein 6	Homo sapiens	131-136	
32012242-5	2020	Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 .	Hydrogen Peroxide	51-56	bone morphogenetic protein 6	Homo sapiens	221-226	
32012242-5	2020	Through PCR and western blotting, we observed that H2 O2 can significantly inhibit the expression of Bone morphogenetic protein-6 (BMP-6) and Hepcidin and increase the intracellular iron concentration in RPE cells, while BMP-6 can reverse the inhibition of Hepcidin and the increase in iron concentration caused by H2 O2 .	Hydrogen Peroxide	315-320	bone morphogenetic protein 6	Homo sapiens	101-129	
32012242-6	2020	In addition, alterations in smad1 and smad5 expression were examined, and pretreatment with BMP-6 was demonstrated to reduce H2 O2 -induced activation of smad1 and smad5.	Hydrogen Peroxide	125-130	bone morphogenetic protein 6	Homo sapiens	92-97	
29767257-6	2018	Cell Counting Kit-8 assay and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining demonstrated that BMP-6 increased RPE cell viability, which was decreased following treatment with hydrogen peroxide (H2O2), and reduced H2O2-induced apoptosis.	Hydrogen Peroxide	199-216	bone morphogenetic protein 6	Homo sapiens	118-123	
29767257-6	2018	Cell Counting Kit-8 assay and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining demonstrated that BMP-6 increased RPE cell viability, which was decreased following treatment with hydrogen peroxide (H2O2), and reduced H2O2-induced apoptosis.	Hydrogen Peroxide	218-222	bone morphogenetic protein 6	Homo sapiens	118-123	
29767257-6	2018	Cell Counting Kit-8 assay and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining demonstrated that BMP-6 increased RPE cell viability, which was decreased following treatment with hydrogen peroxide (H2O2), and reduced H2O2-induced apoptosis.	Hydrogen Peroxide	237-241	bone morphogenetic protein 6	Homo sapiens	118-123	
29767257-7	2018	In addition, western blotting revealed that BMP-6 reversed the decrease in pro-caspase-3 levels and the dysregulation of the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) balance caused by H2O2.	Hydrogen Peroxide	202-206	bone morphogenetic protein 6	Homo sapiens	44-49	
29767257-8	2018	In addition, alterations in c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) expression were examined, and pretreatment with BMP-6 was demonstrated to reduce H2O2-induced activation of JNK and p38 MAPK.	Hydrogen Peroxide	195-199	bone morphogenetic protein 6	Homo sapiens	162-167	
19245827-4	2009	In this study, we demonstrate that BMP6 effectively protects renal proximal tubule cells (HK-2) against hydrogen peroxide (H(2)O(2))-induced cell injury.	Hydrogen Peroxide	104-121	bone morphogenetic protein 6	Homo sapiens	35-39	
19245827-10	2009	In summary, these findings suggest that induction of HO-1 through a Smad-dependent mechanism is responsible for the cytoprotective effect of BMP6 in H(2)O(2)-mediated renal cell injury.	Hydrogen Peroxide	149-157	bone morphogenetic protein 6	Homo sapiens	141-145