PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28684630-7 2017 Scavenging of mitochondrial H2O2 in mCAT mice expressing mitochondria-targeted catalase prevented Sirt3 and SOD2 impairment and attenuated hypertension. Hydrogen Peroxide 28-32 sirtuin 3 Mus musculus 98-103 32403251-6 2020 The alterations measured in enzymatic activities of catalase, glutathione peroxidase, and glutathione reductase in the livers of irradiated Sirt3-/- mice also implied that hydrogen peroxide and hydroperoxide sensitive signaling cascades in the absence of SIRT3 might contribute to the IR-induced long-term liver injury. Hydrogen Peroxide 172-189 sirtuin 3 Mus musculus 140-145 32403251-6 2020 The alterations measured in enzymatic activities of catalase, glutathione peroxidase, and glutathione reductase in the livers of irradiated Sirt3-/- mice also implied that hydrogen peroxide and hydroperoxide sensitive signaling cascades in the absence of SIRT3 might contribute to the IR-induced long-term liver injury. Hydrogen Peroxide 172-189 sirtuin 3 Mus musculus 255-260 32403251-6 2020 The alterations measured in enzymatic activities of catalase, glutathione peroxidase, and glutathione reductase in the livers of irradiated Sirt3-/- mice also implied that hydrogen peroxide and hydroperoxide sensitive signaling cascades in the absence of SIRT3 might contribute to the IR-induced long-term liver injury. Hydrogen Peroxide 194-207 sirtuin 3 Mus musculus 140-145 32403251-6 2020 The alterations measured in enzymatic activities of catalase, glutathione peroxidase, and glutathione reductase in the livers of irradiated Sirt3-/- mice also implied that hydrogen peroxide and hydroperoxide sensitive signaling cascades in the absence of SIRT3 might contribute to the IR-induced long-term liver injury. Hydrogen Peroxide 194-207 sirtuin 3 Mus musculus 255-260 28258190-8 2017 Asbestos and H2O2 diminished AEC SIRT3 protein expression and increased mitochondrial protein acetylation, including MnSODK68 SIRT3 enforced expression reduced oxidant-induced AEC OGG1K338/341 acetylation, mtDNA damage, and apoptosis, whereas SIRT3 silencing promoted these effects. Hydrogen Peroxide 13-17 sirtuin 3 Mus musculus 33-38 28258190-8 2017 Asbestos and H2O2 diminished AEC SIRT3 protein expression and increased mitochondrial protein acetylation, including MnSODK68 SIRT3 enforced expression reduced oxidant-induced AEC OGG1K338/341 acetylation, mtDNA damage, and apoptosis, whereas SIRT3 silencing promoted these effects. Hydrogen Peroxide 13-17 sirtuin 3 Mus musculus 126-131 28258190-8 2017 Asbestos and H2O2 diminished AEC SIRT3 protein expression and increased mitochondrial protein acetylation, including MnSODK68 SIRT3 enforced expression reduced oxidant-induced AEC OGG1K338/341 acetylation, mtDNA damage, and apoptosis, whereas SIRT3 silencing promoted these effects. Hydrogen Peroxide 13-17 sirtuin 3 Mus musculus 126-131 26422756-8 2016 H2S reversed the stimulation of MAPK phosphorylation, downregulation of SIRT3 mRNA and reduction of the superoxide dismutase 2 and isocitrate dehydrogenase 2 expression which were induced by H2O2. Hydrogen Peroxide 191-195 sirtuin 3 Mus musculus 72-77 28559847-8 2017 Ca2+-stimulated H2O2 production was significantly higher in SIRT3-/- mitochondria that was prevented by SfA. Hydrogen Peroxide 16-20 sirtuin 3 Mus musculus 60-65 25090966-0 2014 Sirt3 attenuates hydrogen peroxide-induced oxidative stress through the preservation of mitochondrial function in HT22 cells. Hydrogen Peroxide 17-34 sirtuin 3 Mus musculus 0-5 25090966-2 2014 The present study aimed to investigate the role of Sirt3 in hydrogen peroxide (H(2)O(2))-induced oxidative neuronal injury in HT22 mouse hippocampal cells. Hydrogen Peroxide 60-77 sirtuin 3 Mus musculus 51-56 25090966-2 2014 The present study aimed to investigate the role of Sirt3 in hydrogen peroxide (H(2)O(2))-induced oxidative neuronal injury in HT22 mouse hippocampal cells. Hydrogen Peroxide 79-87 sirtuin 3 Mus musculus 51-56 25090966-3 2014 Treatment with H(2)O(2) increased the expression of Sirt3 in a dose- and time-dependent manner, and the knockdown of Sirt3 using specific small interfering RNA (siRNA) exacerbated the H(2)O(2)-induced neuronal injury. Hydrogen Peroxide 15-23 sirtuin 3 Mus musculus 52-57 24464007-5 2013 Pretreatment of NSC34 cells with lithium (5 mmol/L), VPA (1 mmol/L), or lithium plus VPA for 24 hours, significantly reduced hydrogen peroxide (H2O2)-induced cytotoxicity, and increased SIRT3 and CARM1 levels. Hydrogen Peroxide 125-142 sirtuin 3 Mus musculus 186-191 25090966-3 2014 Treatment with H(2)O(2) increased the expression of Sirt3 in a dose- and time-dependent manner, and the knockdown of Sirt3 using specific small interfering RNA (siRNA) exacerbated the H(2)O(2)-induced neuronal injury. Hydrogen Peroxide 184-192 sirtuin 3 Mus musculus 52-57 25090966-3 2014 Treatment with H(2)O(2) increased the expression of Sirt3 in a dose- and time-dependent manner, and the knockdown of Sirt3 using specific small interfering RNA (siRNA) exacerbated the H(2)O(2)-induced neuronal injury. Hydrogen Peroxide 184-192 sirtuin 3 Mus musculus 117-122 25090966-5 2014 Further experiments revealed that the H(2)O(2)-induced inhibition of mitochondrial complex activity and adenosine triphosphate (ATP) synthesis, the decrease in mitochondrial Ca(2+) buffering capacity and mitochondrial swelling were all partly reversed by Sirt3. Hydrogen Peroxide 38-46 sirtuin 3 Mus musculus 255-260 25090966-6 2014 Furthermore, the overexpression of Sirt3 attenuated the release of cytochrome c, the increase in the Bax/Bcl-2 ratio, as well as caspase-9/caspase-3 activity induced by H(2)O(2), and eventually inhibited apoptotic neuronal cell death. Hydrogen Peroxide 169-177 sirtuin 3 Mus musculus 35-40 25090966-7 2014 These results suggest that Sirt3 acts as a prosurvival factor, playing an essential role in protecting HT22 cells under H(2)O(2)-induced oxidative stress, possibly by inhibiting ROS accumulation and the activation of the mitochondrial apoptotic pathway. Hydrogen Peroxide 120-128 sirtuin 3 Mus musculus 27-32 34630670-0 2021 Metformin attenuates H2O2-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway. Hydrogen Peroxide 21-25 sirtuin 3 Mus musculus 69-74 34630670-13 2021 In addition, experiments with SIRT3 knockdown indicated that metformin reverses H2O2-induced osteoblast apoptosis by upregulating the expression of SIRT3 via the PI3K/AKT pathway. Hydrogen Peroxide 80-84 sirtuin 3 Mus musculus 30-35 34630670-13 2021 In addition, experiments with SIRT3 knockdown indicated that metformin reverses H2O2-induced osteoblast apoptosis by upregulating the expression of SIRT3 via the PI3K/AKT pathway. Hydrogen Peroxide 80-84 sirtuin 3 Mus musculus 148-153