PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32172411-10	2020	Together, our findings suggest that 17beta-E2 upregulates SIRT3 gene expression by activating SIRT3 promoter and then promotes autophagy, which in turn serves to remove dysfunctional mitochondria caused by H2O2 and consequently inhibit H2O2-induced senescence in HUVEC cells.	Hydrogen Peroxide	236-240	sirtuin 3	Homo sapiens	58-63	
34737239-4	2021	We also showed that SIRT3 overexpression attenuated rotenoneor H2O2-induced toxicity in differentiated SH-SY5Y cells (human dopaminergic cell line).	Hydrogen Peroxide	63-67	sirtuin 3	Homo sapiens	20-25	
34737239-5	2021	We further found that knockdown of SIRT3 enhanced rotenone- or H2O2-induced toxicity in differentiated SH-SY5Y cells.	Hydrogen Peroxide	63-67	sirtuin 3	Homo sapiens	35-40	
32172411-0	2020	17beta-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.	Hydrogen Peroxide	26-30	sirtuin 3	Homo sapiens	86-91	
32172411-8	2020	SIRT3 knockdown also blocks 17beta-E2-induced inhibition of cellular senescence triggered by H2O2.	Hydrogen Peroxide	93-97	sirtuin 3	Homo sapiens	0-5	
32172411-9	2020	Our data further reveal that SIRT3 knockdown impairs 17beta-E2-induced co-localization of LC3 and VDAC1, a marker protein on mitochondria, when HUVEC cells were co-treated with H2O2.	Hydrogen Peroxide	177-181	sirtuin 3	Homo sapiens	29-34	
35096052-8	2022	Furthermore, the expression of SIRT3, FOXO3A, and SOD2 proteins declined, except for an initial elevation of SIRT3 between 0 and 0.75 mM H2O2.	Hydrogen Peroxide	137-141	sirtuin 3	Homo sapiens	31-36	
35096052-8	2022	Furthermore, the expression of SIRT3, FOXO3A, and SOD2 proteins declined, except for an initial elevation of SIRT3 between 0 and 0.75 mM H2O2.	Hydrogen Peroxide	137-141	sirtuin 3	Homo sapiens	109-114	
32172411-10	2020	Together, our findings suggest that 17beta-E2 upregulates SIRT3 gene expression by activating SIRT3 promoter and then promotes autophagy, which in turn serves to remove dysfunctional mitochondria caused by H2O2 and consequently inhibit H2O2-induced senescence in HUVEC cells.	Hydrogen Peroxide	206-210	sirtuin 3	Homo sapiens	58-63	
32141579-10	2020	Besides, zoledronic acid protected H2O2-induced SIRT3 down-regulation and AC-SOD2/SOD2 up-regulation in BMSCs.	Hydrogen Peroxide	35-39	sirtuin 3	Homo sapiens	48-53	
29783884-10	2019	RESULTS: Hydrogen peroxide significantly induced cell senescence and p38 MAPK phosphorylation, and it significantly decreased SIRT3 expression in full-thickness fetal membrane explants and chorion cells.	Hydrogen Peroxide	9-26	sirtuin 3	Homo sapiens	126-131	
30618198-8	2019	Reverse transcription polymerase chain reaction and Western blot showed that celastrol elevated the messenger RNA (mRNA) and protein expression of sirtuin 3 (SIRT3) in H2 O2 -induced ARPE-19 cells.	Hydrogen Peroxide	168-173	sirtuin 3	Homo sapiens	147-156	
30618198-8	2019	Reverse transcription polymerase chain reaction and Western blot showed that celastrol elevated the messenger RNA (mRNA) and protein expression of sirtuin 3 (SIRT3) in H2 O2 -induced ARPE-19 cells.	Hydrogen Peroxide	168-173	sirtuin 3	Homo sapiens	158-163	
30618198-9	2019	Inhibition of the level of SIRT3 by SIRT3 small interfering RNA (siRNA) reversed the effects of celastrol on oxidative stress, autophagy, and apoptosis in H2 O2 -induced ARPE-19 cells.	Hydrogen Peroxide	155-160	sirtuin 3	Homo sapiens	27-32	
30618198-9	2019	Inhibition of the level of SIRT3 by SIRT3 small interfering RNA (siRNA) reversed the effects of celastrol on oxidative stress, autophagy, and apoptosis in H2 O2 -induced ARPE-19 cells.	Hydrogen Peroxide	155-160	sirtuin 3	Homo sapiens	36-41	
23665396-4	2013	Here we show that hydrogen peroxide induces SIRT3 to deacetylate FOXO3 at K271 and K290, followed by the upregulation of a set of genes that are essential for mitochondrial homeostasis (mitochondrial biogenesis, fission/fusion, and mitophagy).	Hydrogen Peroxide	18-35	sirtuin 3	Homo sapiens	44-49	
30320335-1	2018	leaves aqueous extract protects against hydrogen peroxide-induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway.	Hydrogen Peroxide	40-57	sirtuin 3	Homo sapiens	109-114	
30027365-4	2019	We show that hippocampal pyramidal neurons in mutUNG1 mice, as well as cultured rat hippocampal neurons and human fibroblasts with H2O2 induced oxidative stress, improve markers of mitochondrial biogenesis, dynamics and function when fed on a KD, and when exposed to the ketone body beta-hydroxybutyrate, respectively, by upregulating PGC1alpha, SIRT3 and UCP2, and (in cultured cells) increasing the oxygen consumption rate (OCR) and the NAD+/NADH ratio.	Hydrogen Peroxide	131-135	sirtuin 3	Homo sapiens	346-351	
24877629-9	2014	The mRNA levels of SIRT3, catalase, and superoxide dismutase 1 were up-regulated by hydrogen peroxide in both COV434 cells and human GCs and down-regulated by human chorionic gonadotropin.	Hydrogen Peroxide	84-101	sirtuin 3	Homo sapiens	19-24