PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34543287-12 2021 Functional studies showed that BDNF increases cell viability and mitigates H2O2-induced oxidative damage in H9c2 cells, demonstrating its protective role in the adult heart. Hydrogen Peroxide 75-79 brain-derived neurotrophic factor Rattus norvegicus 31-35 29288352-5 2018 Transplantation of H2O2-treated cells caused an increase in BDNF expression compared to non-treated cells. Hydrogen Peroxide 19-23 brain-derived neurotrophic factor Rattus norvegicus 60-64 32428522-7 2020 Low level of H2O2 significantly promoted endothelial cell (EC) proliferation, migration and tube formation and upregulated levels of VEGF, BDNF, MMP-9 and phos-JNK. Hydrogen Peroxide 13-17 brain-derived neurotrophic factor Rattus norvegicus 139-143 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 24-41 brain-derived neurotrophic factor Rattus norvegicus 279-283 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 24-41 brain-derived neurotrophic factor Rattus norvegicus 314-318 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 43-47 brain-derived neurotrophic factor Rattus norvegicus 279-283 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 43-47 brain-derived neurotrophic factor Rattus norvegicus 314-318 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 145-149 brain-derived neurotrophic factor Rattus norvegicus 279-283 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 145-149 brain-derived neurotrophic factor Rattus norvegicus 314-318 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 145-149 brain-derived neurotrophic factor Rattus norvegicus 279-283 32029482-3 2020 We found an increase in hydrogen peroxide (H2O2) in the vitreous of patients with DR. We confirmed that human retinal endothelial cells secreted H2O2 by high glucose, and H2O2 reduced cell viability of MIO-M1, Muller glia cell line, PC12D, and the neuronal cell line and lowered BDNF expression in MIO-M1, whereas BDNF administration recovered PC12D cell viability. Hydrogen Peroxide 145-149 brain-derived neurotrophic factor Rattus norvegicus 314-318 33379243-8 2020 Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. Hydrogen Peroxide 136-140 brain-derived neurotrophic factor Rattus norvegicus 59-92 33379243-8 2020 Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. Hydrogen Peroxide 136-140 brain-derived neurotrophic factor Rattus norvegicus 94-98 33379243-9 2020 As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Hydrogen Peroxide 91-95 brain-derived neurotrophic factor Rattus norvegicus 38-42 23847444-12 2013 Furthermore, GRg1 also increased the mRNA levels, protein levels and secretion of NGF and BDNF in SCs after incubation of hydrogen peroxide. Hydrogen Peroxide 122-139 brain-derived neurotrophic factor Rattus norvegicus 90-94 27489501-11 2016 Meanwhile, BDNF protein level was rapidly increased in MI rats and H2O2-treated cardiomyocytes. Hydrogen Peroxide 67-71 brain-derived neurotrophic factor Rattus norvegicus 11-15 25868740-7 2015 Furthermore, H2O2 level and TNF-alpha concentration correlated positively with both BDNF and GDNF concentrations. Hydrogen Peroxide 13-17 brain-derived neurotrophic factor Rattus norvegicus 84-88 25826901-11 2014 Real-time quantitative PCR and Western blot analysis showed that 1.00 mmol/L H2O2 can significantly inhibit BDNF and GDNF expression in SCs when compared with control group (P < 0.05), 50-200 mug/mL CMCS can reverse the oxidative stress-induced BDNF and GDNF expression in SCs in a dose dependent manner, showing significant difference compared with control group and 1.00 mmol/L H2O2 induced group (P < 0.05). Hydrogen Peroxide 77-81 brain-derived neurotrophic factor Rattus norvegicus 108-112 25826901-11 2014 Real-time quantitative PCR and Western blot analysis showed that 1.00 mmol/L H2O2 can significantly inhibit BDNF and GDNF expression in SCs when compared with control group (P < 0.05), 50-200 mug/mL CMCS can reverse the oxidative stress-induced BDNF and GDNF expression in SCs in a dose dependent manner, showing significant difference compared with control group and 1.00 mmol/L H2O2 induced group (P < 0.05). Hydrogen Peroxide 77-81 brain-derived neurotrophic factor Rattus norvegicus 248-252 25424467-0 2014 Subtoxic levels of hydrogen peroxide induce brain-derived neurotrophic factor expression to protect PC12 cells. Hydrogen Peroxide 19-36 brain-derived neurotrophic factor Rattus norvegicus 44-77 25424467-5 2014 We found, intriguingly, that gene expression of brain-derived neurotrophic factor (BDNF), but not PGRN was significantly induced by H2O2. Hydrogen Peroxide 132-136 brain-derived neurotrophic factor Rattus norvegicus 48-81 25424467-5 2014 We found, intriguingly, that gene expression of brain-derived neurotrophic factor (BDNF), but not PGRN was significantly induced by H2O2. Hydrogen Peroxide 132-136 brain-derived neurotrophic factor Rattus norvegicus 83-87 25424467-8 2014 CONCLUSIONS: Based on our results, we conclude that the induction of BDNF by subtoxic levels of H2O2 and its signaling may have roles in PC12 cell protection. Hydrogen Peroxide 96-100 brain-derived neurotrophic factor Rattus norvegicus 69-73 24508265-8 2014 A cell-permeable catalase abolished GTPP/EGCG-induced potentiation of BDNF action, suggesting the possible involvement of H2O2 in the potentiation. Hydrogen Peroxide 122-126 brain-derived neurotrophic factor Rattus norvegicus 70-74 24508265-9 2014 Consistently, exogenous sublethal concentrations of H2O2, added as a bolus dose (5 muM) or more effectively through a steady-state generation (1 muM), potentiated BDNF action. Hydrogen Peroxide 52-56 brain-derived neurotrophic factor Rattus norvegicus 163-167 24508265-10 2014 Collectively, these results suggest that EGCG, dependent on 67 LR and H2O2, potentiates the neuritogenic action of BDNF. Hydrogen Peroxide 70-74 brain-derived neurotrophic factor Rattus norvegicus 115-119 23115189-4 2012 We found that both exogenous H(2)O(2) and endogenous ROS activate TrkB signaling by a Src family kinase-dependent but brain-derived neurotrophic factor-independent mechanism in cultured rat cortical neurons. Hydrogen Peroxide 29-37 brain-derived neurotrophic factor Rattus norvegicus 118-151 9406937-7 1997 We also examined the effect of brain-derived neurotrophic factor (BDNF) on 6-OHDA- or H2O2-induced changes in DNA-binding activities. Hydrogen Peroxide 86-90 brain-derived neurotrophic factor Rattus norvegicus 66-70 9406937-8 1997 In neuronal cells, pre-treatment with BDNF prevented the decrease in DNA-binding activities induced by 6-OHDA or H2O2. Hydrogen Peroxide 113-117 brain-derived neurotrophic factor Rattus norvegicus 38-42 10555159-8 1999 On the other hand, BDNF increased O2- and decreased H2O2- levels in the same cells, although not so strongly as NGF. Hydrogen Peroxide 52-56 brain-derived neurotrophic factor Rattus norvegicus 19-23 10555159-9 1999 These results suggest that decreasing conversion from O2- to H2O2 is also critical for the protection by BDNF, which is considered to play a central role in survival and differentiation of CNS neurons. Hydrogen Peroxide 61-65 brain-derived neurotrophic factor Rattus norvegicus 105-109