PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31217063-0 2019 NANOG Alleviates the Damage of Human Hair Follicle Mesenchymal Stem Cells Caused by H2O2 through Activation of AKT Pathway. Hydrogen Peroxide 84-88 Nanog homeobox Homo sapiens 0-5 23886156-7 2013 Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with H2O2. Hydrogen Peroxide 122-126 Nanog homeobox Homo sapiens 52-57 31217063-1 2019 OBJECTIVE: To explore the protective effect of NANOG against hydrogen peroxide (H2O2) -induced cell damage in the human hair follicle mesenchymal stem cells (hHF-MSCs). Hydrogen Peroxide 61-78 Nanog homeobox Homo sapiens 47-52 31217063-1 2019 OBJECTIVE: To explore the protective effect of NANOG against hydrogen peroxide (H2O2) -induced cell damage in the human hair follicle mesenchymal stem cells (hHF-MSCs). Hydrogen Peroxide 80-84 Nanog homeobox Homo sapiens 47-52 31217063-3 2019 NANOG hHF-MSCs and vector hHF-MSCs were treated with 400 mumol/L hydrogen peroxide (H2O2) for 2 h, the cell survival rate, cell morphology, ROS production, apoptosis and expression of AKT, ERK, and p21 were determined and compared. Hydrogen Peroxide 84-88 Nanog homeobox Homo sapiens 0-5 31217063-5 2019 When treated with 400 mumol/L H2O2, NANOG hHF-MSCs showed higher cell survival rate, lower ROS production and apoptosis, higher expression of p-AKT, higher ratio of p-AKT/AKT. Hydrogen Peroxide 30-34 Nanog homeobox Homo sapiens 36-41 31217063-6 2019 CONCLUSION: Our results suggest that NANOG could protect hHF-MSCs against cell damage caused by H2O2 through activating AKT signaling pathway. Hydrogen Peroxide 96-100 Nanog homeobox Homo sapiens 37-42 29445146-5 2018 Thus, an impulse of hydrogen peroxide depleted Nanog and Hdac4 via a caspase-dependent manner to ameliorate the repression on Gata4 and Nkx2.5 promoters, thereby generating a persistent activation on cardiac differentiation program. Hydrogen Peroxide 20-37 Nanog homeobox Homo sapiens 47-52