PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31895878-2 2020 We have previously demonstrated that endothelium-derived hydrogen peroxide (H2O2) is an EDH factor produced by all types of nitric oxide synthases (NOSs), including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS. Hydrogen Peroxide 57-74 nitric oxide synthase 3, endothelial cell Mus musculus 165-180 11120759-2 2000 In this study, we examined our hypothesis that hydrogen peroxide (H(2)O(2)) derived from endothelial NO synthase (eNOS) is an EDHF. Hydrogen Peroxide 47-64 nitric oxide synthase 3, endothelial cell Mus musculus 89-112 11120759-2 2000 In this study, we examined our hypothesis that hydrogen peroxide (H(2)O(2)) derived from endothelial NO synthase (eNOS) is an EDHF. Hydrogen Peroxide 47-64 nitric oxide synthase 3, endothelial cell Mus musculus 114-118 31895878-2 2020 We have previously demonstrated that endothelium-derived hydrogen peroxide (H2O2) is an EDH factor produced by all types of nitric oxide synthases (NOSs), including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS. Hydrogen Peroxide 57-74 nitric oxide synthase 3, endothelial cell Mus musculus 182-186 31895878-2 2020 We have previously demonstrated that endothelium-derived hydrogen peroxide (H2O2) is an EDH factor produced by all types of nitric oxide synthases (NOSs), including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS. Hydrogen Peroxide 76-80 nitric oxide synthase 3, endothelial cell Mus musculus 165-180 31895878-2 2020 We have previously demonstrated that endothelium-derived hydrogen peroxide (H2O2) is an EDH factor produced by all types of nitric oxide synthases (NOSs), including endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS. Hydrogen Peroxide 76-80 nitric oxide synthase 3, endothelial cell Mus musculus 182-186 29992759-5 2018 Kallistatin reversed H2 O2 -mediated inhibition of endothelial nitric oxide synthase (eNOS), SIRT1, catalase and superoxide dismutase (SOD)-2 expression, and kallistatin alone stimulated the synthesis of these antioxidant enzymes. Hydrogen Peroxide 21-26 nitric oxide synthase 3, endothelial cell Mus musculus 51-84 26462682-7 2016 In our study, H2O2 induced nitrogen monoxide (NO) production and endothelial nitric oxide synthase (eNOS) expression, and progesterone promoted H2O2-induced NO production. Hydrogen Peroxide 14-18 nitric oxide synthase 3, endothelial cell Mus musculus 65-98 28237267-8 2017 Expressions of endothelial nitric oxide synthase and silent information regulator protein 1 (SIRT1) were significantly up-regulated but those of P53 and P21 were markedly down-regulated both in aged mice and in hydrogen peroxide-treated MAECs in the absence of the TRPC5 gene. Hydrogen Peroxide 211-228 nitric oxide synthase 3, endothelial cell Mus musculus 15-48 29030392-4 2017 Exposure of H9c2 cardiomyocytes to H2O2 or pharmacologic inhibition of H2S production increased PYK2 (Y402) and eNOS (Y656) phosphorylation. Hydrogen Peroxide 35-39 nitric oxide synthase 3, endothelial cell Mus musculus 112-116 20624383-11 2010 In eNOS knocked-down mice, pharmacological nNOS inhibition dramatically reduced H(2)O(2) production and further reduced the residual acetylcholine-induced vasodilation. Hydrogen Peroxide 80-88 nitric oxide synthase 3, endothelial cell Mus musculus 3-7 26111938-11 2015 Elevation of .O2(-) and H2O2 might cause oxidation of tetrahydrobiopterin (BH4) to dihydrobiopterin (BH2) and subsequent uncoupling of endothelial nitric oxide synthase (eNOS) (a) thus reducing levels of nitric oxide (NO) and 3",5"-cyclic guanosine monophosphate (cGMP). Hydrogen Peroxide 24-28 nitric oxide synthase 3, endothelial cell Mus musculus 135-168 26111938-11 2015 Elevation of .O2(-) and H2O2 might cause oxidation of tetrahydrobiopterin (BH4) to dihydrobiopterin (BH2) and subsequent uncoupling of endothelial nitric oxide synthase (eNOS) (a) thus reducing levels of nitric oxide (NO) and 3",5"-cyclic guanosine monophosphate (cGMP). Hydrogen Peroxide 24-28 nitric oxide synthase 3, endothelial cell Mus musculus 170-174 26111938-14 2015 Generation of H2O2 by uncoupled eNOS in cerebral microvessels of Tg2576 mice is hypothetical. Hydrogen Peroxide 14-18 nitric oxide synthase 3, endothelial cell Mus musculus 32-36 21617900-1 2011 We previously reported that in healthy mouse cerebral arteries, endothelial nitric oxide synthase (eNOS) produces H2O2, leading to endothelium-dependent dilation. Hydrogen Peroxide 114-118 nitric oxide synthase 3, endothelial cell Mus musculus 64-97 19393613-10 2009 Further studies suggested that hydrogen peroxide promotes the exercise-induced increase of vascular eNOS expression and inhibits the release of endothelial progenitor cells induced by exercise training. Hydrogen Peroxide 31-48 nitric oxide synthase 3, endothelial cell Mus musculus 100-104 19805165-0 2009 Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Hydrogen Peroxide 55-72 nitric oxide synthase 3, endothelial cell Mus musculus 0-33 19805165-8 2009 Cellular imaging studies using the H(2)O(2) biosensor HyPer show that siRNA-mediated eNOS knockdown leads to a marked increase in intracellular H(2)O(2) generation, which is blocked by PEG-catalase. Hydrogen Peroxide 35-43 nitric oxide synthase 3, endothelial cell Mus musculus 85-89 18973548-6 2009 The effect of hydrogen peroxide on endothelial nitric oxide synthase expression in keratinocytes was examined using cultured keratinocytes. Hydrogen Peroxide 14-31 nitric oxide synthase 3, endothelial cell Mus musculus 35-68 19286591-0 2009 Flow-induced dilation is mediated by Akt-dependent activation of endothelial nitric oxide synthase-derived hydrogen peroxide in mouse cerebral arteries. Hydrogen Peroxide 107-124 nitric oxide synthase 3, endothelial cell Mus musculus 65-98 19286591-1 2009 BACKGROUND AND PURPOSE: Endothelial nitric oxide synthase produces superoxide under physiological conditions leading to hydrogen peroxide (H(2)O(2)) -dependent dilations to acetylcholine in isolated mouse cerebral arteries. Hydrogen Peroxide 120-137 nitric oxide synthase 3, endothelial cell Mus musculus 24-57 19286591-13 2009 CONCLUSIONS: In healthy C57Bl/6 mouse cerebral arteries, Akt-dependent activation of endothelial nitric oxide synthase-derived H(2)O(2) mediates flow-dependent dilation. Hydrogen Peroxide 127-135 nitric oxide synthase 3, endothelial cell Mus musculus 85-118 18973548-9 2009 In vitro, stimulation with hydrogen peroxide decreased the expression level of endothelial nitric oxide synthase in cultured keratinocytes, which was restored by the addition of N-acetylcysteine. Hydrogen Peroxide 27-44 nitric oxide synthase 3, endothelial cell Mus musculus 79-112 18973548-10 2009 CONCLUSION: Reactive oxygen species, such as hydrogen peroxide, are responsible for the alveolar bone loss accompanied by decreased endothelial nitric oxide synthase expression in KK-A(y) mice. Hydrogen Peroxide 45-62 nitric oxide synthase 3, endothelial cell Mus musculus 132-165 15621054-1 2005 OBJECTIVE: Recent studies from our groups have indicated that endothelial nitric oxide synthase (eNOS) expression is increased in cell culture by both shear stress and by hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 171-188 nitric oxide synthase 3, endothelial cell Mus musculus 62-95 15471976-10 2005 These data indicate that chronic oxidative stress caused by excessive H(2)O(2) production evokes a compensatory response involving increased eNOS expression and NO production. Hydrogen Peroxide 70-78 nitric oxide synthase 3, endothelial cell Mus musculus 141-145 15621054-1 2005 OBJECTIVE: Recent studies from our groups have indicated that endothelial nitric oxide synthase (eNOS) expression is increased in cell culture by both shear stress and by hydrogen peroxide (H(2)O(2)). Hydrogen Peroxide 171-188 nitric oxide synthase 3, endothelial cell Mus musculus 97-101 15621054-9 2005 CONCLUSIONS: These data suggest that endogenous H(2)O(2) plays a key role in the endothelial adaptation to exercise training by stimulating an up-regulation of eNOS. Hydrogen Peroxide 48-56 nitric oxide synthase 3, endothelial cell Mus musculus 160-164